Fanglei Ye
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View article: Construction and validation of an anoikis-related long non-coding RNA-based prognostic model for head and neck squamous cell carcinoma
Construction and validation of an anoikis-related long non-coding RNA-based prognostic model for head and neck squamous cell carcinoma Open
Overall, we successfully established a novel prognostic model based on ARLncs, which holds significant promise for predicting prognosis and personalized therapy for patients with HNSCC.
View article: [Effects of cochlear implantation on vestibular function in patients with large vestibular aqueduct syndrome].
[Effects of cochlear implantation on vestibular function in patients with large vestibular aqueduct syndrome]. Open
Objective:This study aimed to compare the effects of cochlear implantation（CI） on vestibular function in patients with large vestibular aqueduct syndrome（LVAS） and in patients with extremely severe deafness with normal inner ear structure.…
View article: Clinical practice guidelines for gene therapy to treat hereditary hearing loss
Clinical practice guidelines for gene therapy to treat hereditary hearing loss Open
Hereditary deafness is a common neurosensory disorder, and 148 non‐syndromic deafness genes have been identified to date. Gene therapy has been used to treat a variety of genetic diseases, but no gene therapy drug for hereditary deafness h…
Identification of an immune-related signature as a prognostic classifier for patients with early-stage head and neck squamous cell carcinoma Open
Our novel IRGS is a reliable and robust classifier for accurate patient stratification and prognostic evaluation. Future studies will attempt to affirm the signature's clinical application to early-stage HNSCC.
Piezoelectric biomaterials for neural tissue engineering Open
Nerve injury caused by trauma or iatrogenic trauma can lead to loss of sensory and motor function, resulting in paralysis of patients. Inspired by endogenous bioelectricity and extracellular matrix, various external physical and chemical s…
Mitochondrial dysfunction in hearing loss: Oxidative stress, autophagy and NLRP3 inflammasome Open
Sensorineural deafness becomes an inevitable worldwide healthy problem, yet the current curative therapy is limited. Emerging evidences demonstrate mitochondrial dysfunction plays a vital role of in the pathogenesis of deafness. Reactive o…
Advances in nerve guidance conduits for peripheral nerve repair and regeneration. Open
Peripheral nerve injury (PNI) can cause partial or total motor and sensory nerve function, leading to physical disability and nerve pain that severely affects patients' quality of life. Autologous nerve transplantation is currently the cli…
Circular RNA ciRS-7 promotes laryngeal squamous cell carcinoma development by inducing TGM3 hypermethylation via miR-432–5p/DNMT3B axis Open
ciRS-7 promotes the progression of LSCC through increasing TGM3 methylation via miR-432-5p/DNMT3B axis.
Genome-wide methylation profiling identify hypermethylated HOXL subclass genes as potential markers for esophageal squamous cell carcinoma detection Open
Background： Numerous studies have revealed aberrant DNA methylation in esophageal squamous cell carcinoma (ESCC). However, they often focused on the partial genome, which resulted in an inadequate understanding of the shaped methylation fe…
Genome-wide methylation profiling identify hypermethylated HOXL subclass genes as potential markers for esophageal squamous cell carcinoma detection Open
Background Numerous studies have revealed aberrant DNA methylation in esophageal squamous cell carcinoma (ESCC). However, they often focused on the partial genome, which resulted in an inadequate understanding of the shaped methylation fea…
Association Between the Number of Intratympanic Steroid Injections and Hearing Recovery in Sudden Sensorineural Hearing Loss Open
The frequency of intratympanic (IT) steroid injection varies from once daily to once weekly or less among studies and does not reach a uniform standard. This study investigated the potential association between the number of IT steroid inj…
Association Between Hearing Characteristics/Prognosis and Vestibular Function in Sudden Sensorineural Hearing Loss With Vertigo Open
Sudden sensorineural hearing loss (SSNHL) patients with vertigo have a poorer prognosis. However, the factors associated with hearing recovery remain uncertain. This retrospective study was to evaluate the association between hearing chara…
View article: A rare case of salivary gland choristoma in the middle ear with pharyngeal hamartoma
A rare case of salivary gland choristoma in the middle ear with pharyngeal hamartoma Open
To the Editor: Salivary gland choristoma of the middle ear is a normal salivary gland tissue located in the middle ear. It is a benign and slow growing neoplasm that usually involves the ossicular chain and facial nerve,[1,2] and most of t…
Specific clinical and immune features of CD68 in glioma via 1,024 samples Open
Our results demonstrated that CD68 acted as an immune suppressor and contributed to glioma progression in the tumor microenvironment. These findings may expand our understanding of CD68-specific clinical and immune features in glioma.