Fabian Stuhldreier
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View article: The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism
The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism Open
Inhibition of the mitochondrial metabolism offers a promising therapeutic approach for the treatment of cancer. Here, we identify the mycotoxin viriditoxin (VDT), derived from the endophytic fungus Cladosporium cladosporioides , as an inte…
View article: Heterologously secreted MbxA from Moraxella bovis induces a membrane blebbing response of the human host cell
Heterologously secreted MbxA from Moraxella bovis induces a membrane blebbing response of the human host cell Open
Many proteins of the Repeats in Toxins (RTX) protein family are toxins of Gram-negative pathogens including hemolysin A (HlyA) of uropathogenic E. coli . RTX proteins are secreted via Type I secretion systems (T1SS) and adopt their native …
View article: Heterologously secreted MbxA from<i>Moraxella bovis</i>induces a membrane blebbing response of the human host cell
Heterologously secreted MbxA from<i>Moraxella bovis</i>induces a membrane blebbing response of the human host cell Open
Many proteins of the Repeats in Toxins (RTX) protein family are toxins of Gram-negative pathogens including hemolysin A (HlyA) of uropathogenic E. coli . RTX proteins are secreted via Type I secretion systems (T1SS) and adopt their native …
View article: Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells
Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells Open
View article: FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates
FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates Open
View article: High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol
High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol Open
View article: TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy
TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy Open
Macroautophagy/autophagy and necroptosis represent two opposing cellular s tress responses. Whereas autophagy primarily fulfills a cyto-protective function, necroptosis is a form of regulated cell death induced via death receptors. Here, w…
View article: CCDC 1968536: Experimental Crystal Structure Determination
CCDC 1968536: Experimental Crystal Structure Determination Open
View article: CCDC 1968535: Experimental Crystal Structure Determination
CCDC 1968535: Experimental Crystal Structure Determination Open
View article: Induction of New Lactam Derivatives From the Endophytic Fungus Aplosporella javeedii Through an OSMAC Approach
Induction of New Lactam Derivatives From the Endophytic Fungus Aplosporella javeedii Through an OSMAC Approach Open
Fermentation of the endophytic fungus Aplosporella javeedii on solid rice medium in presence of either 3.5% NaNO3 or 3.5% monosodium glutamate caused a significant change of the fungal metabolite pattern compared to funga…
View article: Natural Products Impacting DNA Methyltransferases and Histone Deacetylases
Natural Products Impacting DNA Methyltransferases and Histone Deacetylases Open
Epigenetics refers to heritable changes in gene expression and chromatin structure without change in a DNA sequence. Several epigenetic modifications and respective regulators have been reported. These include DNA methylation, chromatin re…
View article: The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death
The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death Open
View article: Didymellanosine, a new decahydrofluorene analogue, and ascolactone C from <i>Didymella</i> sp. IEA-3B.1, an endophyte of <i>Terminalia catappa</i>
Didymellanosine, a new decahydrofluorene analogue, and ascolactone C from <i>Didymella</i> sp. IEA-3B.1, an endophyte of <i>Terminalia catappa</i> Open
An unusual decahydrofluorene-class alkaloid from Didymella sp. exhibited NFκB inhibitory and antimicrobial activities.
