Fabian Garreis
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View article: Calcium-Dependent Regulation of Desmosomal Proteins in Human Meibomian Gland Epithelial Cells
Calcium-Dependent Regulation of Desmosomal Proteins in Human Meibomian Gland Epithelial Cells Open
Our study demonstrates the impact of calcium concentration on the expression and localization of desmosomal proteins and their role in meibocyte differentiation in both human and mouse models. To further understand the physiological mechan…
View article: The Potential Role of SP-G and PLUNC in Tumor Pathogenesis and Wound Healing in the Human Larynx
The Potential Role of SP-G and PLUNC in Tumor Pathogenesis and Wound Healing in the Human Larynx Open
Background: Immunological and rheological properties are important factors of the surfactant protein (SP) family, whose impact on tumorigenesis is not yet known, although some SPs have been identified as tumor marker candidates for various…
View article: Alpha- and beta-melanocyte stimulating hormone positively impact lipogenesis of meibomian gland cells in vitro and ex vivo
Alpha- and beta-melanocyte stimulating hormone positively impact lipogenesis of meibomian gland cells in vitro and ex vivo Open
Our data show for the first time that human meibomian glands express MCRs and that stimulation/inhibition of MCRs alters cAMP response, MCR expression, and lipogenesis markers, thereby affecting the genesis of meibum. Therefore, α-/β-MSH p…
View article: Correction: Expression and Localization of Lung Surfactant Proteins in Human Testis
Correction: Expression and Localization of Lung Surfactant Proteins in Human Testis Open
[This corrects the article DOI: 10.1371/journal.pone.0143058.].
View article: Molecular detection of lacrimal apparatus and ocular surface - related ABC transporter genes
Molecular detection of lacrimal apparatus and ocular surface - related ABC transporter genes Open
The ocular system is in constant interaction with the environment and with numerous pathogens. The ATP-binding cassette (ABC) transporters represent one of the largest groups among the transmembrane proteins. Their relevance has been demon…
View article: Thermosensitive TRP Channels Are Functionally Expressed and Influence the Lipogenesis in Human Meibomian Gland Cells
Thermosensitive TRP Channels Are Functionally Expressed and Influence the Lipogenesis in Human Meibomian Gland Cells Open
While the involvement of thermosensitive transient receptor potential channels (TRPs) in dry eye disease (DED) has been known for years, their expression in the meibomian gland (MG) has never been investigated. This study aims to show thei…
View article: Comparative Characterization of Human Meibomian Glands, Free Sebaceous Glands, and Hair-Associated Sebaceous Glands Based on Biomarkers, Analysis of Secretion Composition, and Gland Morphology
Comparative Characterization of Human Meibomian Glands, Free Sebaceous Glands, and Hair-Associated Sebaceous Glands Based on Biomarkers, Analysis of Secretion Composition, and Gland Morphology Open
Meibomian gland dysfunction (MGD) is one of the main causes of dry eye disease. To better understand the physiological functions of human meibomian glands (MGs), the present study compared MGs with free sebaceous glands (SGs) and hair-asso…
View article: C1q/TNF-Related Proteins 1, 6 and 8 Are Involved in Corneal Epithelial Wound Closure by Targeting Relaxin Receptor RXFP1 In Vitro
C1q/TNF-Related Proteins 1, 6 and 8 Are Involved in Corneal Epithelial Wound Closure by Targeting Relaxin Receptor RXFP1 In Vitro Open
Inadequate wound healing of ocular surface injuries can lead to permanent visual impairment. The relaxin ligand-receptor system has been demonstrated to promote corneal wound healing through increased cell migration and modulation of extra…
View article: A New Organotypic 3D Slice Culture of Mouse Meibomian Glands Reveals Impact of Melanocortins
A New Organotypic 3D Slice Culture of Mouse Meibomian Glands Reveals Impact of Melanocortins Open
