F.V. Murphy
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View article: RAPD2: Rapid Automated Processing of Macromolecular Crystallographic Data 2
RAPD2: Rapid Automated Processing of Macromolecular Crystallographic Data 2 Open
RAPD2 is a modular package of programs written for the automated processing of macromolecular crystallographic data at the NE-CAT beamlines. It monitors for collected data, processes snapshots to create strategies for data collection, proc…
View article: Structural evidence for metal ion catalysis in the ribosome
Structural evidence for metal ion catalysis in the ribosome Open
Ribosomes synthesize proteins with an RNA-only active site across all kingdoms of life. Yet, despite decades of high-resolution ribosome structures, the precise catalytic mechanism has remained elusive. Here, we provide structural evidence…
View article: Data analysis in real time with <i>RAPDv2.0</i>
Data analysis in real time with <i>RAPDv2.0</i> Open
RAPD is a modular package of programs written for the automated processing of macromolecular crystallographic data at the NE-CAT beamlines.It watches for collected data, processes snapshots to create strategies for data collection, integra…
View article: NE-CAT: crystallography beamlines for challenging structural biology research
NE-CAT: crystallography beamlines for challenging structural biology research Open
The NorthEastern Collaborative Access Team (NE-CAT) focuses on the design and operation of synchrotron X-ray beamlines for the solution of technically challenging structural biology problems and provides an important resource for the natio…
View article: International Philosophy Olympiad
International Philosophy Olympiad Open
In Plato's Thaetetus, Socrates tells his student that "…wonder is the feeling of a philosopher, and philosophy begins in wonder."This wonder can be either puzzlement or fundamental curiosity about the nature of our world and the meaning of…
View article: Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization–Fragmentation Reaction Sequence
Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization–Fragmentation Reaction Sequence Open
Geosmin synthase from Streptomyces coelicolor (ScGS) catalyzes an unusual, metal-dependent terpenoid cyclization and fragmentation reaction sequence. Two distinct active sites are required for catalysis: the N-terminal domain catalyzes the…
View article: 107 Modifications modulate anticodon loop dynamics and codon recognition in<i>E. coli</i>tRNA<sup>Arg1,2</sup>
107 Modifications modulate anticodon loop dynamics and codon recognition in<i>E. coli</i>tRNA<sup>Arg1,2</sup> Open
In Escherichia coli, three of six arginine codons (CGU, CGC and CGA) are decoded by only two tRNAArg isoacceptors. The anticodon-stem loop (ASL) domains of tRNAArg1 and tRNAArg2 differ only at posi...