Fabin Lin
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View article: Association between different dietary patterns and the risk of major brain disorders: a prospective multi-cohort study
Association between different dietary patterns and the risk of major brain disorders: a prospective multi-cohort study Open
View article: Associations of digestive diseases exposure and lifestyle factors with Parkinson’s disease
Associations of digestive diseases exposure and lifestyle factors with Parkinson’s disease Open
Emerging evidence highlights the importance of gastrointestinal (GI) dysfunction in Parkinson's disease (PD). While inflammatory bowel disease (IBD) has been linked to PD, the association with other GI conditions remains unclear. This stud…
View article: Association between functional gastrointestinal disorders and Parkinson’s disease in a prospective cohort study
Association between functional gastrointestinal disorders and Parkinson’s disease in a prospective cohort study Open
View article: Multicenter study on predicting postoperative upper limb muscle strength improvement in cervical spinal cord injury patients using radiomics and deep learning
Multicenter study on predicting postoperative upper limb muscle strength improvement in cervical spinal cord injury patients using radiomics and deep learning Open
View article: The brain structure underlying the nonlinear association between early-life tobacco smoke exposure and the risk for cognitive decline and dementia in adulthood: a large prospective cohort study
The brain structure underlying the nonlinear association between early-life tobacco smoke exposure and the risk for cognitive decline and dementia in adulthood: a large prospective cohort study Open
View article: Residential blue space, cognitive function, and the role of air pollution in middle-aged and older adults: A cross-sectional study based on UK biobank
Residential blue space, cognitive function, and the role of air pollution in middle-aged and older adults: A cross-sectional study based on UK biobank Open
This study examines the relationship between residential exposure to blue spaces (e.g., rivers, lakes, and seas) and cognitive function in middle-aged and older adults in the United Kingdom, with a specific focus on the mediating effects o…
View article: Development of a Dual‐Plane <scp>MRI</scp>‐Based Deep Learning Model to Assess the 1‐Year Postoperative Outcomes in Lumbar Disc Herniation After Tubular Microdiscectomy
Development of a Dual‐Plane <span>MRI</span>‐Based Deep Learning Model to Assess the 1‐Year Postoperative Outcomes in Lumbar Disc Herniation After Tubular Microdiscectomy Open
Background Tubular microdiscectomy (TMD) is a treatment for lumbar disc herniation (LDH). Although the combination of MRI and deep learning (DL) has shown promise, its application in evaluating postoperative outcomes in TMD has not been fu…
View article: Postoperative One Year Prediction for Patients with Cervical Spinal Cord Injury Based on Deep Learning and Radiomics
Postoperative One Year Prediction for Patients with Cervical Spinal Cord Injury Based on Deep Learning and Radiomics Open
Background: Cervical spinal cord injury (SCI) can lead to significant impairments, requiring extensive care and posing considerable challenges in predicting postoperative outcomes. This study aimed to develop and validate a deep learning r…
View article: Clinical evaluation of enhanced recovery versus conventional care in the perioperative period for intradural extramedullary spinal tumors: a study protocol for a multicenter, randomized controlled trial
Clinical evaluation of enhanced recovery versus conventional care in the perioperative period for intradural extramedullary spinal tumors: a study protocol for a multicenter, randomized controlled trial Open
View article: Hypoxic-preconditioned mesenchymal stem cell-derived small extracellular vesicles inhibit neuronal death after spinal cord injury by regulating the SIRT1/Nrf2/HO-1 pathway
Hypoxic-preconditioned mesenchymal stem cell-derived small extracellular vesicles inhibit neuronal death after spinal cord injury by regulating the SIRT1/Nrf2/HO-1 pathway Open
Background Oxidative stress and apoptosis of neurons significantly contribute to the pathophysiological cascade of spinal cord injury (SCI). However, the role of hypoxic-preconditioned mesenchymal stem cell-derived small extracellular vesi…
View article: Daytime napping and the incidence of Parkinson’s disease: a prospective cohort study with Mendelian randomization
