Yi Fan
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View article: Multimodal Neuroimaging Insights into Central Mechanisms of Overactive Bladder with an Empty Bladder: A Cross-Sectional Study
Multimodal Neuroimaging Insights into Central Mechanisms of Overactive Bladder with an Empty Bladder: A Cross-Sectional Study Open
Background and objective: Overactive bladder (OAB) is a complex condition involving central nervous system (CNS) processes that are not fully understood. We conducted a detailed neuroimaging study to investigate the CNS role in OAB, focusi…
View article: Role of Netrin-1 dysregulation in early neuronal pathology of α-synuclein models of Parkinson’s disease
Role of Netrin-1 dysregulation in early neuronal pathology of α-synuclein models of Parkinson’s disease Open
α-Syn-induced NTN1 reduction exacerbates early PD pathology by impairing axonal and synaptic integrity, while NTN1 restoration mitigates these effects, suggesting therapeutic potential. These findings emphasize axon guidance pathways as ke…
View article: Perspectives of nurses and patients on the misplacement of supportive care information for type 2 diabetes mellitus: a qualitative study in China
Perspectives of nurses and patients on the misplacement of supportive care information for type 2 diabetes mellitus: a qualitative study in China Open
It was essential for patients and nurses to enhance access to information and establish a robust information support framework. In addition to improving the information support capabilities of nurses, it was equally important to enhance pa…
View article: Protein O-GlcNAcylation coupled to Hippo signaling drives vascular dysfunction in diabetic retinopathy
Protein O-GlcNAcylation coupled to Hippo signaling drives vascular dysfunction in diabetic retinopathy Open
Metabolic disorder significantly contributes to diabetic vascular complications, including diabetic retinopathy, the leading cause of blindness in the working-age population. However, the molecular mechanisms by which disturbed metabolic h…
View article: Association between plasma Netrin‐1 levels and motor and nonmotor symptoms in Parkinson's disease
Association between plasma Netrin‐1 levels and motor and nonmotor symptoms in Parkinson's disease Open
Background Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by dopaminergic neuron degeneration and diverse motor and nonmotor symptoms. Early diagnosis and intervention are crucial but challenging due to re…
View article: Antagonism of β-arrestins in IL-4–driven microglia reactivity via the Samd4/mTOR/OXPHOS axis in Parkinson’s disease
Antagonism of β-arrestins in IL-4–driven microglia reactivity via the Samd4/mTOR/OXPHOS axis in Parkinson’s disease Open
Interleukin-4 (IL-4)–exposed microglia acquire neuroprotective properties, but their functions and regulation in Parkinson’s disease (PD) are poorly understood. In this study, we demonstrate that IL-4 enhances anti-inflammatory microglia r…
View article: Phosphorylated α-synuclein deposited in Schwann cells interacting with TLR2 mediates cell damage and induces Parkinson’s disease autonomic dysfunction
Phosphorylated α-synuclein deposited in Schwann cells interacting with TLR2 mediates cell damage and induces Parkinson’s disease autonomic dysfunction Open
Despite the significant frequency of autonomic dysfunction (AutD) in Parkinson’s disease (PD) patients, its pathogenesis and diagnosis are challenging. Here, we aimed to further explore the mechanism of phosphorylated α-synuclein (p-α-syn)…
View article: Locus Coeruleus‐Dorsolateral Septum Projections Modulate Depression‐Like Behaviors via BDNF But Not Norepinephrine
Locus Coeruleus‐Dorsolateral Septum Projections Modulate Depression‐Like Behaviors via BDNF But Not Norepinephrine Open
Locus coeruleus (LC) dysfunction is involved in the pathophysiology of depression; however, the neural circuits and specific molecular mechanisms responsible for this dysfunction remain unclear. Here, it is shown that activation of tyrosin…
View article: A comparative study of muscle nutrition and intermuscular bone number in improved diploid carp
A comparative study of muscle nutrition and intermuscular bone number in improved diploid carp Open
The common carp (Cyprinus carpio L., COC, 2n = 100) is one of the most widely consumed and distributed freshwater fish in the world. It ranks fourth in total freshwater aquaculture volume in various regions of China, behind Ctenopharyngodo…
View article: PB2694: EFFECT OF NARRATIVE NURSING ON ANXIETY, DEPRESSION AND STIGMA IN PATIENTS AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION
PB2694: EFFECT OF NARRATIVE NURSING ON ANXIETY, DEPRESSION AND STIGMA IN PATIENTS AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION Open
Topic: 35. Quality of life and palliative care Background: Allogeneic hematopoietic stem cell transplantation is an effective method for the treatment of hematological malignancies or non-malignant blood diseases. Hematopoietic stem cell t…
View article: An imbalance of netrin‐1 and <scp>DCC</scp> during nigral degeneration in experimental models and patients with Parkinson's disease
An imbalance of netrin‐1 and <span>DCC</span> during nigral degeneration in experimental models and patients with Parkinson's disease Open
Aims Multiple guidance cues, such as netrin‐1 (NTN‐1)/deleted in colorectal carcinoma (DCC), control the guidance of axons and help establish functional neural circuits during development. However, the function of these guidance molecules …
View article: An imbalance of netrin-1 and DCC during nigral degeneration in experimental models and patients with Parkinson's disease
An imbalance of netrin-1 and DCC during nigral degeneration in experimental models and patients with Parkinson's disease Open
