Faming Miao
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View article: Deletion of the African swine fever virus E120R gene completely attenuates its virulence by enhancing host innate immunity and impairing virus release
Deletion of the African swine fever virus E120R gene completely attenuates its virulence by enhancing host innate immunity and impairing virus release Open
African swine fever virus (ASFV) causes a lethal haemorrhagic disease in domestic pigs and poses a major threat to the global swine industry. Currently, no effective commercial vaccines or antiviral drugs are available for ASF control. In …
View article: Newcastle Disease Virus-Vectored African Swine Fever Virus Antigen Cocktail Delays the Onset of ASFV-SY18 but Is Not Protective
Newcastle Disease Virus-Vectored African Swine Fever Virus Antigen Cocktail Delays the Onset of ASFV-SY18 but Is Not Protective Open
African Swine Fever (ASF) is a highly contagious viral disease threatening the global pig industry. Currently, only two gene-deleted live attenuated vaccines are approved, exclusively in Vietnam, and their long-term effectiveness and safet…
View article: Development of Human Monoclonal Antibodies With Broad Reactivity for Rabies Postexposure Prophylaxis
Development of Human Monoclonal Antibodies With Broad Reactivity for Rabies Postexposure Prophylaxis Open
Rabies is an acute lethal disease causing by the neurotropic virus rabies virus (RABV). Rabies immune globulin (RIG) as an indispensable component of rabies postexposure prophylaxis (PEP) always faces with great challenges in terms of cost…
View article: Attenuated African swine fever viruses and the live vaccine candidates: a comprehensive review
Attenuated African swine fever viruses and the live vaccine candidates: a comprehensive review Open
The African swine fever virus (ASFV) is spreading worldwide and causing huge economic losses to the global pig industry. The ASFV genome is 170–193 kb in length, contains approximately 150 open reading frames, and encodes more than 200 pro…
View article: Protection Evaluation of a New Attenuated ASFV by Deletion of the L60L and CD2v Genes against Homologous Challenge
Protection Evaluation of a New Attenuated ASFV by Deletion of the L60L and CD2v Genes against Homologous Challenge Open
African swine fever (ASF) is an acute infectious disease with a high mortality rate in both domestic and wild boars. Commercial vaccines or antiviral drugs for ASF were not available due to the complex diversity of the structure and genome…
View article: Deleting the C84L Gene from the Virulent African Swine Fever Virus SY18 Does Not Affect Its Replication in Porcine Primary Macrophages but Reduces Its Virulence in Swine
Deleting the C84L Gene from the Virulent African Swine Fever Virus SY18 Does Not Affect Its Replication in Porcine Primary Macrophages but Reduces Its Virulence in Swine Open
(1) Background: African swine fever (ASF) is a highly contagious disease that causes high pig mortality. Due to the absence of vaccines, prevention and control are relatively challenging. The pathogenic African swine fever virus (ASFV) has…
View article: Identification of L11L and L7L as virulence-related genes in the African swine fever virus genome
Identification of L11L and L7L as virulence-related genes in the African swine fever virus genome Open
Introduction African swine fever (ASF) is an infectious disease that causes considerable economic losses in pig farming. The agent of this disease, African swine fever virus (ASFV), is a double-stranded DNA virus with a capsid membrane and…
View article: SY18ΔL60L: a new recombinant live attenuated African swine fever virus with protection against homologous challenge
SY18ΔL60L: a new recombinant live attenuated African swine fever virus with protection against homologous challenge Open
Introduction African swine fever (ASF) is an acute and highly contagious disease and its pathogen, the African swine fever virus (ASFV), threatens the global pig industry. At present, management of ASF epidemic mainly relies on biological …
View article: African swine fever virus I196L is a virulence determinant and its deletant induces robust protection in Domestic pig
African swine fever virus I196L is a virulence determinant and its deletant induces robust protection in Domestic pig Open
The worldwide pandemic of African swine fever virus (ASFV) has a profound impact on the global pig industry. ASFV is a complex multilayered structure and the functions of unknown genes are being revealed. Here we deleted I196L from virulen…
View article: Comparison of Genotype II African Swine Fever Virus Strain SY18 Challenge Models
Comparison of Genotype II African Swine Fever Virus Strain SY18 Challenge Models Open
African swine fever (ASF) is a viral haemorrhagic disease found in domestic and wild boars caused by the African swine fever virus (ASFV). A highly virulent strain was used to evaluate the efficacy of newly developed vaccine candidates. Th…
View article: Genetic Diversity, Evolutionary Dynamics, and Pathogenicity of Ferret Badger Rabies Virus Variants in Mainland China, 2008–2018
Genetic Diversity, Evolutionary Dynamics, and Pathogenicity of Ferret Badger Rabies Virus Variants in Mainland China, 2008–2018 Open