Daytime napping and the incidence of Parkinson’s disease: a prospective cohort study with Mendelian randomization Open
Background The causal relationship between daytime napping and the risk of Parkinson’s disease (PD) remains unclear, with prospective studies providing limited evidence. This study investigated the association between daytime napping frequ…
View article: Development of a predictive model for 1-year postoperative recovery in patients with lumbar disk herniation based on deep learning and machine learning
Development of a predictive model for 1-year postoperative recovery in patients with lumbar disk herniation based on deep learning and machine learning Open
Background The aim of this study is to develop a predictive model utilizing deep learning and machine learning techniques that will inform clinical decision-making by predicting the 1-year postoperative recovery of patients with lumbar dis…
View article: Left corticospinal tract could be a biomarker to identify the dual prodromal <scp>LRRK2</scp>/<scp>GBA</scp> mutated Parkinson's disease
Left corticospinal tract could be a biomarker to identify the dual prodromal <span>LRRK2</span>/<span>GBA</span> mutated Parkinson's disease Open
Introduction Prodromal Parkinson's disease (PD) carriers of dual leucine‐rich repeat kinase 2 (LRRK2) and glucosylceramidase β (GBA) variants are rare, and their biomarkers are less well developed. Objective This study aimed to investigate…
View article: Association of physical activity pattern and risk of Parkinson’s disease
Association of physical activity pattern and risk of Parkinson’s disease Open
Increasing evidence suggests an association between exercise duration and Parkinson’s disease. However, no high-quality prospective evidence exists confirming whether differences exist between the two modes of exercise, weekend warrior and…
View article: Early-life tobacco smoke exposure and stroke risk: a prospective study of 341,783 and 352,737 UK Biobank participants
Early-life tobacco smoke exposure and stroke risk: a prospective study of 341,783 and 352,737 UK Biobank participants Open
Introduction Stroke is a life-threatening condition that causes a major medical burden globally. The currently used methods for the prevention or prediction of stroke have certain limitations. Exposure to tobacco in early life, including s…
View article: Fish oil supplementation, physical activity and risk of incident Parkinson’s disease: results of longitudinal analysis from the UK Biobank
Fish oil supplementation, physical activity and risk of incident Parkinson’s disease: results of longitudinal analysis from the UK Biobank Open
Objective Evidence on the individual and combined relationship of physical activity (PA) and fish oil supplement use on the incidence of Parkinson’s disease (PD) risk remains lacking. Materials and methods This UK population-based prospect…
View article: Cortical thickness and white matter microstructure predict freezing of gait development in Parkinson’s disease
Cortical thickness and white matter microstructure predict freezing of gait development in Parkinson’s disease Open
View article: Association of time spent outdoors with the risk of Parkinson’s disease: a prospective cohort study of 329,359 participants
Association of time spent outdoors with the risk of Parkinson’s disease: a prospective cohort study of 329,359 participants Open
Background Studies on the association between time spent outdoors and the development of Parkinson’s disease (PD) are lacking, and whether this relationship differs in different subgroups (age, sex) remains unclear. Objective We here exami…
View article: Association between Physical Activity Pattern and Type 2 Diabetes: A Prospective Study of 89,400 UK Biobank Participants
Association between Physical Activity Pattern and Type 2 Diabetes: A Prospective Study of 89,400 UK Biobank Participants Open
View article: Different impulse control disorder evolution patterns and white matter microstructural damage in the progression of Parkinson’s disease
Different impulse control disorder evolution patterns and white matter microstructural damage in the progression of Parkinson’s disease Open
Background The course of impulse control disorders (ICD) varies in the early stage of Parkinson’s disease (PD). Aim We aimed to delineate the association between the evolution pattern of ICD and the progression of PD. Methods A total of 32…
View article: Coffee consumption and all-cause and cardiovascular mortality in older adults: should we consider cognitive function?
