Rashid Mir
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View article: Exploring the genetic frontier: Unraveling ANRIL, PAI-1, and HNF1α in stroke progression
Exploring the genetic frontier: Unraveling ANRIL, PAI-1, and HNF1α in stroke progression Open
Background Ischemic stroke poses a notable global public health challenge, with the Kingdom of Saudi Arabia (KSA) being no exception. This multifaceted condition is affected by a combination of factors, including hypertension, diabetes, an…
View article: Whole-exome sequencing in Saudi colorectal cancer patients reveals distinct mutational patterns and population specific pathogenic variants
Whole-exome sequencing in Saudi colorectal cancer patients reveals distinct mutational patterns and population specific pathogenic variants Open
Background Colorectal cancer (CRC) shows significant inter-population heterogeneity in its genomic landscape, yet Middle Eastern populations are underrepresented in large-scale sequencing studies. This exploratory study aims to characteriz…
View article: Whole-Exome Sequencing Reveals Rare Genetic Variants in Saudi COVID-19 Patients with Extreme Phenotypes
Whole-Exome Sequencing Reveals Rare Genetic Variants in Saudi COVID-19 Patients with Extreme Phenotypes Open
The global impact of COVID-19 was staggering, with millions of cases and related mortality reported worldwide. Genetic variations play a significant role in determining an individual’s susceptibility to SARS-CoV-2 infection and progress to…
View article: Whole Exome Sequencing in 26 Saudi Patients Expands the Mutational and Clinical Spectrum of Diabetic Nephropathy
Whole Exome Sequencing in 26 Saudi Patients Expands the Mutational and Clinical Spectrum of Diabetic Nephropathy Open
Background and Objectives: Type 2 diabetes mellitus (T2DM) is a health problem all over the world due to its serious complications such as diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, cardiovascular diseases, and limb a…
View article: Foliar application of nano NPK fertilizer improves physiological activities and essential oil production in Coleus aromaticus Benth. (Ajwain Patta)
Foliar application of nano NPK fertilizer improves physiological activities and essential oil production in Coleus aromaticus Benth. (Ajwain Patta) Open
Coleus aromaticus Benth. (commonly known as Ajwain Patta) is an important aromatic plant valued for its essential oils, which possess notable therapeutic properties and substantial commercial relevance in the food and cosmetic industries. …
View article: Unraveling the Mystery of Insulin Resistance: From Principle Mechanistic Insights and Consequences to Therapeutic Interventions
Unraveling the Mystery of Insulin Resistance: From Principle Mechanistic Insights and Consequences to Therapeutic Interventions Open
Insulin resistance (IR) is a significant factor in the development and progression of metabolic-related diseases like dyslipidemia, T2DM, hypertension, nonalcoholic fatty liver disease, cardiovascular and cerebrovascular disorders, and can…
View article: Unraveling The Mystery of Insulin Resistance: From Principle Mechanistic Insights and Consequences to Therapeutic Interventions
Unraveling The Mystery of Insulin Resistance: From Principle Mechanistic Insights and Consequences to Therapeutic Interventions Open
Insulin resistance (IR) is a significant factor in the development and progression of metabolic-related diseases like dyslipidemia, T2DM, hypertension, nonalcoholic fatty liver disease, cardiovascular and cerebrovascular disorders and canc…
View article: Discordance between humoral and cellular immune responses to cytomegalovirus infection in CMV seropositive patients awaiting lung transplantation
Discordance between humoral and cellular immune responses to cytomegalovirus infection in CMV seropositive patients awaiting lung transplantation Open
Introduction Risk stratification for CMV infection in lung transplantation (LT) currently relies on determining donor and recipient CMV IgG before transplantation. However, it has been observed that some patients who test positive for CMV-…
View article: Identification of Interactive Genetic Loci Linked to Insulin Resistance in Metabolic Syndrome—An Update
