Shanfa Yu
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View article: Comprehensive metabolomics reveals glycolipid metabolic disturbance and potential biomarkers in Chinese diesel exhaust-exposed workers: A cohort study
Comprehensive metabolomics reveals glycolipid metabolic disturbance and potential biomarkers in Chinese diesel exhaust-exposed workers: A cohort study Open
Diesel exhaust (DE) is a significant contributor to the traffic-related air pollution (TRAP) and has been linked to multiple adverse health outcomes. However, research on glycolipid metabolic disturbance associated with human exposure to D…
View article: Mechanistic insights into cobalt-induced lung injury: An integrated network toxicology and bioinformatics approach
Mechanistic insights into cobalt-induced lung injury: An integrated network toxicology and bioinformatics approach Open
Background: The widespread environmental contamination by cobalt compounds, coupled with their documented respiratory toxicities, has become a pressing public health concern. Current mechanistic research on the health impacts of these subs…
View article: Discovery of Small Molecules Against Foot-and-Mouth Disease Virus Replication by Targeting 2C Helicase Activity
Discovery of Small Molecules Against Foot-and-Mouth Disease Virus Replication by Targeting 2C Helicase Activity Open
Background: The 2C protein of foot-and-mouth disease virus (FMDV), a member of helicase superfamily 3 (SF3), drives viral genome replication and serves as a critical target for antiviral drug development. Methods: A fluorescence resonance …
View article: Association of Genetic Variations in Energy Metabolism Genes with Noise-Induced Hearing Loss in a Chinese Population: A Case–Control Study
Association of Genetic Variations in Energy Metabolism Genes with Noise-Induced Hearing Loss in a Chinese Population: A Case–Control Study Open
Objective: This study explored the relationship between susceptibility to single-nucleotide polymorphisms (SNP) and noise-induced hearing loss (NIHL) in a population exposed to occupational noise. Methods: Workers exposed to noise in a ste…
View article: Apigenin ameliorates CCl4-induced hepatic fibrosis by inhibiting hepatic stellate cell activation via PI3K/AKT/GSK3β pathway in mice
Apigenin ameliorates CCl4-induced hepatic fibrosis by inhibiting hepatic stellate cell activation via PI3K/AKT/GSK3β pathway in mice Open
Objective: To investigate the effect of apigenin on carbon tetrachloride (CCl 4 )-induced liver fibrosis and elucidate the underlying mechanisms. Methods: A mouse model of CCl 4 -induced liver fibrosis was used to evaluate the effects of a…
View article: Design and Application Research of Multidimensional Intelligent Psychological Assessment System
Design and Application Research of Multidimensional Intelligent Psychological Assessment System Open
The rapid development of society has increasingly highlighted people's mental health issues, and efficient and accurate psychological assessment tools have become an important demand for mental health education and services. This article e…
View article: Hexavalent chromium exposure induces lung injury via activation of NLRP3 and AIM2 inflammasomes in rats
Hexavalent chromium exposure induces lung injury via activation of NLRP3 and AIM2 inflammasomes in rats Open
Hexavalent chromium (Cr(VI)) has been identified as a Class I human carcinogen, but its carcinogenic mechanism is currently unclear. There is still a lack of understanding of its associations with early pulmonary inflammatory damages. Infl…
View article: Low-dose hexavalent chromium induces mitophagy in rat liver via the AMPK-related PINK1/Parkin signaling pathway
Low-dose hexavalent chromium induces mitophagy in rat liver via the AMPK-related PINK1/Parkin signaling pathway Open
Hexavalent chromium (Cr(VI)) is a hazardous metallic compound commonly used in industrial processes. The liver, responsible for metabolism and detoxification, is the main target organ of Cr(VI). Toxicity experiments were performed to inves…
View article: Variations in the Cadherin 23 Gene Associated With Noise-Induced Hearing Loss
Variations in the Cadherin 23 Gene Associated With Noise-Induced Hearing Loss Open
Genetic variations in the CDH23 gene may play an important role in determining individual susceptibility to NIHL. These results provide new insight into the pathogenesis and early prevention of NIHL.
