Fabio Carniato
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View article: Metallo-coiled Coil Stabilization via Chemical Cross-Linking: Implications for Gd(III)-Based MRI Contrast Agents
Metallo-coiled Coil Stabilization via Chemical Cross-Linking: Implications for Gd(III)-Based MRI Contrast Agents Open
Coiled coils are a versatile class of protein-inspired metal-binding ligands with well-defined sequence-to-structure relationships and high synthetic accessibility, making them promising tunable ligands for applications spanning biomedical…
View article: Design of Mn(1,4-DO2A) derivatives as stable and inert contrast agents for magnetic resonance imaging
Design of Mn(1,4-DO2A) derivatives as stable and inert contrast agents for magnetic resonance imaging Open
Manganese(II) is considered a valuable alternative to gadolinium(III) in developing contrast agents (CAs) for magnetic resonance imaging (MRI). However, due to the labile nature of common Mn(II) complexes, designing ligands that enable sta…
View article: Paramagnetic and Luminescent Properties of Gd(III)/Eu(III) Ascorbate Coordination Polymers
Paramagnetic and Luminescent Properties of Gd(III)/Eu(III) Ascorbate Coordination Polymers Open
Gadolinium-based contrast agents (GBCAs) are the gold standard as MRI probes but are nowadays facing medical limitations and environmental concerns. To address these issues, novel strategies focus on the optimization of Gd(III)-based probe…
View article: Cellular Uptake of Hybrid PLGA-Lipid Gadolinium Nanoparticles Functionalized for Magnetic Resonance Imaging of Pancreatic Adenocarcinoma Cells
Cellular Uptake of Hybrid PLGA-Lipid Gadolinium Nanoparticles Functionalized for Magnetic Resonance Imaging of Pancreatic Adenocarcinoma Cells Open
Pancreatic adenocarcinoma (PDAC) presents significant diagnostic challenges, necessitating improved imaging techniques. Here, we develop hybrid poly-(lactic-co-glycolic acid) (PLGA)-phospholipid nanoparticles (NPs) loaded with gadolinium (…
View article: From electron spin to relaxivity: a multidisciplinary perspective on first-row transition metal-based MRI probes
From electron spin to relaxivity: a multidisciplinary perspective on first-row transition metal-based MRI probes Open
EPR spectroscopy complements NMR and DFT in designing next-generation MRI contrast agents based on first-row transition metals, providing key molecular parameters for reliable interpretation of relaxometric data.
View article: The timeless relevance of size-match selectivity in macrocyclic Fe(<scp>iii</scp>) complexes
The timeless relevance of size-match selectivity in macrocyclic Fe(<span>iii</span>) complexes Open
Thermodynamic, kinetic, redox, structural and relaxometric studies were performed on four Fe( iii ) complexes with triaza-macrocyclic triacetate ligands with increasing ring sizes, showing the size-match selectivity of [11]aneN 3 for the F…
View article: Comprehensive relaxometric analysis of Fe(<scp>iii</scp>) coordination polymer nanoparticles for <i>T</i><sub>1</sub>-MRI: unravelling the impact of coating on contrast enhancement
Comprehensive relaxometric analysis of Fe(<span>iii</span>) coordination polymer nanoparticles for <i>T</i><sub>1</sub>-MRI: unravelling the impact of coating on contrast enhancement Open
Gallic acid-based Fe( iii ) nanoparticles, coated with PEG, exhibit remarkable efficacy as T 1 MRI contrast agents thanks to an improved second sphere hydration.
View article: Evaluation of structurally related acyclic ligands OBETA, EHDTA, and EGTA for stable Mn<sup>2+</sup> complex formation
Evaluation of structurally related acyclic ligands OBETA, EHDTA, and EGTA for stable Mn<sup>2+</sup> complex formation Open
Structurally related heptadentate (OBETA, EHDTA) and octadentate (EGTA) ligands form Mn 2+ complexes that exhibit distinct characteristics in terms of relaxivity, thermodynamic stability, and, most notably, kinetic inertness.
