Fabio Cacciapaglia
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View article: Sjögren’s disease and concomitant Fibromyalgia: clinical profile and implications for disease activity assessment
Sjögren’s disease and concomitant Fibromyalgia: clinical profile and implications for disease activity assessment Open
Objectives: Fibromyalgia (FM) is more prevalent in patients with Sjögren’s disease (SjD) than in the general population and a bidirectional association between the two conditions has been proposed. However, the clinical profile of patients…
View article: Gastrointestinal involvement in very early and established systemic sclerosis: insights from the SPRING-SIR national Italian registry
Gastrointestinal involvement in very early and established systemic sclerosis: insights from the SPRING-SIR national Italian registry Open
Objectives To describe the prevalence of gastrointestinal (GI) symptoms in SSc and Very Early Diagnosis of SSc (VEDOSS), identify clinical and serological features associated with GI involvement and explore a cranio-caudal pattern of sympt…
View article: First‐line diagnostic tests to intercept primary heart involvement in systemic sclerosis: Clinical associations from the SPRING‐SIR registry
First‐line diagnostic tests to intercept primary heart involvement in systemic sclerosis: Clinical associations from the SPRING‐SIR registry Open
Introduction Primary heart involvement (pHI) is an overlooked and poorly characterised complication of systemic sclerosis (SSc), associated with the risk of heart failure, arrhythmia and death. Despite consensus definition by the World Scl…
View article: Menopause in systemic sclerosis: the impact on clinical presentation in a multicenter cross-sectional analysis from the National Registry of the Italian Society for Rheumatology (SPRING-SIR)
Menopause in systemic sclerosis: the impact on clinical presentation in a multicenter cross-sectional analysis from the National Registry of the Italian Society for Rheumatology (SPRING-SIR) Open
Background: Hormonal changes in menopause might interact with the presentation of underlying autoimmune diseases, such as systemic sclerosis (SSc). Objectives: Our study aimed to evaluate the association of (1) current menopausal status, (…
View article: Efficacy and Safety of Mepolizumab 300 mg in Eosinophilic Granulomatosis With Polyangiitis: A Meta‐Analysis of Eight Retrospective Studies
Efficacy and Safety of Mepolizumab 300 mg in Eosinophilic Granulomatosis With Polyangiitis: A Meta‐Analysis of Eight Retrospective Studies Open
No abstract available
View article: Long-term effects of selexipag in SSc-associated digital ulcers: a case-control multicentre observational study
Long-term effects of selexipag in SSc-associated digital ulcers: a case-control multicentre observational study Open
Objectives Digital ulcers (DUs) affect ∼50% of SSc patients, causing significant pain and functional impairment. Current management involves both systemic and local therapies. However, the burden in terms of pain and quality of life due to…
View article: ABS1121 REAL-LIFE EFFECTIVENESS OF SELEXIPAG TREATMENT IN SYSTEMIC SCLEROSIS ASSOCIATED PULMONARY ARTERIAL HYPERTENSION: LONG-TERM DATA FROM A MONOCENTRIC ITALIAN COHORT
ABS1121 REAL-LIFE EFFECTIVENESS OF SELEXIPAG TREATMENT IN SYSTEMIC SCLEROSIS ASSOCIATED PULMONARY ARTERIAL HYPERTENSION: LONG-TERM DATA FROM A MONOCENTRIC ITALIAN COHORT Open
View article: POS0972 CLINICAL AND SEROLOGICAL FEATURES OF TRIPLE-NEGATIVE SYSTEMIC SCLEROSIS PATIENTS: INSIGHTS FROM THE ITALIAN MULTICENTRIC SPRING REGISTRY OF THE ITALIAN SOCIETY OF RHEUMATOLOGY
POS0972 CLINICAL AND SEROLOGICAL FEATURES OF TRIPLE-NEGATIVE SYSTEMIC SCLEROSIS PATIENTS: INSIGHTS FROM THE ITALIAN MULTICENTRIC SPRING REGISTRY OF THE ITALIAN SOCIETY OF RHEUMATOLOGY Open
View article: ABS0860 FORCED VITAL CAPACITY AS AN INDEPENDENT SURVIVAL PREDICTOR IN SYSTEMIC SCLEROSIS-ASSOCIATED PULMONARY HYPERTENSION
ABS0860 FORCED VITAL CAPACITY AS AN INDEPENDENT SURVIVAL PREDICTOR IN SYSTEMIC SCLEROSIS-ASSOCIATED PULMONARY HYPERTENSION Open
View article: ABS0687 IMPACT OF CDAI-REMISSION ON CV RISK ESTIMATION OF RA PATIENTS: INSIGHTS FROM THE CORDIS STUDY GROUP OF THE ITALIAN SOCIETY FOR RHEUMATOLOGY
ABS0687 IMPACT OF CDAI-REMISSION ON CV RISK ESTIMATION OF RA PATIENTS: INSIGHTS FROM THE CORDIS STUDY GROUP OF THE ITALIAN SOCIETY FOR RHEUMATOLOGY Open
View article: OP0334 VASODILATION REDUCES THE RISK OF NEW ONSET OF INTERSTITIAL LUNG DISEASE IN SYSTEMIC SCLEROSIS: AN ASSOCIATION STUDY FROM THE EUSTAR DATABASE
OP0334 VASODILATION REDUCES THE RISK OF NEW ONSET OF INTERSTITIAL LUNG DISEASE IN SYSTEMIC SCLEROSIS: AN ASSOCIATION STUDY FROM THE EUSTAR DATABASE Open
