Fabrício Freire de Melo
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View article: Overcoming antibiotic-resistant <i>Helicobacter pylori</i> infection: Current challenges and emerging approaches
Overcoming antibiotic-resistant <i>Helicobacter pylori</i> infection: Current challenges and emerging approaches Open
Recent studies have shown a noticeable increase in global Helicobacter pylori (H. pylori ) resistance , with clarithromycin resistance surpassing 15% in various areas. However, inadequate epidemiological monitoring, especially in developin…
View article: Prevalence of Helicobacter pylori cagA virulence factor and validation of serological tests in a population from Northeastern Brazil
Prevalence of Helicobacter pylori cagA virulence factor and validation of serological tests in a population from Northeastern Brazil Open
Helicobacter pylori is an infectious agent linked to significant gastric pathologies, which makes it a public health concern. The enzyme-linked immunosorbent assay (ELISA) is widely used for epidemiological studies and for investigating vi…
View article: Integrative review on Acinetobacter baumannii as a multidrug-resistant pathogen: resistance mechanisms and therapeutic perspectives in the context of nosocomial infections
Integrative review on Acinetobacter baumannii as a multidrug-resistant pathogen: resistance mechanisms and therapeutic perspectives in the context of nosocomial infections Open
Acinetobacter baumannii is a gram-negative opportunistic pathogen associated with high morbidity and mortality in nosocomial infections, particularly in intensive care units. Multidrug resistance (MDR) is mediated by efflux pumps, lipopoly…
View article: Pathogenesis and clinical management of arboviral diseases
Pathogenesis and clinical management of arboviral diseases Open
Arboviral diseases are viral infections transmitted to humans through the bites of arthropods, such as mosquitoes, often causing a variety of pathologies associated with high levels of morbidity and mortality. Over the past decades, these …
View article: Memórias que formam: a integração do memorial ao Trabalho de Conclusão de Curso na Medicina
Memórias que formam: a integração do memorial ao Trabalho de Conclusão de Curso na Medicina Open
O Trabalho de Conclusão de Curso (TCC) tradicionalmente marca o final da graduação e oportuniza ao estudante demonstrar os conhecimentos técnico-científicos adquiridos. No curso de Medicina do Instituto Multidisciplinar em Saúde da Univers…
View article: Development of a streamlined NGS-based TCGA classification scheme for gastric cancer and its implications for personalized therapy
Development of a streamlined NGS-based TCGA classification scheme for gastric cancer and its implications for personalized therapy Open
The NGS method successfully maps the mutational landscape of GC, providing a practical TCGA classification surrogate to optimize patient-specific treatment strategies.
View article: Personalized medicine: Clinical oncology on molecular view of treatment
Personalized medicine: Clinical oncology on molecular view of treatment Open
Cancer, the second leading global cause of death, impacts both physically and emotionally. Conventional treatments such as surgeries, chemotherapy, and radiotherapy have adverse effects, driving the need for more precise approaches. Precis…
View article: CMTM4 inhibits gastric tumorigenesis and metastasis
CMTM4 inhibits gastric tumorigenesis and metastasis Open
Our results suggest that CMTM4 plays a tumor-suppressive role in GC and may affect the growth, migration, and invasion of GC cells through the STAT1 signaling pathway. CMTM4 might have potential value as a prognosis marker and potential th…
View article: Long chikungunya? An overview to immunopathology of persistent arthralgia
Long chikungunya? An overview to immunopathology of persistent arthralgia Open
Chikungunya fever (CF) is caused by an arbovirus whose manifestations are extremely diverse, and it has evolved with significant severity in recent years. The clinical signs triggered by the Chikungunya virus are similar to those of other …
View article: <i>In silico</i> prospective analysis of the medicinal plants activity on the CagA oncoprotein from <i>Helicobacter pylori</i>
<i>In silico</i> prospective analysis of the medicinal plants activity on the CagA oncoprotein from <i>Helicobacter pylori</i> Open
BACKGROUND Colonization with Helicobacter pylori (H. pylori ) has a strong correlation with gastric cancer, and the virulence factor CagA is implicated in carcinogenesis. Studies have been conducted using medicinal plants with the aim of e…