View article: First Results from a Screening of 300 Naturally Occurring Compounds: 4,6-dibromo-2-(2′,4′-dibromophenoxy)phenol, 4,5,6-tribromo-2-(2′,4′-dibromophenoxy)phenol, and 5-epi-nakijinone Q as Substances with the Potential for Anticancer Therapy
First Results from a Screening of 300 Naturally Occurring Compounds: 4,6-dibromo-2-(2′,4′-dibromophenoxy)phenol, 4,5,6-tribromo-2-(2′,4′-dibromophenoxy)phenol, and 5-epi-nakijinone Q as Substances with the Potential for Anticancer Therapy Open
There is a variety of antineoplastic drugs that are based on natural compounds from ecological niches with high evolutionary pressure. We used two cell lines (Jurkat J16 and Ramos) in a screening to assess 300 different naturally occurring…
View article: Data for: Novel meriolin derivatives as rapid apoptosis inducers
Data for: Novel meriolin derivatives as rapid apoptosis inducers Open
Supporting Information of preparative details, characterization, and NMR spectra
View article: Dithiodiketopiperazine derivatives from endophytic fungi <i>Trichoderma harzianum</i> and <i>Epicoccum nigrum</i>
Dithiodiketopiperazine derivatives from endophytic fungi <i>Trichoderma harzianum</i> and <i>Epicoccum nigrum</i> Open
A new epidithiodiketopiperazine (ETP), pretrichodermamide G (1), along with three known (epi)dithiodiketopiparazines (2-4) were isolated from cultures of Trichoderma harzianum and Epicoccum nigrum, endophytic fu…
View article: The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane
The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane Open
Mitochondria are cellular organelles with crucial functions in the generation and distribution of ATP, the buffering of cytosolic Ca 2+ and the initiation of apoptosis. Compounds that interfere with these functions are termed mitochondrial…
View article: Targeting urothelial carcinoma cells by combining cisplatin with a specific inhibitor of the autophagy-inducing class III PtdIns3K complex
Targeting urothelial carcinoma cells by combining cisplatin with a specific inhibitor of the autophagy-inducing class III PtdIns3K complex Open
Cisplatin-based regimens are routinely employed for the treatment of urothelial carcinoma. However, therapeutic success is hampered by the primary presence of or the development of cisplatin resistance. This chemoresistance is executed by …
View article: Systematic analysis of ATG13 domain requirements for autophagy induction
Systematic analysis of ATG13 domain requirements for autophagy induction Open
Macroautophagy/autophagy is an evolutionarily conserved cellular process whose induction is regulated by the ULK1 protein kinase complex. The subunit ATG13 functions as an adaptor protein by recruiting ULK1, RB1CC1 and ATG101 to a core ULK…
View article: Daldinone derivatives from the mangrove-derived endophytic fungus Annulohypoxylon sp.
Daldinone derivatives from the mangrove-derived endophytic fungus Annulohypoxylon sp. Open
Three new benzo[j]fluoranthene metabolites, including an isolation artefact which induces intrinsic apoptosis and blocks autophagy, were isolated fromAnnulohypoxylonsp.
View article: Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells
Expression of a ULK1/2 binding-deficient ATG13 variant can partially restore autophagic activity in ATG13-deficient cells Open
Autophagy describes an intracellular process responsible for the lysosome-dependent degradation of cytosolic components. The ULK1/2 complex comprising the kinase ULK1/2 and the accessory proteins ATG13, RB1CC1, and ATG101 has been identifi…
View article: Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy
Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy Open
Autophagy represents an intracellular degradation process which is involved in both regular cell homeostasis and disease settings. In recent years, the molecular machinery governing this process has been elucidated. The ULK1 kinase complex…
View article: Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy
Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy Open
Autophagy represents an intracellular degradation process which is involved in both regular cell homeostasis and disease settings. In recent years, the molecular machinery governing this process has been elucidated. The ULK1 kinase complex…
View article: Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy
Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy Open
Autophagy represents an intracellular degradation process which is involved in both regular cell homeostasis and disease settings. In recent years, the molecular machinery governing this process has been elucidated. The ULK1 kinase complex…
View article: Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy
Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy Open
Autophagy represents an intracellular degradation process which is involved in both regular cell homeostasis and disease settings. In recent years, the molecular machinery governing this process has been elucidated. The ULK1 kinase complex…
View article: Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy
Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy Open
Autophagy represents an intracellular degradation process which is involved in both regular cell homeostasis and disease settings. In recent years, the molecular machinery governing this process has been elucidated. The ULK1 kinase complex…
View article: Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy
Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy Open
Autophagy represents an intracellular degradation process which is involved in both regular cell homeostasis and disease settings. In recent years, the molecular machinery governing this process has been elucidated. The ULK1 kinase complex…