Fadi Bittar
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View article: A silent sulfonamide-resistant microbial world: The curious case of missing DHPS in candidate phyla radiation
A silent sulfonamide-resistant microbial world: The curious case of missing DHPS in candidate phyla radiation Open
View article: Global lessons from antibiotic resistance: metformin-hydrolyzing genes in transposable elements, a new threat for type II diabetic patients?
Global lessons from antibiotic resistance: metformin-hydrolyzing genes in transposable elements, a new threat for type II diabetic patients? Open
Metformin drug, widely used to treat type II diabetic patients, is a major pharmaceutical pollutant of wastewater and rivers. This environmental exposure has driven the evolution of bacteria, such as Aminobacter and Pseudomonas , to degrad…
View article: Gut microbiota influences Plasmodium falciparum malaria susceptibility
Gut microbiota influences Plasmodium falciparum malaria susceptibility Open
Further studies are needed to confirm these findings, which point the way to strategies aimed at reducing the risk of malaria by modulating gut microbiota components in at-risk populations.
View article: Clonal dissemination of an NDM-2-producing Acinetobacter baumannii ST103 clone resulting in an outbreak in an intensive care unit of a Lebanese tertiary care hospital
Clonal dissemination of an NDM-2-producing Acinetobacter baumannii ST103 clone resulting in an outbreak in an intensive care unit of a Lebanese tertiary care hospital Open
This study showed that infection control measures and adequate identification of NDM-producing A. baumannii remain a powerful tool to limit the spread of such resistant micro-organisms.
View article: Retraction Note: Culture of previously uncultured members of the human gut microbiota by culturomics
Retraction Note: Culture of previously uncultured members of the human gut microbiota by culturomics Open
View article: Retraction Note: Culturomics and Amplicon-based Metagenomic Approaches for the Study of Fungal Population in Human Gut Microbiota
Retraction Note: Culturomics and Amplicon-based Metagenomic Approaches for the Study of Fungal Population in Human Gut Microbiota Open
View article: Metallo-Beta-Lactamase-like Encoding Genes in Candidate Phyla Radiation: Widespread and Highly Divergent Proteins with Potential Multifunctionality
Metallo-Beta-Lactamase-like Encoding Genes in Candidate Phyla Radiation: Widespread and Highly Divergent Proteins with Potential Multifunctionality Open
The Candidate Phyla Radiation (CPR) was found to harbor a vast repertoire of genes encoding for enzymes with potential antibiotic resistance activity. Among these, as many as 3349 genes were predicted in silico to contain a metallo-beta-la…
View article: Preliminary landscape of Candidatus Saccharibacteria in the human microbiome
Preliminary landscape of Candidatus Saccharibacteria in the human microbiome Open
Introduction Candidate Phyla Radiation (CPR) and more specifically Candidatus Saccharibacteria (TM7) have now been established as ubiquitous members of the human oral microbiota. Additionally, CPR have been reported in the gastrointestinal…
View article: Using Genomics to Decipher the Enigmatic Properties and Survival Adaptation of Candidate Phyla Radiation
Using Genomics to Decipher the Enigmatic Properties and Survival Adaptation of Candidate Phyla Radiation Open
Microbial ecology is a critical field for understanding the composition, diversity, and functions of microorganisms in various environmental and health-related processes. The discovery of Candidate Phyla Radiation (CPR) through culture-ind…
View article: Candidate Phyla Radiation, an Underappreciated Division of the Human Microbiome, and Its Impact on Health and Disease
Candidate Phyla Radiation, an Underappreciated Division of the Human Microbiome, and Its Impact on Health and Disease Open
Candidate phyla radiation (CPR) is an emerging division of the bacterial domain within the human microbiota. Still poorly known, these microorganisms were first described in the environment in 1981 as “ultramicrobacteria” with a cell volum…
View article: New Beta-lactamases in Candidate Phyla Radiation: Owning Pleiotropic Enzymes Is a Smart Paradigm for Microorganisms with a Reduced Genome
New Beta-lactamases in Candidate Phyla Radiation: Owning Pleiotropic Enzymes Is a Smart Paradigm for Microorganisms with a Reduced Genome Open
The increased exploitation of microbial sequencing methods has shed light on the high diversity of new microorganisms named Candidate Phyla Radiation (CPR). CPR are mainly detected via 16S rRNA/metabarcoding analyses or metagenomics and ar…
View article: Emergence of <i>Candida auris</i> in intensive care units in Algeria
Emergence of <i>Candida auris</i> in intensive care units in Algeria Open
Background Currently, Candida auris is among the most serious emerging pathogens that can be associated with nosocomial infections and outbreaks in intensive care units. Clinicians must be able to identify and manage it quickly. Objective …
View article: Reverse Genomics: Design of Universal Epitope Sets to Isolate All Saccharibacteria Members from the Human Oral Cavity
Reverse Genomics: Design of Universal Epitope Sets to Isolate All Saccharibacteria Members from the Human Oral Cavity Open
Microorganisms not yet cultured represent a large proportion of the microbes described to date. Progress in sequencing and metagenomic tools continues to increase microbial diversity without providing information on their physiological and…
View article: Adapted Protocol for <i>Saccharibacteria</i> Cocultivation: Two New Members Join the Club of Candidate Phyla Radiation
Adapted Protocol for <i>Saccharibacteria</i> Cocultivation: Two New Members Join the Club of Candidate Phyla Radiation Open
In this study, the first TaqMan real-time quantitative PCR (qPCR) system has been developed. This technique can specifically quantify Saccharibacteria members in any sample of interest in order to investigate their prevalence.
