Faisal A. Almalki
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View article: Acute and Chronic Q Fever in a Child With Repaired Tetralogy of Fallot: A Case Report
Acute and Chronic Q Fever in a Child With Repaired Tetralogy of Fallot: A Case Report Open
View article: Integrative in silico and Petra/Osiris/Molinspiration (POM) analysis of baicalein: identification of therapeutically relevant pharmacophores against keloid pathology
Integrative in silico and Petra/Osiris/Molinspiration (POM) analysis of baicalein: identification of therapeutically relevant pharmacophores against keloid pathology Open
Introduction: Keloid scars are a kind of skin disorder in which the scar grows beyond the boundaries of the original wound. Baicalein, a flavonoid, may treat keloids by targeting fibrosis, inflammation, and possible viral factors.Methods: …
View article: Opportunistic myiasis is a rare complication in patients with feeding gastrostomy tube
Opportunistic myiasis is a rare complication in patients with feeding gastrostomy tube Open
View article: From silico to benchtop: cosmosiin as a PD-1/PDL-1 immune checkpoint inhibitor revealed through DFT, network pharmacology analysis, and molecular docking integrated experimental verification
From silico to benchtop: cosmosiin as a PD-1/PDL-1 immune checkpoint inhibitor revealed through DFT, network pharmacology analysis, and molecular docking integrated experimental verification Open
This study investigated the anti -PD-1/PD-L1 inhibition potential of the flavonoid cosmosiin against breast cancer (BC) using computational chemistry, network pharmacology, bioinformatics, and validated by experimental assays.
View article: In Silico Study, Antimicrobial and Antiinflammatory Activities of Eighteen Sulfonamide Derivatives: Interaction with Matrix Metalloproteinases (Mmps)
In Silico Study, Antimicrobial and Antiinflammatory Activities of Eighteen Sulfonamide Derivatives: Interaction with Matrix Metalloproteinases (Mmps) Open
View article: Pyrrolizines: natural and synthetic derivatives with diverse biological activities
Pyrrolizines: natural and synthetic derivatives with diverse biological activities Open
The pyrrolizine nucleus is a bicyclic ring system that consists of a pyrrole ring fused to another pyrrolidin ring. It constitutes the basic skeleton in many natural and synthetic compounds with diverse biological activities such as the an…
View article: Recent advances in the green synthesis of indole and its derivatives using microwave irradiation and the role of indole moiety in cancer
Recent advances in the green synthesis of indole and its derivatives using microwave irradiation and the role of indole moiety in cancer Open
Indole moiety is widely present in several natural bioactive products and medicinally important compounds. It is an essential scaffold for the development of novel leads. Nowadays, the synthesis of indoles by conventional methods is replac…
View article: Recent Progress in Synthesis, POM Analyses and SAR of Coumarin-Hybrids as Potential Anti-HIV Agents—A Mini Review
Recent Progress in Synthesis, POM Analyses and SAR of Coumarin-Hybrids as Potential Anti-HIV Agents—A Mini Review Open
The human immunodeficiency virus (HIV) is the primary cause of acquired immune deficiency syndrome (AIDS), one of the deadliest pandemic diseases. Various mechanisms and procedures have been pursued to synthesise several anti-HIV agents, b…
View article: Discovery and optimization of 2,3-diaryl-1,3-thiazolidin-4-one-based derivatives as potent and selective cytotoxic agents with anti-inflammatory activity
Discovery and optimization of 2,3-diaryl-1,3-thiazolidin-4-one-based derivatives as potent and selective cytotoxic agents with anti-inflammatory activity Open
View article: Black Seeds (Nigella sativa) for the Management of COVID-19 in Pregnant and Breastfeeding Women: An Insight
Black Seeds (Nigella sativa) for the Management of COVID-19 in Pregnant and Breastfeeding Women: An Insight Open
Aims: About 10% of pregnant women were suspected or confirmed with SARS-CoV-2 infection, while the risk of admission to the intensive care unit (ICU) and the use of invasive mechanical ventilation reach up to ~ 5%. This review aimed to dis…
View article: Black seeds (Nigella sativa) for the management of Dengue viral disease: POM analyses for the identification of new antiviral pharmacophore sites
