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View article: Organoides como modelos experimentales para estudiar la resistencia a los antibióticos: hallazgos prácticos y perspectivas futuras
Organoides como modelos experimentales para estudiar la resistencia a los antibióticos: hallazgos prácticos y perspectivas futuras Open
Antibiotic resistance remains a major global health challenge, demanding advanced models to study microbial dynamics and host responses. This study explores the use of intestinal and pulmonary organoids as experimental systems to evaluate …
View article: COVID-19 Related Encephalopathy
COVID-19 Related Encephalopathy Open
SARS-CoV-2 infection can present with neurological symptoms due to direct or indirect invasion of the central nervous system. There are many hypotheses of why this happens, focusing on systemic inflammation, cytokines and cells, but none o…
View article: Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations
Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations Open
The predictive value of traditional cardiovascular risk estimators is limited, and young and elderly populations are particularly underrepresented. We aimed to investigate the urine metabolome and its association with cardiovascular risk t…
View article: Molecular evidence of field cancerization initiated by diabetes in colon cancer patients
Molecular evidence of field cancerization initiated by diabetes in colon cancer patients Open
The potential involvement of type 2 diabetes mellitus (T2 DM ) as a risk factor for colon cancer ( CC ) has been previously reported. While several clinical studies show a higher incidence of CC and a lower survival rate in diabetics, othe…
View article: Potential role of new molecular plasma signatures on cardiovascular risk stratification in asymptomatic individuals
Potential role of new molecular plasma signatures on cardiovascular risk stratification in asymptomatic individuals Open
The evaluation of cardiovascular (CV) risk is based on equations derived from epidemiological data in individuals beyond the limits of middle age such as the Framingham and SCORE risk assessments. Lifetime Risk calculator (QRisk ® ), estim…
View article: A comprehensive study of calcific aortic stenosis: from rabbit to human samples
A comprehensive study of calcific aortic stenosis: from rabbit to human samples Open
The global incidence of calcific aortic stenosis (CAS) is increasing due, in part, to a growing elderly population, and poses a great challenge to public health because of the multiple comorbidities of these patients. Using a rabbit model …
View article: Progression of Renal Insufficiency in Patients with Essential Hypertension Treated with Renin Angiotensin Aldosterone System Blockers: An Electrocardiographic Correlation
Progression of Renal Insufficiency in Patients with Essential Hypertension Treated with Renin Angiotensin Aldosterone System Blockers: An Electrocardiographic Correlation Open
Background: There is a frequent association between renal insufficiency and cardiovascular disease in patients with essential hypertension (HTN). The aim of this study was to analyze the relationship between ECG parameters and the progress…
View article: Endothelial Regulator of Calcineurin 1 Promotes Barrier Integrity and Modulates Histamine-Induced Barrier Dysfunction in Anaphylaxis
Endothelial Regulator of Calcineurin 1 Promotes Barrier Integrity and Modulates Histamine-Induced Barrier Dysfunction in Anaphylaxis Open
Anaphylaxis, the most serious and life-threatening allergic reaction, produces the release of inflammatory mediators by mast cells and basophils. Regulator of calcineurin 1 (Rcan1) is a negative regulator of mast-cell degranulation. The ac…
View article: Citric Acid Metabolism in Resistant Hypertension
Citric Acid Metabolism in Resistant Hypertension Open
Resistant hypertension (RH) affects 9% to 12% of hypertensive adults. Prolonged exposure to suboptimal blood pressure control results in end-organ damage and cardiovascular risk. Spironolactone is the most effective drug for treatment, but…
View article: Urinary exosomes reveal protein signatures in hypertensive patients with albuminuria
Urinary exosomes reveal protein signatures in hypertensive patients with albuminuria Open
Albuminuria is an indicator of cardiovascular risk and renal damage in hypertensive individuals. Chronic renin-angiotensin system (RAS) suppression facilitates blood pressure control and prevents development of new-onset-albuminuria. A sig…
View article: Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria
Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria Open
Despite of the great advances in anti-hypertensive therapies, many patients under Renin-Angiotensin- System (RAS) suppression develop albuminuria, which is a clear indicator of therapeutic inefficiency. Hence, indicators of vascular functi…
View article: 2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implications
2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implications Open
Worldwide deaths from diabetes mellitus (DM) and colorectal cancer increased by 90% and 57%, respectively, over the past 20 years. The risk of colorectal cancer was estimated to be 27% higher in patients with type 2 DM than in non-diabetic…
View article: Plasma Molecular Signatures in Hypertensive Patients With Renin–Angiotensin System Suppression
Plasma Molecular Signatures in Hypertensive Patients With Renin–Angiotensin System Suppression Open
Albuminuria is a risk factor strongly associated with cardiovascular disease, the first cause of death in the general population. It is well established that renin–angiotensin system suppressors prevent the development of new-onset albumin…
View article: Urinary Kininogen-1 and Retinol binding protein-4 respond to Acute Kidney Injury: predictors of patient prognosis?
Urinary Kininogen-1 and Retinol binding protein-4 respond to Acute Kidney Injury: predictors of patient prognosis? Open
Implementation of therapy for acute kidney injury (AKI) depends on successful prediction of individual patient prognosis. Clinical markers as serum creatinine (sCr) have limitations in sensitivity and early response. The aim of the study w…
View article: Urinary alpha-1 antitrypsin and CD59 glycoprotein predict albuminuria development in hypertensive patients under chronic renin-angiotensin system suppression
Urinary alpha-1 antitrypsin and CD59 glycoprotein predict albuminuria development in hypertensive patients under chronic renin-angiotensin system suppression Open
CD59 and AAT proteins are significantly altered in hypertensive patients developing albuminuria. Interestingly, CD59 and AAT are able to predict, in normoalbuminuric individuals, who will develop albuminuria in the future, being potential …