Fangjun Chen
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View article: Predictive and prognostic value of genetic aberrations of EGFR-TKI treatment: a real-world analysis of EGFR-mutant non-small cell lung cancer
Predictive and prognostic value of genetic aberrations of EGFR-TKI treatment: a real-world analysis of EGFR-mutant non-small cell lung cancer Open
This study identified key biomarkers associated with the efficacy of EGFR-TKIs and survival in patients with EGFRm NSCLC, thereby providing new insights for personalized therapeutic strategies based on genetic risk stratification.
View article: Identification of the Chenopodium quinoa HSP90 Gene Family and Functional Analysis of CqHSP90.1c and CqHSP90.6a Under High-Temperature Stress in Transgenic Arabidopsis thaliana
Identification of the Chenopodium quinoa HSP90 Gene Family and Functional Analysis of CqHSP90.1c and CqHSP90.6a Under High-Temperature Stress in Transgenic Arabidopsis thaliana Open
Heat shock protein 90 (HSP90) is an evolutionarily conserved molecular chaperone. Numerous studies have shown that it is widely involved in protein folding, assembly, stabilization, activation, and degradation in response to various biotic…
View article: The Relationship Between Hypothyroidism and Pneumonia and Possible Prevention and Treatment Measures
The Relationship Between Hypothyroidism and Pneumonia and Possible Prevention and Treatment Measures Open
Hypothyroidism may elevate the risk of pneumonia, highlighting the need for preventive measures among hypothyroid patients, such as increasing walking pace. Additionally, garcinol shows potential therapeutic effects for pneumonia managemen…
View article: Pan-cancer analysis reveals PRRT4 is a potential prognostic factor of AML
Pan-cancer analysis reveals PRRT4 is a potential prognostic factor of AML Open
PRRT4 may serve as a potential therapeutic target and prognostic marker for various malignancies.
View article: Tanshinone IIA affects the proliferation of A549/Tax by affecting the expression of MMP7 through the PI3K-AKT-mTOR signaling pathway
Tanshinone IIA affects the proliferation of A549/Tax by affecting the expression of MMP7 through the PI3K-AKT-mTOR signaling pathway Open
View article: Comprehensive pan-cancer analysis of HSPG2 as a marker for prognosis
Comprehensive pan-cancer analysis of HSPG2 as a marker for prognosis Open
View article: FAM65A promotes the progression and growth of lung squamous cell carcinoma in vivo and vitro
FAM65A promotes the progression and growth of lung squamous cell carcinoma in vivo and vitro Open
View article: Different treatment modalities on the prognosis of patients with stage I–IIIa small cell lung cancer: a population based study
Different treatment modalities on the prognosis of patients with stage I–IIIa small cell lung cancer: a population based study Open
For stage II-IIIa SCLC patients, lobectomy might have similar efficacy to chemoradiotherapy in improving LCSS and OS, and there is no need for adjuvant chemotherapy ± radiotherapy after surgery. For stage I SCLC patients, lobectomy plus po…
View article: Exploring the link between walking and lung cancer risk: a two-stage Mendelian randomization analysis
Exploring the link between walking and lung cancer risk: a two-stage Mendelian randomization analysis Open
View article: Establishment of a novel tumor neoantigen prediction tool for personalized vaccine design
Establishment of a novel tumor neoantigen prediction tool for personalized vaccine design Open
The personalized neoantigen nanovaccine (PNVAC) platform for patients with gastric cancer we established previously exhibited promising anti-tumor immunoreaction. However, limited by the ability of traditional neoantigen prediction tools, …
View article: Sinus metastasis of lung adenocarcinoma: a case report
Sinus metastasis of lung adenocarcinoma: a case report Open
Metastatic carcinoma of the paranasal sinuses in lung cancer is an extremely uncommon condition. We report here a 57-year-old female patient with epidermal growth factor receptor (EGFR)-positive stage IV non-small cell lung cancer (NSCLC) …
