Fabienne Geiger
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View article: Electrical cell‐substrate impedance sensing (ECIS) in lung biology and disease
Electrical cell‐substrate impedance sensing (ECIS) in lung biology and disease Open
The lungs are exposed to a hostile environment from both sites: the airways and the vasculature. However, an efficient gas exchange of oxygen (O 2 ) and CO 2 is only possible through a very thin alveolo‐capillary membrane. Therefore, maint…
View article: Transient Receptor Potential (TRP) Channels in Airway Toxicity and Disease: An Update
Transient Receptor Potential (TRP) Channels in Airway Toxicity and Disease: An Update Open
Our respiratory system is exposed to toxicants and pathogens from both sides: the airways and the vasculature. While tracheal, bronchial and alveolar epithelial cells form a natural barrier in the airways, endothelial cells protect the lun…
View article: TRPM7 restrains plasmin activity and promotes transforming growth factor-β1 signaling in primary human lung fibroblasts
TRPM7 restrains plasmin activity and promotes transforming growth factor-β1 signaling in primary human lung fibroblasts Open
Sustained exposure of the lung to various environmental or occupational toxins may eventually lead to pulmonary fibrosis, a devastating disease with no cure. Pulmonary fibrosis is characterized by excessive deposition of extracellular matr…
View article: An Inhibitory Function of TRPA1 Channels in TGF-β1-driven Fibroblast to Myofibroblast Differentiation
An Inhibitory Function of TRPA1 Channels in TGF-β1-driven Fibroblast to Myofibroblast Differentiation Open
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective Ca 2+ permeable cation channel, which was originally cloned from human lung fibroblasts (HLFs). TRPA1-mediated Ca 2+ entry is evoked by exposure to several chemicals, includ…
View article: Deciphering the minimal quantity of mouse primary cells to undergo nephrogenesis ex vivo
Deciphering the minimal quantity of mouse primary cells to undergo nephrogenesis ex vivo Open
Background Tissue organoids derived from primary cells have high potential for studying organ development and diseases in numerous organs. They recreate the morphological structure and mimic the functions of given organ while being compact…
View article: Ca2+ Signaling by TRPV4 Channels in Respiratory Function and Disease
Ca2+ Signaling by TRPV4 Channels in Respiratory Function and Disease Open
Members of the transient receptor potential (TRP) superfamily are broadly expressed in our body and contribute to multiple cellular functions. Most interestingly, the fourth member of the vanilloid family of TRP channels (TRPV4) serves dif…