Black seeds (Nigella sativa) for the management of Dengue viral disease: POM analyses for the identification of new antiviral pharmacophore sites Open
The number of Dengue virus (DENV) infection cases has increased dramatically over the past two decades with an estimate of 3.9 billion cases across the globe are potentially at risk. Patients with a DENV infection are managed symptomatical…
View article: An overview of structure-based activity outcomes of pyran derivatives against Alzheimer’s disease
An overview of structure-based activity outcomes of pyran derivatives against Alzheimer’s disease Open
View article: Computer Analysis of the Inhibition of ACE2 by Flavonoids and Identification of Their Potential Antiviral Pharmacophore Site
Computer Analysis of the Inhibition of ACE2 by Flavonoids and Identification of Their Potential Antiviral Pharmacophore Site Open
In the present study, we investigated the antiviral activities of 17 flavonoids as natural products. These derivatives were evaluated for their in vitro antiviral activities against HIV and SARS-CoV-2. Their antiviral activity was evaluate…
View article: Design, Synthesis, In Silico and POM Studies for the Identification of the Pharmacophore Sites of Benzylidene Derivatives
Design, Synthesis, In Silico and POM Studies for the Identification of the Pharmacophore Sites of Benzylidene Derivatives Open
Due to the uneven distribution of glycosidase enzyme expression across bacteria and fungi, glycoside derivatives of antimicrobial compounds provide prospective and promising antimicrobial materials. Therefore, herein, we report the synthes…
View article: Potential SARS-CoV-2 RdRp inhibitors of cytidine derivatives: Molecular docking, molecular dynamic simulations, ADMET, and POM analyses for the identification of pharmacophore sites
Potential SARS-CoV-2 RdRp inhibitors of cytidine derivatives: Molecular docking, molecular dynamic simulations, ADMET, and POM analyses for the identification of pharmacophore sites Open
The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 is one of the optimum targets for antiviral drug design and development. The hydroxyl groups of cytidine structures were modified with different aliphatic and aromatic groups to obtain …
View article: The Prevalence of Anemia and Hematological Findings in COVID-19 Patients in Saudi Arabia
The Prevalence of Anemia and Hematological Findings in COVID-19 Patients in Saudi Arabia Open
Objectives: The aim of this study was to estimate the prevalence of anemia among COVID-19 patients in Saudi Arabia and evaluate their hematological parameters. Materials and Methods: A descriptive, cross-sectional, hospital-based study was…
View article: Knowledge and awareness level of Helicobacter pylori infection among medical students in Umm Al-Qura University: A cross-sectional electronic survey
Knowledge and awareness level of Helicobacter pylori infection among medical students in Umm Al-Qura University: A cross-sectional electronic survey Open
Background and aims: Helicobacter pylori are a significant pathogen that can lead to various complications such as gastric cancer and peptic ulcer.Identifying the infection pattern will help in early diagnosis and treatment to avoid seriou…
View article: CCDC 2151661: Experimental Crystal Structure Determination
CCDC 2151661: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Crystallographic study, biological assessment and POM/Docking studies of pyrazoles-sulfonamide hybrids (PSH): Identification of a combined Antibacterial/Antiviral pharmacophore sites leading to in-silico screening the anti-Covid-19 activity
Crystallographic study, biological assessment and POM/Docking studies of pyrazoles-sulfonamide hybrids (PSH): Identification of a combined Antibacterial/Antiviral pharmacophore sites leading to in-silico screening the anti-Covid-19 activity Open
View article: The Association Between Vitamin D Serum Level and COVID-19 Patients’ Outcomes in a Tertiary Center in Saudi Arabia: A Retrospective Cohort Study
The Association Between Vitamin D Serum Level and COVID-19 Patients’ Outcomes in a Tertiary Center in Saudi Arabia: A Retrospective Cohort Study Open