View article: POS0041 PREVALENCE OF NEOPLASIAS AND DISEASE FEATURES IN PATIENTS WITH SYSTEMIC SCLEROSIS: DATA FROM THE NATIONAL REGISTRY SPRING (Systemic sclerosis PRogression INvestiGation) OF THE ITALIAN SOCIETY OF RHEUMATOLOGY
POS0041 PREVALENCE OF NEOPLASIAS AND DISEASE FEATURES IN PATIENTS WITH SYSTEMIC SCLEROSIS: DATA FROM THE NATIONAL REGISTRY SPRING (Systemic sclerosis PRogression INvestiGation) OF THE ITALIAN SOCIETY OF RHEUMATOLOGY Open
View article: ABS0574 CHARACTERIZING AND PREDICTING GASTROINTESTINAL INVOLVEMENT IN SYSTEMIC SCLEROSIS: DATA FROM THE NATIONAL SYSTEMIC SCLEROSIS PROGRESSION INVESTIGATION (SPRING) REGISTRY OF THE ITALIAN SOCIETY FOR RHEUMATOLOGY
ABS0574 CHARACTERIZING AND PREDICTING GASTROINTESTINAL INVOLVEMENT IN SYSTEMIC SCLEROSIS: DATA FROM THE NATIONAL SYSTEMIC SCLEROSIS PROGRESSION INVESTIGATION (SPRING) REGISTRY OF THE ITALIAN SOCIETY FOR RHEUMATOLOGY Open
View article: Prevalence and clinical relevance of digital ulcers in systemic sclerosis patients from the real-life: the experience of the SPRING Registry of the Italian Society for Rheumatology
Prevalence and clinical relevance of digital ulcers in systemic sclerosis patients from the real-life: the experience of the SPRING Registry of the Italian Society for Rheumatology Open
Introduction Digital ulcers (DU) are one of the most frequent manifestations in systemic sclerosis (SSc). The presence of DU seems to be a sentinel sign of internal organ involvement and is related to a poor prognosis of the disease. The a…
View article: Real-life effectiveness of rituximab in different subsets of idiopathic inflammatory myopathies
Real-life effectiveness of rituximab in different subsets of idiopathic inflammatory myopathies Open
Objective. Idiopathic inflammatory myopathies (IIM) are heterogeneous autoimmune diseases including dermatomyositis (DM), polymyositis (PM), immune-mediated necrotizing myopathy (IMNM), and anti-synthetase syndrome (ASS). Treatment typical…
View article: Transthoracic Lung Ultrasound in Systemic Sclerosis-Associated Interstitial Lung Disease: Capacity to Differentiate Chest Computed-Tomographic Characteristic Patterns
Transthoracic Lung Ultrasound in Systemic Sclerosis-Associated Interstitial Lung Disease: Capacity to Differentiate Chest Computed-Tomographic Characteristic Patterns Open
Background/Objectives: Even today, interstitial lung disease (ILD) is diagnosed by chest high-resolution computed tomography (lung HR-CT). Large amounts of data are available about the usefulness of transthoracic lung ultrasound (LUS) in I…
View article: Predictive Value of the DETECT Algorithm for Pulmonary Arterial Hypertension in Systemic Sclerosis: Findings from an Italian Observational Study
Predictive Value of the DETECT Algorithm for Pulmonary Arterial Hypertension in Systemic Sclerosis: Findings from an Italian Observational Study Open
Background/Objectives: Pulmonary arterial hypertension (PAH) is a complication of systemic sclerosis (SSc), and several screening algorithms have been proposed for the early detection of PAH in SSc. This study aimed to evaluate the predict…
View article: Unsupervised Machine Learning with Cluster Analys in Patients with Rheumatoid Arthritis: Insights in Cv Risk Phenotypes from a Multicentre Italian Cohort
Unsupervised Machine Learning with Cluster Analys in Patients with Rheumatoid Arthritis: Insights in Cv Risk Phenotypes from a Multicentre Italian Cohort Open
View article: Imaging in Systemic Sclerosis-Associated Interstitial Lung Disease: Comparison of Transthoracic Lung Ultrasound and HR Chest CT in Detecting Characteristic Patterns
Imaging in Systemic Sclerosis-Associated Interstitial Lung Disease: Comparison of Transthoracic Lung Ultrasound and HR Chest CT in Detecting Characteristic Patterns Open
Background/Objectives: Even today the interstitial lung disease (ILD) is diagnosed by chest high-resolution computed tomography (lung HR-CT). A large amount of data is available about the use-fulness of lung ultrasound (LUS) in ILD. The ai…
View article: Modulation of IL-6 receptor/STAT3 downstream signaling in rheumatoid arthritis patients
Modulation of IL-6 receptor/STAT3 downstream signaling in rheumatoid arthritis patients Open
Interleukin-6 (IL-6) is a relevant cytokine in rheumatoid arthritis (RA) pathogenesis, potentially activating Janus kinases (JAK)-1, -2, and tyrosine kinase 2 (TYK2), and thus, three signal transducer and activator of transcription (STAT)-…
View article: Sex Differences in Cardiovascular Risk Profiles of Patients with Rheumatoid Arthritis: Results from an Italian Multicentre Cohort
