Chunhai Fan
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View article: Machine learning–powered single-molecule cancer diagnosis using DNA origami tags
Machine learning–powered single-molecule cancer diagnosis using DNA origami tags Open
Single-molecule detection (SMD) holds considerable promise in biomedical research. Although atomic force microscopy (AFM) provides an important technique with nanoscale resolution for SMD, its broader application is limited by labeling cha…
View article: Linked data storage using DNA origami nanostructures
Linked data storage using DNA origami nanostructures Open
DNA-based storage is an alternative solution for archiving vast cold data. Its future development aims to meet the demands of hot data storage, which requires rapid random access and efficient data modification. Here, we present a DNA orig…
View article: Predicting Moisture in Different Alfalfa Product Forms with SWIR Hyperspectral Imaging: Key Wavelengths for Low-Cost Sensor Development
Predicting Moisture in Different Alfalfa Product Forms with SWIR Hyperspectral Imaging: Key Wavelengths for Low-Cost Sensor Development Open
Rapid and accurate moisture detection is critical for alfalfa quality control, yet conventional methods are slow, and non-destructive techniques are challenged by different product forms. This study leveraged Short-Wave Infrared Hyperspect…
View article: Mechanical Constraints Promote Noncanonical Base‐Pairing Interactions
Mechanical Constraints Promote Noncanonical Base‐Pairing Interactions Open
Mechanical perturbations profoundly influence nucleobase interactions in cells, serving as key modulators of fundamental cellular processes such as transcriptional regulation. However, their precise roles remain elusive due to methodologic…
View article: Liquid crystal–guided DNA information storage: Nondestructive recovery and long-term preservation
Liquid crystal–guided DNA information storage: Nondestructive recovery and long-term preservation Open
DNA digital storage features high storage density, low power consumption, and extended digital recovery time. However, conventional DNA preservation methods suffer from limitations like low DNA loading and complex recovery processes. In th…
View article: Macroscopic assembly of centimeter-scale monolayer two-dimensional DNA origami polymers
Macroscopic assembly of centimeter-scale monolayer two-dimensional DNA origami polymers Open
The construction of macroscopic, hierarchically ordered macroscopic superstructures from nanoscale building blocks remains a fundamental challenge in materials science. DNA origami provides a powerful platform for achieving high-precision …
View article: A compact cassette tape for DNA-based data storage
A compact cassette tape for DNA-based data storage Open
DNA with high storage density can serve as an alternative storage medium to respond to the global explosion of data growth and become a powerful personal storage memory if an integrated compact device can store and handle large-scale data.…
View article: Designing a DNA synchronizer for compact single-rail DNA logic circuits
Designing a DNA synchronizer for compact single-rail DNA logic circuits Open
DNA has emerged as a robust platform for engineering molecular circuits with arbitrary logic operations. Nevertheless, implementing DNA circuits for such functions generally relies on the use of dual-rail expression that doubles the number…
View article: Interwoven DNA-MOF crystals for multi-millennial data storage
Interwoven DNA-MOF crystals for multi-millennial data storage Open
DNA has emerged as a promising medium for high-density and energy-efficient data storage, providing a promising solution to capacity constraints and energy demands resulting from the exponential growth of data. Long-term stable storage of …
View article: Programming Directional Strand Polymerization on DNA Origami for Logic Computing
Programming Directional Strand Polymerization on DNA Origami for Logic Computing Open
The nanoscale addressability of DNA origami structures enables precise control of molecular reaction pathways and events within confined spaces, allowing for the construction of localized DNA logic gates, which are critical for achieving m…
View article: Comparative Evaluation of Decadal Predictions of Global <scp>SST</scp> Between <scp>CMIP5</scp> and <scp>CMIP6</scp> Datasets
Comparative Evaluation of Decadal Predictions of Global <span>SST</span> Between <span>CMIP5</span> and <span>CMIP6</span> Datasets Open
Accurate predictions of the Earth's near‐term (1 year and 2–5 year lead‐time) climate are crucial for informed decision‐making in various sectors such as agriculture, energy, public health, and infrastructure planning. Using the yearly ini…
View article: Engineering Liquid Hierarchical Materials with DNA‐Programmed Spherical Nucleic Acids
Engineering Liquid Hierarchical Materials with DNA‐Programmed Spherical Nucleic Acids Open
