Explanipedia

Investigating the Influence of Astringent Compounds on Oral Lubrication and the Protective Role of Proline-Rich Proteins Open

Ianis Ammam, Lucas Ouillon, C. Pailler‐Mattei, R. Vargiolu, Mélanie Lelièvre , et al. · 2025

Astringency, characterized by dryness and roughness in the mouth, is a major challenge for the acceptance of plant-based protein-rich foods. The mechanisms behind this sensation, particularly the role of mucins and the oral epithelium, rem…

Local Entropy in Proteins Open

Patrick Senet, Adrien Guzzo, Patrice Delarue, Christophe Laforge, Gia G. Maisuradze , et al. · 2025

Proteins populate dynamic ensembles, yet how temperature and mutations reshape them remains poorly understood. We introduce a local entropy metric that assigns each residue a Shannon entropy from a graph-based map of accessible substates, …

Local Entropy in Proteins Open

Patrick Senet, Adrien Guzzo, Patrice Delarue, Christophe Laforge, Gia G. Maisuradze , et al. · 2025

Proteins exist as dynamic conformational ensembles, and understanding how temperature and mutations reshape these ensembles remains challenging. We introduce a local entropy measure, assigning each residue a Shannon entropy S derived from …

Inosine-5′-monophosphate interacts with the TAS1R3 subunit to enhance sweet taste detection Open

Christine Belloir, Lucie Moitrier, Adeline Karolkowski, Nicolas Poirier, Fabrice Neiers , et al. · 2025

Umami and sweet taste detection is mediated by the activation of the TAS1R1/TAS1R3 and TAS1R2/TAS1R3 receptors, respectively. TAS1R2-Venus flytrap domain (VFT) constitutes the primary ligand-binding site for most of the sweeteners whereas …

Exploring the role of the MUC1 mucin in human oral lubrication by tribological in vitro studies Open

Ianis Ammam, C. Pailler‐Mattei, Lucas Ouillon, Clément Nivet, R. Vargiolu , et al. · 2024

Optimized vector for functional expression of the human bitter taste receptor TAS2R14 in HEK293 cells Open

Christine Belloir, Axel Gautier, Adeline Karolkowski, Thomas Delompré, Mathilde Jeannin , et al. · 2024

Immunophenotyping and Activation Status of Maternal Lymphocytes to Predict Spontaneous Preterm Birth in Women With Threatened Preterm Labor: A Prospective Observational Study Open

Maëva Wendremaire, Tarik Hadi, Tatiana López, Julien Guy, Fabrice Neiers , et al. · 2024

Problem Preterm birth (PTB) remains the leading cause of neonatal morbidity and mortality. Identifying women at high risk of spontaneous preterm labor (PTL) is challenging due to limited efficient diagnostic markers. Since human parturitio…

A perspective on interdisciplinary learning supported by a systems thinking approach in STEM education Open

Varsha Khare, Sesha Sriniva, Fabrice Neiers, Sang-im Lee, Piotr G. Jabłoński , et al. · 2024

Real-world problems are traditionally viewed through a disciplinary lens at the boundary of the physical, life, mathematical and chemical sciences. The existence of these boundaries in taught classroom courses from a traditional context ma…

The vacuolar sulfate transporter <span>PsSULTR4</span> is a key determinant of seed yield and protein composition in pea Open

Fanélie Bachelet, Myriam Sánchez, Delphine Aimé, Florence Naudé, Nadia Rossin , et al. · 2024

SUMMARY Pea is a grain legume crop with a high potential to accelerate the food transition due to its high seed protein content and relatively well‐balanced amino acid composition. The critical role of external sulfur (S) supply in determi…

Structural Analysis of the Drosophila melanogaster GSTome Open

Nicolas Petiot, Mathieu Schwartz, Patrice Delarue, Patrick Senet, Fabrice Neiers , et al. · 2024

