Fábio Duran
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View article: Inner and outer retinal abnormalities detected in Alzheimer's disease subjects diagnosed by amyloid PET not revealed when classified based on clinical criteria
Inner and outer retinal abnormalities detected in Alzheimer's disease subjects diagnosed by amyloid PET not revealed when classified based on clinical criteria Open
BACKGROUND Previous studies on retinal changes in Alzheimer's disease (AD) using optical coherence tomography (OCT) and electroretinography (ERG) based on clinical diagnostic criteria have yielded inconsistent results. We evaluated retinal…
View article: Cachexia Alters Central Nervous System Morphology and Functionality in Cancer Patients
Cachexia Alters Central Nervous System Morphology and Functionality in Cancer Patients Open
Background Cachexia is a clinically challenging multifactorial and multi‐organ syndrome, associated with poor outcome in cancer patients, and characterised by inflammation, wasting and loss of appetite. The syndrome leads to central nervou…
View article: Stable brain PET metabolic networks using a multiple sampling scheme
Stable brain PET metabolic networks using a multiple sampling scheme Open
Interregional communication within the human brain is essential for maintaining functional integrity. A promising approach for investigating how brain regions communicate relies on the assumption that the brain operates as a complex networ…
View article: Human development, inequality, and their associations with brain structure across 29 countries
Human development, inequality, and their associations with brain structure across 29 countries Open
Background The macro-social and environmental conditions in which people live, such as the level of a country’s development or inequality, are associated with brain-related disorders. However, the relationship between these systemic enviro…
View article: STRUCTURAL BRAIN CHANGES IN LATE ONSET DEPRESSION
STRUCTURAL BRAIN CHANGES IN LATE ONSET DEPRESSION Open
Background Structural brain changes in grey matter in late‐life depression (LLD) remains an intriguing area of research. Furthermore, late‐onset depression (LOD) has been frequently associated with general medical comorbidities, cognitive …
View article: Country-level gender inequality is associated with structural differences in the brains of women and men
Country-level gender inequality is associated with structural differences in the brains of women and men Open
Gender inequality across the world has been associated with a higher risk to mental health problems and lower academic achievement in women compared to men. We also know that the brain is shaped by nurturing and adverse socio-environmental…
View article: An insight into the acute effects of cannabidiol on human brain function and their relationship with the brain expression of its molecular targets: a neuroimaging meta-regression analysis
An insight into the acute effects of cannabidiol on human brain function and their relationship with the brain expression of its molecular targets: a neuroimaging meta-regression analysis Open
Background Cannabidiol (CBD) is a non-intoxicating substance present in the extract of Cannabis sativa popularised by its therapeutic potential. A limited number of neuroimaging studies have investigated CBD effects on brain function prima…
View article: Brain Perfusion Alterations Induced by Standalone and Combined Non-Invasive Brain Stimulation over the Dorsolateral Prefrontal Cortex
Brain Perfusion Alterations Induced by Standalone and Combined Non-Invasive Brain Stimulation over the Dorsolateral Prefrontal Cortex Open
Non-invasive brain stimulation (NIBS) interventions are promising for the treatment of psychiatric disorders. Notwithstanding, the NIBS mechanisms of action over the dorsolateral prefrontal cortex (DLPFC), a hub that modulates affective an…
View article: Task-independent acute effects of delta-9-tetrahydrocannabinol on human brain function and its relationship with cannabinoid receptor gene expression: A neuroimaging meta-regression analysis
Task-independent acute effects of delta-9-tetrahydrocannabinol on human brain function and its relationship with cannabinoid receptor gene expression: A neuroimaging meta-regression analysis Open
The neurobiological mechanisms underlying the effects of delta-9-tetrahydrocannabinol (THC) remain unclear. Here, we examined the spatial acute effect of THC on human regional brain activation or blood flow (hereafter called 'activation si…
View article: Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings
Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings Open
People recovered from COVID-19 may still present complications including respiratory and neurological sequelae. In other viral infections, cognitive impairment occurs due to brain damage or dysfunction caused by vascular lesions and inflam…
View article: Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea
Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea Open
Impaired glucose metabolism reflects neuronal/synaptic dysfunction and cognitive function decline in patients with obstructive sleep apnea (OSA). The study investigated the extent to which exercise training (ET) improves cerebral metabolic…
View article: The Association Between Acquired Color Deficiency and PET Imaging of Neurodegeneration in Mild Cognitive Impairment and Alzheimer Disease
The Association Between Acquired Color Deficiency and PET Imaging of Neurodegeneration in Mild Cognitive Impairment and Alzheimer Disease Open
Here, patients with AD and patients with MCI present acquired color vision deficiency that may be linked with impaired brain metabolism.