Identification of Interactive Genetic Loci Linked to Insulin Resistance in Metabolic Syndrome—An Update Open
Metabolic syndrome is a metabolic disorder characterized by hypertension, dyslipidemia, impaired glucose tolerance, and abdominal obesity. Impaired insulin action or insulin resistance initiates metabolic syndrome. The prevalence of insuli…
View article: GAMSA-ALIGN: A NOVEL APPROACH FOR EFFICIENT PROTEIN SEQUENCE ALIGNMENT USING GENETIC ALGORITHM
GAMSA-ALIGN: A NOVEL APPROACH FOR EFFICIENT PROTEIN SEQUENCE ALIGNMENT USING GENETIC ALGORITHM Open
Bioinformatics has played an important role in discovering medicine because whole-genome sequences can help to find out the many genetic diseases. Bioinformatics uses computational tools to manage, store and analyze the data. Multiple sequ…
View article: Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link
Unraveling molecular interconnections and identifying potential therapeutic targets of significance in obesity-cancer link Open
Obesity, a global health concern, is associated with severe health issues like type 2 diabetes, heart disease, and respiratory complications. It also increases the risk of various cancers, including melanoma, endometrial, prostate, pancrea…
View article: The Respiratory Reflex of Cough: A Comparative Study of Contemporary Medicine and Unani Concepts
The Respiratory Reflex of Cough: A Comparative Study of Contemporary Medicine and Unani Concepts Open
Cough suddenly and frequently helps to remove mucus, irritants, foreign substances, and bacteria from the airways. It can be a symptom of a respiratory infection like the common cold, bronchitis, tuberculosis, influenza, smoking, or other …
View article: Integrating network analysis with differential expression to uncover therapeutic and prognostic biomarkers in esophageal squamous cell carcinoma
Integrating network analysis with differential expression to uncover therapeutic and prognostic biomarkers in esophageal squamous cell carcinoma Open
Introduction: Esophageal squamous cell carcinoma (ESCC) accounts for over 90% of all esophageal tumors. However, the molecular mechanism underlying ESCC development and prognosis remains unclear, and there are still no effective molecular …
View article: The Role of Pro-Inflammatory Chemokines CCL-1, 2, 4, and 5 in the Etiopathogenesis of Type 2 Diabetes Mellitus in Subjects from the Asir Region of Saudi Arabia: Correlation with Different Degrees of Obesity
The Role of Pro-Inflammatory Chemokines CCL-1, 2, 4, and 5 in the Etiopathogenesis of Type 2 Diabetes Mellitus in Subjects from the Asir Region of Saudi Arabia: Correlation with Different Degrees of Obesity Open
Background: Type 2 diabetes mellitus (T2DM) is becoming a major global health concern, especially in developing nations. The high prevalence of obesity and related diabetes cases are attributed to rapid economic progress, physical inactivi…
View article: Epidermal growth factor receptor (EGFR) mutations in the serum of non–small cell lung cancer (NSCLC) patients as a marker to select patients for targeted therapy
Epidermal growth factor receptor (EGFR) mutations in the serum of non–small cell lung cancer (NSCLC) patients as a marker to select patients for targeted therapy Open
Background: The utility of serum as a specimen for epidermal growth factor receptor (EGFR) mutation detection and to select patients most likely to benefit from tyrosine kinase inhibitor (TKI) therapy is unclear. Methods: EGFR mutations (e…
View article: Molecular Dynamics Simulation of Kir6.2 Variants Reveals Potential Association with Diabetes Mellitus
Molecular Dynamics Simulation of Kir6.2 Variants Reveals Potential Association with Diabetes Mellitus Open
Diabetes mellitus (DM) represents a problem for the healthcare system worldwide. DM has very serious complications such as blindness, kidney failure, and cardiovascular disease. In addition to the very bad socioeconomic impacts, it influen…
View article: Molecular Determination of Tumor Necrosis Factor-alpha, Interleukin-8,Interleukin-10, and C-X-C Chemokine Receptor-2 Genetic Variations andtheir Association with Disease Susceptibility and Mortality in COVID-19Patients
