Fabrice Beau
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View article: Targeted approach to determine the impact of cancer-associated protease variants
Targeted approach to determine the impact of cancer-associated protease variants Open
Several steps of cancer progression, from tumor onset to metastasis, critically involve proteolytic activity. To elucidate the role of proteases in cancer, it is particularly important to consider single-nucleotide variants (SNVs) that aff…
View article: Covalent Labeling of Matrix Metalloproteases with Affinity‐Based Probes Containing Tuned Reactive N‐Acyl‐N‐Alkyl Sulfonamide Cleavable Linkers
Covalent Labeling of Matrix Metalloproteases with Affinity‐Based Probes Containing Tuned Reactive N‐Acyl‐N‐Alkyl Sulfonamide Cleavable Linkers Open
Original covalent probes with an N‐acyl‐N‐alkyl sulfonamide cleavable linker were developed to target a broad set of human Matrix Metalloproteases (MMPs). The electrophilicity of this cleavable linker was modulated to improve the selectivi…
View article: X-ray imaging with Micromegas detectors with optical readout
X-ray imaging with Micromegas detectors with optical readout Open
In the last years, optical readout of Micromegas gaseous detectors has been achieved by implementing a Micromegas detector on a glass anode coupled to a CMOS camera. Effective X-ray radiography was demonstrated using integrated imaging app…
View article: Correlative radioimaging and mass spectrometry imaging: a powerful combination to study<sup>14</sup>C-graphene oxide<i>in vivo</i>biodistribution
Correlative radioimaging and mass spectrometry imaging: a powerful combination to study<sup>14</sup>C-graphene oxide<i>in vivo</i>biodistribution Open
Correlative imaging approach based on the combination of radioimaging and MSI to study the 14 C-graphene oxide biodistribution in vivo .
View article: Monitoring In Vivo Performances of Protein–Drug Conjugates Using Site-Selective Dual Radiolabeling and Ex Vivo Digital Imaging
Monitoring In Vivo Performances of Protein–Drug Conjugates Using Site-Selective Dual Radiolabeling and Ex Vivo Digital Imaging Open
In preclinical models, the development and optimization of protein-drug conjugates require accurate determination of the plasma and tissue profiles of both the protein and its conjugated drug. To this aim, we developed a bioanalytical stra…
View article: First evidence that emerging pinnatoxin-G, a contaminant of shellfish, reaches the brain and crosses the placental barrier
First evidence that emerging pinnatoxin-G, a contaminant of shellfish, reaches the brain and crosses the placental barrier Open
Massive proliferation of some toxic marine dinoflagellates is responsible for the occurrence of harmful algal blooms and the contamination of fish and shellfish worldwide. Pinnatoxins (PnTx) (A-H) comprise an emerging phycotoxin family bel…
View article: Medica-Plus: a novel Micromegas detector for high-resolution <i>β</i> imaging for improved pharmacological applications
Medica-Plus: a novel Micromegas detector for high-resolution <i>β</i> imaging for improved pharmacological applications Open
International audience
View article: Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging
Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging Open
Matrix metalloproteinase-12 (MMP-12) is highly upregulated in several inflammatory diseases, including abdominal aortic aneurysm (AAA). Here we report four novel 99mTc-labeled radiotracers derived from a highly selective competitive MMP-12…
View article: Biodistribution of Nanostructured Lipid Carriers in Mice Atherosclerotic Model
Biodistribution of Nanostructured Lipid Carriers in Mice Atherosclerotic Model Open
Atherosclerosis is a major cardiovascular disease worldwide, that could benefit from innovative nanomedicine imaging tools and treatments. In this perspective, we here studied, by fluorescence imaging in ApoE-/- mice, the biodistribution o…
View article: Inhibitors of <scp>BMP</scp>‐1/tolloid‐like proteinases: efficacy, selectivity and cellular toxicity
Inhibitors of <span>BMP</span>‐1/tolloid‐like proteinases: efficacy, selectivity and cellular toxicity Open
BMP ‐1/tolloid‐like proteinases belong to the astacin family of human metalloproteinases, together with meprins and ovastacin. They represent promising targets to treat or prevent a wide range of diseases such as fibrotic disorders or canc…
View article: In Vivo Imaging of MMP‐13 Activity Using a Specific Polymer‐FRET Peptide Conjugate Detects Early Osteoarthritis and Inhibitor Efficacy
In Vivo Imaging of MMP‐13 Activity Using a Specific Polymer‐FRET Peptide Conjugate Detects Early Osteoarthritis and Inhibitor Efficacy Open
Imaging early molecular changes in osteoarthritic (OA) joints is instrumental for the development of disease‐modifying drugs. To this end, a fluorescent resonance energy transfer‐based peptide probe that is cleavable by matrix metalloprote…
View article: Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease
Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease Open
Significance Polycystic kidney diseases (PKDs) are genetic disorders in which multiple cysts grow in kidneys, leading to end-stage renal failure. Vasopressin antagonists (vaptans) currently used to treat PKDs have side effects due to liver…
View article: Zinc–Metalloproteinase Inhibitors: Evaluation of the Complex Role Played by the Zinc-Binding Group on Potency and Selectivity
Zinc–Metalloproteinase Inhibitors: Evaluation of the Complex Role Played by the Zinc-Binding Group on Potency and Selectivity Open
The most exploited strategy to develop potent zinc-metalloprotease inhibitors relies on a core zinc chelator and a peptidic or nonpeptidic scaffold that provides supplementary interactions for optimized potency and selectivity. Applied to …
View article: Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes
Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes Open
In designing new tracers consisting of a small peptide conjugated to a reporter of comparable size, particular attention needs to be paid to the selection of the reporter group, which can dictate both the in vitro and the in vivo performan…