Fang Yu
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View article: The Diagnostic and Progressive Value of Serum GSDMD in Patients with Heart Failure: A Retrospective Study
The Diagnostic and Progressive Value of Serum GSDMD in Patients with Heart Failure: A Retrospective Study Open
View article: The addition of EBV and C3 complement risk factors formed a better angioimmunoblastic T-cell lymphoma prognostic scoring system
The addition of EBV and C3 complement risk factors formed a better angioimmunoblastic T-cell lymphoma prognostic scoring system Open
Background: Angioimmunoblastic T-cell lymphoma (AITL), a distinct subtype of peripheral T-cell lymphoma (PTCL), exhibits unique clinical and pathological characteristics with poor prognosis. Primarily affecting elderly patients, AITL is ch…
View article: Optimizing Nitrogen Management in Acidic Tea Orchard Soils: The Role of Biochar-Based Fertilizers in Reducing Losses and Enhancing Sequestration
Optimizing Nitrogen Management in Acidic Tea Orchard Soils: The Role of Biochar-Based Fertilizers in Reducing Losses and Enhancing Sequestration Open
Biochar-based fertilizers have attracted increasing attention as sustainable soil amendments due to their potential to enhance nitrogen (N) retention and mitigate N losses. However, their effects on N dynamics in tea orchard soils remain i…
View article: Biodiversity assessment of Yunnan province based on the pressure-state-response model
Biodiversity assessment of Yunnan province based on the pressure-state-response model Open
Biodiversity is the foundation of human survival, and its accurate assessment is a prerequisite for effective conservation and sustainable use. Most studies only assessed the state of biodiversity, but lacked a comprehensive understanding …
View article: Protein lactylation of citrate synthase promotes the AKI-CKD transition by activating the NLRP3 inflammasome
Protein lactylation of citrate synthase promotes the AKI-CKD transition by activating the NLRP3 inflammasome Open
Interstitial renal inflammation contributes to the transition from acute kidney injury (AKI) to chronic kidney disease (CKD). Recently, lactylation modification has emerged as a mechanism for mediating chronic organ damage. We investigate …
View article: Predicting the Potential Geographical Distribution of Scolytus scolytus in China Using a Biomod2-Based Ensemble Model
Predicting the Potential Geographical Distribution of Scolytus scolytus in China Using a Biomod2-Based Ensemble Model Open
Dutch elm disease is one of the most devastating plant diseases, primarily spread through bark beetles. Scolytus scolytus is a key vector of this disease. In this study, distribution data of S. scolytus were collected and filtered. Combine…
View article: Calcium Channel Blockers Increased the Risk of Aortic Aneurysm and Dissection
Calcium Channel Blockers Increased the Risk of Aortic Aneurysm and Dissection Open
Aortic aneurysm and dissection (AAD) are life-threatening conditions for which there is a lack of effective pharmacological therapies. Hypertension is a known risk factor for AAD, leading to the common prescription of antihypertensive medi…
View article: Nimotuzumab combined with docetaxel and cisplatin as first-line treatment for patients with recurrent or metastatic nasopharyngeal carcinoma: a multicenter, phase 2 trial
Nimotuzumab combined with docetaxel and cisplatin as first-line treatment for patients with recurrent or metastatic nasopharyngeal carcinoma: a multicenter, phase 2 trial Open
View article: Mesencephalic astrocyte-derived neurotrophic factor upregulates CHOP and ATF6 in the rat retina with retinitis pigmentosa
Mesencephalic astrocyte-derived neurotrophic factor upregulates CHOP and ATF6 in the rat retina with retinitis pigmentosa Open
These results indicate that MANF may play an important role in protecting photoreceptor degeneration in RP.
