Explanipedia

The Landscape of In Situ and Ex Situ Machine Perfusion Utilization for Liver Grafts From Noncardiac Donation After Circulatory Death Donors in the Early era of Machine Perfusion in the United States Open

Anji Wall, Jinyu Du, Matthew Snoddy, Johanna Bayer, Juan S. Danobeitia , et al. · 2025

Background. Donation after circulatory death (DCD) is the major contributor to the growth in deceased organ donation in the United States. Normothermic regional perfusion (NRP) and ex situ machine perfusion (es-MP) have been vital for impr…

Germline Variants Influence Chronic Liver Disease Progression through Distinct Pathways Open

Marijana Vujković, David E. Kaplan, Jonas Ghouse, Bao‐Li Loza, Joseph Brancale , et al. · 2025

Cirrhosis and hepatocellular carcinoma (HCC) are long-term complications of chronic liver disease (CLD). In this large multi-ancestry genome-wide association study of all-cause cirrhosis (35,481 cases, 2.36M controls) and HCC (6,680 cases,…

Application of Perfusion Technologies to Normothermic Regional Perfusion Procedures: State-of-the-Art Open

Conrad W. P. Fischbach, Kara Monday, Grant Richards, Giuliano Testa, Anji Wall · 2025

Purpose of the Review Add to existing literature regarding optimal perfusion strategies during normothermic regional perfusion organ (NRP) procurement based on a single-center experience. Recent Findings The literature surrounding perfusio…

Protocol for an international multicenter, prospective, observational, non-competitive, study to validate and optimise prediction models of 90-day and 1-year allograft failure after liver transplantation: The global IMPROVEMENT Study Open

A.W. Avolio, Gabriele Spoletini, Umberto Cillo, Kristopher P. Croome, Gabriel C. Oniscu , et al. · 2025

Donor-Specific Digital Twin for Living Donor Liver Transplant Recovery Open

Suvankar Halder, Michael C. Lawrence, Giuliano Testa, Vipul Periwal · 2025

Liver resection initiates a meticulously coordinated hyperplasia process characterized by regulated cell proliferation that drives liver regeneration. This process concludes with the complete restoration of liver mass, showcasing the preci…

Liver transplant program utilization of donation after circulatory death liver grafts by procurement technique and storage modality: a survey of US liver transplant surgical directors Open

Nazokat Otajonova, Eric Martinez, Amar Gupta, Johanna Bayer, Giuliano Testa , et al. · 2025

We found variability among transplant programs in DCD liver graft acceptance based on procuring surgeon, procurement technique, and storage modality. Quality and cost are two main barriers to DCD liver utilization, with the main tradeoffs …

Donor-specific digital twin for living donor liver transplant recovery Open

Suvankar Halder, Michael C. Lawrence, Giuliano Testa, Vipul Periwal · 2025

The remarkable capacity of the liver to regenerate its lost mass after resection makes living donor liver transplantation a successful treatment option. However, donor heterogeneity significantly influences recovery trajectories, highlight…

Genome-wide meta-analysis associates donor-recipient non-HLA genetic mismatch with acute cellular rejection post-liver transplantation Open

Lianne M. Nieuwenhuis, Yanni Li, Bao‐Li Loza, Annechien J.A. Lambeck, Shixian Hu , et al. · 2024

Background: Acute cellular rejection (ACR) remains a common complication causing significant morbidity post-liver transplantation. Non–human leukocyte antigen (non-HLA) mismatches were associated with an increased risk of ACR in kidney tra…

Uterus Transplant in Women With Absolute Uterine-Factor Infertility Open

Giuliano Testa, Greg J. McKenna, Anji Wall, Johanna Bayer, Anthony R. Gregg , et al. · 2024

Importance Uterus transplant in women with absolute uterine-factor infertility offers the possibility of carrying their own pregnancy. Objective To determine whether uterus transplant is feasible and safe and results in births of healthy i…

Robotic Living Donor Hysterectomy for Uterus Transplantation: An Update on Donor and Recipient Outcomes Open