Glutathione transferase (GST) is a superfamily of ubiquitous enzymes, multigenic in numerous organisms and which generally present homodimeric structures. GSTs are involved in numerous biological functions such as chemical detoxification a…

Structural and Thermodynamic Insights into Dimerization Interfaces of Drosophila Glutathione Transferases Open

Mathieu Schwartz, Nicolas Petiot, Jeanne Chaloyard, Véronique Senty-Segault, Frédéric Lirussi , et al. · 2024

This study presents a comprehensive analysis of the dimerization interfaces of fly GSTs through sequence alignment. Our investigation revealed GSTE1 as a particularly intriguing target, providing valuable insights into the variations withi…

Microbial β C-S Lyases: Enzymes with Multifaceted Roles in Flavor Generation Open

Mathieu Schwartz, Nicolas Poirier, Jade Moreno, Alena Proskura, Mélanie Lelièvre , et al. · 2024

β C-S lyases (β-CSLs; EC 4.4.1.8) are enzymes catalyzing the dissociation of β carbon–sulfur bonds of cysteine S-conjugates to produce odorant metabolites with a free thiol group. These enzymes are increasingly studied for their role in fl…

Exploring the role of the MUC1 mucin in human oral lubrication by tribological in vitro studies Open

Ianis Ammam, C. Pailler‐Mattei, Lucas Ouillon, Clément Nivet, R. Vargiolu , et al. · 2024

In the context of the oral cavity, an organic layer known as the mucosal pellicle (MP) adheres to the surface of the oral epithelium, playing a pivotal role in lubricating and safeguarding oral tissues. The formation of the MP is driven by…

Correction: The odorant metabolizing enzyme UGT2A1: Immunolocalization and impact of the modulation of its activity on the olfactory response Open

Fabrice Neiers, David Jarriault, Franck Ménétrier, Philippe Fauré, Loı̈c Briand , et al. · 2024

[This corrects the article DOI: 10.1371/journal.pone.0249029.].

A pivotal role for the IL-1β and the inflammasome in preterm labor Open

Tatiana López, Hua Zhang, E. Bouysse, Fabrice Neiers, Xuanlin Ye , et al. · 2024

Development of New Models of Oral Mucosa to Investigate the Impact of the Structure of Transmembrane Mucin-1 on the Mucosal Pellicle Formation and Its Physicochemical Properties Open

Clément Nivet, Irma Čustović, Laure Avoscan, Floris J. Bikker, Aline Bonnotte , et al. · 2024

The mucosal pellicle (MP) is a biological film protecting the oral mucosa. It is composed of bounded salivary proteins and transmembrane mucin MUC1 expressed by oral epithelial cells. Previous research indicates that MUC1 expression enhanc…

The 5’-Ribonucleotide Imp Interacts with Tas1r3 Subunit to Enhance Sweet Taste Detection Open

Christine Belloir, Lucie Moitrier, Adeline Karolkowski, Nicolas Poirier, Fabrice Neiers , et al. · 2024

Unlocking Flavor Potential Using Microbial β-Glucosidases in Food Processing Open

Mariam Muradova, Alena Proskura, Francis Canon, И. А. Александрова, Mathieu Schwartz , et al. · 2023

Aroma is among of the most important criteria that indicate the quality of food and beverage products. Aroma compounds can be found as free molecules or glycosides. Notably, a significant portion of aroma precursors accumulates in numerous…

Structure–activity analysis suggests an olfactory function for the unique antennal delta glutathione transferase of <i>Apis mellifera</i> Open

Mathieu Schwartz, Valentin Boichot, Mariam Muradova, Pablo Fournier, Patrick Senet , et al. · 2023

Glutathione transferases (GST) are detoxification enzymes that conjugate glutathione to a wide array of molecules. In the honey bee Apis mellifera , AmGSTD1 is the sole member of the delta class of GSTs, with expression in antennae. Here, …

Significant influence of four highly conserved amino-acids in lipochaperon-active sHsps on the structure and functions of the Lo18 protein Open

