Fares E.M. Ali
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View article: Down-regulation of TNF-α/RIPK/Caspase-8 axis by combined infliximab and umbelliferone prevents unilateral ureter ligation-induced interstitial renal fibrosis
Down-regulation of TNF-α/RIPK/Caspase-8 axis by combined infliximab and umbelliferone prevents unilateral ureter ligation-induced interstitial renal fibrosis Open
Obstructive nephropathy is a chronic condition that causes progressive kidney damage due to inflammation, oxidative stress, necroptosis, and fibrosis. The present study aimed to evaluate the potential chemopreventive effect of infliximab (…
View article: Azithromycin overview and therapeutic potential of natural products in the management of its toxicity
Azithromycin overview and therapeutic potential of natural products in the management of its toxicity Open
View article: Estimation of Vitamin D levels Among Female Students at University of Sciences and Technology, Aden, Yemen. A Cross-sectional Analysis
Estimation of Vitamin D levels Among Female Students at University of Sciences and Technology, Aden, Yemen. A Cross-sectional Analysis Open
Background: Hypovitaminosis D is considered a major public health problem where it is estimated that more than one billion people are affected around the world. In Yemen, the vitamin D status among young females was not clear. Objective: T…
View article: Morin hydrate: A promising bioflavonoid with different therapeutic effects
Morin hydrate: A promising bioflavonoid with different therapeutic effects Open
View article: Role of International law in Addressing Transnational Threats: A Case Study of Pakistan
Role of International law in Addressing Transnational Threats: A Case Study of Pakistan Open
In recent times transnational threats have posed serious concerns to the international community as the world is proceeding towards globalization. These impacts are huge, especially as advancing globalization and information technology inn…
View article: Correction: MSC–extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation
Correction: MSC–extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation Open
View article: MSC–extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation
MSC–extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation Open
We demonstrated that MSCs-EVs are a potential therapeutic option for treating COVID-19 by preventing viral entry into host cells.
View article: Exploring the cytoprotective role of mesenchymal stem Cell-Derived exosomes in chronic liver Fibrosis: Insights into the Nrf2/Keap1/p62 signaling pathway
Exploring the cytoprotective role of mesenchymal stem Cell-Derived exosomes in chronic liver Fibrosis: Insights into the Nrf2/Keap1/p62 signaling pathway Open
Hepatic fibrosis is a common pathology present in most chronic liver diseases. Autophagy is a lysosome-mediated intracellular catabolic and recycling process that plays an essential role in maintaining normal hepatic functions. Nuclear fac…
View article: Retraction Note: Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-κB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1–7 Signals
Retraction Note: Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-κB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1–7 Signals Open
View article: Sorafenib and edaravone protect against renal fibrosis induced by unilateral ureteral obstruction via inhibition of oxidative stress, inflammation, and RIPK-3/MLKL pathway
Sorafenib and edaravone protect against renal fibrosis induced by unilateral ureteral obstruction via inhibition of oxidative stress, inflammation, and RIPK-3/MLKL pathway Open
Renal fibrosis is the common endpoint of nearly all chronic and progressive nephropathies. Cell death and sterile inflammation are the main characteristics of renal fibrosis, which can lead to end-stage renal failure. The inflammatory reac…
View article: Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway
Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway Open
Alzheimer's disease (AD) is a devastating neurological condition characterized by cognitive decline, motor coordination impairment, and amyloid plaque accumulation. The underlying molecular mechanisms involve oxidative stress, inflammation…
View article: Exploring the potential of drug repurposing for liver diseases: A comprehensive study
Exploring the potential of drug repurposing for liver diseases: A comprehensive study Open
Drug repurposing involves the investigation of existing drugs for new indications. It offers a great opportunity to quickly identify a new drug candidate at a lower cost than novel discovery and development. Despite the importance and pote…
View article: Edaravone and obeticholic acid protect against cisplatin-induced heart toxicity by suppressing oxidative stress and inflammation and modulating Nrf2, TLR4/p38MAPK, and JAK1/STAT3/NF-κB signals
Edaravone and obeticholic acid protect against cisplatin-induced heart toxicity by suppressing oxidative stress and inflammation and modulating Nrf2, TLR4/p38MAPK, and JAK1/STAT3/NF-κB signals Open
Cardiotoxicity is a significant adverse effect of cisplatin (CIS) that necessitates extensive medical care. The current study examines the cardioprotective effects of edaravone (EDV), obeticholic acid (OCA), and their combinations on CIS-i…
View article: Regulation of renal nitric oxide and eNOS/iNOS expression by tadalafil participates in the mitigation of amphotericin B–induced renal injury: Down-regulation of NF-κB/iNOS/caspase-3 signaling
Regulation of renal nitric oxide and eNOS/iNOS expression by tadalafil participates in the mitigation of amphotericin B–induced renal injury: Down-regulation of NF-κB/iNOS/caspase-3 signaling Open
View article: The Efficacy of Canagliflozin on Type 2 Diabetic Nephropathy in Male Rats
The Efficacy of Canagliflozin on Type 2 Diabetic Nephropathy in Male Rats Open
Background: Sodium-glucose Cotransporter-2 inhibitors [SGLT2Is] are new antidiabetic group.Canagliflozin is the first member in this drug class approved for management of patient with type 2 diabetes (T2DM), that affects reabsorption of gl…
