Francesca Zimetti
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View article: Mechanisms, Mediators, and Pharmacological Approaches Targeting Brain Cholesterol Transport in Alzheimer's Disease
Mechanisms, Mediators, and Pharmacological Approaches Targeting Brain Cholesterol Transport in Alzheimer's Disease Open
Cholesterol transport within the brain represents a highly regulated process essential for maintaining neuronal function and central nervous system (CNS) homeostasis. Unlike peripheral tissues, the brain relies on in situ cholesterol synth…
View article: Pro-Inflammatory and Lipid Metabolism Dysregulating Effects of ANGPTL3 in THP-1 Macrophages
Pro-Inflammatory and Lipid Metabolism Dysregulating Effects of ANGPTL3 in THP-1 Macrophages Open
Background and aim: ANGPTL3 is a hepatokine acting as a negative regulator of lipoprotein lipase (LPL) through its N-terminal domain. Besides this activity, the C-terminal domain of ANGPTL3 interacts with integrin αVβ3. Since integrins are…
View article: In vivo MTD study of new potential inhibitors of Proprotein Convertase Subtilisin/Kexin 9 (PCSK9)
In vivo MTD study of new potential inhibitors of Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Open
Aim: This study aims to determine the in vivo safety of newly synthesized PCSK9 inhibitors (MR-compounds). PCSK9 controls peripheral and central cholesterol levels and it plays a crucial role in hypercholesterolemia, being a well-establish…
View article: Anti-atherosclerotic effects of natural compounds targeting lipid metabolism and inflammation: Focus on PPARs, LXRs, and PCSK9
Anti-atherosclerotic effects of natural compounds targeting lipid metabolism and inflammation: Focus on PPARs, LXRs, and PCSK9 Open
A large body of evidence has shown that modulation of the nuclear receptors peroxisome proliferator-activated receptors (PPARs), the liver X receptors (LXRs), the proprotein convertase subtilisin/kexin type 9 (PCSK9) and inflammatory proce…
View article: Changes in serum cholesterol loading capacity are linked to coronary atherosclerosis progression in rheumatoid arthritis
Changes in serum cholesterol loading capacity are linked to coronary atherosclerosis progression in rheumatoid arthritis Open
Objective Excess cholesterol loading on arterial macrophages is linked to foam cell formation, atherosclerosis and cardiovascular risk in rheumatoid arthritis (RA). However, the effect of changes in cholesterol loading on coronary plaque t…
View article: Supplementation of Seaweed Extracts to the Diet Reduces Symptoms of Alzheimer’s Disease in the APPswePS1ΔE9 Mouse Model
Supplementation of Seaweed Extracts to the Diet Reduces Symptoms of Alzheimer’s Disease in the APPswePS1ΔE9 Mouse Model Open
We previously demonstrated that diet supplementation with seaweed Sargassum fusiforme (S. fusiforme) prevented AD-related pathology in a mouse model of Alzheimer’s Disease (AD). Here, we tested a lipid extract of seaweed Himanthalia elonga…
View article: Cholesterol esterification is hampered in alzheimer’s disease and cholesteryl esters composition is consequently altered
Cholesterol esterification is hampered in alzheimer’s disease and cholesteryl esters composition is consequently altered Open
Introduction and Aim: Several epidemiological studies indicate a strong inverse association between the risk of developing Alzheimer’s disease (AD) and plasma HDL-C levels. The mechanism by which plasma HDL influence the pathogenesis and p…
View article: Effect of Empagliflozin with or without the Addition of Evolocumab on HDL Subspecies in Individuals with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the EXCEED-BHS3 Trial
Effect of Empagliflozin with or without the Addition of Evolocumab on HDL Subspecies in Individuals with Type 2 Diabetes Mellitus: A Post Hoc Analysis of the EXCEED-BHS3 Trial Open
Evolocumab and empagliflozin yield a modest rise in plasma high-density lipoprotein cholesterol (HDL-C) through unknown mechanisms. This study aims to assess the effect of evolocumab plus empagliflozin vs. empagliflozin alone on HDL subspe…
View article: Plasma and cerebrospinal fluid cholesterol esterification is hampered in Alzheimer’s disease
Plasma and cerebrospinal fluid cholesterol esterification is hampered in Alzheimer’s disease Open
Introduction: Several epidemiological studies indicate a strong inverse association between the risk of developing Alzheimer’s disease (AD) and plasma HDL-C levels. The mechanism by which plasma HDL influence the pathogenesis and progressi…
View article: Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability
Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability Open