Multiple guidance cues, such as netrin-1 (NTN-1)/deleted in colorectal carcinoma (DCC), control the guidance of axons and help establish functional neural circuits during development. However, the function of these guidance molecules in th…
View article: Evidence mapping of clinical practice guidelines recommendations and quality for depression in children and adolescents
Evidence mapping of clinical practice guidelines recommendations and quality for depression in children and adolescents Open
This study systematically reviewed the clinical practice guidelines (CPGs) for depression in children and adolescents and assessed the quality and recommendation consistency of those CPGs. Evidence mapping was presented to illustrate the r…
View article: α‐synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson’s disease
α‐synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson’s disease Open
The cell‐to‐cell transfer of α‐synuclein (α‐Syn) greatly contributes to Parkinson's disease (PD) pathogenesis and underlies the spread of α‐Syn pathology. During this process, extracellular α‐Syn can activate microglia and neuroinflammatio…
View article: Phosphorylated α-synuclein aggregated in Schwann cells exacerbates peripheral neuroinflammation and nerve dysfunction in Parkinson’s disease through TLR2/NF-κB pathway
Phosphorylated α-synuclein aggregated in Schwann cells exacerbates peripheral neuroinflammation and nerve dysfunction in Parkinson’s disease through TLR2/NF-κB pathway Open
To investigate the mechanism of peripheral neuropathy in Parkinson’s disease (PD), we prepared a PD mice model by long-term exposure of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to mimic PD pathology in humans and the sciatic ner…
View article: Activation of α7-nAChRs Promotes the Clearance of α-Synuclein and Protects Against Apoptotic Cell Death Induced by Exogenous α-Synuclein Fibrils
Activation of α7-nAChRs Promotes the Clearance of α-Synuclein and Protects Against Apoptotic Cell Death Induced by Exogenous α-Synuclein Fibrils Open
Misfolding and abnormal aggregation of α-synuclein (αSyn) have been shown to increase the risk of developing Parkinson's disease (PD). Finding some way to reduce the aggregation of αSyn is particularly important for the treatment of PD. Th…
View article: Minocycline Promotes Functional Recovery in Ischemic Stroke by Modulating Microglia Polarization Through STAT1/STAT6 Pathways
Minocycline Promotes Functional Recovery in Ischemic Stroke by Modulating Microglia Polarization Through STAT1/STAT6 Pathways Open
BackgroundIncreasing evidence suggests that microglia experience two distinct phenotypes after acute ischemic stroke (AIS): a deleterious M1 phenotype and a neuroprotective M2 phenotype. Promoting the phenotype shift of M1 microglia to M2 …
View article: Prognostic value of baseline hemoglobin‐to‐red blood cell distribution width ratio in small cell lung cancer: A retrospective analysis
Prognostic value of baseline hemoglobin‐to‐red blood cell distribution width ratio in small cell lung cancer: A retrospective analysis Open
Background This study aimed to investigate the prognostic value of baseline hemoglobin‐to‐red blood cell distribution width ratio (HRR) in patients with small cell lung cancer (SCLC). Methods We retrospectively analyzed the medical records…
View article: Activation of α7 Nicotinic Acetylcholine Receptor Protects Against 1-Methyl-4-Phenylpyridinium-Induced Astroglial Apoptosis
Activation of α7 Nicotinic Acetylcholine Receptor Protects Against 1-Methyl-4-Phenylpyridinium-Induced Astroglial Apoptosis Open
Astrocytes, as the largest population of glial subtype, play crucial roles in normal brain function and pathological conditions, such as Parkinson's disease (PD). Restoring the functions of astrocyte is a promising new therapeutic target f…
View article: Specific TBC Domain-Containing Proteins Control the ER-Golgi-Plasma Membrane Trafficking of GPCRs
Specific TBC Domain-Containing Proteins Control the ER-Golgi-Plasma Membrane Trafficking of GPCRs Open
Summary: G-protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface signaling proteins. However, the molecular mechanisms underlying their cell surface delivery after synthesis remain poorly understood. Here, we…
View article: [Meta-analysis of Platelet Lymphocyte Ratio as A Prognostic Factor for
Non-small Cell Lung Cancer].
[Meta-analysis of Platelet Lymphocyte Ratio as A Prognostic Factor for
Non-small Cell Lung Cancer]. Open
Increased PLR is associated with poor prognosis in NSCLC, so PLR may be an important biological predictive marker for NSCLC patients, however, its clinical application still needs to be verified through more research in the future.
View article: Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease
Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease Open
This study gives us an insight into the direct linkage between liver inflammation and DA neuron damage in the pathogenesis of PD and provides the potential target of NLRP3 for developing novel drugs for PD therapy.
View article: Aquaporin‐4 knockout mice exhibit increased hypnotic susceptibility to ketamine
Aquaporin‐4 knockout mice exhibit increased hypnotic susceptibility to ketamine Open
Purpose This study examines anesthetic/hypnotic effects of ketamine in AQP 4 knockout ( KO ) and wild‐type ( WT ) mice with the particular focus on neurotransmission. Materials and Methods Ketamine (100 mg/kg) was intraperitoneally injecte…
View article: Ginkgo biloba extract promoted the astrocyte-mediated clearance of intercellular alpha-Syn via autophagy and proteasome pathway
Ginkgo biloba extract promoted the astrocyte-mediated clearance of intercellular alpha-Syn via autophagy and proteasome pathway Open
Background: The accumulation of aggregated forms of the alpha-Synuclein (alpha-Syn) is associated with the pathogenesis of Parkinson's disease (PD). Increasing evidences have shown the protective effects of Ginkgo biloba extract (GBE) on m…