Explanipedia

Bridging Thrombolysis Does Not Achieve Better Outcomes Compared to Direct Mechanical Thrombectomy in Stroke Due to Internal Carotid Artery Occlusion Open

Isabel Siow, Keng Siang Lee, Benjamin Yong‐Qiang Tan, Desmond Y. H. Yap, Ching‐Hui Sia , et al. · 2025

Background and purpose. Mechanical thrombectomy (MT) is an effective treatment for patients with acute ischaemic stroke secondary to internal carotid artery (ICA) occlusion. Intravenous thrombolysis (IVT) prior to MT is also commonly admin…

Large regional variation in endovascular thrombectomy rates for acute ischemic stroke in Sweden Open

Johan Wassélius, Emma Hall, Alex Szólics, Fabian Arnberg, Hani Radhi , et al. · 2025

Introduction: Endovascular thrombectomy (EVT) is a significant improvement in the care of acute ischemic stroke (AIS) patients, but only a small portion of patients receive treatment. Our aim was to analyze EVT implementation in Sweden acc…

Prevalence of large vessel occlusions in an unselected hospital-based stroke cohort in Sweden Open

Mihae Roland, Ioanna Markaki, Fabian Arnberg, Stefanos Klironomos, Christina Sjöstrand · 2025

Introduction Determining the prevalence of large vessel occlusions (LVOs) is important for planning and accessing mechanical thrombectomy treatment. Previous estimates vary greatly in studies, which might be related to different inclusion …

Sickness absence and disability pension in patients treated with mechanical thrombectomy Open

Mihae Roland, Ann‐Sofie Rudberg, Fabian Arnberg, Kristina Alexanderson, Christina Sjöstrand · 2025

One third of thrombectomy-treated patients had no sickness absence nor disability pension at day 30 after stroke, and the proportion of patients without absence increased during follow-up. Absence proportions and predictors for full-time a…

Impact of number of passes and futile reperfusion in basilar artery occlusion acute ischaemic stroke Open

Isabel Siow, Benjamin Yong‐Qiang Tan, Keng Siang Lee, Dominic Wei Ting Yap, Ching‐Hui Sia , et al. · 2025

Introduction: Mechanical thrombectomy (MT) is the standard of care in anterior circulation large vessel occlusion. A vital modifiable factor is successful reperfusion. While multiple passes improve the rates of successful reperfusion, prev…

Endovascular versus Best Medical Treatment for Acute Carotid Occlusion BelOw Circle of Willis (ACOBOW): The ACOBOW Study Open

Lukas Meyer, Gabriel Broocks, Maria Eleni Alexandrou, Álex Lüttich, José Ángel Larrea , et al. · 2025

For patients with symptomatic acute occlusions of the internal carotid artery below the circle of Willis, endovascular and best medical treatment were both effective and safe therapeutic options.

The negative impact of treatment delays on the long-term neurological outcomes of spinal dural arteriovenous fistulas: a longitudinal cohort study Open

Victor Gabriel El-Hajj, Cornelia Daller, Alexander Fletcher‐Sandersjöö, Maria Gharios, Mohamad Bydon , et al. · 2024

OBJECTIVE Dural arteriovenous fistulas are rare vascular malformations that affect the brain and spinal cord. Spinal dural arteriovenous fistulas (sdAVFs) are the most frequently encountered vascular malformation affecting the spinal cord.…

Effect of anesthetic strategies on distal stroke thrombectomy in the anterior and posterior cerebral artery Open

Lukas Meyer, Christian Paul Stracke, Gabriel Broocks, Marta Wallocha, Mohamed Elsharkawy , et al. · 2023

Background Numerous questions regarding procedural details of distal stroke thrombectomy remain unanswered. This study assesses the effect of anesthetic strategies on procedural, clinical and safety outcomes following thrombectomy for dist…

P64 NIMBUS geometric clot extractor for tough clots: SPERO study results and clot composition Open

René van den Berg, Marc Ribó, Fabian Arnberg, Laurent Estrade, John Thornton , et al. · 2022

Introduction The NIMBUS Geometric Clot Extractor was specifically developed for fibrin rich tough clots which are considered challenging to remove using standard mechanical thrombectomy (MT) techniques. Study aim The SPERO Study (NCT038989…

Unusual Histopathological Findings in Mechanically Removed Stroke Thrombi – A Multicenter Experience Open

Oskar Aspegren, Senna Staessens, Sarah Vandelanotte, Linda Desender, Charlotte Cordonnier , et al. · 2022

