Fabio Leonardi
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View article: Ovariectomy in Canine Surgical Medicine: A Comparative Analysis of Surgical Approaches and the Nociceptive, Inflammatory, and Oxidative Stress Responses
Ovariectomy in Canine Surgical Medicine: A Comparative Analysis of Surgical Approaches and the Nociceptive, Inflammatory, and Oxidative Stress Responses Open
This study aimed to compare the physiological impact of open ovariectomy (the O group) and laparoscopic ovariectomy (the LA group) in dogs by evaluating intraoperative nociceptive responses, postoperative pain, inflammatory markers, and ox…
View article: Evaluation of Depth of Anesthesia Sleep Quality in Swine Undergoing Hernia Repair: Effects of Romifidine/Ketamine-Diazepam Protocols with and Without Tramadol and the Potential Role of Serotonin as a Biomarker
Evaluation of Depth of Anesthesia Sleep Quality in Swine Undergoing Hernia Repair: Effects of Romifidine/Ketamine-Diazepam Protocols with and Without Tramadol and the Potential Role of Serotonin as a Biomarker Open
Sedation and anesthesia are essential for ensuring animal welfare during surgical procedures such as hernia repair in swine. However, the number of sedative and anesthetic agents officially approved for livestock use remained limited. This…
View article: Sex-specific cardiac electrophysiological remodeling influences the susceptibility to arrhythmias in elderly rats
Sex-specific cardiac electrophysiological remodeling influences the susceptibility to arrhythmias in elderly rats Open
Aged heart is more prone to develop cardiovascular diseases including arrhythmias. The age-related electrical remodeling of the heart results in specific electrophysiological alterations in male and female rats. Males could experience more…
View article: Analgesic efficacy of tapentadol in chronic joint disorders in horses: plasma serotonin concentration and adrenocortical response as biomarkers of pain-induced stress
Analgesic efficacy of tapentadol in chronic joint disorders in horses: plasma serotonin concentration and adrenocortical response as biomarkers of pain-induced stress Open
The study aimed to evaluate the analgesic efficacy of tapentadol in horses, by determining plasma serotonin concentration and adrenocortical response, as biomarkers of pain stress in chronic joint disorders. Thirty-six horses (20 females a…
View article: Synthetic and Natural Biomaterials in Veterinary Medicine and Ophthalmology: A Review of Clinical Cases and Experimental Studies
Synthetic and Natural Biomaterials in Veterinary Medicine and Ophthalmology: A Review of Clinical Cases and Experimental Studies Open
In recent years, there has been a growing interest in 3D printing technology within the field of bioengineering. This technology offers the ability to create devices with intricate macro- and micro-geometries, as well as specific models. I…
View article: Oxidative stress in relation to serotonin under general anaesthesia in dogs undergoing ovariectomy
Oxidative stress in relation to serotonin under general anaesthesia in dogs undergoing ovariectomy Open
Abdominal surgery such as ovariectomy is a traumatic event that can cause oxidative stress. The aim of the present study was to evaluate the concentration of serotonin in relation to ovariectomy-induced oxidative stress in dogs undergoing …
View article: Effect of surgery on oxidative stress and endogenous tocopherol concentrations in juvenile female dogs
Effect of surgery on oxidative stress and endogenous tocopherol concentrations in juvenile female dogs Open
Background Surgery such as ovariectomy causes an inflammatory and oxidative stress. This study was designed to evaluate endogenous tocopherol levels in response to surgical oxidative stress induced by abdominal surgery (ovariectomy) in thi…
View article: Surgical Site Infiltration with Comfort-in Device and Traditional Syringe in Dogs Undergoing Regional Mastectomy: Evaluation of Intra- and Postoperative Pain and Oxidative Stress
Surgical Site Infiltration with Comfort-in Device and Traditional Syringe in Dogs Undergoing Regional Mastectomy: Evaluation of Intra- and Postoperative Pain and Oxidative Stress Open
The surgical site infiltration of a local anesthetic is defined as the direct injection of a drug. This study aimed to compare the effects of surgical site infiltration with 4 mg kg−1 lidocaine using a Comfort-in device and traditional syr…
View article: Tramadol vs. Lidocaine Administered Intraperitoneally and in Incisional Lines for the Intraoperative and Postoperative Pain Management of Romifidine-Telazol-Anesthetized Swine Undergoing Umbilical Hernia Repair
Tramadol vs. Lidocaine Administered Intraperitoneally and in Incisional Lines for the Intraoperative and Postoperative Pain Management of Romifidine-Telazol-Anesthetized Swine Undergoing Umbilical Hernia Repair Open
The aim of the study was to compare the analgesic efficacy of tramadol and lidocaine for local anesthesia during umbilical hernia repair in swine. The study was performed on 66 large white crossbred swine. The swine received a mixture of t…
