Faïza Tebbji
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View article: Met32 governs transcriptional control of sulfur metabolic flexibility and resistance to reactive sulfur species in the human fungal pathogen <i>Candida albicans</i>
Met32 governs transcriptional control of sulfur metabolic flexibility and resistance to reactive sulfur species in the human fungal pathogen <i>Candida albicans</i> Open
Although considerable advances have been made in understanding the metabolic machinery that enables bacteria to utilize sulfur sources, many aspects of this process remain understudied in fungi. To explore the genetic circuit by which the …
View article: Whole-genome sequencing of the first <i>Candida auris</i> clinical isolate from a patient with sepsis in Palestine
Whole-genome sequencing of the first <i>Candida auris</i> clinical isolate from a patient with sepsis in Palestine Open
An isolate of the multidrug-resistant yeast Candida auris (Pal1) was identified in the urine of a patient with sepsis and sequenced using both Oxford Nanopore and Illumina sequencing technologies. Phylogenetic analysis placed C. auris Pal1…
View article: The first prevalence and antifungal susceptibility profile of Candida infections in Palestine, 2022
The first prevalence and antifungal susceptibility profile of Candida infections in Palestine, 2022 Open
Background Candida spp. are the most common cause of opportunistic fungal infections and are associated with a high mortality rate worldwide. In Palestine, the prevalence of Candida spp. infections remains elusive. Methods We performed our…
View article: Small molecule inhibitors of fungal Δ(9) fatty acid desaturase as antifungal agents against Candida auris
Small molecule inhibitors of fungal Δ(9) fatty acid desaturase as antifungal agents against Candida auris Open
Candida auris has emerged as a significant healthcare-associated pathogen due to its multidrug-resistant nature. Ongoing constraints in the discovery and provision of new antifungals create an urgent imperative to design effective remedies…
View article: The first prevalence and antifungal susceptibility profile of Candida infections in Palestine, 2022
The first prevalence and antifungal susceptibility profile of Candida infections in Palestine, 2022 Open
Background Candida spp. are the most common cause of opportunistic fungal infections and are associated with a high mortality rate worldwide. In Palestine, the prevalence of Candida spp. infections remains elusive. Methods We performed our…
View article: Manganese homeostasis modulates fungal virulence and stress tolerance in <i>Candida albicans</i>
Manganese homeostasis modulates fungal virulence and stress tolerance in <i>Candida albicans</i> Open
Due to the scarcity of transition metals within the human host, fungal pathogens have evolved sophisticated mechanisms to uptake and utilize these micronutrients at the infection interface. While considerable attention was turned to iron a…
View article: Regulation of copper uptake by the SWI/SNF chromatin remodeling complex in <i>Candida albicans</i> affects susceptibility to antifungal and oxidative stresses under hypoxia
Regulation of copper uptake by the SWI/SNF chromatin remodeling complex in <i>Candida albicans</i> affects susceptibility to antifungal and oxidative stresses under hypoxia Open
Candida albicans is a human colonizer and also an opportunistic yeast occupying different niches that are mostly hypoxic. While hypoxia is the prevalent condition within the host, the machinery that integrates oxygen status to tune the fit…
View article: Manganese homeostasis modulates fungal virulence and stress tolerance in<i>Candida albicans</i>
Manganese homeostasis modulates fungal virulence and stress tolerance in<i>Candida albicans</i> Open
Due to the scarcity of transition metals within the human host, fungal pathogens have evolved sophisticated mechanisms to uptake and utilize these micronutrients at the infection interface. While considerable attention was turned to iron a…
View article: Transcriptional Control of Hypoxic Hyphal Growth in the Fungal Pathogen Candida albicans
Transcriptional Control of Hypoxic Hyphal Growth in the Fungal Pathogen Candida albicans Open
The ability of Candida albicans , an important human fungal pathogen, to develop filamentous forms is a crucial determinant for host invasion and virulence. While hypoxia is one of the predominant host cues that promote C. albicans filamen…
View article: Transcriptional control of hypoxic hyphal growth in the fungal pathogen <i>Candida albicans</i>
