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View article: Efficacy and safety of celiac plexus radiotherapy in Pancreatic cancer-related pain management: a systematic review and meta-analysis
Efficacy and safety of celiac plexus radiotherapy in Pancreatic cancer-related pain management: a systematic review and meta-analysis Open
Background: Advanced cancer pain, especially in pancreatic cancer, often requires interventional management. This meta-analysis evaluates the effectiveness and safety of celiac plexus radiotherapy in reducing pain, providing comprehensive …
View article: Sympathetic Shift and Insular Alteration: Unravelling the Link Between Anxiety and Heart Rate Variability in Parkinson's Disease
Sympathetic Shift and Insular Alteration: Unravelling the Link Between Anxiety and Heart Rate Variability in Parkinson's Disease Open
Background Anxiety and autonomic dysfunction are frequent non‐motor symptoms of Parkinson's disease (PD). Their relationship, as well as the neural mechanisms underlying this relationship, remain unexplored. Objectives We aimed to investig…
View article: <b>Functional Characterization of Non-Synonymous SNPs in the Hypertension-Associated AGT Gene Using Bioinformatic Tools</b>
<b>Functional Characterization of Non-Synonymous SNPs in the Hypertension-Associated AGT Gene Using Bioinformatic Tools</b> Open
Background: Hypertension, the “silent killer,” is a multifactorial disorder driven by genetic and environmental factors. Approximately 90% of cases are essential hypertension. Despite effective pharmacotherapy, there is no permanent cure; …
View article: COMPUTATIONAL CHARACTERIZATION OF NON-SYNONYMOUS SNPS OF THE HUMAN PROSTATE CANCER-ASSOCIATED EHBP1 GENE
COMPUTATIONAL CHARACTERIZATION OF NON-SYNONYMOUS SNPS OF THE HUMAN PROSTATE CANCER-ASSOCIATED EHBP1 GENE Open
Prostate cancer is one of the frequently reported cancers in men worldwide, and it is the third most prevalent urogenital cancer among males in the Pakistani population. Variations in several oncogenes and tumor suppressor genes have been …
View article: <b>A Comprehensive Analysis of Non-Synonymous SNPs in the PTPN22 Gene Using in Silico Tools</b>
<b>A Comprehensive Analysis of Non-Synonymous SNPs in the PTPN22 Gene Using in Silico Tools</b> Open
Background: The PTPN22 gene encodes lymphoid tyrosine phosphatase (LYP), a critical regulator of T-cell receptor signaling. Variants in PTPN22 have been implicated in multiple autoimmune diseases, including type 1 diabetes, rheumatoid arth…
View article: <b>In Silico Analysis of Non-Synonymous SNPs in NOS3 Gene</b>
<b>In Silico Analysis of Non-Synonymous SNPs in NOS3 Gene</b> Open
Background: Hypertension, a prevalent chronic disorder characterized by blood pressure ≥130/80 mmHg, results from complex interactions between genetic and environmental factors, affecting approximately 20% of the global population and cont…
View article: DEVELOPMENT OF TETRA-ARMS PCR-BASED GENOTYPING METHOD FOR THE SINGLE NUCLEOTIDE VARIANT “RS699” OF THE AGT GENE
DEVELOPMENT OF TETRA-ARMS PCR-BASED GENOTYPING METHOD FOR THE SINGLE NUCLEOTIDE VARIANT “RS699” OF THE AGT GENE Open
Single Nucleotide Variants (SNVs) are the most common form of sequence alterations found in human genomes, with the potential to influence phenotypic expression and predispose individuals to complex diseases, such as hypertension. One such…
View article: ASSOCIATION STUDY OF AGT<i> </i>GENE POLYMORPHISM “RS699” WITH HYPERTENSION IN A PAKISTANI POPULATION
ASSOCIATION STUDY OF AGT<i> </i>GENE POLYMORPHISM “RS699” WITH HYPERTENSION IN A PAKISTANI POPULATION Open
Hypertension is a complex genetic disorder with numerous genetic and environmental factors. Essential hypertension is recognized as a global health concern, which remarkably increases the possibility of the development of cardiovascular an…
View article: Tremor Asymmetry and the Development of Bilateral Phase‐Specific Deep Brain Stimulation for Postural Tremor
Tremor Asymmetry and the Development of Bilateral Phase‐Specific Deep Brain Stimulation for Postural Tremor Open
Background Tremor phase‐locked deep brain stimulation (DBS) has been shown to modulate symptom severity in postural tremor, including essential and dystonic tremor, with less energy than existing systems. Previous studies focused on unilat…
View article: Tremor asymmetry and the development of bilateral phase-specific deep brain stimulation for postural tremor
Tremor asymmetry and the development of bilateral phase-specific deep brain stimulation for postural tremor Open
Background Tremor phase-locked deep brain stimulation (DBS) has been shown to modulate symptom severity in patients with postural tremor, including essential (ET) and dystonic tremor (DT). This, provides a potential alternative therapy tha…
View article: Cortico-thalamic tremor circuits and their associations with deep brain stimulation effects in essential tremor
Cortico-thalamic tremor circuits and their associations with deep brain stimulation effects in essential tremor Open
Essential tremor is one of the most common movement disorders in adults. Deep brain stimulation (DBS) of the ventralis intermediate nucleus of the thalamus and/or the posterior subthalamic area has been shown to provide significant tremor …
View article: Basal ganglia theta power indexes trait anxiety in people with Parkinson's disease
Basal ganglia theta power indexes trait anxiety in people with Parkinson's disease Open
Neuropsychiatric symptoms are common and disabling in Parkinson's disease, with troublesome anxiety occurring in one-third of patients. Management of anxiety in Parkinson's disease is challenging, hampered by insufficient insight into unde…
View article: Cortico-thalamic tremor circuits and their associations with deep brain stimulation effects in essential tremor
Cortico-thalamic tremor circuits and their associations with deep brain stimulation effects in essential tremor Open
Essential tremor (ET) is one of the most common movement disorders in adults. Deep brain stimulation (DBS) of the ventralis intermediate nucleus (VIM) of the thalamus and/or the posterior subthalamic area (PSA) has been shown to provide si…