View article: Nb(V)-containing saponite: A versatile clay for the catalytic degradation of the hazardous organophosphorus pesticide paraoxon under very mild conditions
Nb(V)-containing saponite: A versatile clay for the catalytic degradation of the hazardous organophosphorus pesticide paraoxon under very mild conditions Open
A synthetic saponite clay containing structural Nb(V) metal centres (NbSAP) was investigated in the abatement of paraoxon-ethyl, an anti-cholinergic organophosphorus pesticide, under mild conditions (neutral pH, room temperature and ambien…
View article: Assessing the Impact of Amide Donor Groups on Stability and NMR Relaxation Efficiency of Monohydrated Fe(III) Complexes
Assessing the Impact of Amide Donor Groups on Stability and NMR Relaxation Efficiency of Monohydrated Fe(III) Complexes Open
This study aims to understand the impact of the overall charge of Fe(III) chelates on their water exchange kinetics, thermodynamic stability, and kinetic inertia. To this end, we synthesized two CDTA‐amide ligands, each characterized by th…
View article: α-Aryl substituted GdDOTA derivatives, the perfect contrast agents for MRI?
α-Aryl substituted GdDOTA derivatives, the perfect contrast agents for MRI? Open
Introducing aryl substituents into the α-position of the well-known GdDOTA affords chelates that have unprecedentedly high relaxivities and robustness.
View article: Aldehyde-containing clays: a sustainable approach against the olive tree pest, <i>Bactrocera oleae</i>
Aldehyde-containing clays: a sustainable approach against the olive tree pest, <i>Bactrocera oleae</i> Open
Aldehyde-containing bentonite natural clays as a method for the long-term release of the bioactive ingredient, reducing the infestation by olive fruit fly.
View article: Relaxometric properties and biocompatibility of a novel nanostructured fluorinated gadolinium metal–organic framework
Relaxometric properties and biocompatibility of a novel nanostructured fluorinated gadolinium metal–organic framework Open
A novel Gd-MOF based on tetrafluoro-terephthalic acid has been synthesized and its structure has been solved using X-ray single crystal diffraction data.
View article: Silica-based monoliths functionalized with DTPA for the removal of transition and lanthanide ions from aqueous solutions
Silica-based monoliths functionalized with DTPA for the removal of transition and lanthanide ions from aqueous solutions Open
DTPA-functionalized silica monoliths were used as solid sorbents for the metal ions from aqueous solutions. These monoliths exhibit high capture efficiency and they are more manageable in comparison to conventional powders.
View article: Incorporation of Antimony Ions in Heptaisobutyl Polyhedral Oligomeric Silsesquioxanes
Incorporation of Antimony Ions in Heptaisobutyl Polyhedral Oligomeric Silsesquioxanes Open
The direct incorporation of Sb(V) ions into a polycondensed silsesquioxane network based on heptaisobutyl POSS units (Sb(V)-POSSs) through a corner-capping reaction is reported for the first time in this work. As a reference sample, a comp…
View article: Novel Nanogels Loaded with Mn(II) Chelates as Effective and Biologically Stable MRI Probes
Novel Nanogels Loaded with Mn(II) Chelates as Effective and Biologically Stable MRI Probes Open
Here it is described nanogels (NG) based on a chitosan matrix, which are covalently stabilized by a bisamide derivative of Mn‐ t ‐CDTA ( t –CDTA = trans ‐1,2‐diaminocyclohexane‐N,N,N′,N′‐tetraacetic acid). the Mn(II) complex acts both as a…
View article: Thermoreversibly crosslinked silica-rubber composite prepared via melt processing
Thermoreversibly crosslinked silica-rubber composite prepared via melt processing Open
This paper addresses the industrially viable and environmentally sustainable preparation of thermoreversibly crosslinked composite rubbers. A maleimide-functionalized silica (Sil-M) is prepared and used as a reinforcement filler and crossl…
View article: Characterization of the Fe(III)-Tiron System in Solution through an Integrated Approach Combining NMR Relaxometric, Thermodynamic, Kinetic, and Computational Data
Characterization of the Fe(III)-Tiron System in Solution through an Integrated Approach Combining NMR Relaxometric, Thermodynamic, Kinetic, and Computational Data Open
The Fe(III)-Tiron system (Tiron = 4,5-dihydroxy-1,3-benzenedisulfonate) was investigated using a combination of 1H and 17O NMR relaxometric studies at variable field and temperature and theoretical calculations at the DFT and NEVPT2 levels…
View article: Magnetic and relaxation properties of vanadium(<scp>iv</scp>) complexes: an integrated <sup>1</sup>H relaxometric, EPR and computational study
Magnetic and relaxation properties of vanadium(<span>iv</span>) complexes: an integrated <sup>1</sup>H relaxometric, EPR and computational study Open
The combination of two complementary magnetic resonance techniques, integrated by computational procedures, allows detailed solution characterization of vanadium( iv ) complexes.
