Fabrice Wendling
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View article: Deep learning on high-density EEG during a cognitive task distinguishes patients with Parkinson’s disease from healthy controls
Deep learning on high-density EEG during a cognitive task distinguishes patients with Parkinson’s disease from healthy controls Open
Objective. Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, including cognitive impairment. Its diagnosis, which used to be based on clinical assessment, increasingly relies on biomark…
View article: Personalized Whole-Brain Models of Seizure Propagation
Personalized Whole-Brain Models of Seizure Propagation Open
Objective: Computational modeling has recently emerged as a powerful tool to better understand seizure dynamics and guide new treatment strategies. This work aims to develop and personalize whole-brain computational models in epilepsy usin…
View article: Personalized multichannel transcranial direct current electrical stimulation ( <scp>tDCS</scp> ) in drug‐resistant epilepsy: A <scp>SEEG</scp> based open‐labeled study
Personalized multichannel transcranial direct current electrical stimulation ( <span>tDCS</span> ) in drug‐resistant epilepsy: A <span>SEEG</span> based open‐labeled study Open
Objective To evaluate the effects of personalized multichannel tDCS on seizure frequency, severity, quality of life, and psychiatric comorbidities in patients with drug‐resistant focal epilepsy. Secondary goals include assessing the safety…
View article: Computational modeling of frequency-dependent neocortical response to thalamic neurostimulation in epilepsy
Computational modeling of frequency-dependent neocortical response to thalamic neurostimulation in epilepsy Open
The therapeutic application of centromedian nucleus stimulation (CMS) has been limited by uncertainties regarding its mechanism of action. In this study, we used stereoelectro-encephalography (SEEG) signals recorded from a patient with ref…
View article: Auditory evoked delta brushes involve stimulus-specific cortical networks in preterm infants
Auditory evoked delta brushes involve stimulus-specific cortical networks in preterm infants Open
View article: NeoCoMM: Neocortical neuro-inspired computational model for realistic microscale simulations
NeoCoMM: Neocortical neuro-inspired computational model for realistic microscale simulations Open
International audience
View article: Epileptogenic zone characteristics determine effectiveness of electrical transcranial stimulation in epilepsy treatment
Epileptogenic zone characteristics determine effectiveness of electrical transcranial stimulation in epilepsy treatment Open
Transcranial direct current stimulation shows promise as a non-invasive therapeutic method for patients with focal drug-resistant epilepsy. However, there is considerable variability in individual responses to transcranial direct current s…
View article: Local and network changes after multichannel transcranial direct current stimulation using magnetoencephalography in patients with refractory epilepsy
Local and network changes after multichannel transcranial direct current stimulation using magnetoencephalography in patients with refractory epilepsy Open
These results provide valuable insights into tDCS effects on epileptic brain networks, informing future clinical applications in epilepsy treatment.
View article: Expansion of epileptogenic networks via neuroplasticity in neural mass models
Expansion of epileptogenic networks via neuroplasticity in neural mass models Open
Neuroplasticity refers to functional and structural changes in brain regions in response to healthy and pathological activity. Activity dependent plasticity induced by epileptic activity can involve healthy brain regions into the epileptog…
View article: Localization of the epileptogenic network from scalp EEG using a patient-specific whole-brain model
Localization of the epileptogenic network from scalp EEG using a patient-specific whole-brain model Open
Computational modeling is a key tool for elucidating the neuronal mechanisms underlying epileptic activity. Despite considerable progress, existing models often lack realistic accuracy in representing electrophysiological epileptic activit…
View article: Transition to seizure in focal epilepsy: From <scp>SEEG</scp> phenomenology to underlying mechanisms
Transition to seizure in focal epilepsy: From <span>SEEG</span> phenomenology to underlying mechanisms Open
Objective For the pre‐surgical evaluation of patients with drug‐resistant focal epilepsy, stereo‐electroencephalographic (SEEG) signals are routinely recorded to identify the epileptogenic zone network (EZN). This network consists of remot…
View article: eCOALIA: Neocortical neural mass model for simulating electroencephalographic signals
eCOALIA: Neocortical neural mass model for simulating electroencephalographic signals Open
View article: NeoCoMM: A neocortical neuroinspired computational model for the reconstruction and simulation of epileptiform events
NeoCoMM: A neocortical neuroinspired computational model for the reconstruction and simulation of epileptiform events Open
The model (NeoCoMM) presented in this work can be of great use in different applications since it offers an in silico framework for sensitivity analysis and hypothesis testing. It can also be used as a starting point for more complex studi…
View article: Whole-brain simulation of interictal epileptic discharges for patient-specific interpretation of interictal SEEG data
Whole-brain simulation of interictal epileptic discharges for patient-specific interpretation of interictal SEEG data Open
In patients with refractory epilepsy, the clinical interpretation of stereoelectroencephalographic (SEEG) signals is crucial to delineate the epileptogenic network that should be targeted by surgery. We propose a pipeline of patient-specif…
View article: Realistic subject-specific simulation of resting state scalp EEG based on physiological model
Realistic subject-specific simulation of resting state scalp EEG based on physiological model Open
Electroencephalography (EEG) recordings are widely used in neuroscience to identify individual-specific signatures. Understanding the cellular origins of scalp EEG signals and their spatiotemporal changes during resting state (RS) in human…
View article: Effects of tACS-induced phase entrainment in cortical neuronal models
Effects of tACS-induced phase entrainment in cortical neuronal models Open
International audience
View article: NeoCoMM: Neocortical Computational Microscale Model
NeoCoMM: Neocortical Computational Microscale Model Open
The Neocortical Computational Microscale model (NeoCoMM) is a unique neurophysiologically-inspired software. It offers a friendly graphical user interface that allows for the simulation of the intracellular and extracellular neural activit…
View article: Modification of brain conductivity in human focal epilepsy: A model‐based estimation from stereoelectroencephalography
Modification of brain conductivity in human focal epilepsy: A model‐based estimation from stereoelectroencephalography Open
Objective We have developed a novel method for estimating brain tissue electrical conductivity using low‐intensity pulse stereoelectroencephalography (SEEG) stimulation coupled with biophysical modeling. We evaluated the hypothesis that br…
View article: Multiscale neuro-inspired models for interpretation of EEG signals in patients with epilepsy
Multiscale neuro-inspired models for interpretation of EEG signals in patients with epilepsy Open
These models are likely to play a key role in the mechanistic interpretation of epileptiform activity.
