Fahu Yuan
YOU?
Author Swipe
View article: Assessing the mechanism of osteosarcoma induced by long-term PET exposure: prediction from combined network toxicology, machine learning and molecular docking
Assessing the mechanism of osteosarcoma induced by long-term PET exposure: prediction from combined network toxicology, machine learning and molecular docking Open
This study reveals that PET may play a critical role in OS development by regulating hub genes and signaling pathways. Molecular docking analysis demonstrates that PET can tightly bind to specific target proteins, suggesting a potential mo…
View article: Dehydrotanshinone II A alleviates osteoarthritis via activating PPARγ to inhibit ferroptosis in chondrocytes
Dehydrotanshinone II A alleviates osteoarthritis via activating PPARγ to inhibit ferroptosis in chondrocytes Open
View article: Molecular Mechanisms of Lobelia nummularia Extract in Breast Cancer: Targeting EGFR/TP53 and PI3K-AKT-mTOR Signaling via ROS-Mediated Apoptosis
Molecular Mechanisms of Lobelia nummularia Extract in Breast Cancer: Targeting EGFR/TP53 and PI3K-AKT-mTOR Signaling via ROS-Mediated Apoptosis Open
Lobelia nummularia Lam. is a traditional medicinal herb of which the anticancer mechanisms remain largely unexplored. Here, we demonstrated that its ethanolic extract (LNE) exerts potent anti-breast cancer activity by inducing ROS-dependen…
View article: Effects of Radix Achyrandii Polysaccharide on Cartilage Morphology of Knee Osteoarthritis in Obese Mice Induced by High-fat Diet
Effects of Radix Achyrandii Polysaccharide on Cartilage Morphology of Knee Osteoarthritis in Obese Mice Induced by High-fat Diet Open
Objective: To study the pathological changes of articular cartilage in the process of osteoarthritis induced by high-fat diet and the mechanism of Radix achyrandii polysaccharide on osteoarthritis cartilage, and to explore the protective e…
View article: Effects of Black Rice Anthocyanin Extract on Depression-Like Behavior in Chronic Unpredictable Mild Stress Model Mice
Effects of Black Rice Anthocyanin Extract on Depression-Like Behavior in Chronic Unpredictable Mild Stress Model Mice Open
Objective: To investigate the effects of black rice anthocyanins extract (BSE) on depression-like behavior in mice with chronic unpredictable mild stress (CUMS). Methods: A total of 30 male Kunming mice were randomly divided into Control g…
View article: Metformin inhibits knee osteoarthritis induced by type 2 diabetes mellitus in rats: S100A8/9 and S100A12 as players and therapeutic targets
Metformin inhibits knee osteoarthritis induced by type 2 diabetes mellitus in rats: S100A8/9 and S100A12 as players and therapeutic targets Open
Type 2 diabetes mellitus (T2DM) is a significant risk factor for osteoarthritis (OA), and metformin, as the main therapeutic drug for T2DM, has shown positive effects on OA without a clear mechanism. This study aimed to explore the protect…
View article: Antibacterial Effect of Three Kinds of Methylene Blue Photosensitizers Mediated Photodynamic Therapy on Streptococcus Mutans
Antibacterial Effect of Three Kinds of Methylene Blue Photosensitizers Mediated Photodynamic Therapy on Streptococcus Mutans Open
In order to study the antibacterial effect of methylene blue (MB) photosensitizer-mediated photodynamic therapy (PDT) on Streptococcus mutans in aqueous solvent form, SDS solution form and their mixed form, the influence of MB-PDT on antib…
View article: Effect of Chunpi Decoction on Ulcerative Colitis Induced by Dextran Sulfate Sodium in Mice
Effect of Chunpi Decoction on Ulcerative Colitis Induced by Dextran Sulfate Sodium in Mice Open
Ulcerative colitis is a chronic disease with unclear pathogenesis and difficult to cure. Its drug treatment is highly dependent and has obvious side effects. In this study, dextran sulfate sodium (DSS) was used to establish a mouse model o…
View article: Comparison of Unilateral and Bilateral Percutaneous Kyphoplasty for Osteoporotic Vertebral Compression Fractures
Comparison of Unilateral and Bilateral Percutaneous Kyphoplasty for Osteoporotic Vertebral Compression Fractures Open
There was no significant difference between the two groups in terms of improvement in VAS score, ODI index, restoration of vertebral body height, and posterior convexity deformity, but unilateral puncture had the advantage of shorter opera…
View article: Intervention of Vine Tea Extract on Non-alcoholic Fatty Liver in Mice
Intervention of Vine Tea Extract on Non-alcoholic Fatty Liver in Mice Open
To investigate the effects of vine tea extract (VTE) on high-fat-diet (HFD) induced obesity in mice. A C57BL/6J mouse model of obesity induced by 8-week high-fat diet was established. By measuring the activities of aspartate aminotransfera…