View article: 1179 Navigating the AI Landscape: Surveying the Use of AI Language Tools for Medical Portfolios
1179 Navigating the AI Landscape: Surveying the Use of AI Language Tools for Medical Portfolios Open
Aim Recent advances in artificial intelligence (AI) driven natural language processing have made it possible to use tools such as ChatGPT to generate pieces of text which are realistic, eloquent, and challenging to distinguish from human-g…
View article: Basal ganglia theta power indexes trait anxiety in people with Parkinson’s disease
Basal ganglia theta power indexes trait anxiety in people with Parkinson’s disease Open
Background Neuropsychiatric symptoms are common and disabling in Parkinson’s disease (PD), with troublesome anxiety occurring in one-third of patients. Management of anxiety in PD is challenging, hampered by insufficient insight into under…
View article: Beta-triggered adaptive deep brain stimulation during reaching movement in Parkinson’s disease
Beta-triggered adaptive deep brain stimulation during reaching movement in Parkinson’s disease Open
Subthalamic nucleus (STN) beta-triggered adaptive deep brain stimulation (ADBS) has been shown to provide clinical improvement comparable to conventional continuous DBS (CDBS) with less energy delivered to the brain and less stimulation in…
View article: The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism
The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism Open
Periodic features of neural time-series data, such as local field potentials (LFPs), are often quantified using power spectra. While the aperiodic exponent of spectra is typically disregarded, it is nevertheless modulated in a physiologica…
View article: Computer vision quantification of whole-body Parkinsonian bradykinesia using a large multi-site population
Computer vision quantification of whole-body Parkinsonian bradykinesia using a large multi-site population Open
Parkinson’s disease (PD) is a common neurological disorder, with bradykinesia being one of its cardinal features. Objective quantification of bradykinesia using computer vision has the potential to standardise decision-making, for patient …
View article: Subthalamic Nucleus Stimulation–Induced Local Field Potential Changes in Dystonia
Subthalamic Nucleus Stimulation–Induced Local Field Potential Changes in Dystonia Open
Background Subthalamic nucleus (STN) stimulation is an effective treatment for Parkinson's disease and induced local field potential (LFP) changes that have been linked with clinical improvement. STN stimulation has also been used in dysto…
View article: Beta-triggered adaptive deep brain stimulation during reaching movement in Parkinson’s disease
Beta-triggered adaptive deep brain stimulation during reaching movement in Parkinson’s disease Open
Subthalamic nucleus (STN) beta-triggered adaptive deep brain stimulation (ADBS) has been shown to provide clinical improvement comparable to conventional continuous DBS (CDBS) in people with Parkinson’s disease (PD) with less energy delive…
View article: Author response: The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism
Author response: The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism Open
Full text Figures and data Side by side Abstract Editor's evaluation Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Metrics Abstract Periodic features of …
View article: The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism: a cross-species study <i>in vivo</i>
The aperiodic exponent of subthalamic field potentials reflects excitation/inhibition balance in Parkinsonism: a cross-species study <i>in vivo</i> Open
A bstract Periodic features of neural time series data, such as local field potentials (LFP), are often quantified using power spectra. While the aperiodic exponent of spectra is typically disregarded, it is nevertheless modulated in a phy…
View article: Genetics of validated Parkinson’s disease subtypes in the Oxford Discovery and Tracking Parkinson’s cohorts
Genetics of validated Parkinson’s disease subtypes in the Oxford Discovery and Tracking Parkinson’s cohorts Open
Objectives To explore the genetics of four Parkinson’s disease (PD) subtypes that have been previously described in two large cohorts of patients with recently diagnosed PD. These subtypes came from a data-driven cluster analysis of phenot…
View article: Computer-vision based method for quantifying rising from chair in Parkinson's disease patients
Computer-vision based method for quantifying rising from chair in Parkinson's disease patients Open
The ability to arise from a sitting to a standing position is often impaired in Parkinson's disease (PD). This impairment is associated with an increased risk of falling, and higher risk of dementia. We propose a novel approach to estimate…
View article: A Clinically Interpretable Computer-Vision Based Method for Quantifying Gait in Parkinson’s Disease
A Clinically Interpretable Computer-Vision Based Method for Quantifying Gait in Parkinson’s Disease Open
Gait is a core motor function and is impaired in numerous neurological diseases, including Parkinson’s disease (PD). Treatment changes in PD are frequently driven by gait assessments in the clinic, commonly rated as part of the Movement Di…
View article: Neurophysiological Correlates of Trait Impulsivity in Parkinson's Disease
Neurophysiological Correlates of Trait Impulsivity in Parkinson's Disease Open
Background Impulsivity is common in people with Parkinson's disease (PD), with many developing impulsive compulsive behavior disorders (ICB). Its pathophysiological basis remains unclear. Objectives We aimed to investigate local field pote…
View article: Closed‐Loop Deep Brain Stimulation for Essential Tremor Based on Thalamic Local Field Potentials
Closed‐Loop Deep Brain Stimulation for Essential Tremor Based on Thalamic Local Field Potentials Open
Background High‐frequency thalamic stimulation is an effective therapy for essential tremor, which mainly affects voluntary movements and/or sustained postures. However, continuous stimulation may deliver unnecessary current to the brain d…