Yunfei Chen
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View article: In vitro and in vivo hemocompatibility study of fish swim bladder-derived biomaterials for the application of chronic venous disease
In vitro and in vivo hemocompatibility study of fish swim bladder-derived biomaterials for the application of chronic venous disease Open
Chronic venous disease (CVD) is a prevalent condition affecting the venous system of the lower limbs, characterized by venous hypertension and regurgitation resulting from congenital or acquired venous valve insufficiency. The global morbi…
View article: Proteomic characterization of neuronal extracellular vesicle interactomes in Alzheimer’s disease mouse model through TurboID-based proximity labeling
Proteomic characterization of neuronal extracellular vesicle interactomes in Alzheimer’s disease mouse model through TurboID-based proximity labeling Open
Extracellular vesicles (EVs) are critical mediators of neuronal communication and have been implicated in propagating pathological processes in neurodegenerative diseases, including Alzheimer’s disease (AD). However, the molecular interact…
View article: Operating State Analysis of Asymmetric Reactive Power Compensator via Data Mining
Operating State Analysis of Asymmetric Reactive Power Compensator via Data Mining Open
Given the inadequacies in the management of reactive power compensation equipment in distribution networks and insufficient power data mining, existing studies pay little attention to asymmetric reactive power compensation equipment and fa…
View article: Einstein Probe Discovery of EP J182730.0−095633: A New Black Hole X-Ray Binary Candidate in Faint Outburst?
Einstein Probe Discovery of EP J182730.0−095633: A New Black Hole X-Ray Binary Candidate in Faint Outburst? Open
Black hole X-ray binaries (candidates) currently identified in our Galaxy are mainly transient sources, with the majority discovered through the detection of their X-ray outbursts. Among these, only four were found during faint outbursts e…
View article: RSK1 reprograms the ubiquitin pathway to promote immune suppression
RSK1 reprograms the ubiquitin pathway to promote immune suppression Open
Although immune checkpoint blockade (ICB) is an effective therapeutic strategy, tumor intrinsic resistance to ICB limits its benefits for a majority of cancer patients. Via multiple in vivo screens, we identified RNF19A as an immune suppre…
View article: Hydrogeochemical Processes and Sustainability Challenges of Arsenic- and Fluoride-Contaminated Groundwater in Arid Regions: Evidence from the Tarim Basin, China
Hydrogeochemical Processes and Sustainability Challenges of Arsenic- and Fluoride-Contaminated Groundwater in Arid Regions: Evidence from the Tarim Basin, China Open
The anomalous enrichment of arsenic (As) and fluoride (F) in groundwater in the oasis area at the southern margin of the Tarim Basin has become a critical environmental and sustainability challenge. It poses not only potential health risks…
View article: Decoding the tumor immune microenvironment in lung squamous cell carcinoma: characteristics, regulatory mechanisms, and future directions in immunotherapy
Decoding the tumor immune microenvironment in lung squamous cell carcinoma: characteristics, regulatory mechanisms, and future directions in immunotherapy Open
Lung squamous cell carcinoma (LUSC), a predominant type of lung cancer, is marked by an unfavorable prognosis and limited therapeutic options. Unlike lung adenocarcinoma (LUAD), LUSC exhibits few driver mutations, resulting in minimal bene…
View article: Dose-optimised recombinant human thrombopoietin versus eltrombopag in patients with immune thrombocytopenia: a multicenter, randomised controlled trial (The TE-ITP Study)
Dose-optimised recombinant human thrombopoietin versus eltrombopag in patients with immune thrombocytopenia: a multicenter, randomised controlled trial (The TE-ITP Study) Open
This trial was supported by grants from the CAMS Innovation Fund for Medical Sciences (CIFMS) (2023-I2M-2-007), Noncommunicable Chronic Diseases-National Science and Technology Major Project (2023ZD0500803), National Natural Science Founda…
View article: Toward the Thermoelectric ZT Limit via the Quantification of Interface‐Driven Carrier Sorting
Toward the Thermoelectric ZT Limit via the Quantification of Interface‐Driven Carrier Sorting Open
Interfacial engineering is a promising strategy to enhance thermoelectric performance, but identifying and optimizing the interfacial carrier transport mechanisms required to approach the theoretical ZT limit remains challenging. Here, a u…
View article: Einstein Probe Discovery of EP J182730.0-095633: A New Black Hole X-ray Binary Candidate in Faint Outburst?