View article: Anthocyanin extract from black rice attenuates chronic inflammation in DSS-induced colitis mouse model by modulating the gut microbiota
Anthocyanin extract from black rice attenuates chronic inflammation in DSS-induced colitis mouse model by modulating the gut microbiota Open
There is substantial evidence for the probiotic activity of anthocyanins, but the relationship between anthocyanins involved in the regulation of microbiota and intestinal inflammation has not been fully elucidated. The aim of this study w…
View article: Green Synthesis of Gold Nanoparticles Using Polyphenols from Pomelo Leaves and its Antibacterial Properties
Green Synthesis of Gold Nanoparticles Using Polyphenols from Pomelo Leaves and its Antibacterial Properties Open
Gold nanoparticles (AuNPs) were synthesized by one-step reduction of chloroauric acid using pomelo leaf polyphenol extract as reducing and protective agent. The AuNPs were characterized by UV-Vis absorption spectroscopy. Compared with AuNP…
View article: Identification and validation of real hub genes in hepatocellular carcinoma based on weighted gene co-expression network analysis
Identification and validation of real hub genes in hepatocellular carcinoma based on weighted gene co-expression network analysis Open
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common liver malignancies in the world. With highly invasive biological characteristics and a lack of obvious clinical manifestations, hepatocellular carcinoma usually has a poo…
View article: Identification and Validation of Real Hub Genes in Hepatocellular Carcinoma Based on Weighted Gene Co-expression Network Analysis
Identification and Validation of Real Hub Genes in Hepatocellular Carcinoma Based on Weighted Gene Co-expression Network Analysis Open
Background: Hepatocellular Carcinoma (HCC) is one of the most common liver malignancies in the world. With highly invasive biological characteristics and lack of obvious clinical manifestations, hepatocellular Carcinoma usually has a poor …
View article: Single-cell analysis reveals cell communication triggered by macrophages associated with the reduction and exhaustion of CD8+ T cells in COVID-19
Single-cell analysis reveals cell communication triggered by macrophages associated with the reduction and exhaustion of CD8+ T cells in COVID-19 Open
View article: Production and characterization of a novel beverage from maize silk through fermentation with kombucha consortium
Production and characterization of a novel beverage from maize silk through fermentation with kombucha consortium Open
Maize silk was taken as raw material, boiled, cooled and fermented by kombucha fungus to prepare maize silk kombucha beverage. The inoculation amount, initial sugar content and fermentation temperature of kombucha were selected as the infl…
View article: Effects of black rice anthocyanins on the behavior and intestinal microbiota of mice with chronic unpredictable mild stress
Effects of black rice anthocyanins on the behavior and intestinal microbiota of mice with chronic unpredictable mild stress Open
In order to study the effect of black rice anthocyanins (BRACs) on the behavior and intestinal microbiota of depression model mice, depression model mice were induced by chronic unpredictable mild stress (CUMS). The anhedonia of BRACs trea…
View article: Nobiletin enhances Pirarubicin chemosensitivity of breast cancer cell MDA-MB-231 by regulating PER2
Nobiletin enhances Pirarubicin chemosensitivity of breast cancer cell MDA-MB-231 by regulating PER2 Open
To explore the potential mechanism of nobiletin in improving the sensitivity of breast cancer MDA-MB-231 cells to Pirarubicin. MDA-MB-231 cells were randomly divided into Control group, Nobiletin group, Pirarubicin group and Nobiletin co-P…
View article: Efficacy of <i>Bifidobacterium animalis subsp. lactis</i> BB-12 against <i>Giardia duodenalis</i> trophozoites: an experimental study
Efficacy of <i>Bifidobacterium animalis subsp. lactis</i> BB-12 against <i>Giardia duodenalis</i> trophozoites: an experimental study Open
Giardia duodenalis , formerly known as Giardia lamblia , is an important zoonotic protozoan parasite. It mainly infects the intestines of humans, dogs, cats and domestic animals, causing diarrhea, abdominal pain, indigestion and weight los…
View article: Characteristics and upregulation of antioxidant capacity of fermented pueraria starch production wastewater with kombucha consortium
Characteristics and upregulation of antioxidant capacity of fermented pueraria starch production wastewater with kombucha consortium Open
Pueraria lobata is a traditional plant used for both medicine and food. Pueraria starch has a long history of folk consumption in China. The processing of pueraria starch produces a lot of waste water and is often discarded, but it contain…