The meibomian glands (MGs) within the eyelids produce a lipid-rich secretion that forms the superficial layer of the tear film. Meibomian gland dysfunction (MGD) results in excessive evaporation of the tear film, which is the leading cause…
View article: Prolactin Inducible Protein, but Not Prolactin, Is Present in Human Tears, Is Involved in Tear Film Quality, and Influences Evaporative Dry Eye Disease
Prolactin Inducible Protein, but Not Prolactin, Is Present in Human Tears, Is Involved in Tear Film Quality, and Influences Evaporative Dry Eye Disease Open
Purpose Decreased production of the aqueous component of the tear film is an important cause of the development of dry eye disease (DED). Tear production is influenced by hormones and hormone-like factors. Prolactin (PLR), a multifunctiona…
View article: The Potential Role of SP-G as Surface Tension Regulator in Tear Film: From Molecular Simulations to Experimental Observations
The Potential Role of SP-G as Surface Tension Regulator in Tear Film: From Molecular Simulations to Experimental Observations Open
The ocular surface is in constant interaction with the environment and with numerous pathogens. Therefore, complex mechanisms such as a stable tear film and local immune defense mechanisms are required to protect the eye. This study descri…
View article: Production and Secretion of Gelsolin by Both Human Macrophage- and Fibroblast-like Synoviocytes and GSN Modulation in the Synovial Fluid of Patients with Various Forms of Arthritis
Production and Secretion of Gelsolin by Both Human Macrophage- and Fibroblast-like Synoviocytes and GSN Modulation in the Synovial Fluid of Patients with Various Forms of Arthritis Open
Gelsolin (GSN) is an actin-binding protein involved in cell formation, metabolism and wound closure processes. Since this protein is known to play a role in arthritis, here we investigate how the synovial membrane with its specific synovio…
View article: The Translational Role of MUC8 in Salivary Glands: A Potential Biomarker for Salivary Stone Disease?
The Translational Role of MUC8 in Salivary Glands: A Potential Biomarker for Salivary Stone Disease? Open
Mucin (MUC) 8 has been shown to play an important role in respiratory disease and inflammatory responses. In the present study, we investigated the question of whether MUC8 is also produced and secreted by salivary glands and whether it ma…
View article: Optimization of polycaprolactone - based nanofiber matrices for the cultivation of corneal endothelial cells
Optimization of polycaprolactone - based nanofiber matrices for the cultivation of corneal endothelial cells Open
View article: Ocular Phenotype of Relaxin Gene Knockout (Rln <sup>-/-</sup> ) Mice
Ocular Phenotype of Relaxin Gene Knockout (Rln <sup>-/-</sup> ) Mice Open
Purpose: To test if relaxin deficiency affects ocular structure and function we investigated expression of relaxin (Rln) and RXFP receptors (Rxfp1, Rxfp2), and compared ocular phenotypes in relaxin gene knockout (Rl…
View article: IgA subclasses have different effector functions associated with distinct glycosylation profiles
IgA subclasses have different effector functions associated with distinct glycosylation profiles Open
View article: Human Synovia Contains Trefoil Factor Family (TFF) Peptides 1–3 Although Synovial Membrane Only Produces TFF3: Implications in Osteoarthritis and Rheumatoid Arthritis
Human Synovia Contains Trefoil Factor Family (TFF) Peptides 1–3 Although Synovial Membrane Only Produces TFF3: Implications in Osteoarthritis and Rheumatoid Arthritis Open
Objective: Trefoil factor family peptide 3 (TFF3) has been shown to support catabolic functions in cases of osteoarthritis (OA). As in joint physiology and diseases such as OA, the synovial membrane (SM) of the joint capsule also plays a c…
View article: Characterization of dry eye disease in a mouse model by optical coherence tomography and fluorescein staining
Characterization of dry eye disease in a mouse model by optical coherence tomography and fluorescein staining Open
A custom-built ultrahigh-resolution optical coherence tomography (UHR-OCT) system and fluorescein staining were employed for investigation of a scopolamine induced dry eye mouse model. Acquired data was used to evaluate common and compleme…
