Faleh Alqahtani
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View article: The Tumor Suppressor p53 Downregulates p107 (RBL1) Through p21–RB/E2F Signaling and Tandem E2F Sites
The Tumor Suppressor p53 Downregulates p107 (RBL1) Through p21–RB/E2F Signaling and Tandem E2F Sites Open
RBL1 (p107) is a member of the retinoblastoma (RB) family of pocket proteins involved in cell cycle regulation and E2F transcriptional repression. While its promoter contains conserved E2F motifs, the integrated regulation of RBL1 by upstr…
View article: A Comprehensive Physiologically Based Pharmacokinetic Framework of Ofloxacin: Predicting Disposition in Renal Impairment
A Comprehensive Physiologically Based Pharmacokinetic Framework of Ofloxacin: Predicting Disposition in Renal Impairment Open
Background: In the last several years, “physiologically based pharmacokinetic (PBPK) modeling” has gathered significant emphasis in the modeling of drug absorption, disposition, and metabolism. This research study aims to elaborate the pla…
View article: Nutritional co-therapy with vitamin D and L-theanine reduces unpredictable mild chronic stress (UCMS) in aged mice by restoring alpha-oscillations, dopamine levels and behavioral improvement
Nutritional co-therapy with vitamin D and L-theanine reduces unpredictable mild chronic stress (UCMS) in aged mice by restoring alpha-oscillations, dopamine levels and behavioral improvement Open
Late-life depression (LLD) arises from the confluence of neurochemical dysfunction, oxidative stress, and neural network disintegration, presenting a formidable therapeutic challenge. Here, we demonstrated that combined vitamin D (Vit D) a…
View article: Incidental breast cancer detection during awareness Campaigns: A multicentre mammography study from Taif, Saudi Arabia
Incidental breast cancer detection during awareness Campaigns: A multicentre mammography study from Taif, Saudi Arabia Open
View article: Advanced Analyses of Coronary Computed Tomography Angiography to Predict Future Cardiac Events
Advanced Analyses of Coronary Computed Tomography Angiography to Predict Future Cardiac Events Open
Advanced coronary CTA-based analyses show consistent association to the occurrence of MACE, suggesting their potential for refining cardiovascular risk stratification on top of conventional clinical risk assessment. Given the heterogeneity…
View article: Clinical pharmacokinetics of metronidazole: a systematic review and meta-analysis
Clinical pharmacokinetics of metronidazole: a systematic review and meta-analysis Open
Metronidazole (MTZ) is used in various clinical settings; however, its pharmacokinetics may vary across patient populations due to physiological and pathological differences. Understanding these variations is important for personalized dos…
View article: Ambulatory Blood Pressure Monitoring in Children: A Cross-Sectional Study of Blood Pressure Indices
Ambulatory Blood Pressure Monitoring in Children: A Cross-Sectional Study of Blood Pressure Indices Open
Background: Ambulatory blood pressure monitoring (ABPM) is increasingly recognized as a more reliable indicator of blood pressure status in children than clinic-based measurements, with superior predictive value for cardiovascular morbidit…
View article: A PBPK modeling approach for personalized dose optimization of nicardipine in renal and hepatic dysfunction
A PBPK modeling approach for personalized dose optimization of nicardipine in renal and hepatic dysfunction Open
Nicardipine is a calcium channel blocker employed to manage hypertension and angina. It is primarily metabolized in the liver; therefore, hepatic impairment patients may experience drug accumulation, potentially resulting in adverse events…
View article: Exploring the Pharmacokinetics of Drugs in Disabled Saudi Patients: A Systematic Review
Exploring the Pharmacokinetics of Drugs in Disabled Saudi Patients: A Systematic Review Open
Background/Objectives: Disability is a term that involves mental, intellectual, or sensory impairment resulting in the loss of one’s ability to walk or perform the activities necessary to live in a society. This study aims to collect all t…
View article: Polypharmacy with tiagabine, levetiracetam, and perampanel in status epilepticus: Insights from EEG, biochemical, and histopathological studies in rats
Polypharmacy with tiagabine, levetiracetam, and perampanel in status epilepticus: Insights from EEG, biochemical, and histopathological studies in rats Open
Objective Status epilepticus (SE) is a condition of neurological emergency, which precipitates various functional and morphological changes in the brain. Due to the risk of drug resistance associated with SE, this study aimed to evaluate a…
