Fading Chen
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View article: Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology
Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology Open
Background Genome-wide association studies have established clusterin (CLU) as a genetic modifier for late-onset Alzheimer’s disease (AD). Both protective and risk alleles have been identified which may be associated with its expression le…
View article: An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease
An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease Open
Blocking epoxide hydrolase with a bioavailable small-molecule inhibitor reduces neuropathology in an Alzheimer’s disease mouse model.
View article: Epoxy fatty acid dysregulation and neuroinflammation in Alzheimer’s disease is resolved by a soluble epoxide hydrolase inhibitor
Epoxy fatty acid dysregulation and neuroinflammation in Alzheimer’s disease is resolved by a soluble epoxide hydrolase inhibitor Open
Neuroinflammation has been increasingly recognized to play critical roles in Alzheimer’s disease (AD). The epoxy fatty acids (EpFAs) are derivatives of the arachidonic acid metabolism with anti-inflammatory activities. However, their effic…
View article: TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading
TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading Open
The progression of tau pathology in Alzheimer’s disease follows a stereotyped pattern, and recent evidence suggests a role of synaptic connections in this process. Astrocytes are well positioned at the neuronal synapse to capture and degra…
View article: [O1–14–03]: THE ROLE OF COMPLEMENT C3 AND C3AR RECEPTOR IN TAU PATHOLOGY IN ALZHEIMER's DISEASE
[O1–14–03]: THE ROLE OF COMPLEMENT C3 AND C3AR RECEPTOR IN TAU PATHOLOGY IN ALZHEIMER's DISEASE Open
Besides the pathological hallmarks of β-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs), increasing evidence suggests that neuroinflammation plays a significant role in AD pathogenesis. The complement pathway is a key regulator of …
View article: The transcription factor NeuroD2 coordinates synaptic innervation and cell intrinsic properties to control excitability of cortical pyramidal neurons
The transcription factor NeuroD2 coordinates synaptic innervation and cell intrinsic properties to control excitability of cortical pyramidal neurons Open
Key points Synaptic excitation and inhibition must be properly balanced in individual neurons and neuronal networks to allow proper brain function. Disrupting this balance may lead to autism spectral disorders and epilepsy. We show the bas…
View article: A common <i>Shox2</i>-<i>Nkx2-5</i> antagonistic mechanism primes the pacemaking cell fate in the pulmonary vein myocardium and sinoatrial node
A common <i>Shox2</i>-<i>Nkx2-5</i> antagonistic mechanism primes the pacemaking cell fate in the pulmonary vein myocardium and sinoatrial node Open
In humans, atrial fibrillation is often triggered by ectopic pacemaking activity in the myocardium sleeves of the pulmonary vein (PV) and systemic venous return. However, the genetic programs that abnormally reinforce pacemaker properties …