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View article: Rad53 regulates RNase H1, which promotes DNA replication through sites of transcription-replication conflict
Rad53 regulates RNase H1, which promotes DNA replication through sites of transcription-replication conflict Open
RNA-DNA hybrids and R-loops can lead to extensive DNA damage and loss of genomic integrity if not regulated in a timely manner. Although RNase H1 overexpression is frequently used as a tool to resolve R-loops, the regulation of RNase H1, o…
View article: A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity Open
Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating protein kinase and ubiquitin ligase domains within a single protein. This module is widespre…
View article: Connecting basal body and mitochondrial DNA: TAC53 and the tubular organization of the tripartite attachment complex
Connecting basal body and mitochondrial DNA: TAC53 and the tubular organization of the tripartite attachment complex Open
The Tripartite Attachment Complex (TAC) is essential for mitochondrial DNA (kDNA) segregation in Trypanosoma brucei , providing a physical link between the flagellar basal body and the mitochondrial genome. Although the TAC’s hierarchical …
View article: DNA methylation at retrotransposons protects the germline by preventing NRF1-mediated activation
DNA methylation at retrotransposons protects the germline by preventing NRF1-mediated activation Open
View article: Unraveling developmental gene regulation in holometabolous insects through comparative transcriptomics and proteomics
Unraveling developmental gene regulation in holometabolous insects through comparative transcriptomics and proteomics Open
Holometabolous insects undergo complex phenotypic changes during development in four major stages: egg, larva, pupa and adult. Such changes are typically driven by strong transcriptome and proteome dynamics, making this process an excellen…
View article: ERH regulates type II interferon immune signaling through post-transcriptional regulation of <i>JAK2</i> mRNA
ERH regulates type II interferon immune signaling through post-transcriptional regulation of <i>JAK2</i> mRNA Open
Type II interferon (IFNγ) signaling is essential for innate immunity and critical for effective immunological checkpoint blockade in cancer immunotherapy. Genetic screen identification of post-transcriptional regulators of this pathway has…
View article: Beyond a Linear Structure: The Tubular Organization of the Tripartite Attachment Complex and the Functional Role of TAC53
Beyond a Linear Structure: The Tubular Organization of the Tripartite Attachment Complex and the Functional Role of TAC53 Open
The Tripartite Attachment Complex (TAC) is essential for mitochondrial DNA (kDNA) segregation in Trypanosoma brucei , providing a physical link between the flagellar basal body and the mitochondrial genome. Although the TAC’s hierarchical …
View article: The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells
The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells Open
View article: Transposable Elements Drive Regulatory and Functional Innovation of F-box Genes
Transposable Elements Drive Regulatory and Functional Innovation of F-box Genes Open
Protein domains of transposable elements (TEs) and viruses increase the protein diversity of host genomes by recombining with other protein domains. By screening 10 million eukaryotic proteins, we identified several domains that define mul…
View article: A SET domain-containing protein and HCF-1 maintain transgenerational epigenetic memory
A SET domain-containing protein and HCF-1 maintain transgenerational epigenetic memory Open
Epigenetic information can be inherited through a process known as transgenerational epigenetic inheritance (TEI). TEI can be initiated and maintained by small RNAs and histone modifications. The latter includes histone methylation, deposi…
View article: Zbtb48 is a regulator of Mtfp1 expression in zebrafish
Zbtb48 is a regulator of Mtfp1 expression in zebrafish Open
ZBTB48 (also known as TZAP) is a transcription factor that has previously been reported to bind to telomeres and act as a negative regulator of telomere length in human cell lines. To explore whether transcription factor activity and telom…
View article: Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis
Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis Open
Mitochondrial tRNA taurine modifications mediated by mitochondrial tRNA translation optimization 1 ( Mto1 ) is essential for the mitochondrial protein translation. Mto1 deficiency was shown to induce proteostress in embryonic stem cells. A…
View article: Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes
Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes Open
View article: The histone methyltransferase DOT1B is dispensable for stage differentiation and macrophage infection of Leishmania mexicana
The histone methyltransferase DOT1B is dispensable for stage differentiation and macrophage infection of Leishmania mexicana Open
Conserved histone methyltransferases of the DOT1 family are involved in replication regulation, cell cycle progression, stage differentiation, and gene regulation in trypanosomatids. However, the specific functions of these enzymes depend …
View article: Quantitative proteomics of infected macrophages reveals novel <i>Leishmania</i> virulence factors
Quantitative proteomics of infected macrophages reveals novel <i>Leishmania</i> virulence factors Open
Leishmaniasis is a major public health problem, causing diseases ranging from self-healing skin lesions to life-threatening chronic infections. Understanding how Leishmania parasites evade the host defense system is crucial for understandi…