Among the strategies to overcome the underperformance of statins in cardiovascular diseases (CVDs), the development of drugs targeting the Proprotein Convertase Subtilisin-like Kexin type 9 (PCSK9) is considered one of the most promising. …
View article: PCSK9 ablation attenuates Aβ pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice
PCSK9 ablation attenuates Aβ pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice Open
View article: Effect of the JAK/STAT Inhibitor Tofacitinib on Macrophage Cholesterol Metabolism
Effect of the JAK/STAT Inhibitor Tofacitinib on Macrophage Cholesterol Metabolism Open
The impact of JAK/STAT inhibitors, which are used in various inflammatory diseases, on cardiovascular risk is controversial and has recently raised safety concerns. Our study investigates the direct effects of tofacitinib on macrophage cho…
View article: Long-term fasting effect on HDL cholesterol efflux and serum cholesterol loading capacity: Preliminary results from a single-arm interventional trial
Long-term fasting effect on HDL cholesterol efflux and serum cholesterol loading capacity: Preliminary results from a single-arm interventional trial Open
View article: Intracellular proprotein convertase subtilisin/kexin type 9 and inflammation: Unveiling the role of extracellular vesicles in atheroma formation
Intracellular proprotein convertase subtilisin/kexin type 9 and inflammation: Unveiling the role of extracellular vesicles in atheroma formation Open
View article: Inflammation and immunomodulatory therapies influence the relationship between ATP-binding cassette A1 membrane transporter-mediated cholesterol efflux capacity and coronary atherosclerosis in rheumatoid arthritis
Inflammation and immunomodulatory therapies influence the relationship between ATP-binding cassette A1 membrane transporter-mediated cholesterol efflux capacity and coronary atherosclerosis in rheumatoid arthritis Open
ABCA1-CEC associated with decreased atherosclerosis in patients with below-median baseline and time-averaged CRP and bDMARD use. Conversely, ABCA1-CEC associated with increased plaque in those with higher CRP, corticosteroid users, methotr…
View article: Statins influence the relationship between ATP-binding cassette A1 membrane transporter-mediated cholesterol efflux capacity and coronary atherosclerosis in rheumatoid arthritis
Statins influence the relationship between ATP-binding cassette A1 membrane transporter-mediated cholesterol efflux capacity and coronary atherosclerosis in rheumatoid arthritis Open
In patients with RA, higher ABCA1-CEC may reflect a proatherogenic state, associated with enhanced cardiovascular risk. Statin use may unmask the protective impact of ABCA1-mediated cholesterol efflux on plaque formation, progression and c…
View article: POS0915 ATP-BINDING CASSETTE G1 MEMBRANE TRANSPORTER-MEDIATED CHOLESTEROL EFFLUX CAPACITY INFLUENCES CORONARY ATHEROSCLEROSIS AND CARDIOVASCULAR RISK IN RHEUMATOID ARTHRITIS
POS0915 ATP-BINDING CASSETTE G1 MEMBRANE TRANSPORTER-MEDIATED CHOLESTEROL EFFLUX CAPACITY INFLUENCES CORONARY ATHEROSCLEROSIS AND CARDIOVASCULAR RISK IN RHEUMATOID ARTHRITIS Open
View article: AB0294 INFLAMMATION AND IMMUNOMODULATORY THERAPIES INFLUENCE THE RELATIONSHIP BETWEEN ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1)-MEDIATED CHOLESTEROL EFFLUX AND CORONARY ATHEROSCLEROSIS IN RHEUMATOID ARTHRITIS
AB0294 INFLAMMATION AND IMMUNOMODULATORY THERAPIES INFLUENCE THE RELATIONSHIP BETWEEN ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1)-MEDIATED CHOLESTEROL EFFLUX AND CORONARY ATHEROSCLEROSIS IN RHEUMATOID ARTHRITIS Open
View article: POS0343 STATINS INFLUENCE THE RELATIONSHIP BETWEEN ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1)-MEDIATED CHOLESTEROL EFFLUX AND CORONARY ATHEROSCLEROSIS IN RHEUMATOID ARTHRITIS
POS0343 STATINS INFLUENCE THE RELATIONSHIP BETWEEN ATP-BINDING CASSETTE TRANSPORTER A1 (ABCA1)-MEDIATED CHOLESTEROL EFFLUX AND CORONARY ATHEROSCLEROSIS IN RHEUMATOID ARTHRITIS Open
Background High-density lipoprotein (HDL) mediated cholesterol efflux capacity (CEC) is facilitated by various membrane transporters based on the maturity of the acceptor HDL particles. ATP-binding-cassette membrane transporter A1 (ABCA1) …
View article: Plasma and cerebrospinal fluid cholesterol esterification is hampered in Alzheimer’s disease
Plasma and cerebrospinal fluid cholesterol esterification is hampered in Alzheimer’s disease Open
Objective The purpose of this study was to evaluate cholesterol esterification and HDL subclasses in plasma and cerebrospinal fluid (CSF) of Alzheimer’s disease (AD) patients. Methods The study enrolled 70 AD patients and 74 cognitively no…
View article: In vitro and in vivo studies on novel pcsk9 inhibitors as pharmacological approach for the treatment of alzheimer’s disease
In vitro and in vivo studies on novel pcsk9 inhibitors as pharmacological approach for the treatment of alzheimer’s disease Open