View article: The Relationship between Hypothyroidism and Pneumonia and Possible Prevention and Treatment Measures: A Comprehensive Analysis of NHANES, Mendelian Randomization, and Network Pharmacology
The Relationship between Hypothyroidism and Pneumonia and Possible Prevention and Treatment Measures: A Comprehensive Analysis of NHANES, Mendelian Randomization, and Network Pharmacology Open
View article: Comparative Analysis of Six Chloroplast Genomes in Chenopodium and Its Related Genera (Amaranthaceae): New Insights into Phylogenetic Relationships and the Development of Species-Specific Molecular Markers
Comparative Analysis of Six Chloroplast Genomes in Chenopodium and Its Related Genera (Amaranthaceae): New Insights into Phylogenetic Relationships and the Development of Species-Specific Molecular Markers Open
Species within the genus Chenopodium hold significant research interest due to their nutritional richness and salt tolerance. However, the morphological similarities among closely related species and a dearth of genomic resources have impe…
View article: The value of folate receptor-positive circulating tumour cells as a diagnostic biomarker for lung cancer: a systematic review and meta-analysis
The value of folate receptor-positive circulating tumour cells as a diagnostic biomarker for lung cancer: a systematic review and meta-analysis Open
Objective To conduct a systematic review and meta-analysis evaluating the diagnostic value of folate receptor-positive (FR+) circulating tumour cells (CTCs) as a potential tumour marker for lung cancer diagnosis. Methods The PubMed, Embase…
View article: Long-term survival and development of chronic graft dysfunction after donor lung perfusion repair in isolated lungs-a meta-analysis
Long-term survival and development of chronic graft dysfunction after donor lung perfusion repair in isolated lungs-a meta-analysis Open
Background EVLP is deemed successful in enhancing the pool of candidates for lung transplantation subject to a reevaluation of the donor lung’s physiological and biological performance, in addition to an increased preservation period, and …
View article: The value of Folate Receptor–Positive Circulating Tumor Cell as a diagnostic biomarker for lung cancer: a meta-analysis and system review
The value of Folate Receptor–Positive Circulating Tumor Cell as a diagnostic biomarker for lung cancer: a meta-analysis and system review Open
View article: Testing the generalizability of cfDNA fragmentomic features across different studies for cancer early detection
Testing the generalizability of cfDNA fragmentomic features across different studies for cancer early detection Open
cfDNA fragmentomic features have been used in cancer detection models; however, the generalizability of the models needs to be tested. We proposed a type of cfDNA fragmentomic feature named chromosomal arm-level fragment size distribution …
View article: Preoperative neutrophil-to-lymphocyte predicts the prognosis of stage I non-small cell lung cancer
Preoperative neutrophil-to-lymphocyte predicts the prognosis of stage I non-small cell lung cancer Open
Objective To investigate the correlation of neutrophil-to-lymphocyte ratios (NLR) with prognosis of stage I non-small cell lung cancer (NSCLC). Methods. Clinical data from 567 stage I NSCLC patients who received surgical treatment in our h…
View article: Individualised adjuvant immunotherapy with neoantigen‐reactive T cells for gastric signet‐ring cell carcinoma
Individualised adjuvant immunotherapy with neoantigen‐reactive T cells for gastric signet‐ring cell carcinoma Open
Objectives The signet‐ring cell carcinoma (SRCC) of the stomach is highly invasive. Patients with stage III gastric SRCC usually experience tumor recurrence within 2 years after radical surgery. Unfortunately, there is no effective treatme…
View article: Benefits of an Immunogenic Personalized Neoantigen Nanovaccine in Patients with High‐Risk Gastric/Gastroesophageal Junction Cancer (Adv. Sci. 1/2023)