View article: Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings
Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings Open
People recovered from COVID-19 may still present complications including respiratory and neurological sequelae. In other viral infections, cognitive impairment occurs due to brain damage or dysfunction caused by vascular lesions and inflam…
View article: Cannabidiol Treatment Improves Glucose Metabolism and Memory in Streptozotocin-Induced Alzheimer’s Disease Rat Model: A Proof-of-Concept Study
Cannabidiol Treatment Improves Glucose Metabolism and Memory in Streptozotocin-Induced Alzheimer’s Disease Rat Model: A Proof-of-Concept Study Open
An early and persistent sign of Alzheimer’s disease (AD) is glucose hypometabolism, which can be evaluated by positron emission tomography (PET) with 18F-2-fluoro-2-deoxy-D-glucose ([18F]FDG). Cannabidiol has demonstrated neuroprotective a…
View article: Evaluation of 10-minute post-injection 11C-PiB PET and its correlation with 18F-FDG PET in older adults who are cognitively healthy, mildly impaired, or with probable Alzheimer's disease
Evaluation of 10-minute post-injection 11C-PiB PET and its correlation with 18F-FDG PET in older adults who are cognitively healthy, mildly impaired, or with probable Alzheimer's disease Open
Our study suggests that early-phase 11C-PiB uptake correlates with 18F-FDG, irrespective of the particular amyloid-beta status. In addition, we observed distinct regional distribution patterns between both biomarkers, reinforcing the need …
View article: Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium
Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium Open
Small average differences in the left-right asymmetry of cerebral cortical thickness have been reported in individuals with autism spectrum disorder (ASD) compared to typically developing controls. Although these alterations affect multipl…
View article: Evaluation of relationships between presence of adhesio interthalamica and cannabis use in first-episode psychosis: a magnetic resonance imaging investigation
Evaluation of relationships between presence of adhesio interthalamica and cannabis use in first-episode psychosis: a magnetic resonance imaging investigation Open
Recent studies suggested that cannabis use influences on the emergence of psychosis by disrupting neurodevelopmental processes that occur during adolescence and early adulthood and which are reflected on brain anatomical changes detectable…
View article: Sex differences in total brain volume in a cognitively unimpaired elderly population
Sex differences in total brain volume in a cognitively unimpaired elderly population Open
Introduction Although a large number of studies have shown brain volumetric differences between men and women, only a few investigations to date have analyzed brain tissue volumes in representative samples of the general elderly population…
View article: Callosal abnormalities, altered cortisol levels, and neurocognitive deficits associated with early maltreatment among adolescents: A voxel‐based diffusion‐tensor imaging study
Callosal abnormalities, altered cortisol levels, and neurocognitive deficits associated with early maltreatment among adolescents: A voxel‐based diffusion‐tensor imaging study Open
Introduction Neuroimaging studies have shown callosal abnormalities among maltreated subjects, but little is known about the functional and neurobiological correlates of these supposed developmental alterations. The aim of this study was t…
View article: Psychiatric neuroimaging research in Brazil: historical overview, current challenges, and future opportunities
Psychiatric neuroimaging research in Brazil: historical overview, current challenges, and future opportunities Open
The last four decades have witnessed tremendous growth in research studies applying neuroimaging methods to evaluate pathophysiological and treatment aspects of psychiatric disorders around the world. This article provides a brief history …
View article: Fully Automated Habenula Segmentation Provides Robust and Reliable Volume Estimation Across Large Magnetic Resonance Imaging Datasets, Suggesting Intriguing Developmental Trajectories in Psychiatric Disease
Fully Automated Habenula Segmentation Provides Robust and Reliable Volume Estimation Across Large Magnetic Resonance Imaging Datasets, Suggesting Intriguing Developmental Trajectories in Psychiatric Disease Open
Studies of habenula (Hb) function and structure provided evidence of its involvement in psychiatric disorders, including schizophrenia and bipolar disorder. Previous studies using magnetic resonance imaging (manual/semiautomated segmentati…
View article: Mnemonic strategy training modulates functional connectivity at rest in mild cognitive impairment: Results from a randomized controlled trial
Mnemonic strategy training modulates functional connectivity at rest in mild cognitive impairment: Results from a randomized controlled trial Open
Introduction Mnemonic strategy training (MST) has been shown to improve cognitive performance and increase brain activation in those with mild cognitive impairment (MCI). However, little is known regarding the effects of MST on functional …