Explanipedia

Hyperglycemia, diabetes, and coronary microvascular dysfunction in INOCA Open

Fahimeh Varzideh, Martina D’Onghia, Marco Savino, Gaetano Santulli · 2025

CARMN orchestrates angiogenesis from behind the opera scenes: signing love letters to the endothelium Open

Shivangi Pande, G.M. Ishak, Fahimeh Varzideh, Gaetano Santulli · 2025

Chronic limb-threatening ischemia (CLTI), the advanced stage of peripheral artery disease (PAD), remains a leading cause of morbidity and limb loss. Effective vascular regeneration strategies will require increased understanding of molecul…

Decoding the coronary paradox of obesity: not all fat is equal! Open

Gaetano Santulli, Shivangi Pande, Pasquale Mone, Fahimeh Varzideh · 2025

Fabry disease cardiomyopathy: A state-of-the-art review Open

Shivangi Pande, Fahimeh Varzideh, Jessica Gambardella, Stanislovas S. Jankauskas, Federica Andrea Cerasuolo , et al. · 2025

Fabry disease or Anderson-Fabry disease is an X-linked lysosomal storage disorder caused by a deficiency of α-galactosidase A (GLA), leading to systemic accumulation of globotriaosyl-ceramide (Gb3). Initially described in 1898 as a dermato…

Reformulation of the Necroptosis Pathway in Reperfused Myocardial Infarction Open

Dongze Qin, Radheshyam Modanwal, Madeeha Ghazi, J. Jose Corbalan, Xiaotong F. Jia , et al. · 2025

Correction: Statin-induced risk of diabetes does not reduce cardiovascular benefits in primary prevention: a 6-year propensity-score matched study in a large population Open

Maria Lembo, Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Stanislovas S. Jankauskas , et al. · 2025

The COVID-19 pandemic increased the incidence of newly diagnosed cancers: evidence from a large cohort study in Southern Italy Open

Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Maria Virginia Manzi, Fahimeh Varzideh , et al. · 2025

Taken together, these findings highlight a concerning increase in cancer diagnoses in the Campania Region during the COVID-19 pandemic, contrasting with earlier reports that pointed to a decline in cases, mostly attributed to interrupted s…

Correction: Bhutani et al. Doxorubicin-Induced Cardiotoxicity: A Comprehensive Update. J. Cardiovasc. Dev. Dis. 2025, 12, 207 Open

V K Bhutani, Fahimeh Varzideh, Scott Wilson, Urna Kansakar, Stanislovas S. Jankauskas , et al. · 2025

In the original publication [...]

Statin-induced risk of diabetes does not reduce cardiovascular benefits in primary prevention: a 6-year propensity-score matched study in a large population Open

Maria Lembo, Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Stanislovas S. Jankauskas , et al. · 2025

Doxorubicin-Induced Cardiotoxicity: A Comprehensive Update Open

V K Bhutani, Fahimeh Varzideh, Scott Wilson, Urna Kansakar, Stanislovas S. Jankauskas , et al. · 2025

Doxorubicin is an anthracycline chemotherapeutic that is widely used for treating various malignancies, including breast cancer, lymphomas, and sarcomas. Despite its efficacy, its clinical utility is limited by a well-documented risk of ca…

Functional role of circular RNA XYLT1 in vascular remodeling and oxidative stress in aging Open

Fahimeh Varzideh, Pasquale Mone, Urna Kansakar, Gaetano Santulli · 2025

Low LDL-cholesterol drives the risk of bleeding in patients treated with aspirin: A 15-year study in a real-world large population Open

Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Fahimeh Varzideh, Maria Virginia Manzi , et al. · 2025

Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential Open

Cheryl Tung, Fahimeh Varzideh, Emanuele Farroni, Pasquale Mone, Urna Kansakar , et al. · 2025

Mitochondria serve an essential metabolic and energetic role in cellular activity, and their dysfunction has been implicated in a wide range of disorders, including cardiovascular conditions, neurodegenerative disorders, and metabolic synd…

TMAO accelerates cellular aging by disrupting endoplasmic reticulum integrity and mitochondrial unfolded protein response Open

Fahimeh Varzideh, Emanuele Farroni, Urna Kaunsakar, Mahaba Eiwaz, Stanislovas S. Jankauskas , et al. · 2025

L-Arginine supplementation as mitochondrial therapy in diabetic cardiomyopathy Open

Antonella Fiordelisi, Federica Andrea Cerasuolo, Roberta Avvisato, Antonietta Buonaiuto, Marianna Maisto , et al. · 2024