View article: Expansion of epileptogenic networks via neuroplasticity
Expansion of epileptogenic networks via neuroplasticity Open
View article: Large-scale simulation of interictal epileptic discharges with neural mass models: patient specific interpretation of the interictal SEEG data
Large-scale simulation of interictal epileptic discharges with neural mass models: patient specific interpretation of the interictal SEEG data Open
In patients with refractory epilepsy, the clinical interpretation of stereoelectroencephalographic (SEEG) signals is crucial to delineate the epileptogenic network that should be targeted by surgery. We propose a pipeline of patient-specif…
View article: Tuning the Physically Induced Crystallinity of Microfabricated Bioresorbable Guides for Insertion of Flexible Neural Implants
Tuning the Physically Induced Crystallinity of Microfabricated Bioresorbable Guides for Insertion of Flexible Neural Implants Open
Devices that safely interface with the brain are critical to advancing neuroengineering. Thin and flexible neural implants show great promise alongside established silicon technologies. They therefore require a physical stiffener to allow …
View article: Tuning Microelectrodes’ Impedance to Improve Fast Ripples Recording
Tuning Microelectrodes’ Impedance to Improve Fast Ripples Recording Open
Epilepsy is a chronic neurological disorder characterized by recurrent seizures resulting from abnormal neuronal hyperexcitability. In the case of pharmacoresistant epilepsy requiring resection surgery, the identification of the Epileptoge…
View article: NeoCOMM: A Neocortical Neuroinspired Computational Model for the Reconstruction and Simulation of Epileptiform Events
NeoCOMM: A Neocortical Neuroinspired Computational Model for the Reconstruction and Simulation of Epileptiform Events Open
Understanding the pathophysiological dynamics which underline interictal epileptiform events (IEEs) such as epileptic spikes, spike-and-waves or High-frequency oscillations (HFOs) is of major importance in the context of neocortical refrac…
View article: Neocomm: Neocortical Neuro-Inspired Computational Model for Realistic Microscale Simulations
Neocomm: Neocortical Neuro-Inspired Computational Model for Realistic Microscale Simulations Open
View article: Frequency-dependent phase entrainment of cortical cell types during tACS: Converging modeling evidence
Frequency-dependent phase entrainment of cortical cell types during tACS: Converging modeling evidence Open
Background: Transcranial alternating current stimulation (tACS) enables non-invasive modulation of brain activity, holding promise for clinical and research applications. Yet, it remains unclear how the stimulation frequency affects variou…
View article: Tuning Microelectrodes Impedance to Improve Fast Ripples Recording
Tuning Microelectrodes Impedance to Improve Fast Ripples Recording Open
Epilepsy is a chronic neurological disorder characterized by recurring seizures resulting from abnormal neuronal hyperexcitability. In the case of pharmacoresistant epilepsy requiring resection surgery, identifying the epileptogenic zone (…
View article: Spontaneous fast‐ultradian dynamics of polymorphic interictal events in drug‐resistant focal epilepsy
Spontaneous fast‐ultradian dynamics of polymorphic interictal events in drug‐resistant focal epilepsy Open
Objective We studied the rate dynamics of interictal events occurring over fast‐ultradian time scales, as commonly examined in clinics to guide surgical planning in epilepsy. Methods Stereo‐electroencephalography (SEEG) traces of 35 patien…
View article: Biophysical modeling of the electric field magnitude and distribution induced by electrical stimulation with intracerebral electrodes
Biophysical modeling of the electric field magnitude and distribution induced by electrical stimulation with intracerebral electrodes Open
Intracranial electrodes are used clinically for diagnostic or therapeutic purposes, notably in drug-refractory epilepsy (DRE) among others. Visualization and quantification of the energy delivered through such electrodes is key to understa…
View article: Spontaneous fast-ultradian dynamics of polymorphic interictal events in drug-resistant focal epilepsy
Spontaneous fast-ultradian dynamics of polymorphic interictal events in drug-resistant focal epilepsy Open
Objective We studied the rate dynamics of interictal events occurring over fast-ultradian time scales, as commonly examined in clinics to guide surgical planning in epilepsy. Methods Stereoelectroencephalography (SEEG) traces of 35 patient…