Background Several studies have investigated the histopathology of mechanically retrieved thrombi from stroke patients. Thrombi with unusual components constitute about 1–2% of all stroke thrombi in clinical practice. Knowledge about these…

Clot composition characterization using diffuse reflectance spectroscopy in acute ischemic stroke Open

Simon Skyrman, Gustav Burström, Oskar Aspegren, Draženko Babić, Gerald W. Lucassen , et al. · 2022

Acute ischemic stroke caused by large vessel occlusion is treated with endovascular thrombectomy, but treatment failure may occur when clot composition and thrombectomy technique mismatch. In this proof-of-concept study, diffuse reflectanc…

Aspiration Versus Stent Retriever Thrombectomy for Distal, Medium Vessel Occlusion Stroke in the Posterior Circulation: A Subanalysis of the TOPMOST Study Open

Lukas Meyer, Christian Paul Stracke, Marta Wallocha, Gabriel Broocks, Peter B. Sporns , et al. · 2022

Background: The optimal endovascular strategy for reperfusing distal medium-vessel occlusions (DMVO) remains unknown. This study evaluates angiographic and clinical outcomes of thrombectomy strategies in DMVO stroke of the posterior circul…

Endovascular thrombectomy for anterior circulation stroke beyond 6 hours of onset in Sweden 2015 to 2020: rates and outcomes in a nationwide register-based study Open

Teresa Ullberg, Mia von Euler, Per Wester, Fabian Arnberg, Bo Norrving , et al. · 2022

Background Endovascular thrombectomy (EVT) for ischemic stroke (IS) beyond 6 hours has been proven effective in randomized controlled trials. We present data on implementation and outcomes for EVT beyond 6 hours in Sweden. Methods We inclu…

Endovascular thrombectomy for acute ischemic stroke Open

Johan Wassélius, Fabian Arnberg, Mia von Euler, Per Wester, Teresa Ullberg · 2022

This review describes the evolution of endovascular treatment for acute ischemic stroke, current state of the art, and the challenges for the next decade. The rapid development of endovascular thrombectomy (EVT), from the first attempts in…

The Role of Carbon Dioxide in the Rat Acute Stroke Penumbra Open

Leonard L.L. Yeo, Fabian Arnberg, Arvin Chireh, Vijay K. Sharma, Benjamin Yong‐Qiang Tan , et al. · 2022

Purpose The vasodilatory response to inhaled CO 2 occurs in the acute stroke ischemic penumbra and may be a potential therapeutic modality. Methods Twenty-two Sprague-Dawley rats were subjected to 90-min occlusion of the M2 segment of the …

Mechanical thrombectomy in stroke patients of working age: Real-world outcomes in Sweden Open

Mihae Roland, Ioanna Markaki, Tommy Andersson, Fabian Arnberg, Christina Sjöstrand · 2022

Introduction Outcomes after mechanical thrombectomy (MT) in young stroke patients remain elusive due to small patient cohorts. We sought to determine outcomes after MT in stroke patients between ages 18 and 64 years and compare with outcom…

Bridging Thrombolysis versus Direct Mechanical Thrombectomy in Stroke Due to Basilar Artery Occlusion Open

Isabel Siow, Benjamin Yong‐Qiang Tan, Keng Siang Lee, S. K. Ong, Emma Min Shuen Toh , et al. · 2022

Background and Purpose Mechanical thrombectomy (MT) is an effective treatment for patients with basilar artery occlusion (BAO) acute ischemic stroke. It remains unclear whether bridging intravenous thrombolysis (IVT) prior to MT confers an…

Survival and functional outcome following endovascular thrombectomy for anterior circulation acute ischemic stroke caused by large vessel occlusion in Sweden 2017–2019–a nationwide, prospective, observational study Open

Teresa Ullberg, Mia von Euler, Johan Wassélius, Per Wester, Fabian Arnberg · 2022

Background Endovascular thrombectomy (EVT) is standard of care for anterior circulation acute ischemic stroke (AIS) caused by large vessel occlusion (LVO), but data on nationwide performance in routine healthcare are sparse. The study aims…

Effect of Sex on Outcomes of Mechanical Thrombectomy in Basilar Artery Occlusion: A Multicentre Cohort Study Open

Benjamin Yong‐Qiang Tan, Isabel Siow, Keng Siang Lee, Vanessa Chen, S. K. Ong , et al. · 2022

Introduction: Identifying differences in outcome of basilar artery occlusion (BAO) between males and females may be useful in aiding clinical management. Recent studies have demonstrated widespread underrepresentation of wome…