GLP-1 receptor agonists and SGLT2 inhibitors: new anti-aging tools? Open

Gaetano Santulli, Pasquale Mone, Fahimeh Varzideh · 2024

Lipoprotein(a) and cardiovascular risk: new insights Open

Fahimeh Varzideh, Urna Kansakar, Gaetano Santulli · 2024

Mechanistic role of mesencephalic astrocyte-derived neurotrophic factor in myocardial ischemia/reperfusion injury Open

Fahimeh Varzideh, Brandon Wang, Yifei Qin, Urna Kansakar, Gaetano Santulli , et al. · 2024

A six-year study in a real-world population reveals an increased incidence of dyslipidemia during COVID-19 Open

Valentina Trimarco, Raffaele Izzo, Stanislovas S. Jankauskas, Mario Fordellone, Giuseppe Signoriello , et al. · 2024

BACKGROUNDRecent studies conducted in individuals who survived COVID-19 suggest that SARS-CoV-2 infection is associated with an increased risk of dyslipidemia. However, it remains unclear whether this augmented risk is confirmed in the gen…

Circulating levels of cadherins are associated with atherosclerosis and cardiovascular outcomes Open

Gaetano Santulli, Fahimeh Varzideh, Yifei Qin, Brandon Wang, Urna Kansakar , et al. · 2024

Endothelial microRNAs in INOCA patients with diabetes mellitus Open

Marco Ferrone, Michele Ciccarelli, Fahimeh Varzideh, Urna Kansakar, Germano Guerra , et al. · 2024

Extracellular RNA and Endothelial TLR3 Link Inflammation and Venous Thromboembolism Open

Luigi Savino, Marco Savino, Urna Kansakar, Tommaso Dazzetti, Fahimeh Varzideh , et al. · 2024

Insights into molecular and cellular functions of the Golgi calcium/manganese-proton antiporter TMEM165 Open

Stanislovas S. Jankauskas, Fahimeh Varzideh, Urna Kansakar, Ghaith Al Tibi, Esther Densu Agyapong , et al. · 2024

Endothelial Extracellular Vesicles Enriched in microRNA-34a Predict New-Onset Diabetes in Coronavirus Disease 2019 (COVID-19) Patients: Novel Insights for Long COVID Metabolic Sequelae Open

Pasquale Mone, Stanislovas S. Jankauskas, Maria Virginia Manzi, Jessica Gambardella, Antonietta Coppola , et al. · 2024

Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy Open

Stanislovas S. Jankauskas, Fahimeh Varzideh, Pasquale Mone, Urna Kansakar, Francesco Di Lorenzo , et al. · 2024

Dysfunctional mitochondria elicit bioenergetic decline in the aged heart Open

Pasquale Mone, Esther Densu Agyapong, Giampaolo Morciano, Stanislovas S. Jankauskas, Antonio De Luca , et al. · 2024

Aging represents a complex biological progression affecting the entire body, marked by a gradual decline in tissue function, rendering organs more susceptible to stress and diseases. The human heart holds significant importance in this con…

Targeting miR-199a reduces fibrosis in hypertrophic cardiomyopathy Open

Stanislovas S. Jankauskas, Fahimeh Varzideh, Urna Kansakar, Gaetano Santulli · 2023

Functional Role of Taurine in Aging and Cardiovascular Health: An Updated Overview Open

Gaetano Santulli, Urna Kansakar, Fahimeh Varzideh, Pasquale Mone, Stanislovas S. Jankauskas , et al. · 2023

Taurine, a naturally occurring sulfur-containing amino acid, has attracted significant attention in recent years due to its potential health benefits. Found in various foods and often used in energy drinks and supplements, taurine has been…

SGLT2 inhibitors: an evidence-based update on cardiovascular implications Open

Imma Forzano, Scott Wilson, Angela Lombardi, Stanislovas S. Jankauskas, Urna Kansakar , et al. · 2023

The favorable results of several clinical trials have broadened the therapeutic scenario for SGLT2 inhibitors, opening, at the same time, new challenges. Additionally, recent preclinical findings have evidenced off-target effects of SGLT2 …

Myosin activator omecamtiv mecarbil exhibits divergent inotropic and lusitropic effects in cardiac slices from patients with heart failure Open

Fahimeh Varzideh, Pasquale Mone, Luigi Salemme, Imma Forzano, Angelo Cioppa , et al. · 2023

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