Fangzhen Luo
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View article: Intratumoral microbiota: a new perspective in cancer initiation, development, and therapy
Intratumoral microbiota: a new perspective in cancer initiation, development, and therapy Open
This review summarizes how intratumoral microbiota influence tumor development and explores their potential as targets for drug delivery and immunotherapy enhancement.
MAP4K4 promotes chlamydial infectivity and genital tract inflammatory injury by negatively regulating protective immunity in Chlamydia infection Open
Persistent Chlamydia trachomatis infection is a risk factor for tubal infertility, and the pathology is largely due to the inflammatory response; however, the underlying molecular mechanism remains to be elucidated. MAP4K4, which has been …
Comparative mitogenomic analyses provide evolutionary insights into the retrolateral tibial apophysis clade (Araneae: Entelegynae) Open
The retrolateral tibial apophysis (RTA) clade is the largest spider lineage within Araneae. To better understand the diversity and evolution, we newly determined mitogenomes of ten RTA species from six families and performed a comparative …
Lactobacillus Modulates Chlamydia Infectivity and Genital Tract Pathology in vitro and in vivo Open
Since we previously reported that women infected with chlamydia had a significant overall reduction in Lactobacillus in the vagina microbiota as compared to those uninfected individuals; the interactions between the altered Lactobacillus a…
LncRNA ZEB1-AS1/miR-1224-5p / MAP4K4 axis regulates mitochondria-mediated HeLa cell apoptosis in persistent <i>Chlamydia trachomatis</i> infection Open
Persistent infection of Chlamydia trachomatis is thought to be responsible for the debilitating sequelae of blinding trachoma and infertility. Inhibition of host cell apoptosis is a persistent C. trachomatis infection mechanism. ZEB1-AS1 i…
Mitochondrial phylogenomics provides insights into the phylogeny and evolution of spiders (Arthropoda: Araneae) Open
Spiders are among the most varied terrestrial predators, with highly diverse morphology, ecology, and behavior. Morphological and molecular data have greatly contributed to advances in the phylogeny and evolutionary dynamics of spiders. He…
<i>Chlamydia trachomatis</i> induces lncRNA MIAT upregulation to regulate mitochondria‐mediated host cell apoptosis and chlamydial development Open
Chlamydia trachomatis persistent infection is the leading cause of male prostatitis and female genital tract diseases. Inhibition of host cell apoptosis is the key to maintaining Chlamydia survival in vivo, and long noncoding RNAs (lncRNAs…
Long Non-Coding RNA FGD5-AS1 Induced by Chlamydia trachomatis Infection Inhibits Apoptosis via Wnt/β-Catenin Signaling Pathway Open
Background Chlamydia trachomatis (Ct) is one of the most common bacterial sexually transmitted infection (STI) pathogens in the world, but the exact pathogenic mechanism still needs to be further elucidated. Long non-coding RNAs (lncRNAs) …
Chlamydia trachomatis Plasmid Protein pORF5 Up-Regulates ZFAS1 to Promote Host Cell Survival via MAPK/p38 Pathway Open
Long non-coding RNAs (lncRNAs) have been demonstrated to play essential roles in many diseases. However, few studies have shown that lncRNAs take part in the pathogenesis of Chlamydia trachomatis ( C. trachomatis ). Here, we used a lncRNA …
Antiapoptotic activity of <i>Chlamydia trachomatis</i> Pgp3 protein involves activation of the ERK1/2 pathway mediated by upregulation of DJ-1 protein Open
Chlamydia trachomatis has evolved strategies to prevent host cell apoptosis to evade the host immune defense. However, the precise mechanisms of antiapoptotic activity of C. trachomatis still need to be clarified. Pgp3, one of eight plasmi…
The Complete Mitogenome of Pyrrhocoris tibialis (Hemiptera: Pyrrhocoridae) and Phylogenetic Implications Open
We determined the complete mitogenome of Pyrrhocoris tibialis (Hemiptera: Heteroptera: Pyrrhocoridae) to better understand the diversity and phylogeny within Pentatomomorpha, which is the second largest infra-order of Heteroptera. Gene con…
Mitochondrial genome of <i>Amphimallon solstitiale</i> (Coleoptera: Scarabaeidae: Melolonthinae) and phylogenetic analysis Open
To better understand the diversity and phylogeny of Scarabaeidae, we sequenced and annotated the nearly complete mitochondrial genome (mitogenome) of Amphimallon solstitiale (Coleoptera: Scarabaeidae: Melolonthinae). This mitogenome was 13…