Inspired by nature, the orchestration of self‐assembling building blocks into hierarchical superstructures offers a transformative approach to functional materials design. While significant advances have been made in engineering solid‐stat…
View article: EPiC: Towards Lossless Speedup for Reasoning Training through Edge-Preserving CoT Condensation
EPiC: Towards Lossless Speedup for Reasoning Training through Edge-Preserving CoT Condensation Open
Large language models (LLMs) have shown remarkable reasoning capabilities when trained with chain-of-thought (CoT) supervision. However, the long and verbose CoT traces, especially those distilled from large reasoning models (LRMs) such as…
View article: DNA framework array enables ultra-high throughput DNA synthesis
DNA framework array enables ultra-high throughput DNA synthesis Open
High-throughput DNA synthesis has revolutionized synthetic biology, molecular diagnostics, genome engineering, and DNA data storage by enabling the scalable and precise construction of nucleotide-based information systems. However, existin…
View article: Near‐Freezing‐Temperature Golgi Neuronal Staining for X‐ray Imaging of Human Brain
Near‐Freezing‐Temperature Golgi Neuronal Staining for X‐ray Imaging of Human Brain Open
Achieving detailed neuronal structural information in large‐volume brain tissue has been a longstanding challenge in human brain imaging. A key obstacle arises from the trade‐off between staining efficiency and tissue autolysis. Traditiona…
View article: Eliciting Dual-Niche Immunological Priming by Acupoint Delivery of Nanovaccines
Eliciting Dual-Niche Immunological Priming by Acupoint Delivery of Nanovaccines Open
Immunization has long played essential roles in preventing diseases. However, the desire for precision delivery of vaccines to boost a robust immune response remains largely unmet. Here, we describe the use of acupoint delivery of nanovacc…
View article: Photodynamic therapy in esophageal cancer: trends, innovations, and future directions from a global perspective (1985–2024)
Photodynamic therapy in esophageal cancer: trends, innovations, and future directions from a global perspective (1985–2024) Open
This bibliometric study reveals a global expansion in PDT research for EC, emphasizing new directions such as nanotechnology-enhanced drug delivery, immunotherapy integration, and tumor microenvironment studies. These advancements are expe…
View article: Robust Accessibility of Addressable Sites in Defective DNA Origami
Robust Accessibility of Addressable Sites in Defective DNA Origami Open
Owing to its unique programmability and addressability, DNA origami-based nanofabrication has been widely utilized in fields such as nanomedicine and nanophotonics. The accessibility of addressable sites on DNA origami structures is crucia…
View article: DNA Logic-Integrated Quantum Nanosensor for MicroRNA Diagnostics
DNA Logic-Integrated Quantum Nanosensor for MicroRNA Diagnostics Open
Nanodiamonds (NDs) with nitrogen-vacancy (NV) centers are emerging as powerful quantum nanosensors (QNs) in biomedical applications due to their exceptional sensitivity. However, achieving optimal diagnostics performance necessitates both …
View article: Programming One‐Dimensional Open‐Channel Superlattices with Edge‐Bonding of Meta‐DNA
Programming One‐Dimensional Open‐Channel Superlattices with Edge‐Bonding of Meta‐DNA Open
The physicochemical properties of one‐dimensional (1D) porous nanomaterials are fundamentally influenced by their channel geometrical and topological characteristics. However, synthesis of geometrically and topologically diversified 1D por…
View article: Implementing complex nucleic acid circuits in living cells
Implementing complex nucleic acid circuits in living cells Open
Synthetic nucleic acid–based computing has demonstrated complex computational capabilities in vitro. However, translating these circuits into living cells remains challenging because of instability and cellular interference. We introduce a…
View article: DNA origami–enhanced force spectroscopy and AlphaFold structural analyses reveal the folding landscape of calcium-binding proteins
DNA origami–enhanced force spectroscopy and AlphaFold structural analyses reveal the folding landscape of calcium-binding proteins Open
Understanding the intricate folding process of proteins and characterizing the intermediates they populate en route to their native state remain challenging despite the remarkable accuracy achieved through in silico approaches for predicti…
View article: Proximity-activated DNA scanning encoded sequencing for massive access to membrane proteins nanoscale organization
Proximity-activated DNA scanning encoded sequencing for massive access to membrane proteins nanoscale organization Open
Cellular structure maintenance and function regulation critically depend on the composition and spatial distribution of numerous membrane proteins. However, current methods face limitations in spatial coverage and data scalability, hinderi…