View article: ASTRAGALOSIDE-IV INHIBITS TIBIAL DYSCHONDROPLASIA VIA PI3K/AKT /HIF-1α SIGNALING IN CHICKENS
ASTRAGALOSIDE-IV INHIBITS TIBIAL DYSCHONDROPLASIA VIA PI3K/AKT /HIF-1α SIGNALING IN CHICKENS Open
Tibial dyschondroplasia (TD) is a common leg-pathology of meat type broiler birds which is characterized by defective tibial growth plate (GP) cartilage failing to become bone. This study deals with an attempt to treat TD using Astragalosi…
View article: Acetovanillone augmented the cardioprotective effect of carvedilol against cadmium-induced heart injury via suppression of oxidative stress and inflammation signaling pathways
Acetovanillone augmented the cardioprotective effect of carvedilol against cadmium-induced heart injury via suppression of oxidative stress and inflammation signaling pathways Open
Cardiac toxicity is a public health issue that can be caused by both environmental and occupational exposures. The current study aimed to investigate the effectiveness of carvedilol (CV), Acetovanillone (ACET), and their combination for am…
View article: Therapeutic interventions target the NLRP3 inflammasome in ulcerative colitis: Comprehensive study
Therapeutic interventions target the NLRP3 inflammasome in ulcerative colitis: Comprehensive study Open
One of the significant health issues in the world is the prevalence of ulcerative colitis (UC). UC is a chronic disorder that mainly affects the colon, beginning with the rectum, and can progress from asymptomatic mild inflammation to exte…
View article: Lansoprazole attenuates cyclophosphamide-induced cardiopulmonary injury by modulating redox-sensitive pathways and inflammation
Lansoprazole attenuates cyclophosphamide-induced cardiopulmonary injury by modulating redox-sensitive pathways and inflammation Open
View article: Therapeutic interventions of acute and chronic liver disorders: A comprehensive review
Therapeutic interventions of acute and chronic liver disorders: A comprehensive review Open
Liver disorders are one of the most common pathological problems worldwide. It affects more than 1.5 billion worldwide. Many types of hepatic cells have been reported to be involved in the initiation and propagation of both acute and chron…
View article: COVID-19 and hepatic injury: Diversity and risk assessment
COVID-19 and hepatic injury: Diversity and risk assessment Open
The coronavirus disease 2019 (COVID-19) represents a global health and economic challenge. Hepatic injuries have been approved to be associated with severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection. The viral tropism pa…
View article: Azilsartan Modulates HMGB1/NF-κB/p38/ERK1/2/JNK and Apoptosis Pathways during Renal Ischemia Reperfusion Injury
Azilsartan Modulates HMGB1/NF-κB/p38/ERK1/2/JNK and Apoptosis Pathways during Renal Ischemia Reperfusion Injury Open
Renal ischemia/reperfusion (IR) injury is characterized by an unexpected impairment of blood flow to the kidney. Azilsartan is an angiotensin receptor blocker that is approved for the management of hypertension. The present study aimed to …
View article: Design, Synthesis, Modeling Studies and Biological Evaluation of New Scaffold from Vicinal Diaryl Pyrazole Core with Tetrazole Functionality as ACE-1 / COX-2 Inhibitors with Anti-Hypertensive, Anti-Fibrotic and Anti-Inflammatory Activities
Design, Synthesis, Modeling Studies and Biological Evaluation of New Scaffold from Vicinal Diaryl Pyrazole Core with Tetrazole Functionality as ACE-1 / COX-2 Inhibitors with Anti-Hypertensive, Anti-Fibrotic and Anti-Inflammatory Activities Open
View article: Fasudil Ameliorates Methotrexate-Induced Hepatotoxicity by Modulation of Redox-Sensitive Signals
Fasudil Ameliorates Methotrexate-Induced Hepatotoxicity by Modulation of Redox-Sensitive Signals Open
Methotrexate (MTX) is one of the most widely used cytotoxic chemotherapeutic agents, and it is used in the treatment of different autoimmune disorders. However, the clinical applications of MTX are limited by its hepatic toxicity. Hence, t…
View article: Dual Topoisomerase I/II Inhibition-Induced Apoptosis and Necro-Apoptosis in Cancer Cells by a Novel Ciprofloxacin Derivative via RIPK1/RIPK3/MLKL Activation
Dual Topoisomerase I/II Inhibition-Induced Apoptosis and Necro-Apoptosis in Cancer Cells by a Novel Ciprofloxacin Derivative via RIPK1/RIPK3/MLKL Activation Open
Fluoroquinolones (FQs) are synthetic broad-spectrum antimicrobial agents that have been recently repurposed to anticancer candidates. Designing new derivatives of FQs with different moieties to target DNA topoisomerases could improve their…
View article: Inhibition of NF-kB/IL-6/JAK2/STAT3 Pathway and Epithelial-Mesenchymal Transition in Breast Cancer Cells by Azilsartan
Inhibition of NF-kB/IL-6/JAK2/STAT3 Pathway and Epithelial-Mesenchymal Transition in Breast Cancer Cells by Azilsartan Open
Metastatic breast cancer is an incurable form of breast cancer that exhibits high levels of epithelial-mesenchymal transition (EMT) markers. Angiotensin II has been linked to various signaling pathways involved in tumor cell growth and met…
View article: RETRACTED ARTICLE: Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-κB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1–7 Signals
RETRACTED ARTICLE: Candesartan Protects Against Cadmium-Induced Hepatorenal Syndrome by Affecting Nrf2, NF-κB, Bax/Bcl-2/Cyt-C, and Ang II/Ang 1–7 Signals Open
Cadmium (Cd) is a serious pollutant in the environment. Candesartan is an angiotensin II (Ang II) receptor antagonist with promising diverse health benefits. The current study is planned to investigate the hepatorenal protective effects of…
View article: Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges
Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges Open
Coronavirus disease 2019 (COVID-19) is a devastating worldwide pandemic infection caused by a severe acute respiratory syndrome namely coronavirus 2 (SARS-CoV-2) that is associated with a high spreading and mortality rate. On the date this…