Fanglin Liu
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View article: Metabolic profiling and pharmacological evaluation of alkaloids in three Murraya species
Metabolic profiling and pharmacological evaluation of alkaloids in three Murraya species Open
This study comprehensively investigated the metabolic profiling, pharmacological potential, and biosynthetic regulation of alkaloids in three Murraya species ( M. exotica , M. kwangsiensis , and M. tetramera ). Through integrative multi-om…
View article: Scutellarin suppresses Mycobacterium tuberculosis-induced pyroptosis in macrophages by inhibiting the HIF-1α-mediated Warburg effect
Scutellarin suppresses Mycobacterium tuberculosis-induced pyroptosis in macrophages by inhibiting the HIF-1α-mediated Warburg effect Open
SCU alleviates Mtb-induced pyroptosis and inflammation in macrophages by inhibiting the HIF-1α-mediated Warburg effect.
View article: A ventral hippocampus-basolateral amygdala circuit regulates the unconditioned stimulus retrieval-induced reconsolidation of remote fear memory
A ventral hippocampus-basolateral amygdala circuit regulates the unconditioned stimulus retrieval-induced reconsolidation of remote fear memory Open
Our findings suggest that the vCA1-BLA circuit becomes increasingly important for remote fear memory reconsolidation, particularly induced by US retrieval. This study highlights the potential for targeting specific circuits involved in rec…
View article: Animal acoustic identification, denoising and source separation using generative adversarial networks
Animal acoustic identification, denoising and source separation using generative adversarial networks Open
Soundscapes contain rich ecological information, offering insights into both biodiversity and ecosystem dynamics. However, the sheer volume of data produced by passive acoustic monitoring presents significant challenges for scalable analys…
View article: Clinical Application of 'Flying Needle' Painless Phlebotomy Technology
Clinical Application of 'Flying Needle' Painless Phlebotomy Technology Open
"Flying Needle" painless phlebotomy was explored in a comparative study on 600 outpatients in Xiamen Humanity Hospital from September to December The patients were randomly divided into experimental and control groups. The experimental gro…
View article: Comparative nutrient profiling of three Murraya species through combined metabolomic and transcriptomic analyses
Comparative nutrient profiling of three Murraya species through combined metabolomic and transcriptomic analyses Open
Murraya, a valuable plant resource, plays a critical role in medicine, industry, and landscaping. Despite its significance, research on Murraya, as well as its development and utilization, remains limited. Therefore, investigating the meta…
View article: Honeybee colony soundscapes: Decoding distance-based cues and environmental stressors
Honeybee colony soundscapes: Decoding distance-based cues and environmental stressors Open
Honey bees play a crucial role in agricultural productivity and ecological stability, yet their interactions with environmental stressors, particularly volatile organic compounds (VOCs) and pollutants, pose significant challenges to their …
View article: Social–Ecological Factors and Ecosystem Service Trade-Offs/Synergies in Vegetation Change Zones of Qilian Mountain National Park During 2000–2020
Social–Ecological Factors and Ecosystem Service Trade-Offs/Synergies in Vegetation Change Zones of Qilian Mountain National Park During 2000–2020 Open
An ecological restoration assessment aims to evaluate whether ecological restoration projects (ERPs) have achieved predefined ecological objectives, such as improving fractional vegetation cover (FVC) and enhancing ecosystem services (ESs)…
View article: Decoding the Chloroplast Genome of Bitterwood (<i>Picrasma quassioides</i>): Structure, Variability, and Evolutionary Relationships
Decoding the Chloroplast Genome of Bitterwood (<i>Picrasma quassioides</i>): Structure, Variability, and Evolutionary Relationships Open
The chloroplast genome of Picrasma quassioides , a medicinally significant plant in traditional Asian medicine, was sequenced and analyzed to understand its genetic architecture and evolutionary relationships within Simaroubaceae. High‐thr…
View article: Saikosaponin A targets HDAC6 to inhibit Mycobacterium tuberculosis-induced macrophage Pyroptosis via autophagy-mediated NLRP3 inflammasome inactivation
Saikosaponin A targets HDAC6 to inhibit Mycobacterium tuberculosis-induced macrophage Pyroptosis via autophagy-mediated NLRP3 inflammasome inactivation Open
SSA targets HDAC6 and exerts an immunomodulatory effect, highlighting its potential as a promising novel host-directed anti-tuberculosis agent.