Supplementary Material for: Effect of Sex on Outcomes of Mechanical Thrombectomy in Basilar Artery Occlusion: A Multicentre Cohort Study Open

Tan B.Y.Q., Isabel Siow, Lee S, Vivien Chen, Ong C N , et al. · 2022

Introduction: Identifying differences in outcome of basilar artery occlusion (BAO) between males and females may be useful in aiding clinical management. Recent studies have demonstrated widespread underrepresentation of wome…

Safety evaluation of high-risk myocardial micro-biopsy in a swine model Open

Arvin Chireh, Mikael Sandell, Rikard Grankvist, Victoria Lövljung, Jonathan Al‐Saadi , et al. · 2021

Evidence-Based Updates to Thrombectomy: Targets, New Techniques, and Devices Open

Leonard L.L. Yeo, Mingxue Jing, Pervinder Bhogal, Tian Ming Tu, Anil Gopinathan , et al. · 2021

Endovascular thrombectomy (EVT) has been validated in several randomized controlled trials in recent years for its efficacy in the treatment of acute ischemic strokes (AIS) and is now the standard of care according to international guideli…

Micro-biopsy for detection of gene expression changes in ischemic swine myocardium: A pilot study Open

Arvin Chireh, Rikard Grankvist, Mikael Sandell, Abdul Kadir Mukarram, Fabian Arnberg , et al. · 2021

Micro-endomyocardial biopsy (micro-EMB) is a novel catheter-based biopsy technique, aiming to increase flexibility and safety compared to conventional EMB. The technique was developed and evaluated in healthy swine. Therefore, the ability …

Identifying clot composition using intravascular diffuse reflectance spectroscopy in a porcine model of endovascular thrombectomy Open

Simon Skyrman, Gustav Burström, Oskar Aspegren, Gerald W. Lucassen, Adrian Elmi‐Terander , et al. · 2021

Background Endovascular thrombectomy has revolutionized the management of acute ischemic stroke and proven superior to stand-alone intravenous thrombolysis for large vessel occlusions. However, failed or delayed revascularization may occur…

Thrombectomy for Primary Distal Posterior Cerebral Artery Occlusion Stroke Open

Lukas Meyer, Christian Paul Stracke, Noël Jungi, Marta Wallocha, Gabriel Broocks , et al. · 2021

This study suggested that, although rarely performed at comprehensive stroke centers, mechanical thrombectomy for posterior circulation DMVO is a safe, and technically feasible treatment option for occlusions of the P2 or P3 segment of the…

[68Ga]ABY-028: an albumin-binding domain (ABD) protein-based imaging tracer for positron emission tomography (PET) studies of altered vascular permeability and predictions of albumin-drug conjugate transport Open

Emma Jussing, Frank Leigh Lu, Jonas Grafström, Tetyana Tegnebratt, Fabian Arnberg , et al. · 2020

The cellular basis of increased PET hypoxia tracer uptake in focal cerebral ischemia with comparison between [<sup>18</sup>F]FMISO and [<sup>64</sup>Cu]CuATSM Open

Philip Little, Fabian Arnberg, Emma Jussing, Frank Leigh Lu, Andreas I. Jensen , et al. · 2020

PET hypoxia imaging can assess tissue viability in acute ischemic stroke (AIS). [ 18 F]FMISO is an established tracer but requires substantial accumulation time, limiting its use in hyperacute AIS. [ 64 Cu]CuATSM requires less accumulation…

Myocardial micro-biopsy procedure for molecular characterization with increased precision and reduced trauma Open

Rikard Grankvist, Arvin Chireh, Mikael Sandell, Abdul Kadir Mukarram, Nasren Jaff , et al. · 2020

Preclinical Toxicity Evaluation of Clinical Grade Placenta-Derived Decidua Stromal Cells Open

Behnam Sadeghi, Gianluca Moretti, Fabian Arnberg, Erik Samén, Bita Kohein , et al. · 2019

Placenta-derived decidua stromal cells (DSCs) are being investigated as an alternative to other sources of mesenchymal stromal cells (MSCs) for cellular therapy. DSCs are more effective in treating acute inflammatory diseases in human and …

Superselective endovascular tissue access using trans‐vessel wall technique: feasibility study for treatment applications in heart, pancreas and kidney in swine Open

Rikard Grankvist, Mats Jensen‐Urstad, Jonathan Clarke, Miia Lehtinen, Philip Little , et al. · 2018

Objectives With the emergence of targeted cell transplantation and gene therapy, there is a need for minimally invasive tissue access to facilitate delivery of therapeutic substrate. The objective of this study was to demonstrate the suita…

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