Benefits of an Immunogenic Personalized Neoantigen Nanovaccine in Patients with High‐Risk Gastric/Gastroesophageal Junction Cancer (Adv. Sci. 1/2023) Open
Nanovaccine In article number 2203298, Baorui Liu, Jia Wei, and co‐workers prepare a personalized neoantigen nanovaccine (PNVAC) which spatially displays impressively enhanced lymph nodes trafficking capacity, and functionally induces more…
View article: Benefits of an Immunogenic Personalized Neoantigen Nanovaccine in Patients with High‐Risk Gastric/Gastroesophageal Junction Cancer
Benefits of an Immunogenic Personalized Neoantigen Nanovaccine in Patients with High‐Risk Gastric/Gastroesophageal Junction Cancer Open
Personalized neoantigen vaccines have shown strong immunogenicity in clinical trial, but still face various challenges in facilitating an efficient antitumor immune response. Here, a personalized neoantigen nanovaccine (PNVAC) platform for…
View article: Antigen-Specific T Cell Immunotherapy Targeting Claudin18.2 in Gastric Cancer
Antigen-Specific T Cell Immunotherapy Targeting Claudin18.2 in Gastric Cancer Open
T cell-based immunotherapy has led to many breakthroughs in the treatment of solid tumors. In this study, we found that membrane protein Claudin18.2 was a promising antigen in T cell-based immunotherapy for gastric cancer (GC). Firstly, we…
View article: Benefits of an immunogenic personalized neoantigen nanovaccine in patients with high-risk gastric/gastroesophageal junction cancer
Benefits of an immunogenic personalized neoantigen nanovaccine in patients with high-risk gastric/gastroesophageal junction cancer Open
Personalized neoantigen vaccines have shown strong immunogenicity in clinical trial, but still face various challenges in facilitating an efficient antitumour immune response. Here we prepared a personalized neoantigen nanovaccine (PNVAC) …
View article: Advanced HCC Patient Benefit From Neoantigen Reactive T Cells Based Immunotherapy: A Case Report
Advanced HCC Patient Benefit From Neoantigen Reactive T Cells Based Immunotherapy: A Case Report Open
Advanced hepatocellular carcinoma (HCC) is a highly lethal disease, mainly due to the late stage at diagnosis and its rapid progression. Although patients with advanced HCC can choose targeted therapy or chemotherapy, overall, the treatmen…
View article: <p>Immune-Mediated Antitumor Effect By VEGFR2 Selective Inhibitor For Gastric Cancer</p>
Immune-Mediated Antitumor Effect By VEGFR2 Selective Inhibitor For Gastric Cancer Open
Our results indicate that YN968D1 can enhance the T cell-mediated antitumor immunity.
View article: iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer
iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer Open
View article: Cancer-Testis Antigen Peptide Vaccine for Cancer Immunotherapy: Progress and Prospects
Cancer-Testis Antigen Peptide Vaccine for Cancer Immunotherapy: Progress and Prospects Open
View article: Correction: HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression
Correction: HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression Open
[This corrects the article DOI: 10.18632/oncotarget.21195.].
View article: Neoantigen identification strategies enable personalized immunotherapy in refractory solid tumors
Neoantigen identification strategies enable personalized immunotherapy in refractory solid tumors Open
This work was funded by grants from the National Key Research and Development Program of China (Grant No. 2017YFC1308900), the National Major Projects for "Major New Drugs Innovation and Development" (Grant No.2018ZX09301048-003), the Nati…
View article: Unraveling the Novel Protective Effect of Patchouli Alcohol Against Helicobacter pylori-Induced Gastritis: Insights Into the Molecular Mechanism in vitro and in vivo
Unraveling the Novel Protective Effect of Patchouli Alcohol Against Helicobacter pylori-Induced Gastritis: Insights Into the Molecular Mechanism in vitro and in vivo Open
Patchouli alcohol (PA), a natural tricyclic sesquiterpene extracted from Pogostemon cablin (Blanco) Benth. (Labiatae), has been found to exhibit anti-Helicobacter pylori and anti-inflammatory properties. In this study, we inv…