View article: New avenues for the treatment of immunotherapy-resistant pancreatic cancer
New avenues for the treatment of immunotherapy-resistant pancreatic cancer Open
Pancreatic cancer (PC) is characterized by its extremely aggressive nature and ranks 14th in the number of new cancer cases worldwide. However, due to its complexity, it ranks 7th in the list of the most lethal cancers worldwide. The patho…
View article: Urea breath test for <i>Helicobacter pylori</i> infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy
Urea breath test for <i>Helicobacter pylori</i> infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy Open
BACKGROUND Helicobacter pylori (H. pylori ) infection has been well-established as a significant risk factor for several gastrointestinal disorders. The urea breath test (UBT) has emerged as a leading non-invasive method for detecting H. p…
View article: Usher syndrome: Genetic diagnosis and current therapeutic approaches
Usher syndrome: Genetic diagnosis and current therapeutic approaches Open
Usher Syndrome (USH) is the most common deaf-blind syndrome, affecting approximately 1 in 6000 people in the deaf population. This genetic condition is characterized by a combination of hearing loss (HL), retinitis pigmentosa, and, in some…
View article: Biologic drugs usei in inflammatory bowel diseases: a systematic review and meta-analysis
Biologic drugs usei in inflammatory bowel diseases: a systematic review and meta-analysis Open
Os autores externos submeteram sua publicação para apresentação de trabalho no evento "International Symposium on Immunobiologicals", que foi coordenado e organizado pelo Instituto de Tecnologia em Imunobiológicos (Bio-Manguinhos), da Fund…
View article: <i>Helicobacter pylori</i> infection in pregnant women: Gastrointestinal symptoms and pregnancy- related disorders
<i>Helicobacter pylori</i> infection in pregnant women: Gastrointestinal symptoms and pregnancy- related disorders Open
Helicobacter pylori (H. Pylori) is a gram-negative, flagellated and spiral-shaped bacterial pathogen that impacts approximately 46% among pregnant women globally and has been associated with various maternal-fetal complications. Iron defic…
View article: Crohn's disease and clinical management today: How it does?
Crohn's disease and clinical management today: How it does? Open
Crohn’s Disease (CD) is an Inflammatory Bowel Disease and is characterized by an immune-mediated nature. Its etiology results from the interaction between genetic, enviromental and microbial factors. Regarding pathophysiology, it involves …
View article: Interplay of homologous-recombination genes and Helicobacter pylori in gastric cancer susceptibility
Interplay of homologous-recombination genes and Helicobacter pylori in gastric cancer susceptibility Open
View article: CORRELAÇÃO ENTRE CONCENTRAÇÕES ELEVADAS DAS CITOCINAS ASSOCIADAS À RESPOSTA TH17 E DESFECHOS DESFAVORÁVEIS EM PACIENTES COM COVID-19 ADMITIDOS À UNIDADE DE TERAPIA INTENSIVA (UTI): UM ESTUDO PROSPECTIVO
CORRELAÇÃO ENTRE CONCENTRAÇÕES ELEVADAS DAS CITOCINAS ASSOCIADAS À RESPOSTA TH17 E DESFECHOS DESFAVORÁVEIS EM PACIENTES COM COVID-19 ADMITIDOS À UNIDADE DE TERAPIA INTENSIVA (UTI): UM ESTUDO PROSPECTIVO Open
Introdução/Objetivo: A COVID-19 é uma doença infeciosa causada pelo SARS-CoV-2. Sabe-se, hoje, que a resposta imunológica desempenha um papel fundamental na modulação da gravidade e desfecho dessa doença; e, nesse contexto, a resposta Th17…
View article: ERRADICAÇÃO DE HELICOBACTER PYLORI NO TRATAMENTO DO LINFOMA DO TECIDO LINFOIDE ASSOCIADO À MUCOSA GÁSTRICA EM ESTÁGIO INICIAL: UMA META-ANÁLISE ATUALIZADA
ERRADICAÇÃO DE HELICOBACTER PYLORI NO TRATAMENTO DO LINFOMA DO TECIDO LINFOIDE ASSOCIADO À MUCOSA GÁSTRICA EM ESTÁGIO INICIAL: UMA META-ANÁLISE ATUALIZADA Open
Introdução/Objetivo: O linfoma do tecido linfoide associado à mucosa (MALT) gástrica (LMG) é uma neoplasia de células B de baixo grau fortemente associada à gastrite crônica induzida por Helicobacter pylori. As diretrizes clínicas recomend…
View article: The influence of gut microbiota on immunotherapy for Colorectal Cancer
The influence of gut microbiota on immunotherapy for Colorectal Cancer Open
Colorectal cancer (CRC) is the third most prevalent cancer globally and the second deadliest cancer for both men and women. To change this situation, novel therapeutic approaches have been developed, with immunotherapy being one of the mos…
View article: Role of non-<i>Helicobacter pylori</i> gastric Helicobacters in <i>helicobacter pylori</i>-negative gastric mucosa-associated lymphoid tissue lymphoma
