Fei Li
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View article: Plasma interferon predicts pulmonary hypertension severity and outcome
Plasma interferon predicts pulmonary hypertension severity and outcome Open
Background Pulmonary hypertension (PH) is a complex and progressive disease characterized by elevated pulmonary vascular resistance. Inflammation plays an important role in the pathogenesis of PH. Interferons (IFNs) are key immune cytokine…
View article: Efficacy and safety profile of inaticabtagene autoleucel in Chinese patients with B-cell acute lymphoblastic leukemia: Insights from real-world data
Efficacy and safety profile of inaticabtagene autoleucel in Chinese patients with B-cell acute lymphoblastic leukemia: Insights from real-world data Open
Introduction: Inaticabtagene autoleucel (Inati-cel), featuring a CD19 scFv derived from the HI19a clone and a 4-1BB/CD3-ζ costimulatory domain, was approved in China for adult patients with r/r B-ALL and demonstrated high MRD-negative CR/C…
View article: Trium study: Exploring MRD-guided triplet therapy with sonrotoclax, zanubrutinib, and CD20mab in Untreated Mantle Cell Lymphoma: A prospective, multicenter, Phase II Study
Trium study: Exploring MRD-guided triplet therapy with sonrotoclax, zanubrutinib, and CD20mab in Untreated Mantle Cell Lymphoma: A prospective, multicenter, Phase II Study Open
Background Targeted therapy-based induction regimens provide novel treatment options for newly diagnosed mantle cell lymphoma (MCL). Recent studies have demonstrated the promising efficacy of triple-drug combinations comprising BCL-2 inhib…
View article: Global burden of myocarditis in adolescents and young adults, 1990–2019
Global burden of myocarditis in adolescents and young adults, 1990–2019 Open
While the total number of cases has grown globally in the past three-decades, the incidence rate of myocarditis has declined, with the burden disproportionately affecting males and middle-SDI populations, which highlights the need for targ…
View article: A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids
A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids Open
Conventional chemical or biological synthetic methods often encounter challenges in conveniently preparing chiral natural and unnatural products with the same skeleton at a scalable level, due to their complexity with numerous chiral cente…
View article: Construction of decision tree prediction model and group intervention for the mindfulness level of community pre-frail elderly: A cross-sectional study
Construction of decision tree prediction model and group intervention for the mindfulness level of community pre-frail elderly: A cross-sectional study Open
Pre-frailty, a reversible state before frailty, is key for intervention. Mindfulness, a protective factor against frailty, is underexplored in community-dwelling pre-frail older adults. This study identified its influences, built predictiv…
View article: Comparison of Seven Artificial Intelligence-Assisted Prediction Models for Renal Fibrosis in Chronic Kidney Disease Using Aggregate Index of Systemic Inflammation and Ultrasound Radiomics
Comparison of Seven Artificial Intelligence-Assisted Prediction Models for Renal Fibrosis in Chronic Kidney Disease Using Aggregate Index of Systemic Inflammation and Ultrasound Radiomics Open
The RF-based model effectively evaluates renal fibrosis in CKD patients. Integrating AISI and ultrasound radiomics offers a novel strategy for dynamic assessment and biopsy guidance.
View article: Metabolome Analysis Of Dental Plaque From Early Childhood Caries
Metabolome Analysis Of Dental Plaque From Early Childhood Caries Open
Aim or purpose: This longitudinal study aimed to explore the association between dental plaque metabolites with the progression of early childhood caries (ECC) in preschool children. Materials and methods: 141 children aged 36 months were …
View article: Prognostic value of integrated inflammatory-nutritional evaluation in neoadjuvant-treated rectal cancer: a retrospective cohort analysis
Prognostic value of integrated inflammatory-nutritional evaluation in neoadjuvant-treated rectal cancer: a retrospective cohort analysis Open
Background Inflammatory responses, immune status, and nutritional conditions are critical determinants of tumor progression and treatment outcomes in rectal cancer. However, the prognostic value of integrated inflammatory-nutritional score…
View article: Comparison of factors and prognosis in transthoracic vs. transthoracic-abdominal surgery for EGJA
Comparison of factors and prognosis in transthoracic vs. transthoracic-abdominal surgery for EGJA Open
Background : Esophagogastric junction adenocarcinoma (EGJA) is a malignant tumor with special location and complex condition, mainly occurring at the junction of esophagus and stomach. With the increasing incidence, its surgical treatment …
View article: PRP and hypertonic glucose injections improve outcomes in patients with early- to middle-stage knee osteoarthritis: a multicenter retrospective study
PRP and hypertonic glucose injections improve outcomes in patients with early- to middle-stage knee osteoarthritis: a multicenter retrospective study Open
Background Platelet-rich plasma (PRP) injection therapy and hyperosmotic glucose hyperplasia therapy are commonly used methods for treating knee osteoarthritis (KOA). This study evaluates the differences in efficacy and cost-effectiveness …
View article: Case report: Primary giant osteosarcoma of the heart protruding into the pericardial space in a young woman: a case of multimodal imaging
Case report: Primary giant osteosarcoma of the heart protruding into the pericardial space in a young woman: a case of multimodal imaging Open
Background Primary cardiac malignancies are rare, and primary cardiac osteosarcoma is even rarer. The prognosis is poor. Four multimodality imaging data of the same case have not been retrieved yet. Case We report a 21-year-old woman with …
View article: [Development, reliability, and validity of a treatment-related quality of life scale for Chinese patients with multiple myeloma].