View article: Oxytocin Protects PC12 Cells Against β-Amyloid-Induced Cell Injury
Oxytocin Protects PC12 Cells Against β-Amyloid-Induced Cell Injury Open
Background/Objectives: Neurodegenerative diseases, particularly Alzheimer’s disease (AD), are characterized by progressive cognitive decline and non-cognitive symptoms that significantly affect health and quality of life. Beta-amyloid (Aβ)…
View article: Unraveling the neuroprotective effect of perampanel and lacosamide combination in the corneal kindling model for epilepsy in mice
Unraveling the neuroprotective effect of perampanel and lacosamide combination in the corneal kindling model for epilepsy in mice Open
Background Scientific evidence to guide clinicians on the use of different antiseizure drugs in combination therapy is either very limited or lacking. In this study, the impact of lacosamide and perampanel alone and in combination was test…
View article: The Clinical Pharmacokinetics and Pharmacodynamics of Glimepiride—A Systematic Review and Meta-Analysis
The Clinical Pharmacokinetics and Pharmacodynamics of Glimepiride—A Systematic Review and Meta-Analysis Open
Background/Objectives: Glimepiride (GLM), a commonly used sulphonylurea drug for the management of type 2 diabetes mellitus (T2DM), has been the subject of numerous studies exploring its kinetic behaviors. However, a comprehensive evaluati…
View article: Incidental Breast Cancer Findings During Breast Cancer Awareness Campaigns in Taif, Saudi Arabia: A Multicentre Study
Incidental Breast Cancer Findings During Breast Cancer Awareness Campaigns in Taif, Saudi Arabia: A Multicentre Study Open
View article: Erqember Mitigates Neurotoxic Effects of Aluminum Chloride in Mice: Phytochemical Insights With Neurobehavioral and In Silico Approaches
Erqember Mitigates Neurotoxic Effects of Aluminum Chloride in Mice: Phytochemical Insights With Neurobehavioral and In Silico Approaches Open
The increasing popularity of herbal preparations has prompted people around the world to incorporate herbal products into their balanced diet, aiming to improve brain health and protect against neurological disorders. Erqember(Erq‐Em) poss…
View article: Adherence of Ophthalmologists and Rheumatologist to the Latest Recommendations of HCQ Retinopathy Screening in Saudi Arabia
Adherence of Ophthalmologists and Rheumatologist to the Latest Recommendations of HCQ Retinopathy Screening in Saudi Arabia Open
View article: Pharmaceutical Analysis and Standardization of Herbal Medicines
Pharmaceutical Analysis and Standardization of Herbal Medicines Open
This paper provides a comprehensive overview of the criteria used to test and standardize medicinal plants and components in the pharmaceutical sector. Natural or herbal therapies are becoming increasingly popular as alternatives to commer…
View article: Clinical Pharmacokinetics of Fexofenadine: A Systematic Review
Clinical Pharmacokinetics of Fexofenadine: A Systematic Review Open
Background/Objectives: Fexofenadine hydrochloride is a widely prescribed drug for treating histamine-mediated allergic reactions. This review systematically collates existing research on the clinical pharmacokinetics (PK) of fexofenadine, …
View article: Co-administration of coenzyme Q10 and curcumin mitigates cognitive deficits and exerts neuroprotective effects in aluminum chloride-induced Alzheimer's disease in aged mice
Co-administration of coenzyme Q10 and curcumin mitigates cognitive deficits and exerts neuroprotective effects in aluminum chloride-induced Alzheimer's disease in aged mice Open
Aluminum chloride (AlCl3), a known neurotoxic and Alzheimerogenic metal disrupts redox homeostasis which plays a pivotal role in pathophysiology of neurodegenerative disorders, particularly cognitive decline. The current study w…
View article: Syzygium cumini fresh juice ameliorated memory impairment in a scopolamine-induced amnesic mouse model through active avoidance paradigm
Syzygium cumini fresh juice ameliorated memory impairment in a scopolamine-induced amnesic mouse model through active avoidance paradigm Open
The active avoidance paradigm is a reliable tool for the assessment of associative learning/memory. Nutritional manipulation is an emerging approach for the improvisation of brain health. Syzygium cumini (SC) fruit with enriched phytoconst…
View article: Integration of Ontogeny-Based Changes for Predicting the Exposure of Diphenhydramine in the Pediatric Population: A PBPK Modeling Approach
Integration of Ontogeny-Based Changes for Predicting the Exposure of Diphenhydramine in the Pediatric Population: A PBPK Modeling Approach Open
Background: Diphenhydramine is an anti-tussive used periodically to treat seasonal colds, contact dermatitis, and anaphylactic reactions. This study aimed to develop a physiologically based pharmacokinetic (PBPK) model of diphenhydramine i…