Vitamin D deficiency has been associated with the risk for immune-mediated inflammatory reactions in various respiratory infections. Our study investigated the association between vitamin D deficiency and coronavirus disease 2019 (COVID-19…
View article: Phytochemical Characterization and Bioactivity of Different Honey Samples Collected in the Pre-Saharan Region in Algeria
Phytochemical Characterization and Bioactivity of Different Honey Samples Collected in the Pre-Saharan Region in Algeria Open
Despite the challenging conditions in the pre-Saharan areas of Algeria, such as weak plant cover and a harsh climate, beekeeping is being developed and spread. In the present work, honey samples collected from ten locations in the El Oued …
View article: A Comprehensive Overview of Globally Approved JAK Inhibitors
A Comprehensive Overview of Globally Approved JAK Inhibitors Open
Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling through the JAK-STAT pathway, which regulates the transcriptio…
View article: Synthesis, antimicrobial, molecular docking and molecular dynamics studies of lauroyl thymidine analogs against SARS-CoV-2: POM study and identification of the pharmacophore sites
Synthesis, antimicrobial, molecular docking and molecular dynamics studies of lauroyl thymidine analogs against SARS-CoV-2: POM study and identification of the pharmacophore sites Open
View article: Triazoles and Their Derivatives: Chemistry, Synthesis, and Therapeutic Applications
Triazoles and Their Derivatives: Chemistry, Synthesis, and Therapeutic Applications Open
Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications. Structurally, there are two types of five-membered triazoles: 1,2,3-triazole and 1,2,4-triazole. Due to the structural chara…
View article: Pyrrolizine/indolizine-cinnamaldehyde Schiff bases: Design, synthesis, biological evaluation, ADME, and molecular docking study
Pyrrolizine/indolizine-cinnamaldehyde Schiff bases: Design, synthesis, biological evaluation, ADME, and molecular docking study Open
View article: In vitro potential antiviral SARS-CoV-19- activity of natural product thymohydroquinone and dithymoquinone from Nigella sativa
In vitro potential antiviral SARS-CoV-19- activity of natural product thymohydroquinone and dithymoquinone from Nigella sativa Open
View article: Evaluation of the Potential of National Sharing of a Unified Progress Test Among Colleges of Pharmacy in the Kingdom of Saudi Arabia
Evaluation of the Potential of National Sharing of a Unified Progress Test Among Colleges of Pharmacy in the Kingdom of Saudi Arabia Open
The results indicated growth and maintenance of the gained knowledge and skills by the students as they progress through the years of the professional program with consistency in the results among the participating colleges. Sharing a unif…
View article: Pyrrolizine/Indolizine-NSAID Hybrids: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies
Pyrrolizine/Indolizine-NSAID Hybrids: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies Open
In the current study, eight new hybrids of the NSAIDs, ibuprofen and ketoprofen with five pyrrolizine/indolizine derivatives were designed and synthesized. The chemical structures of these hybrids were confirmed by spectral and elemental a…
View article: Icotinib, Almonertinib, and Olmutinib: A 2D Similarity/Docking-Based Study to Predict the Potential Binding Modes and Interactions into EGFR
Icotinib, Almonertinib, and Olmutinib: A 2D Similarity/Docking-Based Study to Predict the Potential Binding Modes and Interactions into EGFR Open
In the current study, a 2D similarity/docking-based study was used to predict the potential binding modes of icotinib, almonertinib, and olmutinib into EGFR. The similarity search of icotinib, almonertinib, and olmutinib against a database…
View article: In Silico Approach Using Free Software to Optimize the Antiproliferative Activity and Predict the Potential Mechanism of Action of Pyrrolizine-Based Schiff Bases
In Silico Approach Using Free Software to Optimize the Antiproliferative Activity and Predict the Potential Mechanism of Action of Pyrrolizine-Based Schiff Bases Open
In the current study, a simple in silico approach using free software was used with the experimental studies to optimize the antiproliferative activity and predict the potential mechanism of action of pyrrolizine-based Schiff bases. A comp…