Explanipedia

The Role of Radiation Therapy for Metastatic Cervical Cancer Open

Fahong Wu, Xiaolong Tang, Yong Zhang, Wei Li, Ting Wang , et al. · 2023

<i>Rhubarb</i> Anthraquinones Ameliorates Inflammatory Lung Injury by Enhancing Alveolar Epithelium Tight Junction Proteins through RhoA/ROCK1 Signalling Open

Guiyuan Liu, Yinliang Bai, Guangxian Leng, Hanwei Ma, Yin Kong , et al. · 2023

Background: Leakage of the alveolar epithelial barrier can lead to pulmonary oedema, leading to organ dysfunction. Objectives: Combination anthraquinone (CA) and free anthraquinone (FA) were extracted from Rhubarb, and the prevention and t…

Current Status of Lymphangiogenesis: Molecular Mechanism, Immune Tolerance, and Application Prospect Open

Hongyang Deng, Jiaxing Zhang, Fahong Wu, Fengxian Wei, Wei Han , et al. · 2023

The lymphatic system is a channel for fluid transport and cell migration, but it has always been controversial in promoting and suppressing cancer. VEGFC/VEGFR3 signaling has long been recognized as a major molecular driver of lymphangioge…

lncRNA <italic>ELFN1-AS1</italic> promotes proliferation, migration and invasion and suppresses apoptosis in colorectal cancer cells by enhancing <italic>G6PD</italic> activity Open

Fahong Wu, Wei Zhang, Hangzhi Wei, Hanwei Ma, Guangxian Leng , et al. · 2023

Tumour cells change their metabolic patterns to support high proliferation rates and cope with oxidative stress. The lncRNA ELFN1-AS1 is highly expressed in a wide range of cancers and is essential to the proliferation and apoptosis…

Licoricidin combats gastric cancer by targeting the ICMT/Ras pathway in vitro and in vivo Open

Hanwei Ma, Fahong Wu, Yinliang Bai, Tianwei Wang, Shangxian Ma , et al. · 2022

Licoricidin, a type of isoflavonoid, is extracted from the root of Glycyrrhiza glabra . It has been widely proven that licoricidin possesses multiple biological activities, including anti-cancer effects and a powerful antimicrobial effect …

PARP in colorectal cancer: Molecular mechanisms, immunity, clinical trials, and drug combinations Open

Fahong Wu, Hangzhi Wei, Hong-Yang Deng, Guohui Xiao, Youcheng Zhang · 2022

The changes in cell homeostasis in the tumor microenvironment may affect the development of colorectal cancer (CRC). Genomic instability is an important factor. Persistent genomic instability leads to epigenetic changes, and mutations are …

CTPS1 inhibition suppresses proliferation and migration in colorectal cancer cells Open

Fahong Wu, Yudong Mao, Tao Ma, Xiaoli Wang, Hangzhi Wei , et al. · 2022

Colorectal cancer (CRC) is now the third most prevalent tumor and one of the deadliest cancers worldwide, with an increasing prevalence every year. Therefore, we urgently need to understand the mechanisms regulating the progression of colo…

The Role of The Tumor Microbiome in Tumor Development and Its Treatment Open

Yan Chen, Fahong Wu, Pengqiang Wu, H. Rosie Xing, Tao Ma · 2022

Commensal bacteria and other microorganisms that reside in the human body are closely associated with the development and treatment of cancers. Recently, tumor microbiome (TM) has been identified in a variety of cancers such as pancreatic,…

WITHDRAWN: Alpha-fetoprotein Promotes Hepatocellular Carcinoma Progression by Negatively Regulating Hippo Signaling Pathway Running title: AFP Regulate the Hippo Signaling Pathway Open

Guangxian Leng, Fahong Wu, Hongxia Gong, Guiyuan Liu, Hangzhi Wei , et al. · 2022

Background: Alpha-fetoprotein (AFP) is a specific tumor marker for hepatocellular carcinoma (HCC) and promotes tumor cell proliferation in HCC, but the mechanism is not completely clear. This research aimed to supplement the mechanism of A…

Long Non-Coding RNA MCM3AP-AS1: A Crucial Role in Human Malignancies Open

Tao Ma, Fahong Wu, Hongxia Wu, Qiong Fa, Yan Chen · 2022

The incidence of cancer continues to grow and is one of the leading causes of death in the world. Long noncoding RNAs (LncRNAs) is a group of RNA transcripts greater than 200 nucleotides in length, and although it cannot encode proteins, i…

The histidine phosphatase LHPP: an emerging player in cancer Open

Fahong Wu, Hanwei Ma, Xiaoli Wang, Hangzhi Wei, Wei Zhang , et al. · 2022

Cancers continue to have high incidence and mortality rates worldwide. Therefore, cancer control remains the main public health goal. Growing research evidence suggests that phospholysine phosphohistidine inorganic pyrophosphate phosphatas…

CTPS1 inhibition suppresses proliferation and migration in colorectal cancer cells Open

Fahong Wu, Yudong Mao, Tao Ma, Xiaoli Wang, Hangzhi Wei , et al. · 2022

Colorectal cancer (CRC) is now the third most prevalent tumor and one of the deadliest cancers worldwide, with an increasing prevalence every year. Therefore, we urgently need to understand the mechanisms regulating the progression of colo…

CTPS1 suppresses proliferation and migration in colorectal cancer cells Open

Fahong Wu, Yudong Mao, Tao Ma, Xiaoli Wang, Hangzhi Wei , et al. · 2022

Colorectal cancer (CRC) is now the third most prevalent tumor and one of the deadliest cancers worldwide, with an increasing prevalence every year. Therefore, we urgently need to understand the mechanisms regulating the progression of colo…

Measurement of soluble PD-1 and soluble PD-L1 as well as PD-L1 and PD-1 from perioperative patients with gastric carcinoma Open

Hangzhi Wei, Fahong Wu, Yudong Mao, Youcheng Zhang, Guangxian Leng , et al. · 2021

Background Till now, no experiment has been performed to detect programmed death ligand 1 (PD-L1)/programmed death 1 (PD-1), soluble PD-L1/soluble PD-1 simultaneously in perioperative patients of gastric carcinoma. Our experiment aims at d…

Bioinformatics Profiling of Five Immune-Related lncRNAs for a Prognostic Model of Hepatocellular Carcinoma Open

Fahong Wu, Hangzhi Wei, Guiyuan Liu, Youcheng Zhang · 2021

Hepatocellular carcinoma (HCC), one of the most common tumors worldwide, has the fifth highest mortality rate, which is increasing every year. At present, many studies have revealed that immunotherapy has an important effect on many malign…

LHPP suppresses proliferation, migration, and invasion and promotes apoptosis in pancreatic cancer Open

Fahong Wu, Yanling Chen, Jinhai Zhu · 2020

Pancreatic cancer (PaCa) is a common malignant tumor of the digestive system with poor prognosis and no ideal treatment for inoperable patients, which is partly due to delayed diagnoses. It is recently reported that the protein histidine p…

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