[Development, reliability, and validity of a treatment-related quality of life scale for Chinese patients with multiple myeloma]. Open
Objective: To develop a treatment-related quality of life scale for Chinese patients with multiple myeloma (MM) and to test its reliability and validity. Methods: The initial scale was constructed through a literature search,…
View article: [Clinical characteristics and survival outcomes of patients with immunoglobulin A multiple myeloma in the bortezomib era: A single-center retrospective cohort study].
[Clinical characteristics and survival outcomes of patients with immunoglobulin A multiple myeloma in the bortezomib era: A single-center retrospective cohort study]. Open
Objective: To analyze the clinical characteristics, treatment response, and prognosis of patients newly diagnosed with immunoglobulin A multiple myeloma (IgA MM), and to ascertain whether the IgA isotype remains a poor prognostic fa…
View article: Novel Miniature Mobile Integrated Operating Cabin-Theatre: A Clinical Application
Novel Miniature Mobile Integrated Operating Cabin-Theatre: A Clinical Application Open
Objective: This study aimed to investigate the feasibility, efficacy, and safety of using a miniature mobile integrated cabin-theatre equipped with angiography and surgical operating room capabilities, and to explore its therapeutic scope,…
View article: A comorbidity of cardiac atherosclerotic disease with cardiac myxomas being concomitantly treated by coronary artery bypass grafting coupling with tumor resection: a case report
A comorbidity of cardiac atherosclerotic disease with cardiac myxomas being concomitantly treated by coronary artery bypass grafting coupling with tumor resection: a case report Open
Introduction and importance: Cardiac atherosclerotic disease (CAD), the leading cause to cardiovascular disease-related death, coexisting with cardiac myxoma, the commonest benign primary cardiac neoplasm, is rare. The treatment of the com…
View article: Global, regional, and national burden and trends of traumatic brain injury in China and worldwide from 1990 to 2021: insights from the Global Burden of Disease Study 2021
Global, regional, and national burden and trends of traumatic brain injury in China and worldwide from 1990 to 2021: insights from the Global Burden of Disease Study 2021 Open
Objectives This study aimed to describe the temporal trends in age- and gender-specific burdens of traumatic brain injury (TBI) in China from 1990 to 2021, including incidence, prevalence, and years lived with disability (YLDs), and to com…
View article: Primary hepatic neuroendocrine tumor with multiple intrahepatic metastases and concurrent hepatic angiomyolipoma: a case report and review of the literature
Primary hepatic neuroendocrine tumor with multiple intrahepatic metastases and concurrent hepatic angiomyolipoma: a case report and review of the literature Open
In the extremely rare case reported herein, concurrent primary hepatic neuroendocrine tumor and hepatic angiomyolipoma was confirmed by imaging and pathology, and diarrhea was confirmed to be related to primary hepatic neuroendocrine tumor…
View article: A chance diagnosis of appendiceal goblet-cell adenocarcinoma in acute appendicitis being treated by ileocecectomy plus partial right-hemicolectomy: A case report
A chance diagnosis of appendiceal goblet-cell adenocarcinoma in acute appendicitis being treated by ileocecectomy plus partial right-hemicolectomy: A case report Open
The case highlights the ileocecectomy plus partial right-hemicolectomy to treat GCA on the specific preoperative evaluation ruling out metastasis and followed by the recommendation of 5-FU-based chemotherapy.
