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View article: Elexacaftor/tezacaftor/ivacaftor (ETI) therapy modifies the expression of interferon beta and inflammatory genes in the airways of adult patients with cystic fibrosis: a pilot study
Elexacaftor/tezacaftor/ivacaftor (ETI) therapy modifies the expression of interferon beta and inflammatory genes in the airways of adult patients with cystic fibrosis: a pilot study Open
Cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies have revolutionized the treatment of cystic fibrosis (CF) by targeting the underlying protein defect. Investigating how elexacaftor/tezacaftor/ivacaftor (ETI) t…
View article: Cost-Effectiveness Analysis of Nirsevimab for the Prevention of Respiratory Syncytial Virus among Italian Infants
Cost-Effectiveness Analysis of Nirsevimab for the Prevention of Respiratory Syncytial Virus among Italian Infants Open
A prophylaxis strategy against RSV infection targeting all infants with nirsevimab could represent a cost-effective option for both NHS and societal perspectives, and supports the implementation and the equity of RSV prevention for all inf…
View article: Long COVID in pediatric age: an observational, prospective, longitudinal, multicenter study in Italy
Long COVID in pediatric age: an observational, prospective, longitudinal, multicenter study in Italy Open
Introduction This observational prospective longitudinal multicenter study examines the occurrence and characteristics of long COVID (LC) in the Italian pediatric population. Methods Conducted across 12 Pediatric Units in Italy from Januar…
View article: Treatment of sinusitis in children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-SIM-FIMMG)
Treatment of sinusitis in children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-SIM-FIMMG) Open
Sinusitis is an inflammation of the mucous membrane of the paranasal sinuses. Bacterial sinusitis usually occurs as a complication of viral infections of the upper respiratory tract and is a frequent cause of medical consultation. The clin…
View article: Economic and clinical burden associated with respiratory syncytial virus and impact of universal immunization with nirsevimab in Italy
Economic and clinical burden associated with respiratory syncytial virus and impact of universal immunization with nirsevimab in Italy Open
Objectives: To describe the seasonal respiratory syncytial virus (RSV) burden in Italy considering the current prophylaxis strategy with palivizumab recommended only for high-risk infants (representing only 4.4% of an estimated birth cohor…
View article: NRF2 Antioxidant Response and Interferon‐Stimulated Genes Are Differentially Expressed in SARS‐CoV‐2‐Positive Young Subjects
NRF2 Antioxidant Response and Interferon‐Stimulated Genes Are Differentially Expressed in SARS‐CoV‐2‐Positive Young Subjects Open
Background Several respiratory viruses, including Severe Acute Respiratory Syndrome‐Coronavirus‐2 (SARS‐CoV‐2), suppress nuclear factor‐E2‐related factor‐2 (NRF2) antioxidant response, generating oxidative stress conditions to its advantag…
View article: Respiratory Syncytial Virus: The Urgent Need for Innovative Preventive Strategies
Respiratory Syncytial Virus: The Urgent Need for Innovative Preventive Strategies Open
Respiratory Syncytial Virus (RSV) is a medium-sized enveloped Pneumovirus belonging to the Paramyxoviridae family [...]