Sex Differences in Cardiovascular Risk Profiles of Patients with Rheumatoid Arthritis: Results from an Italian Multicentre Cohort Open
Objective: The effect of sex and gender-related variables on the evaluation of cardiovascular (CV) risk in rheumatoid arthritis patients has been poorly explored. We investigated the differences in CV risk features and scores according to …
View article: Adherence to the 2019 ESC/EAS guidelines for dyslipidaemia management in a large rheumatoid arthritis cohort: Data from the CORDIS Study Group of the Italian Society of Rheumatology
Adherence to the 2019 ESC/EAS guidelines for dyslipidaemia management in a large rheumatoid arthritis cohort: Data from the CORDIS Study Group of the Italian Society of Rheumatology Open
In a wide Italian RA cohort, more than 50% of patients had high or very high CV risk. In these, lipid-lowering treatment prescription is suboptimal leading to not achievement of LDL-c target. Physicians should improve lipid screening and p…
View article: Long-term retention rate, adverse event temporal patterns and rescue treatment strategies of mycophenolate mofetil in systemic sclerosis: insights from real-life
Long-term retention rate, adverse event temporal patterns and rescue treatment strategies of mycophenolate mofetil in systemic sclerosis: insights from real-life Open
Objectives MMF is a mainstay for the treatment of SSc. The occurrence and implications of MMF-related adverse events (AEs) on drug retention rates in real life remain poorly defined. We aimed to determine the MMF retention rate and to inve…
View article: Pulmonary and extra-pulmonary effects of lung transplantation in an Italian cohort of patients with systemic sclerosis
Pulmonary and extra-pulmonary effects of lung transplantation in an Italian cohort of patients with systemic sclerosis Open
Objectives Lung transplantation (LuTx) is a life-saving intervention for SSc patients with end-stage lung disease. The aim of this study was to evaluate patients’ survival and LuTx outcomes on systemic disease manifestations. Methods A ret…
View article: Disease activity assessment for juvenile idiopathic arthritis in transitional care
Disease activity assessment for juvenile idiopathic arthritis in transitional care Open
Objective. The indices to measure disease activity of chronic arthritis in adulthood and childhood are different. Therefore, assessing the status of the disease in young patients with juvenile idiopathic arthritis (JIA) can be tricky, espe…
View article: Rituximab retention rate in systemic sclerosis: a long term real-life multicentre study
Rituximab retention rate in systemic sclerosis: a long term real-life multicentre study Open
Objectives To report real-life data on rituximab retention rate as an indicator of safety and efficacy in a multicentric national cohort of systemic sclerosis patients. Methods SSc patients treated with rituximab and followed for at least …
View article: Practice pattern for the use of intravenous iloprost for the treatment of peripheral vasculopathy in systemic sclerosis: A case–control study from the Italian national multicenter “SPRING” (Systemic Sclerosis Progression InvestiGation) Registry
Practice pattern for the use of intravenous iloprost for the treatment of peripheral vasculopathy in systemic sclerosis: A case–control study from the Italian national multicenter “SPRING” (Systemic Sclerosis Progression InvestiGation) Registry Open
Background: Intravenous iloprost has been widely used for the treatment of systemic sclerosis peripheral vasculopathy. No agreement has been found on the regimen and the dosage of intravenous iloprost in different scleroderma subset condit…
View article: Modulation of Il-6 Receptor/Stat3 Downstream Signaling in Rheumatoid Arthritis Patients
Modulation of Il-6 Receptor/Stat3 Downstream Signaling in Rheumatoid Arthritis Patients Open
View article: Janus kinase inhibitors: between prescription authorization and reimbursability
Janus kinase inhibitors: between prescription authorization and reimbursability Open
Following the restrictions on the reimbursability of Janus kinase inhibitors introduced by the Italian Medicines Agency, the Italian Society of Rheumatology has drafted this document to shed light on the clinical conditions and reimbursabi…
View article: Effects of cytotoxic T-lymphocyte-associated protein 4 compared to TNF inhibitors on lipid profile: Results from an observational multicentre rheumatoid arthritis cohort
Effects of cytotoxic T-lymphocyte-associated protein 4 compared to TNF inhibitors on lipid profile: Results from an observational multicentre rheumatoid arthritis cohort Open