View article: Ruxolitinib combined with dexamethasone for adult patients with newly diagnosed hemophagocytic lymphohistiocytosis in China
Ruxolitinib combined with dexamethasone for adult patients with newly diagnosed hemophagocytic lymphohistiocytosis in China Open
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome, and the overall survival (OS) of adult patients is poor. Ruxolitinib, a Janus kinase 1/2 (JAK1/2) inhibitor, has shown promise in treating HLH and exerts syne…
View article: Identification of blood-derived exosomal tumor RNA signatures as noninvasive diagnostic biomarkers for multi-cancer: a multi-phase, multi-center study
Identification of blood-derived exosomal tumor RNA signatures as noninvasive diagnostic biomarkers for multi-cancer: a multi-phase, multi-center study Open
View article: Tracheal carina reconstruction, fistula repair and esophageal reconstruction assisted by extra-corporeal membrane oxygenation for complex huge tracheoesophageal fistula: a case report
Tracheal carina reconstruction, fistula repair and esophageal reconstruction assisted by extra-corporeal membrane oxygenation for complex huge tracheoesophageal fistula: a case report Open
The "double-flaps of esophagus" method assisted by ECMO can be used as an effective surgical treatment for patients with complex tracheoesophageal fistula, and can significantly improve the prognosis of patients.
View article: Source-oriented health risk of heavy metals in sediments: A case study of an industrial city in China
Source-oriented health risk of heavy metals in sediments: A case study of an industrial city in China Open
The heavy metals (HMs) pollution caused by accelerated urbanization poses a significant risk to environmental and human health. Sediments, as an important component of aquatic ecosystems, have become a global environmental problem due to t…
View article: KRAS mutants confer platinum resistance by regulating ALKBH5 posttranslational modifications in lung cancer
KRAS mutants confer platinum resistance by regulating ALKBH5 posttranslational modifications in lung cancer Open
Constitutively active mutations of KRAS are prevalent in non-small cell lung cancer (NSCLC). However, the relationship between these mutations and resistance to platinum-based chemotherapy and the underlying mechanisms remain elusive. In t…
View article: MicroRNA Expression Profile in the Patient's Plasma Exosomes of Alcohol‐Induced Osteonecrosis of Femoral Head: Potential Vascular Regulation Mechanism
MicroRNA Expression Profile in the Patient's Plasma Exosomes of Alcohol‐Induced Osteonecrosis of Femoral Head: Potential Vascular Regulation Mechanism Open
The purpose of this study is to reveal the expression profile of microRNA (miRNA) in the plasma exosomes of patients with alcohol‐induced osteonecrosis of the femoral head (AIONFH), and to further explore the potential effect of alcohol‐st…
View article: Chromosome-level genome assembly of the pine wood nematode carrier Arhopalus unicolor
Chromosome-level genome assembly of the pine wood nematode carrier Arhopalus unicolor Open
Arhopalus unicolor is a carrier of the pine wood nematode (PWN), which causes pine wilt disease, killing pine trees and causing considerable economic and environmental losses. While the A. unicolor mitochondrial genome has been published, …
View article: Circumflex Scapular Artery Perforator Flap and Its Surgical Refinements in Soft Tissue Reconstruction for Various Regions of the Foot and Ankle in Pediatric Patients
Circumflex Scapular Artery Perforator Flap and Its Surgical Refinements in Soft Tissue Reconstruction for Various Regions of the Foot and Ankle in Pediatric Patients Open
Introduction Reconstruction for various regions of the foot and ankle in pediatric patients remains a challenging topic. This study presents the circumflex scapular artery perforator (CSAP) flap and its surgical refinements for addressing …
View article: E3 ubiquitin ligase TRIM2 identified as a novel suppressor of CYP11B2 and aldosterone production
E3 ubiquitin ligase TRIM2 identified as a novel suppressor of CYP11B2 and aldosterone production Open
Aldosterone-producing adenoma (APA) is a leading cause of primary aldosteronism (PA), a condition marked by excessive aldosterone secretion. CYP11B2, the aldosterone synthase, plays a critical role in aldosterone biosynthesis and the devel…
View article: The Impact of Different Regional Anesthesia Techniques on the Incidence of Chronic Post-surgical Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery: A Network Meta-analysis
The Impact of Different Regional Anesthesia Techniques on the Incidence of Chronic Post-surgical Pain in Patients Undergoing Video-Assisted Thoracoscopic Surgery: A Network Meta-analysis Open
PVB, ICNB, and TEA exhibit significant effects on reducing CPSP incidence following VATS. Conversely, SAPB is not recommended for reducing CPSP incidence post-VATS. Nonetheless, considering the limitation of a small sample size in this net…
View article: Special-form radial collateral artery perforator flaps for the reconstruction of complex hand defects
Special-form radial collateral artery perforator flaps for the reconstruction of complex hand defects Open
View article: Diffuse large B‐cell lymphoma with <scp><i>BRAF</i><sup>V600E</sup></scp> mutation mimicking thyroid carcinoma in fine‐needle aspiration: A diagnostic pitfall
Diffuse large B‐cell lymphoma with <span><i>BRAF</i><sup>V600E</sup></span> mutation mimicking thyroid carcinoma in fine‐needle aspiration: A diagnostic pitfall Open
Key Clinical Message We report a rare case of thyroid diffuse large B‐cell lymphoma with a BRAF V600E mutation, which mimics poorly differentiated thyroid cancer in fine needle aspiration cytology.