View article: A review on the impacts of fluorinated organic additives in lithium battery industry—an emerging source of per-and polyfluoroalkyl substances
A review on the impacts of fluorinated organic additives in lithium battery industry—an emerging source of per-and polyfluoroalkyl substances Open
Lithium-ion batteries (LIBs) industry is expanding rapidly in the context of addressing the challenge of climate change and energy crisis. As a technology-intensive product, large number of new synthetic chemicals are applied in LIBs produ…
View article: Hexavalent chromium caused DNA damage repair and apoptosis via the PI3K/AKT/FOXO1 pathway triggered by oxidative stress in the lung of rat
Hexavalent chromium caused DNA damage repair and apoptosis via the PI3K/AKT/FOXO1 pathway triggered by oxidative stress in the lung of rat Open
Hexavalent chromium [Cr(VI)] is an occupational carcinogen that accumulates in the lungs and causes lung injury and even lung cancer. 36 SD male rats received inhalable intratracheal instillation of Cr(VI) (0.05, 0.25 mg Cr/kg) or the same…
View article: Dysregulations of metabolites and gut microbes and their associations in rats with noise induced hearing loss
Dysregulations of metabolites and gut microbes and their associations in rats with noise induced hearing loss Open
Background Noise exposure could lead to hearing loss and disorders of various organs. Recent studies have reported the close relations of environmental noise exposure to the metabolomics dysregulations and gut microbiota disturbance in the…
View article: Plasma metabolomics analyses highlight the multifaceted effects of noise exposure and the diagnostic power of dysregulated metabolites for noise-induced hearing loss in steel workers
Plasma metabolomics analyses highlight the multifaceted effects of noise exposure and the diagnostic power of dysregulated metabolites for noise-induced hearing loss in steel workers Open
Noise exposure can lead to various kinds of disorders. Noise-induced hearing loss (NIHL) is one of the leading disorders confusing the noise-exposed workers. It is essential to identify NIHL markers for its early diagnosis and new therapeu…
View article: Blood leukocyte count as a systemic inflammatory biomarker associated with a more rapid spirometric decline in a large cohort of iron and steel industry workers
Blood leukocyte count as a systemic inflammatory biomarker associated with a more rapid spirometric decline in a large cohort of iron and steel industry workers Open
Objective: Iron and steel industry workers are exposed to high levels of inhalable dust particles that contain various elements, including metals, and cause occupational lung diseases. We aim to assess the relationship between occupational…
View article: Relationship between CDH23 gene and risk of noise-induced hearing loss
Relationship between CDH23 gene and risk of noise-induced hearing loss Open
Objective: To investigate the relationship between CDH23 gene and the risk of noise-induced hearing loss (NIHL). Methods: This was a case-control study. Noise-exposed workers worked in a steel factory in North China was recruited and been …
View article: Small Airway Wall Thickening Assessed by Computerized Tomography Is Associated With Low Lung Function in Chinese Carbon Black Packers
Small Airway Wall Thickening Assessed by Computerized Tomography Is Associated With Low Lung Function in Chinese Carbon Black Packers Open
Nanoscale carbon black as virtually pure elemental carbon can deposit deep in the lungs and cause pulmonary injury. Airway remodeling assessed using computed tomography (CT) correlates well with spirometry in patients with obstructive lung…
View article: Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study
Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study Open
The results suggest that the mutant allele C of rs1485175 in GRM7 may reduce the susceptibility to NIHL in Chinese Han population.
View article: Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study
Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study Open
Noise-induced hearing loss (NIHL) is the second-most frequent form of sensorineural hearing loss. When exposed to the same noise, some workers develop NIHL while others do not, suggesting that NIHL may be associated with genetic factors. T…
View article: Effects of occupational exposure to carbon black on peripheral white blood cell counts and lymphocyte subsets
Effects of occupational exposure to carbon black on peripheral white blood cell counts and lymphocyte subsets Open
The International Agency for Research on Cancer has classified carbon black (CB) as a possible (Group 2B) human carcinogen. Given that most CB manufacturing processes result in the emission of various types of chemicals, it is uncertain if…
View article: Using the Job Burden-Capital Model of Occupational Stress to Predict Depression and Well-Being among Electronic Manufacturing Service Employees in China
Using the Job Burden-Capital Model of Occupational Stress to Predict Depression and Well-Being among Electronic Manufacturing Service Employees in China Open
Background: This study aimed to identify the association between occupational stress and depression-well-being by proposing a comprehensive and flexible job burden-capital model with its corresponding hypotheses. Methods: For this research…
View article: Using the Job Burden-Capital Model of Occupational Stress to Predict Depression and Well-Being among Electronic Manufacturing Service Employees in China
Using the Job Burden-Capital Model of Occupational Stress to Predict Depression and Well-Being among Electronic Manufacturing Service Employees in China Open
Background: This study aimed to identify the association between occupational stress and depression-well-being by proposing a comprehensive and flexible job burden-capital model with its corresponding hypotheses. Methods: For this research…
View article: Using the Job Burden-Capital Model of Occupational Stress to Predict Depression and Well-being among Electronic Manufacturing Service Employees in China
Using the Job Burden-Capital Model of Occupational Stress to Predict Depression and Well-being among Electronic Manufacturing Service Employees in China Open
Background: This study aims to detect the association between occupational stress, depression and well-being. An exploratory theory as job burden-capital model is proposed and the corresponding hypotheses are to be discussed. Methods: 1618…