Einstein Probe Discovery of EP J182730.0-095633: A New Black Hole X-ray Binary Candidate in Faint Outburst? Open
Black hole X-ray binaries (candidates) currently identified in our galaxy are mainly transient sources, with the majority discovered through the detection of their X-ray outbursts. Among these, only four were found during faint outbursts e…
View article: Scutellarin mitigates LPS-ATP-induced cardiomyocyte pyroptosis through the inhibition of the NLRP3/caspase-1/GSDMD signalling pathway
Scutellarin mitigates LPS-ATP-induced cardiomyocyte pyroptosis through the inhibition of the NLRP3/caspase-1/GSDMD signalling pathway Open
Scutellarin has a good myocardial protective effect. However, the underlying mechanism of scutellarin on cardiomyocyte pyroptosis remains unclear. In this study, we elucidated the mechanism of scutellarin to protect the injured myocardium.…
View article: Efficacy and safety of first-line PD-1/PD-L1 inhibitors combined with or without anti-angiogenesis therapy for extensive-stage small-cell lung cancer: a network meta-analysis
Efficacy and safety of first-line PD-1/PD-L1 inhibitors combined with or without anti-angiogenesis therapy for extensive-stage small-cell lung cancer: a network meta-analysis Open
Background: Immune checkpoint inhibitors (ICIs) combined with chemotherapy, with or without angiogenesis inhibitors, have been investigated as the first-line treatment for extensive-stage small-cell lung cancer (ES-SCLC). However, it remai…
View article: A four gene risk score model for prognosis and immune microenvironment insights in small cell lung cancer based on CAF functional-related genes
A four gene risk score model for prognosis and immune microenvironment insights in small cell lung cancer based on CAF functional-related genes Open
Small cell lung cancer (SCLC) is still one of the most formidable challenges in oncology. In this study, we introduce an innovative risk scoring model rooted in cancer-associated fibroblast (CAF)-related functional genes, designed to predi…
View article: Moiré Energy Dissipation Driven by Nonlinear Dynamics
Moiré Energy Dissipation Driven by Nonlinear Dynamics Open
The moiré superlattice in twisted van der Waals heterostructures is of central importance for the modulation of the electronic and optical properties of the system, yet the mechanical dissipation of such moiré systems remains largely unexp…
View article: Corrigendum: Advances in application of hypoxia-preconditioned mesenchymal stem cell-derived exosomes
Corrigendum: Advances in application of hypoxia-preconditioned mesenchymal stem cell-derived exosomes Open
[This corrects the article DOI: 10.3389/fcell.2024.1446050.].
View article: Study on internal resistance of Li-ion power battery
Study on internal resistance of Li-ion power battery Open
Purpose The internal resistance of a single power lithium-ion battery is an important representation of its power characteristics. When the current flows through a single battery with high internal resistance, the amount of heat generated …
View article: <scp>YBX1</scp> Modulates Intimal Hyperplasia by Regulating Expression and Alternative Splicing of Cell Cycle Associated Genes in <scp>RASMCs</scp>
<span>YBX1</span> Modulates Intimal Hyperplasia by Regulating Expression and Alternative Splicing of Cell Cycle Associated Genes in <span>RASMCs</span> Open
YBX1, a DNA‐/RNA‐binding protein, is implicated in various diseases, yet its role in intimal hyperplasia (IH) remains unclear. This study investigates YBX1's function in rat aortic smooth muscle cells (RASMCs) through knockdown experiments…
View article: Achieving impact-buffered compressible batteries through 3D printing-assisted design of negative Poisson's ratio structural electrodes
Achieving impact-buffered compressible batteries through 3D printing-assisted design of negative Poisson's ratio structural electrodes Open
Deformable batteries with compressive and impact-buffered abilities are essential for enhancing battery safety. However, existing compressible electrodes often face limited physical deformation and generate high stress, leading to package …
View article: Dihydromyricetin: an emerging compound with comprehensive effects on multiple systems
Dihydromyricetin: an emerging compound with comprehensive effects on multiple systems Open
Dihydromyricetin (DHM or DMY) is a flavonoid derived from natural sources with a range of confirmed biological benefits. It exhibits anti-inflammatory, antioxidant, anti-tumor, and anti-viral activities. DHM is recognized for its high bios…
View article: P1058 Trajectories of response in patients with moderately-to-severely active Crohn’s disease treated with mirikizumab based on biofailed status: Post hoc results from the VIVID-1 study
P1058 Trajectories of response in patients with moderately-to-severely active Crohn’s disease treated with mirikizumab based on biofailed status: Post hoc results from the VIVID-1 study Open
Background Mirikizumab, an anti-IL-23p19 antibody, demonstrated robust efficacy in improving clinical and endoscopic endpoints with an acceptable safety profile1. We explored the trajectory of response to treatment in patients with moderat…
View article: Profiling the impact of different tau species on glial cell biology.
Profiling the impact of different tau species on glial cell biology. Open
Our findings reveal that different patterns of tau accumulation elicit fundamentally distinct glial responses. Insoluble tau deposition (P301L) primarily triggers microglial inflammatory pathways without substantial metabolic disruption, s…
View article: P1122 Identification of responder subpopulations in moderately-to-severely active Crohn’s disease patients treated with mirikizumab: Results from the VIVID-1 study
P1122 Identification of responder subpopulations in moderately-to-severely active Crohn’s disease patients treated with mirikizumab: Results from the VIVID-1 study Open
Background Mirikizumab (MIRI), an anti-IL-23p19 antibody, demonstrated robust efficacy in improving clinical and endoscopic endpoints with an acceptable safety profile in IBD1. Bowel urgency is common and impactful among patients with Croh…
View article: P0833 Trajectories of response in patients with moderately-to-severely active Crohn’s disease treated with mirikizumab or ustekinumab: Post hoc results from the VIVID-1 study
P0833 Trajectories of response in patients with moderately-to-severely active Crohn’s disease treated with mirikizumab or ustekinumab: Post hoc results from the VIVID-1 study Open
Background Mirikizumab (MIRI), an anti-IL-23p19 antibody, demonstrated robust efficacy in improving clinical and endoscopic endpoints with an acceptable safety profile1. In patients with moderate-to-severely active Crohn’s disease (CD), we…
View article: Phononic insights into sliding friction
Phononic insights into sliding friction Open
Traditionally, the friction force has been the benchmark for quantifying energy dissipation in frictional phenomena. In this study, we introduce an atomic chain friction model that illuminates the conversion of kinetic energy into potentia…