View article: Model-Based Dose Selection of a Sphingosine-1-Phosphate Modulator, Etrasimod, in Patients with Various Degrees of Hepatic Impairment
Model-Based Dose Selection of a Sphingosine-1-Phosphate Modulator, Etrasimod, in Patients with Various Degrees of Hepatic Impairment Open
Background/Objectives: Etrasimod is a newly FDA-approved Sphingosine-1-Phosphate modulator indicated for moderate and severe ulcerative colitis. It is extensively metabolized in the liver via the cytochrome P450 system and may accumulate m…
View article: Probiotics by Modulating Gut–Brain Axis Together With Brivaracetam Mitigate Seizure Progression, Behavioral Incongruities, and Prevented Neurodegeneration in Pentylenetetrazole‐Kindled Mice
Probiotics by Modulating Gut–Brain Axis Together With Brivaracetam Mitigate Seizure Progression, Behavioral Incongruities, and Prevented Neurodegeneration in Pentylenetetrazole‐Kindled Mice Open
Background The microbiota–gut–brain axis (MGBA) is a central nexus that integrates higher cognitive and emotional centers of the central nervous system (CNS) within the intricate functioning of the intestine. Accumulating evidence suggests…
View article: Brivaracetam and rufinamide combination increased seizure threshold and improved neurobehavioral deficits in corneal kindling model of epilepsy
Brivaracetam and rufinamide combination increased seizure threshold and improved neurobehavioral deficits in corneal kindling model of epilepsy Open
Background Besides seizures, a myriad of overlapping neuropsychiatric and cognitive comorbidities occur in patients with epilepsy, which further debilitates their quality of life. This study provides an in‐depth characterization of the imp…
View article: Metabolomics and pathways analyses in traumatic brain injury animal model
Metabolomics and pathways analyses in traumatic brain injury animal model Open
Traumatic brain injury (TBI), a progressive neurological disease caused by physical injury to the brain tissue, impacting its functions. This study employed metabolomics based on untargeted mass spectrometry method to examine plasma specim…
View article: The Economic Burden of Type 2 Diabetes Mellitus in Pakistan: A Cost of Illness Study
The Economic Burden of Type 2 Diabetes Mellitus in Pakistan: A Cost of Illness Study Open
Background: Type 2 Diabetes Mellitus (T2DM) is a highly prevalent disease with a chronic nature and poses a significant health burden worldwide, with no exception in Pakistan. Hence, this study aimed to explore the financial burden of T2DM…
View article: Polycaprolactone—Vitamin E TPGS Micellar Formulation for Oral Delivery of Paclitaxel
Polycaprolactone—Vitamin E TPGS Micellar Formulation for Oral Delivery of Paclitaxel Open
This study aimed to investigate the potential of polycaprolactone–vitamin E TPGS (PCL-TPGS) micelles as a delivery system for oral administration of paclitaxel (PTX). The PCL-TPGS copolymer was synthesized using ring opening polymerization…
View article: Increased Permeability of the Blood–Brain Barrier in a Diabetic Mouse Model (Leprdb/db Mice)
Increased Permeability of the Blood–Brain Barrier in a Diabetic Mouse Model (Leprdb/db Mice) Open
Type 2 Diabetes Mellitus (T2DM) is linked to multiple complications, including cognitive impairment, and the prevalence of memory-related neurodegenerative diseases is higher in T2DM patients. One possible theory is the alteration of the m…
View article: A Comprehensive Physiologically Based Pharmacokinetic Model for Predicting Vildagliptin Pharmacokinetics: Insights into Dosing in Renal Impairment
A Comprehensive Physiologically Based Pharmacokinetic Model for Predicting Vildagliptin Pharmacokinetics: Insights into Dosing in Renal Impairment Open
Physiologically based pharmacokinetic (PBPK) modeling is of great importance in the field of medicine. This study aims to construct a PBPK model, which can provide reliable drug pharmacokinetic (PK) predictions in both healthy and chronic …
View article: Synthesis of N, N-Bis([1,1′-Biphenyl]-4-ylmethyl)-4-morpholinoaniline derivatives via SMC reaction: Assessing their anti-seizure potential through electroencephalogram evaluation and molecular docking studies
Synthesis of N, N-Bis([1,1′-Biphenyl]-4-ylmethyl)-4-morpholinoaniline derivatives via SMC reaction: Assessing their anti-seizure potential through electroencephalogram evaluation and molecular docking studies Open
A new series of N, N-bis([1,1′-biphenyl]-4-ylmethyl)-4-morpholinoaniline derivatives (6a − h, 7i) were synthesized and evaluated their anticonvulsant potential through in vivo and in silico studies. 6 Hz Psychomotor and acute pentylenetetr…