Faizan Mazhar
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View article: Systemic Inflammation and the Risks of Adverse Kidney Outcomes in Adults With Atherosclerotic Cardiovascular Disease
Systemic Inflammation and the Risks of Adverse Kidney Outcomes in Adults With Atherosclerotic Cardiovascular Disease Open
Inconsistent evidence exists regarding the association between the circulating blood marker of inflammation C-reactive protein (CRP) and kidney outcomes. We conducted an observational study in more than 83,000 adults with atherosclerotic c…
View article: Characteristics, use of guideline–recommended medical therapies and clinical outcomes of patients with heart failure not enrolled in a quality registry: a comparison with the Swedish Heart Failure Registry
Characteristics, use of guideline–recommended medical therapies and clinical outcomes of patients with heart failure not enrolled in a quality registry: a comparison with the Swedish Heart Failure Registry Open
Introduction Quality registries may involve specific inclusion criteria, detailed investigations, or selected hospitals and practitioners, which are not random. Whether the care and outcomes in quality registries are generalizable to the b…
View article: Mapping Unseen Connections: Graph Clustering to Expose User Interaction Patterns
Mapping Unseen Connections: Graph Clustering to Expose User Interaction Patterns Open
Expanding extensive and intricate social networks has required sophisticated community detection techniques. This study presents an innovative hybrid methodology that utilizes node space similarity and local knowledge to enhance community …
View article: Early compensatory increase in single-kidney estimated GFR after unilateral nephrectomy is associated with a lower long-term risk of estimated GFR decline
Early compensatory increase in single-kidney estimated GFR after unilateral nephrectomy is associated with a lower long-term risk of estimated GFR decline Open
Background and hypothesis A more pronounced short-term increase in single-kidney GFR (ΔskGFR) has been associated with better long-term kidney function in living kidney donors. Whether this also applies to non-donors is unknown. We evaluat…
View article: Epidemiology of transthyretin (ATTR) amyloidosis: a systematic literature review
Epidemiology of transthyretin (ATTR) amyloidosis: a systematic literature review Open
Introduction Significant advances in the treatment of transthyretin (ATTR) amyloidosis has led to an evolving understanding of the epidemiology of this condition. This systematic literature review (SLR) aims to synthesize current evidence …
View article: Enhanced Diagnosis of Skin Cancer from Dermoscopic Images Using Alignment Optimized Convolutional Neural Networks and Grey Wolf Optimization
Enhanced Diagnosis of Skin Cancer from Dermoscopic Images Using Alignment Optimized Convolutional Neural Networks and Grey Wolf Optimization Open
Skin cancer (SC) is a highly serious kind of cancer that, if not addressed swiftly, might result in the patient’s demise. Early detection of this condition allows for more effective therapy and prevents disease development. Deep Learning (…
View article: Drug use and acute kidney injury: a Drug-Wide Association Study (DWAS) in Denmark and Sweden
Drug use and acute kidney injury: a Drug-Wide Association Study (DWAS) in Denmark and Sweden Open
Background Knowledge of which medications may lead to acute kidney injury (AKI) is limited, relying mostly on spontaneous reporting in pharmacovigilance systems. We here conducted an exploratory drug-wide association study (DWAS) to screen…
View article: Systemic inflammation and health outcomes in patients receiving treatment for atherosclerotic cardiovascular disease
Systemic inflammation and health outcomes in patients receiving treatment for atherosclerotic cardiovascular disease Open
Background and Aims The burden and outcomes of inflammation in patients with atherosclerotic cardiovascular disease (ASCVD) are not well defined beyond the controlled settings of trials and research cohorts. Methods This was an observation…
View article: Temporomandibular Disorders Treatment, Symptoms
Temporomandibular Disorders Treatment, Symptoms Open
Joint and muscular discomfort associated with temporomandibular joint disease is a common symptom of TMJ disorder. The following symptoms may manifest simultaneously: vertigo, ringing in the ears, hearing loss, jaw stiffness, restricted mo…
View article: Intensity of and adherence to lipid-lowering therapy as predictors of goal attainment and major adverse cardiovascular events in primary prevention
Intensity of and adherence to lipid-lowering therapy as predictors of goal attainment and major adverse cardiovascular events in primary prevention Open
In routine-care primary prevention, better adherence to LLT was associated with a lower risk of MACE across all treatment intensities. Improving adherence is especially important among patients with very high ASCVD risk.
