Fábio Trindade Maranhão Costa
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View article: Evaluation of the Activity of 4-Quinolones against Multi-Life Stages of <i>Plasmodium</i> spp.
Evaluation of the Activity of 4-Quinolones against Multi-Life Stages of <i>Plasmodium</i> spp. Open
Malaria is a critical global health problem, with high mortality and morbidity rates, which ultimately hinder socioeconomic development in endemic areas. The evolution of drug resistance in malaria parasites, particularly in the case of
View article: Exploring the naturally acquired response to Pvs47 gametocyte antigen
Exploring the naturally acquired response to Pvs47 gametocyte antigen Open
Malaria represents a challenging global public health task, with Plasmodium vivax being the predominant parasite in Brazil and the most widely distributed species throughout the world. Developing a vaccine against P. vivax malaria demands …
View article: Host metabolomic responses in recurrent P. vivax malaria
Host metabolomic responses in recurrent P. vivax malaria Open
Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as a promising tool for combating the disease. The study evaluated plasma metabolomic pr…
View article: Pathophysiology of chikungunya virus infection associated with fatal outcomes
Pathophysiology of chikungunya virus infection associated with fatal outcomes Open
View article: Selective Bias Virtual Screening for Discovery of Promising Antimalarial Candidates targeting Plasmodium N-Myristoyltransferase
Selective Bias Virtual Screening for Discovery of Promising Antimalarial Candidates targeting Plasmodium N-Myristoyltransferase Open
View article: Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated response
Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated response Open
Postmortem single-cell studies have transformed understanding of lower respiratory tract diseases (LRTD) including Covid19 but there is almost no data from African settings where HIV, malaria and other environmental exposures may affect di…
View article: Unveiling the antiviral capabilities of targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2
Unveiling the antiviral capabilities of targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2 Open
The urgent need for effective treatments against emerging viral diseases, driven by drug-resistant strains and new viral variants, remains critical. We focus on inhibiting the human dihydroorotate dehydrogenase ( Hs DHODH), one of the enzy…
View article: Disease trajectories in hospitalized COVID-19 patients are predicted by clinical and peripheral blood signatures representing distinct lung pathologies
Disease trajectories in hospitalized COVID-19 patients are predicted by clinical and peripheral blood signatures representing distinct lung pathologies Open
Summary Linking clinical biomarkers and lung pathology still is necessary to understand COVID-19 pathogenesis and the basis of progression to lethal outcomes. Resolving these knowledge gaps enables optimal treatment approaches of severe CO…
View article: Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations – a study protocol from the clinical and applied research in Chikungunya (REPLICK network)
Multicenter study of the natural history and therapeutic responses of patients with chikungunya, focusing on acute and chronic musculoskeletal manifestations – a study protocol from the clinical and applied research in Chikungunya (REPLICK network) Open
Background Chikungunya is associated with high morbidity and the natural history of symptomatic infection has been divided into three phases (acute, post-acute, and chronic) according to the duration of musculoskeletal symptoms. Although t…
View article: Podoplanin and CLEC-2 levels in patients with COVID-19
Podoplanin and CLEC-2 levels in patients with COVID-19 Open
View article: Comparative analysis of pulmonary immunopathology in COVID-19 patients and experimentally SARS-CoV-2 infected hamsters
Comparative analysis of pulmonary immunopathology in COVID-19 patients and experimentally SARS-CoV-2 infected hamsters Open
View article: Association of Ang/Tie2 pathway mediators with endothelial barrier integrity and disease severity in COVID-19
Association of Ang/Tie2 pathway mediators with endothelial barrier integrity and disease severity in COVID-19 Open
Endothelial barrier (EB) disruption contributes to acute lung injury in COVID-19, and levels of both VEGF-A and Ang-2, which are mediators of EB integrity, have been associated with COVID-19 severity. Here we explored the participation of …
View article: Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis
Rosette formation by Plasmodium vivax gametocytes favors the infection in Anopheles aquasalis Open
Plasmodium vivax is a public health problem and the most common type of malaria outside sub-Saharan Africa. The capacity of cytoadhesion, rosetting, and liver latent phase development could impact treatment and disease control. Although th…
View article: Author Correction: Events associated with susceptibility to invasive Salmonella enterica serovar Typhi in BALB/c mice previously infected with Plasmodium berghei ANKA
Author Correction: Events associated with susceptibility to invasive Salmonella enterica serovar Typhi in BALB/c mice previously infected with Plasmodium berghei ANKA Open
View article: Antiplasmodial activity of aurora kinase-2 inhibitor compounds from Plasmodium spp.
Antiplasmodial activity of aurora kinase-2 inhibitor compounds from Plasmodium spp. Open
Anais do GBMeeting: Encontro Anual da Pós Graduação em Genética e Biologia Molecular da UNICAMP (978-85-5722-785-9) - Antiplasmodial Activity Of Aurora Kinase-2 Inhibitor Compounds From Plasmodium Spp.