View article: Research Progress of Inflammatory Biomarkers in Patients with Post-stroke Cognitive Impairment
Research Progress of Inflammatory Biomarkers in Patients with Post-stroke Cognitive Impairment Open
Post-stroke cognitive impairment (PSCI) is a common complication of stroke, which seriously affects the quality of life of stroke survivors. Inflammatory response is considered to be an important link in the pathogenesis of PSCI. The neuro…
View article: Isoforms of MUC16 activate oncogenic signaling through EGF receptors to enhance the progression of pancreatic cancer
Isoforms of MUC16 activate oncogenic signaling through EGF receptors to enhance the progression of pancreatic cancer Open
View article: JR14a: A novel antagonist of C3aR attenuates neuroinflammation in cerebral ischemia-reperfusion injury
JR14a: A novel antagonist of C3aR attenuates neuroinflammation in cerebral ischemia-reperfusion injury Open
Cerebral ischemia-reperfusion injury (CIRI), a prevalent stroke-related complication, can lead to severe brain damage. Inflammation is a crucial factor in CIRI pathogenesis, and the complement component 3a receptor (C3aR) could be a key me…
View article: Individualized design program of multiple flaps for adapting different zones to repair large irregular wounds in children
Individualized design program of multiple flaps for adapting different zones to repair large irregular wounds in children Open
III, Retrospective.
View article: Establishment of a prognostic model for gastric cancer patients who underwent radical gastrectomy using machine learning: a two-center study
Establishment of a prognostic model for gastric cancer patients who underwent radical gastrectomy using machine learning: a two-center study Open
Objective Gastric cancer is a prevalent gastrointestinal malignancy worldwide. In this study, a prognostic model was developed for gastric cancer patients who underwent radical gastrectomy using machine learning, employing advanced computa…
View article: Integrative Single Cell Atlas Revealed Intratumoral Heterogeneity Generation from an Adaptive Epigenetic Cell State in Human Bladder Urothelial Carcinoma
Integrative Single Cell Atlas Revealed Intratumoral Heterogeneity Generation from an Adaptive Epigenetic Cell State in Human Bladder Urothelial Carcinoma Open
Intratumor heterogeneity (ITH) of bladder cancer (BLCA) contributes to therapy resistance and immune evasion affecting clinical prognosis. The molecular and cellular mechanisms contributing to BLCA ITH generation remain elusive. It is foun…
View article: Exploring the complex trade-offs and synergies of global ecosystem services
Exploring the complex trade-offs and synergies of global ecosystem services Open
View article: Molecular mechanism of Xuebijing in treating pyogenic liver abscess complicated with sepsis
Molecular mechanism of Xuebijing in treating pyogenic liver abscess complicated with sepsis Open
XBJ may exert therapeutic effects on PLA complicated with sepsis by modulating signaling pathways, such as the IL-17, TNF, NF-κB, and TLR pathways, and targeting IL-1β, IL-6, and TNF.
View article: Comparison of Machine Learning and Logic Regression Algorithms for Predicting Lymph Node Metastasis in Patients with Gastric Cancer: A two-Center Study
Comparison of Machine Learning and Logic Regression Algorithms for Predicting Lymph Node Metastasis in Patients with Gastric Cancer: A two-Center Study Open
Objectives This two-center study aimed to establish a model for predicting the risk of lymph node metastasis in gastric cancer patients using machine learning (ML) and logistic regression (LR) algorithms, and to evaluate its predictive per…