Fabian Föttinger
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View article: Prognostic value of kappa free light chain index in patients with primary progressive multiple sclerosis
Prognostic value of kappa free light chain index in patients with primary progressive multiple sclerosis Open
Background The kappa free light chain (κ-FLC) index is a well-established biomarker in multiple sclerosis (MS). While the prognostic value of the κ-FLC index has been demonstrated in early relapsing–remitting MS, its prognostic value in pr…
View article: Measures of Comorbidities and Frailty in Multiple Sclerosis—Systematic Review on Evidence and Applicability of Utilized Scoring Systems in Clinical Routine and Real‐World Data
Measures of Comorbidities and Frailty in Multiple Sclerosis—Systematic Review on Evidence and Applicability of Utilized Scoring Systems in Clinical Routine and Real‐World Data Open
Background In multiple sclerosis (MS), comorbidities and frailty are receiving increasing attention influencing disease course, treatment and quality of life. The objective of this literature review is to evaluate the evidence, strengths a…
View article: Serum neurofilament light chain and glial fibrillary acidic protein levels are associated with inner retinal layer thinning in multiple sclerosis
Serum neurofilament light chain and glial fibrillary acidic protein levels are associated with inner retinal layer thinning in multiple sclerosis Open
Background: Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (GFAP) are emerging biomarkers of axonal damage and astrocytic activation. The value of sNfL and GFAP in predicting retinal layer thinning remains under…
View article: Risk stratification for disease reactivation after therapy de-escalation/discontinuation in relapsing multiple sclerosis by the VIAADISC score
Risk stratification for disease reactivation after therapy de-escalation/discontinuation in relapsing multiple sclerosis by the VIAADISC score Open
Risk of disease reactivation after discontinuation from DMF/TERI can be stratified with the VIAADISC score and appears to be safe above age 45-55 and with long-lasting stability. However, risk after de-escalation from NTZ/FTY is too high t…
View article: The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis
The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis Open
Objective To investigate whether the rs10191329 risk allele in the DYSF–ZNF638 locus, which is implicated in central nervous system resilience rather than immune‐mediated pathology, is associated with retinal layer thinning, a biomarker of…
View article: The role of age in choosing high-efficacy treatment for multiple sclerosis – an Austrian MS Database study
The role of age in choosing high-efficacy treatment for multiple sclerosis – an Austrian MS Database study Open
Background Treatment strategy for relapsing multiple sclerosis (RMS) is increasingly shifting towards first-line use of high-efficacy DMT (H-DMT). However, DMT efficacy declines with increasing age and the benefit of first line H-DMT at hi…
View article: Diagnostic accuracy of inter-eye difference of ganglion cell layer alone in identifying optic neuritis in multiple sclerosis
Diagnostic accuracy of inter-eye difference of ganglion cell layer alone in identifying optic neuritis in multiple sclerosis Open
Introduction: The 2024 McDonald criteria for diagnosing multiple sclerosis (MS) include optic nerve involvement as a fifth region for establishing dissemination in space. Optic neuritis (ON) can be detected through optical coherence tomogr…
View article: Impact of renal function impairment on kappa free light chain index
Impact of renal function impairment on kappa free light chain index Open
Objectives To investigate whether renal function impacts CSF κ-FLC concentration and/or κ-FLC index. Methods Patients with non-inflammatory neurological diseases were eligible. κ-FLC index was calculated as (CSF κ-FLC/serum κ-FLC)/albumin …
View article: Reactive Pleocytosis After Repeated Lumbar Puncture—Implications for Clinical Practice
Reactive Pleocytosis After Repeated Lumbar Puncture—Implications for Clinical Practice Open
Introduction Lumbar puncture (LP) is a routine clinical procedure and, in some cases, is repeatedly performed for diagnostic or therapeutic reasons. The impact of repeated LP on cerebrospinal fluid (CSF) findings is not clear. Objective To…
View article: Retinal thinning differentiates treatment effects in relapsing multiple sclerosis below the clinical threshold
Retinal thinning differentiates treatment effects in relapsing multiple sclerosis below the clinical threshold Open
Objective To investigate retinal layer thinning as a biomarker of disease‐modifying treatment (DMT) effects in relapsing multiple sclerosis (RMS). Methods From an ongoing prospective observational study, we included patients with RMS, who …
View article: Switching from natalizumab to <scp>antiCD20</scp> monoclonal antibodies: Short transition interval is associated with improved outcome
Switching from natalizumab to <span>antiCD20</span> monoclonal antibodies: Short transition interval is associated with improved outcome Open
Objective To investigate the impact of transition interval length when switching from natalizumab (NTZ) to anti‐CD20 monoclonal antibodies (antiCD20) on recurrent disease activity and safety in relapsing multiple sclerosis (RMS). Methods A…
View article: Autoimmune screening panel in patients with multiple sclerosis: A Vienna multiple sclerosis database study
Autoimmune screening panel in patients with multiple sclerosis: A Vienna multiple sclerosis database study Open
Background and purpose Autoimmune screening panels (ASPs) are often ordered as a part of the diagnostic workup in people with suspected multiple sclerosis (MS). However, data on the significance of ASP seropositivity in MS are scarce. This…
View article: Paramagnetic rim lesions are associated with inner retinal layer thinning and progression independent of relapse activity in multiple sclerosis
Paramagnetic rim lesions are associated with inner retinal layer thinning and progression independent of relapse activity in multiple sclerosis Open
Background and purpose Paramagnetic rim lesions (PRLs) are chronic active lesions associated with a severe disease course in multiple sclerosis (MS). This study was undertaken to investigate an association between retinal layer thinning (a…
View article: Retinal layer thinning for monitoring disease-modifying treatment in relapsing multiple sclerosis—Evidence for applying a rebaselining concept
Retinal layer thinning for monitoring disease-modifying treatment in relapsing multiple sclerosis—Evidence for applying a rebaselining concept Open
Background: Employing a rebaselining concept may reduce noise in retinal layer thinning measured by optical coherence tomography (OCT). Methods: From an ongoing prospective observational study, we included patients with relapsing multiple …