View article: Short-Course of Methylprednisolone Improves Respiratory Functional Parameters After 120 Days in Hospitalized COVID-19 Patients (Metcovid Trial): A Randomized Clinical Trial
Short-Course of Methylprednisolone Improves Respiratory Functional Parameters After 120 Days in Hospitalized COVID-19 Patients (Metcovid Trial): A Randomized Clinical Trial Open
Background: The use of corticosteroids may help control the cytokine storm occurring in acute respiratory failure due to the severe form of COVID-19. We evaluated the postacute effect of corticosteroids used during the acute phase, such as…
View article: Circulating Levels of Ang/Tie2 and VEGF-a Pathway Mediators Are Associated with Clinical Severity, Endothelial Barrier Disruption and Coagulation Activation in COVID-19
Circulating Levels of Ang/Tie2 and VEGF-a Pathway Mediators Are Associated with Clinical Severity, Endothelial Barrier Disruption and Coagulation Activation in COVID-19 Open
Background: the pathogenesis of severe COVID-19 involves the deregulated activation of different compartments of immunothrombosis, which are otherwise important for pathogen eradication and tissue repair. Coagulation activation, angiogenes…
View article: A prenylated dsRNA sensor protects against severe COVID-19
A prenylated dsRNA sensor protects against severe COVID-19 Open
The bat connection The heterogeneity of COVID-19 makes it challenging to predict the course of infection in an individual. Upon virus infection, interferons (IFNs) generate the initial signals for cellular defenses. Knowing that defects in…
View article: Author response: Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients
Author response: Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in Plasmodium vivax patients Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Plasmodium vivax is the major cause of hum…
View article: Plasmodium vivax Gametocytes Adherence to Bone Marrow Endothelial Cells
Plasmodium vivax Gametocytes Adherence to Bone Marrow Endothelial Cells Open
In a Plasmodium vivax infection, it was shown a proportionally increased on gametocyte distribution within the bone marrow aspirant, suggesting a role of this organ as a reservoir for this parasite stage. Here, we evaluated the ex vivo cyt…
View article: A Prenylated dsRNA Sensor Protects Against Severe COVID-19 and is Absent in Horseshoe Bats
A Prenylated dsRNA Sensor Protects Against Severe COVID-19 and is Absent in Horseshoe Bats Open
Cell autonomous antiviral defenses can inhibit the replication of viruses and reduce transmission and disease severity. To better understand the antiviral response to SARS-CoV-2, we used interferon-stimulated gene (ISG) expression screenin…
View article: Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in <i>Plasmodium vivax</i> patients
Total parasite biomass but not peripheral parasitaemia is associated with endothelial and haematological perturbations in <i>Plasmodium vivax</i> patients Open
Plasmodium vivax is the major cause of human malaria in the Americas. How P. vivax infection can lead to poor clinical outcomes, despite low peripheral parasitaemia remains a matter of intense debate. Estimation of total P. vivax biomass b…
View article: Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: <i>In Vitro</i> Activity against SARS-CoV-2 and Potential Mechanisms
Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: <i>In Vitro</i> Activity against SARS-CoV-2 and Potential Mechanisms Open
Severe acute respiratory coronavirus 2 (SARS-CoV-2) is a newly identified virus that has resulted in over 2.5 million deaths globally and over 116 million cases globally in March, 2021. Small-molecule inhibitors that reverse disease severi…
View article: A suitable RNA preparation methodology for whole transcriptome shotgun sequencing harvested from Plasmodium vivax-infected patients
A suitable RNA preparation methodology for whole transcriptome shotgun sequencing harvested from Plasmodium vivax-infected patients Open
View article: Events associated with susceptibility to invasive Salmonella enterica serovar Typhi in BALB/c mice previously infected with Plasmodium berghei ANKA
Events associated with susceptibility to invasive Salmonella enterica serovar Typhi in BALB/c mice previously infected with Plasmodium berghei ANKA Open
View article: Gas6 drives Zika virus-induced neurological complications in humans and congenital syndrome in immunocompetent mice
Gas6 drives Zika virus-induced neurological complications in humans and congenital syndrome in immunocompetent mice Open
Zika virus (ZIKV) has the ability to cross placental and brain barriers, causing congenital malformations in neonates and neurological disorders in adults. However, the pathogenic mechanisms of ZIKV-induced neurological complications in ad…
View article: Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms
Repurposing the Ebola and Marburg Virus Inhibitors Tilorone, Quinacrine, and Pyronaridine: In Vitro Activity against SARS-CoV-2 and Potential Mechanisms Open
Severe acute respiratory coronavirus 2 (SARS-CoV-2) is a newly identified virus that has resulted in over 2.5 million deaths globally and over 116 million cases globally in March, 2021. Small-molecule inhibitors that reverse disease severi…
View article: Increased platelet distribution width and reduced IL-2 and IL-12 are associated with thrombocytopenia in Plasmodium vivax malaria
Increased platelet distribution width and reduced IL-2 and IL-12 are associated with thrombocytopenia in Plasmodium vivax malaria Open
BACKGROUND Thrombocytopenia in malaria involves platelet destruction and consumption; however, the cellular response underlying this phenomenon has still not been elucidated. OBJECTIVE To find associations between platelet indices and unba…
View article: Transmission-blocking compound candidates against Plasmodium vivax using P. berghei as an initial screening
Transmission-blocking compound candidates against Plasmodium vivax using P. berghei as an initial screening Open
Our results showed that P. berghei is suitable as an initial screening system to test compounds against P. vivax.
View article: Antigenicity and adhesiveness of a Plasmodium vivax VIR-E protein from Brazilian isolates
Antigenicity and adhesiveness of a Plasmodium vivax VIR-E protein from Brazilian isolates Open
PvBrVIR-E was antigenic and adhesive to CHO-ICAM1.