View article: Sharenting: characteristics and awareness of parents publishing sensitive content of their children on online platforms
Sharenting: characteristics and awareness of parents publishing sensitive content of their children on online platforms Open
Background The term “sharenting” describes the increasingly popular habit of parents to share photos, videos, or other information regarding their children on their social profiles, through online platforms. It is highly likely that many p…
View article: Pertussis outbreak in neonates and young infants across Italy, January to May 2024: implications for vaccination strategies
Pertussis outbreak in neonates and young infants across Italy, January to May 2024: implications for vaccination strategies Open
Since January 2024, Italy experiences a pertussis outbreak, primarily affecting neonates and unvaccinated infants at high risk of severe complications and mortality; 11 major paediatric centres noted 108 hospitalisations and three deaths b…
View article: Sharenting: risks and awareness when parents publish sensitive content of their children on online platforms
Sharenting: risks and awareness when parents publish sensitive content of their children on online platforms Open
Background The term "sharenting’' describes the increasingly popular habit of parents to share photos, videos, or other information regarding their children on their social profiles, through online platforms. It is highly likely that many …
View article: Expiratory braking defines the breathing patterns of asphyxiated neonates during therapeutic hypothermia
Expiratory braking defines the breathing patterns of asphyxiated neonates during therapeutic hypothermia Open
Introduction Although neonatal breathing patterns vary after perinatal asphyxia, whether they change during therapeutic hypothermia (TH) remains unclear. We characterized breathing patterns in infants during TH for hypoxic-ischemic encepha…
View article: Sequence analysis of respiratory syncytial virus cases reveals a novel subgroup -B strain circulating in north-central Italy after pandemic restrictions
Sequence analysis of respiratory syncytial virus cases reveals a novel subgroup -B strain circulating in north-central Italy after pandemic restrictions Open
This study describes the temporal dynamics of post-pandemic RSV subgroups and uncovers a lineage of RSV-B with high genetic divergence that may have increased the impact of decreased population immunity.
View article: Reduced Serum Brain-Derived Neurotrophic Factor in Infants Affected by Severe Bronchiolitis
Reduced Serum Brain-Derived Neurotrophic Factor in Infants Affected by Severe Bronchiolitis Open
Background: Bronchiolitis is an acute viral infection of the lower respiratory tract, typical of infants in their first year of life and causing hypoxia in the most serious cases. Bronchiolitis recognizes various demographic risk factors t…
View article: SARS-CoV-2–specific mucosal immune response in vaccinated versus infected children
SARS-CoV-2–specific mucosal immune response in vaccinated versus infected children Open
The anti-COVID-19 intramuscular vaccination induces a strong systemic but a weak mucosal immune response in adults. Little is known about the mucosal immune response in children infected or vaccinated against SARS-CoV-2. We found that 28% …
View article: Evaluation of platelet indices as early biomarkers for bacterial infections in pediatric emergency departments
Evaluation of platelet indices as early biomarkers for bacterial infections in pediatric emergency departments Open
Discriminating bacterial from viral etiology of infectious diseases can be challenging in pediatric age, especially during the �irst year of life and even more in an emergency setting.Recent research has identi�ied in platelet indices a po…
View article: Acute Pupillary Disorders in Children: A 10-Year Retrospective Study of 101 Patients
Acute Pupillary Disorders in Children: A 10-Year Retrospective Study of 101 Patients Open
Background: To date, no study has specifically examined children with acute-onset pupillary motility disorders (APMD). Especially in the Emergency Department (ED), it is crucial to distinguish benign and transient conditions from life-thre…
View article: Interferon system I e III protects patients with cystic fibrosis from Sars Cov2 infection
Interferon system I e III protects patients with cystic fibrosis from Sars Cov2 infection Open
Interferon system I e III protects patients with cystic fibrosis from SARS-CoV2 infection
View article: A Single Center Observational Study on Clinical Manifestations and Associated Factors of Pediatric Long COVID
A Single Center Observational Study on Clinical Manifestations and Associated Factors of Pediatric Long COVID Open
Children with SARS-CoV-2 are mostly mild symptomatic, but they may develop conditions, such as persisting symptoms, that may put them at greater risk of complications. Our aim was to evaluate the frequency and the presence of risk factors …
View article: Investigating the Relationship Between COVID‐19 and Celiac Disease. A Dual Research Approach
Investigating the Relationship Between COVID‐19 and Celiac Disease. A Dual Research Approach Open
Background: Most evidence on the coronavirus disease 2019 (COVID‐19) pandemic, has been obtained from web‐ or telephone‐based surveys. In particular, few laboratory data, often incomplete, have been reported on the frequency of COVID‐19‐re…