Frédéric Amant
YOU?
Author Swipe
View article: Management of Cancer During Pregnancy: ASCO Guideline
Management of Cancer During Pregnancy: ASCO Guideline Open
ASCO Guidelines provide recommendations with comprehensive review and analyses of the relevant literature for each recommendation, following the guideline development process as outlined in the ASCO Guidelines Methodology Manual . ASCO Gui…
View article: Validation of Monte Carlo simulations with measurement data for fetal dose assessment in proton therapy for breast cancer
Validation of Monte Carlo simulations with measurement data for fetal dose assessment in proton therapy for breast cancer Open
Objective . This study aims to validate a Monte Carlo model for fetal dose estimation in the complex secondary field of pencil beam scanning (PBS) proton therapy for breast cancer, one of the most common cancers occurring during pregnancy.…
View article: ENDORISK-2: A personalized Bayesian network for preoperative risk stratification in endometrial cancer, integrating molecular classification and preoperative myometrial invasion assessment
ENDORISK-2: A personalized Bayesian network for preoperative risk stratification in endometrial cancer, integrating molecular classification and preoperative myometrial invasion assessment Open
Incorporation of molecular data and preoperative MI improved the flexibility of ENDORISK with comparable diagnostic accuracy for estimating LNM as when based on low-cost immunohistochemical biomarkers. In addition, the high diagnostic accu…
View article: Advanced stage melanoma during pregnancy: recommendations from a retrospective, multicentre, registry-based study
Advanced stage melanoma during pregnancy: recommendations from a retrospective, multicentre, registry-based study Open
Not applicable.
View article: Hearing assesment in children after intrauterine exposure to platinum-based treatment of pregnant cancer patients: A study from the International Network on Cancer, Infertility and Pregnancy
Hearing assesment in children after intrauterine exposure to platinum-based treatment of pregnant cancer patients: A study from the International Network on Cancer, Infertility and Pregnancy Open
Background Literature on the effects of prenatal exposure to platinum-based chemotherapy on the auditory capacity of the offspring is scarce. The current study aims to describe the occurrence of hearing impairment in a well-documented seri…
View article: Vulvar and vaginal cancer during pregnancy: A pooled analysis of 15 cases from the International Network on Cancer, Infertility and Pregnancy and review of the literature
Vulvar and vaginal cancer during pregnancy: A pooled analysis of 15 cases from the International Network on Cancer, Infertility and Pregnancy and review of the literature Open
Introduction Vulvovaginal cancer in pregnancy is rare. Limited data complicate decision‐making and patient counseling. Our review, coupled with new case data, fills a current gap in the literature and provides practical insights. Material …
View article: Cancer and fertility management: <scp>FIGO</scp> best practice advice
Cancer and fertility management: <span>FIGO</span> best practice advice Open
Cancer diagnoses in patients of reproductive age require balancing urgent oncological treatment with the need to preserve fertility. This FIGO Best Practice Advice outlines key considerations for fertility management in this population giv…
View article: Cancer in pregnancy: <scp>FIGO</scp> Best practice advice and narrative review
Cancer in pregnancy: <span>FIGO</span> Best practice advice and narrative review Open
Cancer during pregnancy is relatively rare. The incidence is underestimated due to the lack of international registries covering both high‐income and low‐ and middle‐income countries, and is expected to rise with increasing maternal age an…
View article: GWAS meta-analysis identifies five susceptibility loci for endometrial cancer
GWAS meta-analysis identifies five susceptibility loci for endometrial cancer Open
This study was mainly supported by funding from the Wilhelm Sander Foundation, Germany, and the National Health and Medical Research Council (NHMRC) of Australia. A complete list of funding organisations is provided in the acknowledgements.
View article: Cancer of the corpus uteri: A 2025 update
Cancer of the corpus uteri: A 2025 update Open
Endometrial cancer comprises a heterogeneous group of neoplasms. Its incidence is increasing, as is mortality from endometrial cancer. This article updates many aspects surrounding endometrial cancer, covering histopathology, staging, surg…
View article: A discrete region of the D4Z4 is sufficient to initiate epigenetic silencing
A discrete region of the D4Z4 is sufficient to initiate epigenetic silencing Open
The DUX4 transcription factor is briefly expressed in the early embryo and is epigenetically repressed in somatic tissues. Loss of epigenetic repression can result in the aberrant expression of DUX4 in skeletal muscle and can cause faciosc…
View article: The First 6 Years’ Experiences of a National Centralized Offspring Surveillance Setting for Dutch Children Prenatally Exposed to Maternal Cancer to Inform Future International Practice: Protocol for a Demographic Review of Referred Families and Key Lessons Learned
The First 6 Years’ Experiences of a National Centralized Offspring Surveillance Setting for Dutch Children Prenatally Exposed to Maternal Cancer to Inform Future International Practice: Protocol for a Demographic Review of Referred Families and Key Lessons Learned Open
Background Cancer during pregnancy is a rare and significant life-changing event affecting approximately 1 in 1000-2000 pregnancies. With increasing maternal age and broader application of prenatal screening programs such as the Dutch Non-…
View article: Pregnancy after cancer: <scp>FIGO</scp> Best practice advice
Pregnancy after cancer: <span>FIGO</span> Best practice advice Open
Advances in cancer care have led to a growing number of cancer survivors globally. As cancer increasingly affects women and people of reproductive age, more individuals will be experiencing pregnancy after completing cancer treatment. This…
View article: Figure S2 from Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells
Figure S2 from Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells Open
Figure S2 showing DBS and indel count in the cord blood DNA.
View article: Tables S1-3 from Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells
Tables S1-3 from Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells Open
Supplementary tables listing demographic, oncological and obstetrical data per patient (Table S1), statistical comparisons (Table S2) and annotated variants (Table S3).
View article: Figure S5 from Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells
Figure S5 from Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells Open
Figure S5 showing a comparison between the in vitro generated mutational signatures and the COSMIC database.
View article: Figure S1 from Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells
Figure S1 from Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells Open
FigureS1 showing the assessment of possible maternal contamination in the cord blood samples.
View article: Figure S3 from Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells
Figure S3 from Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells Open
Figure S3 showing a comparison between identified mutational signatures from the samples and the COSMIC database.
View article: Data from Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells
Data from Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells Open
Chemotherapy is included in the standard-of-care for cancer treatment during pregnancy. However, whether prenatal exposure to maternal chemotherapy treatment has a mutagenic impact on the fetal genome remains unexplored. Therefore, we inve…
View article: Figure S4 from Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells
Figure S4 from Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells Open
Figure S4 showing the identified indel signatures in the cord blood samples.
View article: Copy-number alterations in cell-free DNA can be transient or harbingers of clonal hematopoiesis
Copy-number alterations in cell-free DNA can be transient or harbingers of clonal hematopoiesis Open
Genome-wide plasma cfDNA pan-cancer screening of 1002 healthy elderly identified 15 individuals with CNAs of unknown origin. Nine participants were reassessed over 3-5 years through health questionnaires, WB-MRI, and cfDNA and blood analys…
View article: A Swedish genome-wide haplotype association analysis identifies novel candidate loci associated with endometrial cancer risk
A Swedish genome-wide haplotype association analysis identifies novel candidate loci associated with endometrial cancer risk Open
Genome-wide association studies [GWAS] have identified a limited number of endometrial cancer risk loci by analyzing single nucleotide polymorphisms [SNPs]. We hypothesized that analyzing haplotypes rather than SNPs could provide novel and…