Andrew Jacques, Giuliano Testa, Liza Johannesson · 2024

Background/Objectives: Uterus transplantation (UTx) has evolved into a clinical reality for women with absolute uterine infertility. The international experience with UTx has predominantly utilized living donor grafts—and strategies to min…

Exploring Divergent Views: A Comparative Study of Uterus Transplantation Perceptions among Transplant and Obstetrics/Gynecology Providers Open

Prema Vyas, Danielle Sader, Giuliano Testa, Jinyu Du, Anji Wall , et al. · 2024

Background: Uterus transplantation (UTx) provides women with absolute uterine-factor infertility (AUFI) the opportunity to carry their own pregnancy and deliver a child. There are multiple ethical and medical concerns associated with UTx. …

The Dallas Donation after Circulatory Death Transplantation Summit: expanding donation after circulatory death procedures through process improvement, broader utilization, and innovation Open

Michele Finotti, Anji Wall, Anthony M. D’Alessandro, Gary Schwartz, C.J. Sonnenday , et al. · 2024

Despite a significant increase in utilization over the past decade, the number of donation after circulatory death (DCD) organs that are procured and transplanted in the United States (US) remains well below its potential. There is still r…

Uterus transplantation: what the world’s religions have to say Open

Briget da Graca, Anji Wall, Giuliano Testa, Liza Johannesson · 2024

Uterus transplantation (UTx) has evolved from a purely experimental procedure to a clinical treatment option available outside the clinical trial context, offering women with absolute uterine-factor infertility an opportunity to experience…

Availability of Deceased Donors for Uterus Transplantation in the United States: Perception vs. Reality Open

Kathleen O’Neill, Elliott G. Richards, Jessica Walter, Sharon West, Richard Hasz , et al. · 2024

Uterus transplantation (UTx) is a rapidly evolving treatment for uterine factor infertility. New centers offering this treatment must decide whether to utilize living donors, deceased donors, or both. Although limiting UTx to deceased dono…

(043) Tensile Contention: A Novel Reconstructive Technique for Unstable Erections Secondary to Penile Suspensory Ligament (PSL) Deficiency Open

R Calopedos, Giuliano Testa, Anand K. Deva · 2024

Introduction PSL division remains the mainstay of cosmetic penile lengthening surgery. Its proponents argue that superficial PSL can be divided without risking erection destabilisation. However, there are multiple published reports on resu…

The ethics surrounding normothermic regional perfusion in donors following circulatory death Open

Anji Wall, Giuliano Testa · 2024

Persistence Pays Off: Live Birth after Uterus Transplant, Overcoming Recurrent Pregnancy Loss with Cerclage Placement Open

Liza Johannesson, Sophie Anderson, J. Michael Putman, Robert T. Gunby, Lilly Zhang , et al. · 2023

Recipients of uterus transplantation have unique factors that may increase their risk of cervical insufficiency. This report describes a uterus transplant recipient with cervical insufficiency resulting in two second-trimester miscarriages…

Improved Quality of Life Among Chronic Pancreatitis Patients Undergoing Total Pancreatectomy With Islet Autotransplantation—Single Center Experience With Large Cohort of Patients Open

Mariagrazia Coluzzi, Morihito Takita, Giovanna Saracino, Abdul Rub Hakim Mohammed, Carly M. Darden , et al. · 2023

Total pancreatectomy with islet autotransplantation (TPIAT) is the treatment of choice to preserve pancreatic endocrine function, alleviate pain, and improve quality of life (QoL) when other strategies are ineffective for chronic pancreati…

Persistence Pays Off: Live Birth after Uterus Transplant, Over-coming Recurrent Pregnancy Loss with Cerclage Placement Open

Liza Johannesson, Sophie Anderson, J. Michael Putman, Robert T. Gunby, Lilly Zhang , et al. · 2023

Recipients of uterus transplantation have unique factors that may increase their risk of cervical insufficiency. This report describes a uterus transplant recipient with cervical insufficiency resulting in two second-trimester miscarriages…

An Approach to Anesthetic Management of Venous Anomalies and Outflow Reconstruction in Liver Transplants Open

Hamza Malick, Sabine Itani, Daniel C Gunn, Amar Gupta, Giuliano Testa , et al. · 2023