Transcriptional control of hypoxic hyphal growth in the fungal pathogen <i>Candida albicans</i> Open
Background The ability of Candida albicans , an important human fungal pathogen, to develop filamentous forms is a crucial determinant for host invasion and virulence. Filamentation is triggered by different host environmental cues. Hypoxi…
View article: High-Resolution Genome-Wide Occupancy in <i>Candida</i> spp. Using ChEC-seq
High-Resolution Genome-Wide Occupancy in <i>Candida</i> spp. Using ChEC-seq Open
Systemic fungal infections caused by Candida albicans and the “superbug” Candida auris are becoming a serious public health threat. The ability of these yeasts to cause disease is linked to their faculty to modulate the expression of genes…
View article: High resolution genome-wide occupancy in<i>Candida spp</i>. using ChEC-seq
High resolution genome-wide occupancy in<i>Candida spp</i>. using ChEC-seq Open
To persist in their hostile and dynamic human host environments, fungal pathogens has to sense and adapt by modulating their gene expression to fulfil their cellular needs. Understanding transcriptional regulation on a global scale would u…
View article: Transcriptome Analysis Uncovers a Link Between Copper Metabolism, and Both Fungal Fitness and Antifungal Sensitivity in the Opportunistic Yeast Candida albicans
Transcriptome Analysis Uncovers a Link Between Copper Metabolism, and Both Fungal Fitness and Antifungal Sensitivity in the Opportunistic Yeast Candida albicans Open
Copper homeostasis is an important determinant for virulence of many human pathogenic fungi such as the highly prevalent yeast Candida albicans. However, beyond the copper transporter Ctr1, little is known regarding other genes and biologi…
View article: Transcriptome analysis uncovers a link between copper metabolism, and both fungal fitness and antifungal sensitivity in the opportunistic yeast <i>Candida albicans</i>
Transcriptome analysis uncovers a link between copper metabolism, and both fungal fitness and antifungal sensitivity in the opportunistic yeast <i>Candida albicans</i> Open
Copper homeostasis is an important determinant for virulence of many human pathogenic fungi such as the highly prevalent yeast Candida albicans . However, beyond the copper transporter Ctr1, little is known regarding other genes and biolog…
View article: Metabolic Reprogramming in the Opportunistic Yeast Candida albicans in Response to Hypoxia
Metabolic Reprogramming in the Opportunistic Yeast Candida albicans in Response to Hypoxia Open
A critical aspect of cell fitness is the ability to sense and adapt to variations in oxygen levels in their local environment. Candida albicans is an opportunistic yeast that is the most prevalent human fungal pathogen. While hypoxia is th…
View article: A novel genetic circuitry governing hypoxic metabolic flexibility, commensalism and virulence in the fungal pathogen Candida albicans
A novel genetic circuitry governing hypoxic metabolic flexibility, commensalism and virulence in the fungal pathogen Candida albicans Open
Inside the human host, the pathogenic yeast Candida albicans colonizes predominantly oxygen-poor niches such as the gastrointestinal and vaginal tracts, but also oxygen-rich environments such as cutaneous epithelial cells and oral mucosa. …
View article: Pollination Type Recognition from a Distance by the Ovary Is Revealed Through a Global Transcriptomic Analysis
Pollination Type Recognition from a Distance by the Ovary Is Revealed Through a Global Transcriptomic Analysis Open
Sexual reproduction in flowering plants involves intimate contact and continuous interactions between the growing pollen tube and the female reproductive structures. These interactions can trigger responses in distal regions of the flower …
View article: A novel genetic circuitry governing hypoxic metabolic flexibility, commensalism and virulence in the fungal pathogen <i>Candida albicans</i>
A novel genetic circuitry governing hypoxic metabolic flexibility, commensalism and virulence in the fungal pathogen <i>Candida albicans</i> Open
Inside the human host, the pathogenic yeast Candida albicans colonizes predominantly oxygen-poor niches such as the gastrointestinal and vaginal tracts, but also oxygen-rich environments such as cutaneous epithelial cells and oral mucosa. …
View article: The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicans
The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicans Open
Cell size is a complex trait that responds to developmental and environmental cues. Quantitative size analysis of mutant strain collections disrupted for protein kinases and transcriptional regulators in the pathogenic yeast Candida albica…