Role of non-<i>Helicobacter pylori</i> gastric Helicobacters in <i>helicobacter pylori</i>-negative gastric mucosa-associated lymphoid tissue lymphoma Open
The robotic liver resection (RLR) has been increasingly applied in recent years and its benefits shown in some aspects owing to the technical advancement of robotic surgical system, however, controversies still exist. Based on the foundati…
View article: Immune response modulation in inflammatory bowel diseases by <i>Helicobacter pylori</i> infection
Immune response modulation in inflammatory bowel diseases by <i>Helicobacter pylori</i> infection Open
Many studies point to an association between Helicobacter pylori (H. pylori ) infection and inflammatory bowel diseases (IBD). Although controversial, this association indicates that the presence of the bacterium somehow affects the course…
View article: <i>In silico</i> evidence of Remdesivir action in blood coagulation cascade modulation in COVID-19 treatment
<i>In silico</i> evidence of Remdesivir action in blood coagulation cascade modulation in COVID-19 treatment Open
Because of the in silico significant affinity, Remdesivir possibly could act in the severe acute respiratory syndrome coronavirus 2 infection blockade by interacting with ACE2 and concomitantly act in the modulation of the coagulati…
View article: PERFIL SOCIODEMOGRÁFICO DE HOMENS E MULHERES ADULTOS COM TRANSTORNOS MENTAIS EM UM HOSPITAL ESPECIALIZADO NO INTERIOR DA BAHIA
PERFIL SOCIODEMOGRÁFICO DE HOMENS E MULHERES ADULTOS COM TRANSTORNOS MENTAIS EM UM HOSPITAL ESPECIALIZADO NO INTERIOR DA BAHIA Open
Introdução: Os Transtornos Mentais (TM) se comportam de forma distinta entre o sexo feminino e masculino, tornando um importante fator contribuinte que envolvem questões atribuídas ao comportamento dos agravos de saúde men…
View article: PERFIL SOCIODEMOGRÁFICO DE HOMENS E MULHERES ADULTOS COM TRANSTORNOS MENTAIS EM UM HOSPITAL ESPECIALIZADO NO INTERIOR DA BAHIA
PERFIL SOCIODEMOGRÁFICO DE HOMENS E MULHERES ADULTOS COM TRANSTORNOS MENTAIS EM UM HOSPITAL ESPECIALIZADO NO INTERIOR DA BAHIA Open
Introdução: Os Transtornos Mentais (TM) se comportam de forma distinta entre o sexo feminino e masculino, tornando um importante fator contribuinte que envolvem questões atribuídas ao comportamento dos agravos de saúde men…
View article: Pediatric multisystem inflammatory syndrome associated with COVID-19: Insights in pathogenesis and clinical management
Pediatric multisystem inflammatory syndrome associated with COVID-19: Insights in pathogenesis and clinical management Open
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been a major challenge to be faced in recent years. While adults suffered the highest morbidity and mortality rates of coronavirus disease 20…
View article: Correction to “Performance of a serological IgM and IgG qualitative test for COVID-19 diagnosis: An experimental study in Brazil”
Correction to “Performance of a serological IgM and IgG qualitative test for COVID-19 diagnosis: An experimental study in Brazil” Open
Correction to “Freire de Melo F, Martins Oliveira Diniz L, Nélio Januário J, Fernando Gonçalves Ferreira J, Dórea RSDM, de Brito BB, Marques HS, Lemos FFB, Silva Luz M, Rocha Pinheiro SL, de Magalhães Queiroz DM. Performance of a serologic…
View article: Haploidentical hematopoietic stem cell transplantation as promising therapy in the improved survival of pediatric patients with leukemias and myelodysplasias
Haploidentical hematopoietic stem cell transplantation as promising therapy in the improved survival of pediatric patients with leukemias and myelodysplasias Open
View article: Immunotherapy in glioblastoma treatment: Current state and future prospects
Immunotherapy in glioblastoma treatment: Current state and future prospects Open
Glioblastoma remains as the most common and aggressive malignant brain tumor, standing with a poor prognosis and treatment prospective. Despite the aggressive standard care, such as surgical resection and chemoradiation, median survival ra…
View article: Effectiveness of <i>Helicobacter pylori</i> eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma: An up-to-date meta-analysis
Effectiveness of <i>Helicobacter pylori</i> eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma: An up-to-date meta-analysis Open
Comprehensive synthesis of available evidence suggests that H. pylori eradication is effective as the sole initial therapy for early-stage GML. Although the substantial heterogeneity observed across studies limits the interpretation…