View article: Aloin protects against UVB-induced apoptosis by modulating integrated signaling pathways
Aloin protects against UVB-induced apoptosis by modulating integrated signaling pathways Open
Aloin, an anthraquinone compound, is naturally abundant in the Aloe . This study comprehensively investigates the photoprotective effects of aloin against UVB-induced damage in HaCaT cells, elucidating its antioxidant capacity and its role…
View article: Albumin-corrected anion gap predicts acute kidney injury in critically ill patients with acute pancreatitis: a retrospective cohort study
Albumin-corrected anion gap predicts acute kidney injury in critically ill patients with acute pancreatitis: a retrospective cohort study Open
View article: 550 | PHASE II TRIAL OF ORELABRUTINIB, FLUDARABINE, CYCLOPHOSPHAMIDE, AND OBINUTUZUMAB FOR FIRST‐LINE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA: THE CWCLL‐001 TRIAL
550 | PHASE II TRIAL OF ORELABRUTINIB, FLUDARABINE, CYCLOPHOSPHAMIDE, AND OBINUTUZUMAB FOR FIRST‐LINE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA: THE CWCLL‐001 TRIAL Open
View article: 235 | NEMTABRUTINIB IN RELAPSED OR REFRACTORY FOLLICULAR LYMPHOMA: UPDATED RESULTS FROM COHORT G OF THE PHASE 2 BELLWAVE‐003 STUDY
235 | NEMTABRUTINIB IN RELAPSED OR REFRACTORY FOLLICULAR LYMPHOMA: UPDATED RESULTS FROM COHORT G OF THE PHASE 2 BELLWAVE‐003 STUDY Open
View article: LBA2 | ZANUBRUTINIB PLUS LENALIDOMIDE AND RITUXIMAB VERSUS R‐miniCHOP IN UNFIT OR FRAIL PATIENTS WITH NEWLY DIAGNOSED DIFFUSE LARGE B‐CELL LYMPHOMA AGED 70 YEARS OR OLDER
LBA2 | ZANUBRUTINIB PLUS LENALIDOMIDE AND RITUXIMAB VERSUS R‐miniCHOP IN UNFIT OR FRAIL PATIENTS WITH NEWLY DIAGNOSED DIFFUSE LARGE B‐CELL LYMPHOMA AGED 70 YEARS OR OLDER Open
View article: 754 | REAL WORLD PATIENT CHARACTERISTICS, TREATMENT PATTERNS, AND OUTCOMES FOR CHINESE PATIENTS WITH CD30‐POSITIVE PERIPHERAL T‐CELL LYMPHOMA
754 | REAL WORLD PATIENT CHARACTERISTICS, TREATMENT PATTERNS, AND OUTCOMES FOR CHINESE PATIENTS WITH CD30‐POSITIVE PERIPHERAL T‐CELL LYMPHOMA Open
View article: 167 | MAINTENANCE THERAPY OF GOLIDOCITINIB, A JAK1 SELECTIVE INHIBITOR, IN PATIENTS WITH PTCLS AFTER FIRST‐LINE SYSTEMIC THERAPY: UPDATES OF THE PHASE 2 STUDY (JACKPOT26)
167 | MAINTENANCE THERAPY OF GOLIDOCITINIB, A JAK1 SELECTIVE INHIBITOR, IN PATIENTS WITH PTCLS AFTER FIRST‐LINE SYSTEMIC THERAPY: UPDATES OF THE PHASE 2 STUDY (JACKPOT26) Open
View article: Correction: PEGylated gas vesicles: a promising novel ultrasound contrast agent for diagnosis and guiding radiofrequency ablation of liver tumor
Correction: PEGylated gas vesicles: a promising novel ultrasound contrast agent for diagnosis and guiding radiofrequency ablation of liver tumor Open
View article: Progress on Traditional Chinese Medicine Prevention and Treatment of Polycystic Ovary Syndrome based on PI3K/AKT Signaling Pathway
Progress on Traditional Chinese Medicine Prevention and Treatment of Polycystic Ovary Syndrome based on PI3K/AKT Signaling Pathway Open
Polycystic ovary syndrome (PCOS) is a multifactorial reproductive endocrine metabolism disorder, which is closely related to granulosa cell dysfunction, high androgen, insulin resistance, oxidative stress and cellular autophagy. Phosphatid…
View article: Identification of mitophagy-related biomarkers in severe acute pancreatitis: integration of WGCNA, machine learning algorithms and scRNA-seq
Identification of mitophagy-related biomarkers in severe acute pancreatitis: integration of WGCNA, machine learning algorithms and scRNA-seq Open
Background Mitophagy is a highly conserved cellular process in eukaryotic cells that selectively clears dysfunctional or damaged mitochondria through autophagy mechanisms to maintain mitochondrial homeostasis. However, the role of mitophag…
View article: Dynamic relationship between gut microbiota and post-necrotizing pancreatitis: insights from a multi-stage 16S rRNA sequencing study
Dynamic relationship between gut microbiota and post-necrotizing pancreatitis: insights from a multi-stage 16S rRNA sequencing study Open
Background Acute pancreatitis (AP) is a common digestive disorder, with necrotizing pancreatitis (NP) occurring in 20% of cases. Long-term complications can include pancreatic exocrine and endocrine insufficiency, with gut microbiota (GM) …