View article: Functional divergence of a global regulatory complex governing fungal filamentation
Functional divergence of a global regulatory complex governing fungal filamentation Open
Morphogenetic transitions are prevalent in the fungal kingdom. For a leading human fungal pathogen, Candida albicans, the capacity to transition between yeast and filaments is key for virulence. For the model yeast Saccharomyces cerevisiae…
View article: Integration of Growth and Cell Size via the TOR Pathway and the Dot6 Transcription Factor in <i>Candida albicans</i>
Integration of Growth and Cell Size via the TOR Pathway and the Dot6 Transcription Factor in <i>Candida albicans</i> Open
In most species, size homeostasis appears to be exerted in late G1 phase as cells commit to division, called Start in yeast and the Restriction Point in metazoans. This size threshold couples cell growth to division, and, thereby, establis…
View article: Mms21: A Putative SUMO E3 Ligase in <i>Candida albicans</i> That Negatively Regulates Invasiveness and Filamentation, and Is Required for the Genotoxic and Cellular Stress Response
Mms21: A Putative SUMO E3 Ligase in <i>Candida albicans</i> That Negatively Regulates Invasiveness and Filamentation, and Is Required for the Genotoxic and Cellular Stress Response Open
In the life cycle of the fungal pathogen Candida albicans, the formation of filamentous cells is a differentiation process that is critically involved in host tissue invasion, and in adaptation to host cell and environmental stresses. Here…
View article: Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space
Tuning Hsf1 levels drives distinct fungal morphogenetic programs with depletion impairing Hsp90 function and overexpression expanding the target space Open
The capacity to respond to temperature fluctuations is critical for microorganisms to survive within mammalian hosts, and temperature modulates virulence traits of diverse pathogens. One key temperature-dependent virulence trait of the fun…
View article: Islam et al. Suplemental material 2018
Islam et al. Suplemental material 2018 Open
Table S1 contains 69 invasive strains recovered from GRACE library screening.Table S2 shows strains used in this study.Table S3 shows plasmids and primers used.Table S4 contains 373 hits from transcription profiling.Table S5 represents RNA…
View article: Islam et al. Supplemental material 2018
Islam et al. Supplemental material 2018 Open
Table S1 contains 69 invasive strains recovered from GRACE library screening.Table S2 shows strains used in this study.Table S3 shows plasmids and primers used.Table S4 contains 373 hits from transcription profiling.Table S5 represents RNA…
View article: The Human Gut Microbial Metabolome Modulates Fungal Growth via the TOR Signaling Pathway
The Human Gut Microbial Metabolome Modulates Fungal Growth via the TOR Signaling Pathway Open
Candida albicans is a natural component of the human microbiota but also an opportunistic pathogen that causes life-threatening infections. The human gastrointestinal tract is the main reservoir of C. albicans , from where systemic infecti…
View article: The Genomic Landscape of the Fungus-Specific SWI/SNF Complex Subunit, Snf6, in Candida albicans
The Genomic Landscape of the Fungus-Specific SWI/SNF Complex Subunit, Snf6, in Candida albicans Open
Candida albicans is a natural component of the human microbiota but also an opportunistic pathogen that causes life-threatening infections in immunosuppressed patients. Current therapeutics include a limited number of molecules that suffer…
View article: pH-Dependant Antifungal Activity of Valproic Acid against the Human Fungal Pathogen Candida albicans
pH-Dependant Antifungal Activity of Valproic Acid against the Human Fungal Pathogen Candida albicans Open
Current antifungal drugs suffer from limitations including toxicity, the emergence of resistance and decreased efficacy at low pH that are typical of human vaginal surfaces. Here, we have shown that the antipsychotic drug valproic acid (VP…
View article: A systematic cell size screen uncovers coupling of growth to division by the p38/HOG network in<i>Candida albicans</i>
A systematic cell size screen uncovers coupling of growth to division by the p38/HOG network in<i>Candida albicans</i> Open
Cell size is a complex trait that responds to developmental and environmental cues. Quantitative analysis of the size phenome in the pathogenic yeast Candida albicans uncovered 195 genes that markedly altered cell size, few of which overla…