In contrast to dog-associated human rabies cases decline year by year due to the rabies vaccination coverage rates increase in China, ferret badger (FB, Melogale moschata )-associated human rabies cases emerged in the 1990s, and are now an…
View article: Proteomic and Metabolomic Characterization of SARS-CoV-2-Infected Cynomolgus Macaque at Early Stage
Proteomic and Metabolomic Characterization of SARS-CoV-2-Infected Cynomolgus Macaque at Early Stage Open
Although tremendous effort has been exerted to elucidate the pathogenesis of severe COVID-19 cases, the detailed mechanism of moderate cases, which accounts for 90% of all patients, remains unclear yet, partly limited by lacking the biopsy…
View article: I267L Is Neither the Virulence- Nor the Replication-Related Gene of African Swine Fever Virus and Its Deletant Is an Ideal Fluorescent-Tagged Virulence Strain
I267L Is Neither the Virulence- Nor the Replication-Related Gene of African Swine Fever Virus and Its Deletant Is an Ideal Fluorescent-Tagged Virulence Strain Open
African swine fever virus (ASFV) is the causative agent of African swine fever (ASF) which reaches up to 100% case fatality in domestic pigs and wild boar and causes significant economic losses in the swine industry. Lack of knowledge of t…
View article: SARS-CoV-2 Aerosol Exhaled by Experimentally Infected Cynomolgus Monkeys
SARS-CoV-2 Aerosol Exhaled by Experimentally Infected Cynomolgus Monkeys Open
We analyzed size of severe acute respiratory coronavirus 2 (SARS-CoV-2) aerosol particles shed by experimentally infected cynomolgus monkeys. Most exhaled particles were small, and virus was mainly released early during infection. By posti…
View article: Genetic diversity, evolutionary dynamics and pathogenicity of ferret badger rabies virus variants in mainland China, 2008-2018
Genetic diversity, evolutionary dynamics and pathogenicity of ferret badger rabies virus variants in mainland China, 2008-2018 Open
In contrast to dog associated human rabies cases decline year by year due to the rabies vaccination coverage rates increase in China, ferret badger (FB, Melogale moschata )–associated human rabies cases emerged in the 1990s, and are now an…
View article: The Mink Circovirus Capsid Subunit Expressed by Recombinant Baculovirus Protects Minks against Refractory Diarrhea in Field
The Mink Circovirus Capsid Subunit Expressed by Recombinant Baculovirus Protects Minks against Refractory Diarrhea in Field Open
Mink refractory diarrhea is a seasonal disease that occurs in many mink farms in China. Mink circovirus (MiCV) has been recognized as the causative agent of the disease. The aim of the study was to develop a subunit vaccine against mink re…
View article: Deletion of the L7L-L11L Genes Attenuates ASFV and Induces Protection against Homologous Challenge
Deletion of the L7L-L11L Genes Attenuates ASFV and Induces Protection against Homologous Challenge Open
African swine fever (ASF), caused by the African swine fever virus (ASFV), is a major epidemic disease endangering the swine industry. Although a number of vaccine candidates have been reported, none are commercially available yet. To expl…
View article: Cytokine Storm in Domestic Pigs Induced by Infection of Virulent African Swine Fever Virus
Cytokine Storm in Domestic Pigs Induced by Infection of Virulent African Swine Fever Virus Open
African swine fever, caused by African swine fever virus (ASFV), is a highly contagious hemorrhagic disease of domestic pigs. The current continent-wide pandemic has persisted for over 10 years, and its economy-devastating effect was highl…
View article: Rapid and Sensitive Recombinase Polymerase Amplification Combined With Lateral Flow Strip for Detecting African Swine Fever Virus
Rapid and Sensitive Recombinase Polymerase Amplification Combined With Lateral Flow Strip for Detecting African Swine Fever Virus Open
African swine fever virus (ASFV), the etiological agent of African swine fever (ASF), a hemorrhagic fever of domestic pigs, has devastating consequences for the pig farming industry. More than 1,000,000 pigs have been slaughtered since 3 A…
View article: Letter to the editor in response to ‘Molecular detection of rabies virus strain with N-gene that clustered with China lineage 2 co-circulating with Africa lineages in Monrovia, Liberia: first reported case in Africa’
Letter to the editor in response to ‘Molecular detection of rabies virus strain with N-gene that clustered with China lineage 2 co-circulating with Africa lineages in Monrovia, Liberia: first reported case in Africa’ Open
Letter to the editor in response to ‘Molecular detection of rabies virus strain with N-gene that clustered with China lineage 2 co-circulating with Africa lineages in Monrovia, Liberia: first reported case in Africa’ - Volume 147
View article: Emergence of African Swine Fever in China, 2018
Emergence of African Swine Fever in China, 2018 Open
Transboundary and Emerging DiseasesVolume 65, Issue 6 p. 1482-1484 OUTBREAK ALERTS Emergence of African Swine Fever in China, 2018 Xintao Zhou, Xintao Zhou Institute of Military Veterinary Medicine, Academy of Military Medical Sciences, Ch…