Tiffany Bellanger, David da Silva Barreira, Frank Wien, Patrice Delarue, Patrick Senet , et al. · 2023

Understanding the in-mouth release of aroma sulfur compounds from food precursors and the role of microbial C-S lyases Open

Mathieu Schwartz, Nicolas Poirier, Jade Moreno, Francis Canon, Fabrice Neiers · 2023

International audience

Impact of aldehyde dehydrogenases and aldo-keto reductases on human olfactory peri-receptor events Open

Valentin Boichot, Franck Ménétrier, Jean‐Michel Saliou, Frédéric Lirussi, Francis Canon , et al. · 2023

Meeting Abstract bjad029.01 ; 45. Annual Meeting of the Association-for-Chemoreception-Sciences, Bonita Springs, FL (USA), APR 19-22, 2023.

Characterization of human oxidoreductases involved in aldehyde odorant metabolism Open

Valentin Boichot, Franck Ménétrier, Jean‐Michel Saliou, Frédéric Lirussi, Francis Canon , et al. · 2023

Oxidoreductases are major enzymes of xenobiotic metabolism. Consequently, they are essential in the chemoprotection of the human body. Many xenobiotic metabolism enzymes have been shown to be involved in chemosensory tissue protection. Amo…

Role of Insect and Mammal Glutathione Transferases in Chemoperception Open

Mathieu Schwartz, Valentin Boichot, Stéphane Fraichard, Mariam Muradova, Patrick Senet , et al. · 2023

Glutathione transferases (GSTs) are ubiquitous key enzymes with different activities as transferases or isomerases. As key detoxifying enzymes, GSTs are expressed in the chemosensory organs. They fulfill an essential protective role becaus…

The role of perireceptor events in flavor perception Open

Valentin Boichot, Mariam Muradova, Clément Nivet, Alena Proskura, Jean‐Marie Heydel , et al. · 2022

The sensory perception of food is a complex phenomenon involving the integration of different stimuli (aroma, taste, trigeminal sensations, texture and visual). Flavor compounds activate odorant, taste and trigeminal chemoreceptors, genera…

In-mouth metabolism and production of flavor sulfur compounds by oral microbiota enzymes Open

Mathieu Schwartz, Nicolas Poirier, Karine Gourrat, Francis Canon, Fabrice Neiers · 2022

International audience

Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor Open

Anni Laffitte, Christine Belloir, Fabrice Neiers, Loı̈c Briand · 2022

The human sweet taste receptor is a heterodimeric receptor composed of two distinct G-protein-coupled receptors (GPCRs), TAS1R2 and TAS1R3. The TAS1R2 and TAS1R3 subunits are members of a small family of class C GPCRs whose members share t…

Free-Energy Landscape Analysis of Protein-Ligand Binding: The Case of Human Glutathione Transferase A1 Open

Adrien Nicolaı̈, Nicolas Petiot, Paul Grassein, Patrice Delarue, Fabrice Neiers , et al. · 2022

Glutathione transferases (GSTs) are a superfamily of enzymes which have in common the ability to catalyze the nucleophilic addition of the thiol group of reduced glutathione (GSH) onto electrophilic and hydrophobic substrates. This conjuga…

Expression Patterns of Drosophila Melanogaster Glutathione Transferases Open

Elodie Gonis, Stéphane Fraichard, Thomas Chertemps, Arnaud Hecker, Mathieu Schwartz , et al. · 2022

Glutathione transferases (GSTs) are ubiquitous enzymes that catalyze the conjugation of glutathione to various molecules. Among the 42 GSTs identified in Drosophila melanogaster, Delta and Epsilon are the largest classes, with 25 members. …

Role of human salivary enzymes in bitter taste perception Open

Mathieu Schwartz, Hélène Brignot, Gilles Féron, Thomas Hummel, Yunmeng Zhu , et al. · 2022

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