Coffee consumption and all-cause and cardiovascular mortality in older adults: should we consider cognitive function? Open
Background The association between coffee and mortality risk has been found in most previous studies, and recent studies have found an association between coffee consumption and cognition. However, there is still a lack of research explori…
View article: Hypoxic‐preconditioned mesenchymal stem cell‐derived small extracellular vesicles promote the recovery of spinal cord injury by affecting the phenotype of astrocytes through the <scp>miR</scp>‐21/<scp>JAK2</scp>/<scp>STAT3</scp> pathway
Hypoxic‐preconditioned mesenchymal stem cell‐derived small extracellular vesicles promote the recovery of spinal cord injury by affecting the phenotype of astrocytes through the <span>miR</span>‐21/<span>JAK2</span>/<span>STAT3</span> pathway Open
Background Secondary injury after spinal cord injury (SCI) is a major obstacle to their neurological recovery. Among them, changes in astrocyte phenotype regulate secondary injury dominated by neuroinflammation. Hypoxia‐preconditioned mese…
View article: Association of pro-inflammatory diet with increased risk of all-cause dementia and Alzheimer's dementia: a prospective study of 166,377 UK Biobank participants
Association of pro-inflammatory diet with increased risk of all-cause dementia and Alzheimer's dementia: a prospective study of 166,377 UK Biobank participants Open
View article: Development of a predictive model for one-year postoperative recovery in patients with lumbar disc herniation based on deep learning and machine learning
Development of a predictive model for one-year postoperative recovery in patients with lumbar disc herniation based on deep learning and machine learning Open
Background The aim of this study is to develop a predictive model utilizing deep learning and machine learning techniques that will inform clinical decision-making by predicting the one-year postoperative recovery of patients with lumbar d…
View article: Mesenchymal stem cell-derived extracellular vesicles therapy in traumatic central nervous system diseases: a systematic review and meta-analysis
Mesenchymal stem cell-derived extracellular vesicles therapy in traumatic central nervous system diseases: a systematic review and meta-analysis Open
Although there are challenges in treating traumatic central nervous system diseases, mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have recently proven to be a promising non-cellular therapy. We comprehensively evaluated t…
View article: Efficacy of extracellular vesicles of different cell origins in traumatic brain injury: A systematic review and network meta-analysis
Efficacy of extracellular vesicles of different cell origins in traumatic brain injury: A systematic review and network meta-analysis Open
Background There was still no effective treatment for traumatic brain injury (TBI). Recently, many preclinical studies had shown promising efficacy of extracellular vesicles (EVs) from various cell sources. Our aim was to compare which cel…
View article: Development, validation, and visualization of a web-based nomogram to predict the effect of tubular microdiscectomy for lumbar disc herniation
Development, validation, and visualization of a web-based nomogram to predict the effect of tubular microdiscectomy for lumbar disc herniation Open
Objective The purpose of this study was to retrospectively collect the relevant clinical data of lumbar disc herniation (LDH) patients treated with the tubular microdiscectomy (TMD) technique, and to develop and validate a prediction model…
View article: The treatment efficacy of pharmacotherapies for rapid eye movement sleep behavior disorder with polysomnography evaluation: A systematic review and meta-analysis
The treatment efficacy of pharmacotherapies for rapid eye movement sleep behavior disorder with polysomnography evaluation: A systematic review and meta-analysis Open
View article: Efficacy of miRNA-modified mesenchymal stem cell extracellular vesicles in spinal cord injury: A systematic review of the literature and network meta-analysis
Efficacy of miRNA-modified mesenchymal stem cell extracellular vesicles in spinal cord injury: A systematic review of the literature and network meta-analysis Open
Background Although some previous studies have indicated that extracellular vesicles (EVs) secreted from miRNA-modified mesenchymal stem cells (MSCs) may be more effective as compared with control EVs in the treatment of rats with spinal c…
View article: Comparison of efficacy of deep brain stimulation, repeat transcranial magnetic stimulation, and behavioral therapy in Tourette syndrome: A systematic review and Bayesian Network Meta-Analysis
Comparison of efficacy of deep brain stimulation, repeat transcranial magnetic stimulation, and behavioral therapy in Tourette syndrome: A systematic review and Bayesian Network Meta-Analysis Open