View article: Effect of Meloxicam in a Protocol of Balanced Anaesthesia with Propofol and Sevoflurane on the α- δ- γ-Tocopherols in Response to Inflammatory Oxidative Stress Induced by Ovariectomy in Dogs
Effect of Meloxicam in a Protocol of Balanced Anaesthesia with Propofol and Sevoflurane on the α- δ- γ-Tocopherols in Response to Inflammatory Oxidative Stress Induced by Ovariectomy in Dogs Open
The present clinical study was approved by the Review Board for Animals Care of the University of Parma prot N. 03/CESA /2023, which provided a consent to the clinical study: regulation (EU) no. 536/2014. (22A01712) (GU General Series n.65…
View article: Tramadol Administered Intravenously Either as a Bolus or a Slow Injection in Pain Management of Romifidine-Sedated Calves Undergoing Umbilical Hernia Repair
Tramadol Administered Intravenously Either as a Bolus or a Slow Injection in Pain Management of Romifidine-Sedated Calves Undergoing Umbilical Hernia Repair Open
Umbilical hernias in calves occur with relative frequency. Most abdominal surgeries can be performed in cattle using standing sedation and local blocks. Romifidine is widely used in calves, alone or in combination with opioids. Tramadol ad…
View article: Effect on physiological parameters and anaesthetic dose requirement of isoflurane when tramadol given as a continuous rate infusion vs a single intravenous bolus injection during ovariohysterectomy in dogs
Effect on physiological parameters and anaesthetic dose requirement of isoflurane when tramadol given as a continuous rate infusion vs a single intravenous bolus injection during ovariohysterectomy in dogs Open
Background Tramadol produces a significant reduction in both sevoflurane and isoflurane minimum alveolar concentrations in dogs under experimental conditions. This study aims to compare the effects of tramadol administered as a constant ra…
View article: Levobupivacaine Combined with Cisatracurium in Peribulbar Anaesthesia in Cats Undergoing Corneal and Lens Surgery
Levobupivacaine Combined with Cisatracurium in Peribulbar Anaesthesia in Cats Undergoing Corneal and Lens Surgery Open
The aims of the study included evaluating the effects of levobupivacaine combined with cisatracurium on akinesia and mydriasis when administered by peribulbar injection, and evaluating if the chosen dose of cisatracurium is enough to avoid…
View article: Is pneumothorax secondary to pneumoperitoneum a real risk in dogs undergoing total laparoscopic gastropexy?
Is pneumothorax secondary to pneumoperitoneum a real risk in dogs undergoing total laparoscopic gastropexy? Open
Background: There were described in veterinary literature the possibility of pneumothorax as a complication of laparoscopic surgery in dogs undergoing laparoscopic ovariectomy associated with total laparoscopic gastropexy. Aim: To assess i…
View article: Crossed Corticostriatal Projections in the Macaque Brain
Crossed Corticostriatal Projections in the Macaque Brain Open
In nonhuman primates, major input to the striatum originates from ipsilateral cortex and thalamus. The striatum is a target also of crossed corticostriatal (CSt) projections from the contralateral hemisphere, which have been so far somewha…
View article: Case Report: A Novel Ventilated Thermoplastic Mesh Bandage for Post-operative Management of Large Soft Tissue Defects: A Case Series of Three Dogs Treated With Autologous Platelet Concentrates
Case Report: A Novel Ventilated Thermoplastic Mesh Bandage for Post-operative Management of Large Soft Tissue Defects: A Case Series of Three Dogs Treated With Autologous Platelet Concentrates Open
A ventilated thermoplastic mesh bandage was used for the post-operative management of large soft tissue defects in three dogs. Once the granulation tissue appeared, the wounds were treated with liquid or jellified autologous platelet conce…
View article: Evaluation of the paw withdrawal latency for the comparison between tramadol and butorphanol administered locally, in the plantar surface of rat, preliminary study
Evaluation of the paw withdrawal latency for the comparison between tramadol and butorphanol administered locally, in the plantar surface of rat, preliminary study Open
The aim of the study was to evaluate the analgesic efficacy of tramadol compared to butorphanol administered locally in ventral surface of the hind paw of rats. Prospective, randomized experimental study; twenty-one adult male Wistar rats …
View article: Comparison of analgesic and sedative effects between three doses of tramadol in calves
Comparison of analgesic and sedative effects between three doses of tramadol in calves Open
Aim - The aim of this study was to evaluate and compare the analgesia and ataxia degree between three dosages of tramadol in cattle.Methods - Thirty Friesian cows undergoing transrectal and transvaginal ultrasound examination were enrolled…
View article: Peribulbar Sub-Tenon’s Anaesthesia With Levo-Bupivacaine and Cis-Atracurium Besilate in Ophthalmic Intraocular Surgery in Cat: Clinical Study.