View article: Study on the mechanism of Erzhi Pill in the treatment of breast cancer based on network pharmacology
Study on the mechanism of Erzhi Pill in the treatment of breast cancer based on network pharmacology Open
Objective: To explore the possible mechanism of Erzhi Pill in the treatment of breast cancer based on network pharmacology. Methods: Through systematic pharmacology database and analysis platform of Traditional Chinese medicine (TCMSP) and…
View article: The role of health managers in community prevention and control of Corona Virus Disease 2019
The role of health managers in community prevention and control of Corona Virus Disease 2019 Open
Since the outbreak of Corona Virus Disease 2019 (COVID-19) in December 2019, more than 26 million people have been infected. Urban and rural communities are the first line of defense for epidemic prevention and control. As an effective mea…
View article: Supplementation of <i>Rhodomyrtus tomentosa</i> fruit polyphenols improved dextran sulfate induced colitis in mice by regulating gut microbiota
Supplementation of <i>Rhodomyrtus tomentosa</i> fruit polyphenols improved dextran sulfate induced colitis in mice by regulating gut microbiota Open
To investigate the therapeutic effect of polyphenol from the fruits of Rhodomyrtus tomentosa (RTFP) on experimental colitis induced by dextran sulphate sodium(DSS) in mice. A total of 24 Babl/c mice were randomly divided into normal contro…
View article: Polyphenolic extract from Artemisia selengensis Turcz ameliorates experimental oral mucositis
Polyphenolic extract from Artemisia selengensis Turcz ameliorates experimental oral mucositis Open
Oral mucositis is a common and frequentoccurring disease and there is no effective treatment. In this study, we investigated the efficacy of polyphenolic extract from Artemisia selengensis Turcz (PPAST) in the prevention and treatment of o…
View article: KIR2DL2/C1 is a Risk Factor for Chronic Infection and Associated with Non-response to PEG-IFN and RBV Combination Therapy in Hepatitis C Virus Genotype 1b Patients in China
KIR2DL2/C1 is a Risk Factor for Chronic Infection and Associated with Non-response to PEG-IFN and RBV Combination Therapy in Hepatitis C Virus Genotype 1b Patients in China Open
View article: Corilagin attenuates the Parkinsonismin Japanese encephalitis virus induced Parkinsonism
Corilagin attenuates the Parkinsonismin Japanese encephalitis virus induced Parkinsonism Open
This study evaluates the protective effect of corilagin against Parkinsonismin Japanese encephalitis virus (JEV) induced Parkinson’s disease. The JaGAr-01 strain of virus was used to induce JE. The virus was injected into the rats (13 days…
View article: Anti-trypanosomal effect of Malva sylvestris (Malvaceae) extract on a Trypanosoma brucei brucei-infected mouse model of sleeping sickness
Anti-trypanosomal effect of Malva sylvestris (Malvaceae) extract on a Trypanosoma brucei brucei-infected mouse model of sleeping sickness Open
Purpose: To evaluate the antitrypanosomal activity of Malva sylvestris (MS) extract in a Trypanosoma brucei brucei-infected mouse model of sleeping sickness.Methods: Sleeping sickness was induced by the intraperitoneal injection of Trypano…
View article: Fish Oil Feeding Modulates the Expression of Hepatic MicroRNAs in a Western-Style Diet-Induced Nonalcoholic Fatty Liver Disease Rat Model
Fish Oil Feeding Modulates the Expression of Hepatic MicroRNAs in a Western-Style Diet-Induced Nonalcoholic Fatty Liver Disease Rat Model Open
Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases worldwide. Recent studies have indicated that fish oil supplementation has benefits against NAFLD. Our previous transcriptomic study has validated…
View article: Diagnostic Value of CK-18, FGF-21, and Related Biomarker Panel in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Diagnostic Value of CK-18, FGF-21, and Related Biomarker Panel in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis Open
Liver biopsy still remains the gold standard for diagnosing nonalcoholic steatohepatitis (NASH), but with limitations. There is an urgent need to develop noninvasive tests that accurately distinguish NASH from simple steatosis. The purpose…
View article: Fish oil alleviated high-fat diet–induced non-alcoholic fatty liver disease via regulating hepatic lipids metabolism and metaflammation: a transcriptomic study
Fish oil alleviated high-fat diet–induced non-alcoholic fatty liver disease via regulating hepatic lipids metabolism and metaflammation: a transcriptomic study Open
The present study demonstrates fish oil protects against WD-induced NALFD via improving lipid metabolism and ameliorating hepatic inflammation. Our findings add to the current understanding on the benefits of n-3 PUFAs against NAFLD.