View article: Poor recognition and undertreatment of anemia in patients with chronic kidney disease managed in primary care
Poor recognition and undertreatment of anemia in patients with chronic kidney disease managed in primary care Open
Background Anemia is a common complication of chronic kidney disease (CKD), but limited awareness and treatment options may hinder its management among CKD patients followed in primary care. Methods We evaluated adults with CKD stages 3–5 …
View article: Albuminuria and the risk of cancer: the Stockholm CREAtinine Measurements (SCREAM) project
Albuminuria and the risk of cancer: the Stockholm CREAtinine Measurements (SCREAM) project Open
Background Studies investigating the association of chronic kidney disease and cancer have focused on estimated glomerular filtration (eGFR) rather than on albuminuria. This study aimed to examine whether albuminuria is associated with can…
View article: Psoriasis/Psoriatic Arthritis Patients’ Long-term Treatment Patterns and Adherence to Systemic Treatments Monitoring Recommendations
Psoriasis/Psoriatic Arthritis Patients’ Long-term Treatment Patterns and Adherence to Systemic Treatments Monitoring Recommendations Open
Limited information exists regarding treatment of patients with psoriasis/psoriatic arthritis in primary care. The aim of this study is to assess treatment patterns, adherence, persistence, and compliance in newly diagnosed patients with p…
View article: #2499 ALBUMINURIA AND THE RISK OF CANCER: THE STOCKHOLM CREATININE MEASUREMENTS (SCREAM) PROJECT
#2499 ALBUMINURIA AND THE RISK OF CANCER: THE STOCKHOLM CREATININE MEASUREMENTS (SCREAM) PROJECT Open
Background and Aims Studies investigating the association of chronic kidney disease and cancer have focused on estimated glomerular filtration (eGFR) rather than on albuminuria. The few studies focusing on albuminuria provide results that …
View article: #4946 PREVALENCE OF CHRONIC KIDNEY DISEASE IN WOMEN OF REPRODUCTIVE AGE AND OBSERVED BIRTH RATES
#4946 PREVALENCE OF CHRONIC KIDNEY DISEASE IN WOMEN OF REPRODUCTIVE AGE AND OBSERVED BIRTH RATES Open
Background and Aims Women of reproductive age with chronic kidney disease (CKD) are recognised to have decreased fertility and a higher risk of adverse pregnancy outcomes, such as hypertensive diseases, preterm birth and longer hospital st…
View article: #5661 EARLY COMPENSATORY INCREASE IN SINGLE-KIDNEY EGFR AFTER UNILATERAL NEPHRECTOMY IS ASSOCIATED WITH A LOWER LONG-TERM RISK OF EGFR DECLINE
#5661 EARLY COMPENSATORY INCREASE IN SINGLE-KIDNEY EGFR AFTER UNILATERAL NEPHRECTOMY IS ASSOCIATED WITH A LOWER LONG-TERM RISK OF EGFR DECLINE Open
Background and Aims The healthy kidney has reserve capacity, allowing for an increase in single-kidney GFR (ΔskGFR) in the remaining kidney after nephrectomy. We evaluated whether higher ΔskGFR, as a reflection of renal resilience, is asso…
View article: Occurrence of adverse events associated with the initiation of methotrexate and biologics for the treatment of psoriasis in routine clinical practice
Occurrence of adverse events associated with the initiation of methotrexate and biologics for the treatment of psoriasis in routine clinical practice Open
Background: Limited information exists on the risk of adverse events (AEs) attributed to methotrexate (MTX) and biologics for the treatment of psoriasis/psoriatic arthritis (PsA/PsO) in heterogeneous clinical practice and beyond the durati…
View article: Estimating the prevalence of chronic kidney disease while accounting for nonrandom testing with inverse probability weighting
Estimating the prevalence of chronic kidney disease while accounting for nonrandom testing with inverse probability weighting Open
