Fang‐Hsuean Liao
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View article: Priming cell-degradable ubiquitination of Aβ42 with molecular crosstalk
Priming cell-degradable ubiquitination of Aβ42 with molecular crosstalk Open
Cell-degradable ubiquitin (Ub) linkages are crucial for breaking down abnormal proteins. However, K48-linked ubiquitination—a canonical Ub linkage driven by a Ub variant that becomes predominant with aging—impedes proteasome function, lead…
View article: Oxygen-Binding Sites of Enriched Gold Nanoclusters for Capturing Mitochondrial Reverse Electrons
Oxygen-Binding Sites of Enriched Gold Nanoclusters for Capturing Mitochondrial Reverse Electrons Open
Reverse electron transfer (RET), an abnormal backward flow of electrons from complexes III/IV to II/I of mitochondria, causes the overproduction of a reduced-type CoQ to boost downstream production of mitochondrial superoxide anions that l…
View article: Transdermal Delivery of Succinate Accelerates Energy Dissipation of Brown Adipocytes to Reduce Remote Fat Accumulation
Transdermal Delivery of Succinate Accelerates Energy Dissipation of Brown Adipocytes to Reduce Remote Fat Accumulation Open
Weight loss by increasing energy consumption of thermogenic adipocytes to overcome obesity remains a challenge. Herein, we established a transdermal device that was based on the local and temporarily controlled delivery of succinate (SC), …
View article: Ultra-Small Platinum Nanoparticle-Enabled Catalysis and Corrosion Susceptibility Reverse Tumor Hypoxia for Cancer Chemoimmunotherapy
Ultra-Small Platinum Nanoparticle-Enabled Catalysis and Corrosion Susceptibility Reverse Tumor Hypoxia for Cancer Chemoimmunotherapy Open
A major challenge in the use of chemotherapy and immunotherapy is hypoxia-induced progression of tumor cells. We aim to curb hypoxia using metal-based O2-producing nanomedicine. The key focus is therapeutic targeting of hypoxia-…
View article: The Bioactive Core and Corona Synergism of Quantized Gold Enables Slowed Inflammation and Increased Tissue Regeneration in Wound Hypoxia
The Bioactive Core and Corona Synergism of Quantized Gold Enables Slowed Inflammation and Increased Tissue Regeneration in Wound Hypoxia Open
The progress of wound regeneration relies on inflammation management, while neovascular angiogenesis is a critical aspect of wound healing. In this study, the bioactive core and corona synergism of quantized gold (QG) were developed to sim…
View article: Frontispiz: A Supramolecular Trap to Increase the Antibacterial Activity of Colistin
Frontispiz: A Supramolecular Trap to Increase the Antibacterial Activity of Colistin Open
Antibiotika Eine Gold-Nanoschicht bindet an Lipopolysaccharid (LPS) und verhindert so die Bindung von Colistin an freies LPS. Wie S. Y. Lin et al. in ihrer Zuschrift auf S. 1446 schildern, steigt dadurch die antibakterielle Wirkung von Col…
View article: Frontispiece: A Supramolecular Trap to Increase the Antibacterial Activity of Colistin
Frontispiece: A Supramolecular Trap to Increase the Antibacterial Activity of Colistin Open
Antibiotics A gold nanosheet binds to lipopolysaccharide (LPS), preventing free LPS from binding colistin. This increases the antibacterial efficacy of colistin, decreasing the required dose and the risk of resistance, as reported by S. Y.…
View article: A Supramolecular Trap to Increase the Antibacterial Activity of Colistin
A Supramolecular Trap to Increase the Antibacterial Activity of Colistin Open
A strong interaction between colistin, a last‐resort antibiotic of the polymyxin family, and free lipopolysaccharide (LPS, also referred to as endotoxin), released from the Gram‐negative bacterial (GNB) outer membrane (OM), has been identi…
View article: A Supramolecular Trap to Increase the Antibacterial Activity of Colistin
A Supramolecular Trap to Increase the Antibacterial Activity of Colistin Open
A strong interaction between colistin, a last‐resort antibiotic of the polymyxin family, and free lipopolysaccharide (LPS, also referred to as endotoxin), released from the Gram‐negative bacterial (GNB) outer membrane (OM), has been identi…
View article: Fatty Acids and Cardiometabolic Health
Fatty Acids and Cardiometabolic Health Open
The impact of fat intake on hypercholesterolemia and related atherosclerotic cardiovascular diseases has been studied for decades. However, the current evidence base suggests that fatty acids also influences cardiometabolic diseases throug…
View article: Medium-Chain Triglycerides Lower Blood Lipids and Body Weight in Streptozotocin-Induced Type 2 Diabetes Rats
Medium-Chain Triglycerides Lower Blood Lipids and Body Weight in Streptozotocin-Induced Type 2 Diabetes Rats Open
Medium-chain triglycerides (MCTs) are distinguished from other triglycerides in that each fat molecule consists of 6 to 12 carbons in length. MCTs and long-chain triglycerides (LCTs) are absorbed and utilized in different ways. The aim of …
View article: T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4
T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4 Open
The clonal expansion of activated T cells is pivotal for the induction of protective immunity. Protein phosphatase 4 (PP4) is a ubiquitously expressed serine/threonine phosphatase with reported functions in thymocyte development and DNA da…
View article: A Prebiotic Formula Improves the Gastrointestinal Bacterial Flora in Toddlers
A Prebiotic Formula Improves the Gastrointestinal Bacterial Flora in Toddlers Open
We aimed to investigate the effect of enriched 3-prebiotic formula (including inulin, fructooligosaccharides, and galactooligosaccharides) on toddler gut health by measuring fecal microbiota. Our results revealed that the consumption of 3-…
View article: Dual-Specificity Phosphatase 4 Regulates STAT5 Protein Stability and Helper T Cell Polarization*
Dual-Specificity Phosphatase 4 Regulates STAT5 Protein Stability and Helper T Cell Polarization* Open
Immune responses are critically regulated by the functions of CD4 helper T cells. Based on their secreted cytokines, helper T cells are further categorized into different subsets like Treg or Th17 cells, which suppress or promote inflammat…