View article: Influence of psoriasin on VEGF-mediated corneal neovascularization
Influence of psoriasin on VEGF-mediated corneal neovascularization Open
View article: Impact of prolactin and prolactin-inducible protein (PIP) for dry eye disease
Impact of prolactin and prolactin-inducible protein (PIP) for dry eye disease Open
View article: Table of Contents
Table of Contents Open
View article: E-Cadherin Is Important for Meibomian Gland Function as Revealed by a New Human ex Vivo Slice Culture Model
E-Cadherin Is Important for Meibomian Gland Function as Revealed by a New Human ex Vivo Slice Culture Model Open
Meibomian glands within the eyelid are important for the maintenance of the integrity and health of the ocular surface. Patients with the blistering skin disease pemphigus vulgaris (PV), which is caused by autoantibodies against desmosomal…
View article: Vascular Endothelial Growth Factor (VEGF) Induced Downstream Responses to Transient Receptor Potential Vanilloid 1 (TRPV1) and 3-Iodothyronamine (3-T1AM) in Human Corneal Keratocytes
Vascular Endothelial Growth Factor (VEGF) Induced Downstream Responses to Transient Receptor Potential Vanilloid 1 (TRPV1) and 3-Iodothyronamine (3-T1AM) in Human Corneal Keratocytes Open
This study was undertaken to determine if crosstalk among the transient receptor potential (TRP) melastatin 8 (TRPM8), TRP vanilloid 1 (TRPV1), and vascular endothelial growth factor (VEGF) receptor triad modulates VEGF-induced Ca2+ signal…
View article: Evaluation of surfactant proteins A, B, C, and D in articular cartilage, synovial membrane and synovial fluid of healthy as well as patients with osteoarthritis and rheumatoid arthritis
Evaluation of surfactant proteins A, B, C, and D in articular cartilage, synovial membrane and synovial fluid of healthy as well as patients with osteoarthritis and rheumatoid arthritis Open
These results show the distribution and amount of SPs in tissues of articular joints. They are produced by chondrocytes and synoviocytes and occur in measurable amounts in synovial fluid. All four SPs seem to be differently regulated under…
View article: Plasma gelsolin promotes re-epithelialization
Plasma gelsolin promotes re-epithelialization Open
View article: Developmental change in the gene-expression of transient receptor potential melanostatin channel 3 (TRPM3) in murine lacrimal gland
Developmental change in the gene-expression of transient receptor potential melanostatin channel 3 (TRPM3) in murine lacrimal gland Open
View article: Surfactant protein H is part of the tear film, lowers surface tension, is increased in dry eye disease and accelerates corneal wound healing
Surfactant protein H is part of the tear film, lowers surface tension, is increased in dry eye disease and accelerates corneal wound healing Open
View article: SFTA3 – a novel surfactant protein of the ocular surface and its role in corneal wound healing and tear film surface tension
SFTA3 – a novel surfactant protein of the ocular surface and its role in corneal wound healing and tear film surface tension Open
View article: Differentiation Patterns of Immortalized Human Meibomian Gland Epithelial Cells in Three-Dimensional Culture
Differentiation Patterns of Immortalized Human Meibomian Gland Epithelial Cells in Three-Dimensional Culture Open
HMGECs have the capability to differentiate in a long-term 3D culture, especially when adapted to an air-rich environment. However, even in the 3D format, HMGECs only reach a state of differentiating meibocytes.
View article: Expression and Regulation of S100 Fused-Type Protein Hornerin at the Ocular Surface and Lacrimal Apparatus
Expression and Regulation of S100 Fused-Type Protein Hornerin at the Ocular Surface and Lacrimal Apparatus Open
The data suggest that HRNR, but not FLG2, is a component of the ocular surface and lacrimal apparatus, including meibomian glands. HRNR seems to contribute to the maintenance of the epithelial barrier at the ocular surface and, thus, also …