Aim: Impairment of cholesterol homeostasis is one of the multiple etiopathological mechanisms at the origin of both cardiovascular and neurodegenerative diseases. The PCSK9 protein, known for its role in the degradation of hepatic LDLR and…
View article: Hydroxypropyl-β-Cyclodextrin Depletes Membrane Cholesterol and Inhibits SARS-CoV-2 Entry into HEK293T-ACEhi Cells
Hydroxypropyl-β-Cyclodextrin Depletes Membrane Cholesterol and Inhibits SARS-CoV-2 Entry into HEK293T-ACEhi Cells Open
Vaccination has drastically decreased mortality due to coronavirus disease 19 (COVID-19), but not the rate of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Alternative strategies such as inhibition of virus entry by inte…
View article: Identification of Side Chain Oxidized Sterols as Novel Liver X Receptor Agonists with Therapeutic Potential in the Treatment of Cardiovascular and Neurodegenerative Diseases
Identification of Side Chain Oxidized Sterols as Novel Liver X Receptor Agonists with Therapeutic Potential in the Treatment of Cardiovascular and Neurodegenerative Diseases Open
The nuclear receptors—liver X receptors (LXR α and β) are potential therapeutic targets in cardiovascular and neurodegenerative diseases because of their key role in the regulation of lipid homeostasis and inflammatory processes. Specific …
View article: Effects of Antirheumatic Treatment on Cell Cholesterol Efflux and Loading Capacity of Serum Lipoproteins in Spondylarthropathies
Effects of Antirheumatic Treatment on Cell Cholesterol Efflux and Loading Capacity of Serum Lipoproteins in Spondylarthropathies Open
Spondyloarthropathies (SpA) are associated with increased cardiovascular risk. Among possible mechanisms is the dysfunction of serum lipoproteins in regulating cell cholesterol homeostasis. Cholesterol efflux capacity (CEC)—the atheroprote…
View article: Hydroxypropyl-β-Cyclodextrin depletes membrane cholesterol and inhibits SARS-COV-2 entry into HEK293T-ACEhi cells
Hydroxypropyl-β-Cyclodextrin depletes membrane cholesterol and inhibits SARS-COV-2 entry into HEK293T-ACEhi cells Open
Vaccination has drastically decreased mortality due to COVID-19 but not the rate of SARS-CoV-2 infection. Alternative strategies like inhibition of virus entry by interference with ACE2 receptors, could be warranted. Cyclodextrins (CDs) ar…
View article: PCSK9 Confers Inflammatory Properties to Extracellular Vesicles Released by Vascular Smooth Muscle Cells
PCSK9 Confers Inflammatory Properties to Extracellular Vesicles Released by Vascular Smooth Muscle Cells Open
Vascular smooth muscle cells (VSMCs) are key participants in both early- and late-stage atherosclerosis and influence neighbouring cells possibly by means of bioactive molecules, some of which are packed into extracellular vesicles (EVs). …
View article: PCSK9 Affects Astrocyte Cholesterol Metabolism and Reduces Neuron Cholesterol Supplying In Vitro: Potential Implications in Alzheimer’s Disease
PCSK9 Affects Astrocyte Cholesterol Metabolism and Reduces Neuron Cholesterol Supplying In Vitro: Potential Implications in Alzheimer’s Disease Open
The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) involvement in Alzheimer’s disease (AD) is poorly investigated. We evaluated the in vitro PCSK9 modulation of astrocyte cholesterol metabolism and neuronal cholesterol supplying, wh…
View article: HDL metabolism and functions impacting on cell cholesterol homeostasis are specifically altered in patients with abdominal aortic aneurysm
HDL metabolism and functions impacting on cell cholesterol homeostasis are specifically altered in patients with abdominal aortic aneurysm Open
Background The etiopathogenesis of abdominal aortic aneurysm (AAA) is still unclarified, but vascular inflammation and matrix metalloproteases activation have a recognized role in AAA development and progression. Circulating lipoproteins a…
View article: Serum cholesterol loading capacity on macrophages is linked to coronary atherosclerosis and cardiovascular event risk in rheumatoid arthritis
Serum cholesterol loading capacity on macrophages is linked to coronary atherosclerosis and cardiovascular event risk in rheumatoid arthritis Open
Objectives Cholesterol loading capacity (CLC) describes the ability of serum to deliver cholesterol to cells. It is linked to foam cell formation, a pivotal step in atherosclerotic plaque development. We evaluate the associations of CLC wi…
View article: Cholesterol efflux capacity of high-density lipoprotein particles is impaired in age-related macular degeneration patients with high plasma HDL-C levels
Cholesterol efflux capacity of high-density lipoprotein particles is impaired in age-related macular degeneration patients with high plasma HDL-C levels Open