Chronic kidney disease (CKD) prevalence estimation is central to guiding the medical community and policymakers on where to focus prevention and disease management strategies. Population sources make the estimation of CKD prevalence challe…
View article: Intensity of and Adherence to Lipid‐Lowering Therapy as Predictors of Major Adverse Cardiovascular Outcomes in Patients With Coronary Heart Disease
Intensity of and Adherence to Lipid‐Lowering Therapy as Predictors of Major Adverse Cardiovascular Outcomes in Patients With Coronary Heart Disease Open
Background The effectiveness of lipid‐lowering therapy (LLT) is affected by both intensity and adherence. This study evaluated the associations of LLT intensity, adherence, and the combination of these 2 aspects of LLT management with the …
View article: Lipid-lowering treatment intensity, persistence, adherence and goal attainment in patients with coronary heart disease
Lipid-lowering treatment intensity, persistence, adherence and goal attainment in patients with coronary heart disease Open
In secondary prevention for patients with established coronary heart disease, the proportion of LDL-C target attainment was low throughout the time period of the study, despite increasing use of high-intensity LLT and good treatment persis…
View article: Health-related quality of life and its predictors among adults living with HIV/AIDS and receiving antiretroviral therapy in Pakistan
Health-related quality of life and its predictors among adults living with HIV/AIDS and receiving antiretroviral therapy in Pakistan Open
Background Health-related quality of life (HRQoL) is considered to be the fourth 90 of UNAIDS 90-90-90 target to monitor the effects of combination antiretroviral therapy (ART). ART has significantly increased the life expectancy of people…
View article: Hyponatremia Following Antipsychotic Treatment: In Silico Pharmacodynamics Analysis of Spontaneous Reports From the US Food and Drug Administration Adverse Event Reporting System Database and an Updated Systematic Review
Hyponatremia Following Antipsychotic Treatment: In Silico Pharmacodynamics Analysis of Spontaneous Reports From the US Food and Drug Administration Adverse Event Reporting System Database and an Updated Systematic Review Open
Background Hyponatremia associated with antipsychotic drugs is a rare but potentially life-threatening adverse drug reaction; the underlying pharmacological mechanism has not yet been explained. Methods We investigated the relationship bet…
View article: Beta‐blocker‐associated hypoglycaemia: New insights from a real‐world pharmacovigilance study
Beta‐blocker‐associated hypoglycaemia: New insights from a real‐world pharmacovigilance study Open
Aims To investigate the statistical association between hypoglycaemia and β‐blocker use and to define what patient and drug characteristics could potentially increase the risk for its occurrence. Methods We investigated the relationship be…
View article: Inflammasome Targeted Therapy in Pregnancy: New Insights From an Analysis of Real-World Data From the FAERS Database and a Systematic Review
Inflammasome Targeted Therapy in Pregnancy: New Insights From an Analysis of Real-World Data From the FAERS Database and a Systematic Review Open
The published experience with biologics in childbearing age with autoimmune and inflammatory diseases mainly deals with the use of TNFα inhibitors (TNFα-i). Limited data are available for biologics targeting other cytokines or immunocompet…
View article: Online Teaching Practices During the COVID-19 Pandemic
Online Teaching Practices During the COVID-19 Pandemic Open
The COVID-19 pandemic has had a remarkable economic impact worldwide, including in Pakistan, and was soon declared an international public health issue. The education sector in Pakistan, specifically school (K-12) education, has seen a sta…