Hepatic venous outflow is a pivotal factor in liver transplant. However, venous anomalies and the potential for hepatic venous congestion continue to remain major points of concern to ensure the viability of transplanted livers and maximiz…

Long-term outcomes (beyond 5 years) of liver transplant recipients—A transatlantic multicenter study Open

Naaventhan Palaniyappan, Emily Peach, Fiona Pearce, Amritpal Dhaliwal, Isabel Campos‐Varela , et al. · 2023

The long-term (>5 y) outcomes following liver transplantation (LT) have not been extensively reported. The aim was to evaluate outcomes of LT recipients who have survived the first 5 years. A multicenter retrospective analysis of prospecti…

A Multi-Institutional Report of Intermediate-Term Kidney Outcomes in Uterus Transplant Recipients Open

Liza Johannesson, Deirdre Sawinski, David M. Vock, Jakub Křístek, Jiří Froněk , et al. · 2023

Uterus transplant (UTx) is a treatment for uterine factor infertility (UFI). Globally, the number of UTx recipients is increasing (1Brannstrom M, Tulius SG, Brucker S et al. Registry of the International Society of Uterus Transplantation: …

Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US Open

Liza Johannesson, Giuliano Testa, Menas M. Beshara, Briget da Graca, Jessica Walter , et al. · 2023

This study describes the characteristics of women who contacted an active program performing uterus transplantation (UTx) in the US, expressing interest in becoming a uterus transplant recipient or a living donor. Basic demographic and sel…

Awareness and Interest in Uterus Transplantation Over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US Open

Liza Johannesson, Giuliano Testa, Menas M Beshara, Briget DaGraca, Jessica Walter , et al. · 2023

This study describes the characteristics of women who contacted an active program performing uterus transplantation (UTx) in the US expressing interest in becoming a uterus transplant recipient or a living donor. Basic demographic and self…

How Surgical Research Gave Birth to a New Clinical Surgical Field: A Viewpoint from the Dallas Uterus Transplant Study Open

Liza Johannesson, Giuliano Testa, Briget da Graca, Anji Wall · 2023

Background: Uterus transplantation (UTx) has come of age in the 21st century, building on the 20th century developments in vascular anastomosis and effective immunosuppressive protocols that have enabled solid organ transplantation to beco…

The carbon footprint of organ acquisition in the United States Open

Anji Wall, Trevor Borries, Vikrant Reddy, Sumeet K. Asrani, Giuliano Testa , et al. · 2022

Assessment of donor quality and risk of graft failure after liver transplantation: The ID2EAL score Open

Sumeet K. Asrani, Giovanna Saracino, Anji Wall, James F. Trotter, Giuliano Testa , et al. · 2022

Research Outcomes Following Uterus Transplantation at Royal Prince Alfred Hospital Open

Dana Georgevsky, Ying Li, Selvan Pather, Trevor TEJADAS-BERGES, David Robinson , et al. · 2022

Background: Absolute Uterine Factor infertility (AUFI) can be congenital such as Mayer-Rokitansky Küster syndrome (MRKH), or acquired resulting from conditions rendering the uterus non-functional or following a hysterectomy. In 2014 the fi…

Uterus Transplantation and Pregnancy Induction: An Approved Protocol at Royal Prince Alfred Hospital (RPA) Open

Dana Georgevsky, Ying Li, Selvan Pather, Trevor TEJADAS-BERGES, David Robinson , et al. · 2022

Background: Absolute Uterine Factor infertility (AUFI) can be congenital such as Mayer-Rokitansky Küster syndrome (MRKH), or acquired resulting from conditions rendering the uterus non-functional or hysterectomy. Prior to the year 2014, wo…

Uterus Transplantation and Pregnancy Induction: An Approved Protocol at Royal Prince Alfred Hospital (RPA) Open

Dana Georgevsky, Ying Li, Selvan Pather, Trevor TEJADAS-BERGES, David Robinson , et al. · 2022

Background: Absolute Uterine Factor infertility (AUFI) can be congenital such as Mayer-Rokitansky Küster syndrome (MRKH), or acquired resulting from conditions rendering the uterus non-functional or hysterectomy. Prior to the year 2014, wo…

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