Fabien Lamret
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View article: A novel synthetic synovial fluid model for investigating biofilm formation and antibiotic susceptibility in prosthetic joint infections
A novel synthetic synovial fluid model for investigating biofilm formation and antibiotic susceptibility in prosthetic joint infections Open
There is growing evidence that bacteria encountered in prosthetic joint infections (PJIs) form surface-attached biofilms on prostheses, as well as biofilm aggregates embedded in synovial fluid and tissues. However, in vitro models allowing…
View article: Cutibacterium acnes strains associated with bone prosthesis infections cannot evade the host immune system
Cutibacterium acnes strains associated with bone prosthesis infections cannot evade the host immune system Open
Introduction Cutibacterium acnes is a commensal skin bacterium that is involved in bone prosthesis infections (BPIs) and presents low-grade clinical symptoms. C. acnes has been thought to escape the immune system at bone sites. Material an…
View article: Staphylococcus aureus Behavior on Artificial Surfaces Mimicking Bone Environment
Staphylococcus aureus Behavior on Artificial Surfaces Mimicking Bone Environment Open
Infections, which interfere with bone regeneration, may be a critical issue to consider during the development of biomimetic material. Calcium phosphate (CaP) and type I collagen substrates, both suitable for bone-regeneration dedicated sc…
View article: Human Osteoblast-Conditioned Media Can Influence Staphylococcus aureus Biofilm Formation
Human Osteoblast-Conditioned Media Can Influence Staphylococcus aureus Biofilm Formation Open
Osteoblasts are bone-forming and highly active cells participating in bone homeostasis. In the case of osteomyelitis and more specifically prosthetic joint infections (PJI) for which Staphylococcus aureus (S. aureus) is mainly involved, th…
View article: Pyridazinone Derivatives Limit Osteosarcoma-Cells Growth In Vitro and In Vivo
Pyridazinone Derivatives Limit Osteosarcoma-Cells Growth In Vitro and In Vivo Open
Osteosarcoma is a rare primary bone cancer that mostly affects children and young adults. Current therapeutic approaches consist of combining surgery and chemotherapy but remain unfortunately insufficient to avoid relapse and metastases. P…
View article: Comparison of Two Cutibacterium acnes Biofilm Models
Comparison of Two Cutibacterium acnes Biofilm Models Open
The study of biofilms in vitro is complex and often limited by technical problems due to simplified models. Here, we compared C. acnes biofilm formation, from species involved in bone and prosthesis infection, in a static model with a dyna…
View article: Staphylococcus aureus Strain-Dependent Biofilm Formation in Bone-Like Environment
Staphylococcus aureus Strain-Dependent Biofilm Formation in Bone-Like Environment Open
Staphylococcus aureus species is an important threat for hospital healthcare because of frequent colonization of indwelling medical devices such as bone and joint prostheses through biofilm formations, leading to therapeutic failure. Furth…
View article: Interaction of implant infection-related commensal bacteria with mesenchymal stem cells: a comparison between <i>Cutibacterium acnes</i> and <i>Staphylococcus aureus</i>
Interaction of implant infection-related commensal bacteria with mesenchymal stem cells: a comparison between <i>Cutibacterium acnes</i> and <i>Staphylococcus aureus</i> Open
Staphylococcus aureus and Cutibacterium acnes are involved in several tissue infections and can encounter mesenchymal stem cells (MSCs) during their role in tissue regenerative process. C. acnes and S. aureus internalization by three types…
View article: Cutibacterium acnes Biofilm Study during Bone Cells Interaction
Cutibacterium acnes Biofilm Study during Bone Cells Interaction Open
Cutibacterium acnes is an opportunistic pathogen involved in Bone and Prosthesis Infections (BPIs). In this study, we observed the behavior of commensal and BPI C. acnes strains in the bone environment through bacterial internalization by …
View article: Antibiotic Tolerance of Staphylococcus aureus Biofilm in Periprosthetic Joint Infections and Antibiofilm Strategies
Antibiotic Tolerance of Staphylococcus aureus Biofilm in Periprosthetic Joint Infections and Antibiofilm Strategies Open
The need for bone and joint prostheses is currently growing due to population aging, leading to an increase in prosthetic joint infection cases. Biofilms represent an adaptive and quite common bacterial response to several stress factors w…
View article: Staphylococcus aureus biofilm matrix under bone environment influence
Staphylococcus aureus biofilm matrix under bone environment influence Open
<p>Bone and joint infections linked to implanted materials are mostly due to Staphylococcus aureus. Deciphering the biofilm structure appears to be a promising strategy to develop antibiofilm molecules in order to curb infection occu…
View article: Bone Environment Influences Irreversible Adhesion of a Methicillin-Susceptible Staphylococcus aureus Strain
Bone Environment Influences Irreversible Adhesion of a Methicillin-Susceptible Staphylococcus aureus Strain Open
Prosthesis and joint infections are an important threat in public health, especially due to the development of bacterial biofilms and their high resistance to antimicrobials. Biofilm-associated infections increase mortality and morbidity r…