View article: Effect of hydration equilibria on the relaxometric properties of Gd(<scp>iii</scp>) complexes: new insights into old systems
Effect of hydration equilibria on the relaxometric properties of Gd(<span>iii</span>) complexes: new insights into old systems Open
Proposed is a multidisciplinary study of three Gd( iii ) complexes that exist in solution as an equilibrium of two species with distinct hydration states. Data analysis is enhanced by taking into account the influence of the hydration equi…
View article: Peptide-Based Hydrogels and Nanogels Containing Gd(III) Complexes as T1 Relaxation Agents
Peptide-Based Hydrogels and Nanogels Containing Gd(III) Complexes as T1 Relaxation Agents Open
New peptide-based hydrogels incorporating Gd(III) chelates with different hydration states, molecular structures and overall negative charges ([Gd(BOPTA)]2−), [Gd(DTPA)]2−, and ([Gd(AAZTA)]−) were prepared and characterized. N-terminal Fmo…
View article: Eu3+ and Tb3+ @ PSQ: Dual Luminescent Polyhedral Oligomeric Polysilsesquioxanes
Eu3+ and Tb3+ @ PSQ: Dual Luminescent Polyhedral Oligomeric Polysilsesquioxanes Open
The synthesis and characterization of novel luminescent amorphous POSS-based polysilsesquioxanes (PSQs) with Tb3+ and Eu3+ ions directly integrated in the polysilsesquioxane matrix is presented. Two different Tb3+/Eu3+ molar ratios were ap…
View article: Impregnation of Synthetic Saponites with Aldehydes: A Green Approach in the Intercalation of Bioactive Principles
Impregnation of Synthetic Saponites with Aldehydes: A Green Approach in the Intercalation of Bioactive Principles Open
Synthetic saponite clay was impregnated with either linear saturated or unsaturated aldehydes through an incipient-wetness deposition approach. To increase the aldehyde loading, saponite was also intercalated with positively charged cetylt…
View article: The Control of the Coordination Chemistry for the Genesis of Heterogeneous Catalytically Active Sites in Oxidation Reactions**
The Control of the Coordination Chemistry for the Genesis of Heterogeneous Catalytically Active Sites in Oxidation Reactions** Open
This Review provides a summary of the use and the role of coordination complexes as precursors for the generation of heterogeneous catalysts for oxidation reactions of interest for fine chemical synthesis. Specific attention is paid to the…
View article: Derivatives of GdAAZTA Conjugated to Amino Acids: A Multinuclear and Multifrequency NMR Study
Derivatives of GdAAZTA Conjugated to Amino Acids: A Multinuclear and Multifrequency NMR Study Open
The GdAAZTA (AAZTA = 6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) complex represents a platform of great interest for the design of innovative MRI probes due to its remarkable magnetic properties, thermodynamic stability, kineti…
View article: Synthesis of Novel Luminescent Double-Decker Silsesquioxanes Based on Partially Condensed TetraSilanolPhenyl POSS and Tb3+/Eu3+ Lanthanide Ions
Synthesis of Novel Luminescent Double-Decker Silsesquioxanes Based on Partially Condensed TetraSilanolPhenyl POSS and Tb3+/Eu3+ Lanthanide Ions Open
In this study, novel lanthanide-containing double-decker polyhedral oligomeric silsesquioxanes (POSS) were prepared by combining the partially condensed TetraSilanolPhenyl POSS with terbium (Tb3+) and europium (Eu3+) ions. This open-cage P…
View article: High Relaxivity with No Coordinated Waters: A Seemingly Paradoxical Behavior of [Gd(DOTP)]<sup>5–</sup> Embedded in Nanogels
High Relaxivity with No Coordinated Waters: A Seemingly Paradoxical Behavior of [Gd(DOTP)]<sup>5–</sup> Embedded in Nanogels Open
Nanogels (NGs) obtained by electrostatic interactions between chitosan and hyaluronic acid and comprising paramagnetic Gd chelates are gaining increasing attention for their potential application in magnetic resonance bioimaging. Herein, t…
View article: Application of NMR relaxometry for real-time monitoring of the removal of metal ions from water by synthetic clays
Application of NMR relaxometry for real-time monitoring of the removal of metal ions from water by synthetic clays Open
The removal of paramagnetic metal ions from aqueous solutions with a synthetic saponite clay was monitored in real time by 1 H NMR relaxometry.