View article: Transposable elements drive regulatory and functional innovation of F-box genes
Transposable elements drive regulatory and functional innovation of F-box genes Open
Protein domains of transposable elements (TEs) and viruses increase the protein diversity of host genomes by recombining with other protein domains. By screening 10 million eukaryotic proteins, we identified several domains that define mul…
View article: TelAP2 links TelAP1 to the telomere complex in Trypanosoma brucei
TelAP2 links TelAP1 to the telomere complex in Trypanosoma brucei Open
The extracellular parasite Trypanosoma brucei evades the immune system of the mammalian host by periodically exchanging its variant surface glycoprotein (VSG) coat. Hereby, only one VSG gene is transcribed from one of 15 subtelomeric so-ca…
View article: ISWI1 complex proteins facilitate developmental genome editing in<i>Paramecium</i>
ISWI1 complex proteins facilitate developmental genome editing in<i>Paramecium</i> Open
One of the most extensive forms of natural genome editing occurs in ciliates, a group of microbial eukaryotes. Ciliate germline and somatic genomes are contained in distinct nuclei within the same cell. During the massive reorganization pr…
View article: ZNF512B binds RBBP4 via a variant NuRD interaction motif and aggregates chromatin in a NuRD complex-independent manner
ZNF512B binds RBBP4 via a variant NuRD interaction motif and aggregates chromatin in a NuRD complex-independent manner Open
The evolutionarily conserved histone variant H2A.Z plays a crucial role in various DNA-based processes, but the mechanisms underlying its activity are not completely understood. Recently, we identified the zinc finger (ZF) protein ZNF512B …
View article: Bacterial RNA sensing by TLR8 requires RNase 6 processing and is inhibited by RNA 2’O-methylation
Bacterial RNA sensing by TLR8 requires RNase 6 processing and is inhibited by RNA 2’O-methylation Open
TLR8 senses single-stranded RNA (ssRNA) fragments, processed via cleavage by ribonuclease (RNase) T2 and RNase A family members. Processing by these RNases releases uridines and purine-terminated residues resulting in TLR8 activation. Mono…
View article: Unbiased screening identifies regulators of cell-cell adhesion and treatment options in pemphigus
Unbiased screening identifies regulators of cell-cell adhesion and treatment options in pemphigus Open
View article: ERH regulates type II interferon immune signaling through post-transcriptional regulation of<i>JAK2</i>mRNA
ERH regulates type II interferon immune signaling through post-transcriptional regulation of<i>JAK2</i>mRNA Open
Type II interferon (IFNγ) signaling is essential for innate immunity and critical for effective immunological checkpoint blockade in cancer immunotherapy. Genetic screen identification of post-transcriptional regulators of this pathway has…
View article: Author Correction: piRNA processing by a trimeric Schlafen-domain nuclease
Author Correction: piRNA processing by a trimeric Schlafen-domain nuclease Open
View article: Revealing the Arabidopsis AtGRP7 mRNA binding proteome by specific enhanced RNA interactome capture
Revealing the Arabidopsis AtGRP7 mRNA binding proteome by specific enhanced RNA interactome capture Open
View article: Msc1 is a nuclear envelope protein that reinforces DNA repair in late mitosis
Msc1 is a nuclear envelope protein that reinforces DNA repair in late mitosis Open
Precise double-strand break (DSB) repair is a paramount for genome stability. Homologous recombination (HR) repairs DSBs when cyclin-dependent kinase (CDK) activity is high, which correlates with the availability of the sister chromatid as…
View article: TelAP2 links TelAP1 to the telomere complex in<i>Trypanosoma brucei</i>
TelAP2 links TelAP1 to the telomere complex in<i>Trypanosoma brucei</i> Open
The extracellular parasite Trypanosoma brucei evades the immune system of the mammalian host by periodically exchanging its variant surface glycoprotein (VSG) coat. Hereby, only one VSG gene is transcribed from one of 15 subtelomeric so-ca…
View article: Revealing the Arabidopsis<i>AtGRP7</i>mRNA binding proteome by specific enhanced RNA interactome capture
Revealing the Arabidopsis<i>AtGRP7</i>mRNA binding proteome by specific enhanced RNA interactome capture Open
Background The interaction of proteins with RNA in the cell is crucial to orchestrate all steps of RNA processing. RNA interactome capture (RIC) techniques have been implemented to catalogue RNA-binding proteins in the cell. In RIC, RNA-pr…
View article: The protein phosphatase-2A subunit PR130 is involved in the formation of cytotoxic protein aggregates in pancreatic ductal adenocarcinoma cells
The protein phosphatase-2A subunit PR130 is involved in the formation of cytotoxic protein aggregates in pancreatic ductal adenocarcinoma cells Open
View article: Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes
Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes Open
East African cichlid fishes have diversified in an explosive fashion, but the (epi)genetic basis of the phenotypic diversity of these fishes remains largely unknown. Although transposable elements (TEs) have been associated with phenotypic…
View article: The TELOMERE REPEAT BINDING proteins TRB4 and TRB5 function as transcriptional activators of PRC2-controlled genes to regulate plant development
The TELOMERE REPEAT BINDING proteins TRB4 and TRB5 function as transcriptional activators of PRC2-controlled genes to regulate plant development Open