Molecular Determination of Tumor Necrosis Factor-alpha, Interleukin-8,Interleukin-10, and C-X-C Chemokine Receptor-2 Genetic Variations andtheir Association with Disease Susceptibility and Mortality in COVID-19Patients Open
Background: Altered cytokine levels have been associated with poor outcomes among COVID-19 patients. TNF-α, IL-8 and IL-10 are key cytokines in COVID-19 pathogenesis, and CXCR-2 is a major chemokine receptor involved in inflammatory respon…
View article: Whole-Exome Sequencing Detecting a Recurrent Pathogenic Mutation, <i>HFE</i> p.His63Asp (H63D) in COVID-19 Patients and Its Effect on Mortality
Whole-Exome Sequencing Detecting a Recurrent Pathogenic Mutation, <i>HFE</i> p.His63Asp (H63D) in COVID-19 Patients and Its Effect on Mortality Open
A recurrent pathogenic mutation, HFE p.His63Asp (H63D), was identified in 7 patients, suggesting its potential contribution to disease severity. Additionally, a likely pathogenic variant, HBB p.Glu7Val (E7V), was present in 2 patients, hig…
View article: Dysregulated Vitamin D, <i>CYP2R1</i>, <i>TCF7L2</i>, and <i>CCR5</i> Δ32 Gene Variations are Associated with Coronary Artery Disease
Dysregulated Vitamin D, <i>CYP2R1</i>, <i>TCF7L2</i>, and <i>CCR5</i> Δ32 Gene Variations are Associated with Coronary Artery Disease Open
The CYP2R1 rs1562902 C > T, CCR5 Δ32 (rs333), and TCF7L2 rs12255372 G > T polymorphisms are potential genetic loci associated with increased CAD risk. Furthermore, CYP2R1 variants are associated with vitamin D deficiency, predisposing carr…
View article: Unlocking the Secrets of Extracellular Vesicles: Orchestrating Tumor Microenvironment Dynamics in Metastasis, Drug Resistance, and Immune Evasion
Unlocking the Secrets of Extracellular Vesicles: Orchestrating Tumor Microenvironment Dynamics in Metastasis, Drug Resistance, and Immune Evasion Open
Extracellular vehicles (EVs) are gaining increasing recognition as central contributors to the intricate landscape of the tumor microenvironment (TME). This manuscript provides an extensive examination of the multifaceted roles played by E…
View article: Etiopathogenesis of Type 2 Diabetes in Patients from the Asir Region of Saudi Arabia: Association of Pro-inflammatory Cytokines CCL-1, 2, 4, and 5 with Varying Levels of Obesity
Etiopathogenesis of Type 2 Diabetes in Patients from the Asir Region of Saudi Arabia: Association of Pro-inflammatory Cytokines CCL-1, 2, 4, and 5 with Varying Levels of Obesity Open
Background. Type 2 diabetes mellitus (T2DM) is becoming a major global health concern, especially in poorer nations. The high prevalence of obesity and the ensuing diabetes is attributed to rapid economic progress, physical inactivity, con…
View article: Selective roles of Interleukin-10 Family Members (IL-10, IL-19, IL-22) and Varying Levels of Obesity in the Pathogenesis of Type 2 Diabetes in Patients from Asir Region of Saudi Arabia
Selective roles of Interleukin-10 Family Members (IL-10, IL-19, IL-22) and Varying Levels of Obesity in the Pathogenesis of Type 2 Diabetes in Patients from Asir Region of Saudi Arabia Open
Background. Type 2 diabetes mellitus (T2DM) is becoming a major global health concern, especially in poorer nations. The high prevalence of obesity and the ensuing diabetes I attributed to rapid economic progress, physical inactivity, cons…
View article: In Silico Investigation of AKT2 Gene and Protein Abnormalities Reveals Potential Association with Insulin Resistance and Type 2 Diabetes
In Silico Investigation of AKT2 Gene and Protein Abnormalities Reveals Potential Association with Insulin Resistance and Type 2 Diabetes Open
Type 2 diabetes (T2D) develops from insulin resistance (IR) and the dysfunction of pancreatic beta cells. The AKT2 protein is very important for the protein signaling pathway, and the non-synonymous SNP (nsSNPs) in AKT2 gene may be associa…
View article: Application of Artificial Intelligence in Medical Education: Current Scenario and Future Perspectives.
Application of Artificial Intelligence in Medical Education: Current Scenario and Future Perspectives. Open
It can be used in medical education in the following forms: Virtual Inquiry System, Medical Distance Learning and Management, and Recording teaching videos in medical schools. It can also enhance the value of the non-analytical humanistic …