Peribulbar Sub-Tenon’s Anaesthesia With Levo-Bupivacaine and Cis-Atracurium Besilate in Ophthalmic Intraocular Surgery in Cat: Clinical Study. Open
Backgroundthis study aims to evaluate the efficacy of Levo-bupivacaine with the addition of a small dose of cisatracurium by sub-Tenon’s injection on akinesia and mydriasis. Then, to evaluate if such a small dose of cisatracurium could det…
View article: Epithelial to Mesenchymal Transition (EMT) in a Laryngeal Squamous Cell Carcinoma of a Horse: Future Perspectives
Epithelial to Mesenchymal Transition (EMT) in a Laryngeal Squamous Cell Carcinoma of a Horse: Future Perspectives Open
Squamous cell carcinoma (SCC) is one of the most frequent tumors of skin and muco-cutaneous junctions in the horse. Equine papillomavirus type 2 (EcPV2) has been detected in equine SCC of the oral tract and genitals, and recently also in t…
View article: Combined laparoscopic ovariectomy and laparoscopic‐assisted gastropexy versus combined laparoscopic ovariectomy and total laparoscopic gastropexy: A comparison of surgical time, complications and postoperative pain in dogs
Combined laparoscopic ovariectomy and laparoscopic‐assisted gastropexy versus combined laparoscopic ovariectomy and total laparoscopic gastropexy: A comparison of surgical time, complications and postoperative pain in dogs Open
The trend in laparoscopy is to develop easy and rapid techniques associated with reduced intraoperative complications and decreased postoperative pain. The aim of this study was to compare combined laparoscopic ovariectomy (OIE) and laparo…
View article: Issue Information
Issue Information Open
Cover IllustrationFrom Specchi and D'Anjou.Schematic illustration of collateral vascular pathways caused by caudal vena cava obstructions in dogs.Superficial (A), intermediate (B), portal (C), and deep (D) collateral pathways.Caudal vena c…
View article: Ovarian remnant syndrome after laparoscopic ovariectomy in a cat
Ovarian remnant syndrome after laparoscopic ovariectomy in a cat Open
The first case of accidental implantation of ovarian tissue at the port site after laparoscopic ovariectomy in a cat was described. A 2-year-old, spayed female, domestic cat showed recurrent behavioral oestrus signs (vocalization, increase…
View article: Spontaneous pneumothorax in two dogs undergoing combined laparoscopic ovariectomy and total laparoscopic gastropexy
Spontaneous pneumothorax in two dogs undergoing combined laparoscopic ovariectomy and total laparoscopic gastropexy Open
Two dogs underwent a combined laparoscopic ovariectomy and total laparoscopic gastropexy. The intra-abdominal pressure and pulmonary compliance decreased, but the peak airway pressure increased at 20 min after the start of gastropexy with …
View article: Polymeric films loaded with cisplatin for malignant pleural mesothelioma: a pharmacokinetic study in an ovine model
Polymeric films loaded with cisplatin for malignant pleural mesothelioma: a pharmacokinetic study in an ovine model Open
Polymeric films loaded with cisplatin allowed to reach significantly higher intrapleural and plasmatic cisplatin concentrations compared to intrapleural and intravenous cisplatin solution, providing at the same time, a significant reductio…
View article: The Contribution of Adipose Tissue-Derived Mesenchymal Stem Cells and Platelet-Rich Plasma to the Treatment of Chronic Equine Laminitis: A Proof of Concept
The Contribution of Adipose Tissue-Derived Mesenchymal Stem Cells and Platelet-Rich Plasma to the Treatment of Chronic Equine Laminitis: A Proof of Concept Open
Laminitis, a highly debilitating disease of the foot in ungulates, is characterized by pathological changes of the complex lamellar structures that maintain the appendicular skeleton within the hoof. Laminitis is a multifactorial disease t…