View article: Adapted protocol for <i>Saccharibacteria</i> co-cultivation: two new members join the club of Candidate Phyla radiation
Adapted protocol for <i>Saccharibacteria</i> co-cultivation: two new members join the club of Candidate Phyla radiation Open
The growing application of metagenomics to different ecological and microbiome niches in recent years has enhanced our knowledge of global microbial biodiversity. Among these abundant and widespread microbes, Candidate Phyla Radiation or C…
View article: Small and equipped: the rich repertoire of antibiotic resistance genes in <i>Candidate Phyla Radiation</i> genomes
Small and equipped: the rich repertoire of antibiotic resistance genes in <i>Candidate Phyla Radiation</i> genomes Open
Microbes belonging to Candidate Phyla Radiation (CPR) have joined the tree of life as a new unique branch, thanks to the intensive application of metagenomics and advances of sequencing technologies. Despite their ultra-small size, reduced…
View article: Gut Microbiota Influences Plasmodium Falciparum Malaria Susceptibility
Gut Microbiota Influences Plasmodium Falciparum Malaria Susceptibility Open
The gut microbiota has recently been associated with susceptibility/resistance to malaria in animal models and humans, yet the impact of the gut microbiota on the risk of a malaria attack remains to be assessed. This study aims at assessin…
View article: SCA Medium: A New Culture Medium for the Isolation of All Candida auris Clades
SCA Medium: A New Culture Medium for the Isolation of All Candida auris Clades Open
Candida auris is an emerging multidrug-resistant yeast causing nosocomial infections and associated with high mortality in immunocompromised patients. Rapid identification and characterisation are necessary for diagnosis and containing its…
View article: Rhizomal Reclassification of Living Organisms
Rhizomal Reclassification of Living Organisms Open
Living organisms interact with each other during their lifetime, leading to genomes rearrangement and sequences transfer. These well-known phenomena give these organisms mosaic genomes, which challenge their classification. Moreover, many …
View article: Drug Repurposing in Medical Mycology: Identification of Compounds as Potential Antifungals to Overcome the Emergence of Multidrug-Resistant Fungi
Drug Repurposing in Medical Mycology: Identification of Compounds as Potential Antifungals to Overcome the Emergence of Multidrug-Resistant Fungi Open
Immunodepression, whether due to HIV infection or organ transplantation, has increased human vulnerability to fungal infections. These conditions have created an optimal environment for the emergence of opportunistic infections, which is c…
View article: SCA Medium: A New Culture Medium for the Isolation of all <em>Candida auris</em> Clade
SCA Medium: A New Culture Medium for the Isolation of all <em>Candida auris</em> Clade Open
Candida auris is an emerging multidrug resistant yeast causing nosocomial infections and associated with high mortality in immunocompromised patients. Rapid identification and characterisation is necessary for its diagnosis and containing …
View article: Occurrence of Ten Protozoan Enteric Pathogens in Three Non-Human Primate Populations
Occurrence of Ten Protozoan Enteric Pathogens in Three Non-Human Primate Populations Open
Non-human primate populations act as potential reservoirs for human pathogens, including viruses, bacteria and parasites, which can lead to zoonotic infections. Furthermore, intestinal microorganisms may be pathogenic organisms to both non…
View article: Comparison of Three Skin Sampling Methods and Two Media for Culturing Malassezia Yeast
Comparison of Three Skin Sampling Methods and Two Media for Culturing Malassezia Yeast Open
Malassezia is a lipid-dependent commensal yeast of the human skin. The different culture media and skin sampling methods used to grow these fastidious yeasts are a source of heterogeneity in culture-based epidemiological study results. Thi…
View article: FastFung: A novel medium for the culture and isolation of fastidious fungal species from clinical samples
FastFung: A novel medium for the culture and isolation of fastidious fungal species from clinical samples Open
View article: Comparison of Three Skin Sampling Methods and Two Media for Culturing <em>Malassezia</em> Yeast
Comparison of Three Skin Sampling Methods and Two Media for Culturing <em>Malassezia</em> Yeast Open
Malassezia is lipid-dependent commensal yeast of the human skin. The different culture media and skin sampling methods used to grow these fastidious yeasts are a source of heterogeneity in culture-based epidemiological study results. This …
View article: RETRACTED ARTICLE: Gorillibacterium timonense sp. nov., isolated from an obese patient
RETRACTED ARTICLE: Gorillibacterium timonense sp. nov., isolated from an obese patient Open
View article: Identification of repositionable drugs with novel antimycotic activity by screening the Prestwick Chemical Library against emerging invasive moulds
Identification of repositionable drugs with novel antimycotic activity by screening the Prestwick Chemical Library against emerging invasive moulds Open
View article: Blastocystis Colonization Is Associated with Increased Diversity and Altered Gut Bacterial Communities in Healthy Malian Children
Blastocystis Colonization Is Associated with Increased Diversity and Altered Gut Bacterial Communities in Healthy Malian Children Open
Blastocystis is the most common protozoan colonizing the gut of vertebrates. It modulates the human digestive microbiota in the absence of inflammation and gastrointestinal disease. Although it has been associated with human diseases, incl…
View article: Repurposing of Ribavirin as an Adjunct Therapy against Invasive <i>Candida</i> Strains in an <i>In Vitro</i> Study
Repurposing of Ribavirin as an Adjunct Therapy against Invasive <i>Candida</i> Strains in an <i>In Vitro</i> Study Open
The use of antifungal agents in clinical settings is limited by the appearance of drug resistance and adverse side effects. There is, therefore, an urgent need to develop new drugs to strengthen the treatment of invasive fungal diseases. T…
View article: In vitro polymyxin activity against clinical multidrug-resistant fungi
In vitro polymyxin activity against clinical multidrug-resistant fungi Open