View article: Construction of Hierarchically Porous Metal‐Organic Frameworks via A Novel Metal Ion‐Modulation Approach: A Complementary Approach to Linker‐Modulation
Construction of Hierarchically Porous Metal‐Organic Frameworks via A Novel Metal Ion‐Modulation Approach: A Complementary Approach to Linker‐Modulation Open
Hierarchically porous metal‐organic frameworks (HP‐MOFs) always present novel and advanced performances in many applications. Herein, we demonstrated a novel mechanochemical metal modulation strategy to construct the HP‐MOFs. The metal mod…
View article: A synonymous mutation of rs1137070 cause the mice Maoa gene transcription and translation to decrease
A synonymous mutation of rs1137070 cause the mice Maoa gene transcription and translation to decrease Open
The Monoamine Oxidase-A ( MAOA ) EcoRV polymorphism (rs1137070) is a unique synonymous mutation (c.1409 T > C) within the MAOA gene, which plays a crucial role in Maoa gene expression and function. This study aimed to explore the relati…
View article: Antiviral effect of the viroporin inhibitors against Taiwan isolates of infectious bronchitis virus (IBV)
Antiviral effect of the viroporin inhibitors against Taiwan isolates of infectious bronchitis virus (IBV) Open
Coronaviruses (CoVs) are significant animal and human pathogens, characterized by being enveloped RNA viruses with positive-sense single-stranded RNA. The Coronaviridae family encompasses four genera, among which gammacoronaviruses pose a …
View article: Identifying foraging spatial cues in beehive sound activity using machine learning methods
Identifying foraging spatial cues in beehive sound activity using machine learning methods Open
The beehive sound, a continuous signal produced by bees within the hive, has been found to correlate with different behavioral states of the colony, like being queenless and swarming. We investigated the possibility of identifying foraging…
View article: The chain mediating effect of spiritual well‐being and anticipatory grief between benefit finding and meaning in life of patients with advanced lung cancer: Empirical research quantitative
The chain mediating effect of spiritual well‐being and anticipatory grief between benefit finding and meaning in life of patients with advanced lung cancer: Empirical research quantitative Open
Aim This study aimed to explore the chain mediating effect of spiritual well‐being and anticipatory grief between benefit finding and meaning in life of patients with advanced lung cancer. Design This was a cross‐sectional study. Methods T…
View article: Correction to “De-Ammonium Ba<sub>0.18</sub>V<sub>2</sub>O<sub>4.95</sub>/NH<sub>4</sub>V<sub>4</sub>O<sub>10</sub> Film Electrodes as High-Performance Cathode Materials for Magnesium-Ion Batteries”
Correction to “De-Ammonium Ba<sub>0.18</sub>V<sub>2</sub>O<sub>4.95</sub>/NH<sub>4</sub>V<sub>4</sub>O<sub>10</sub> Film Electrodes as High-Performance Cathode Materials for Magnesium-Ion Batteries” Open
ADVERTISEMENT RETURN TO ARTICLES ASAPPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "De-Ammonium Ba0.18V2O4.95/NH4V4O10 Film Electrodes as High-Performance Cathode Materials for Magnesium-Ion Batteries"…
View article: The association of platelet to white blood cell ratio with diabetes: a nationwide survey in China
The association of platelet to white blood cell ratio with diabetes: a nationwide survey in China Open
Background Inflammation is integral to diabetes pathogenesis. The novel hematological inflammatory biomarker, platelet to white blood cell ratio (PWR), is linked with various conditions such as chronic kidney disease and stroke. However, t…
View article: A hybrid water quality prediction model based on variational mode decomposition and bidirectional gated recursive unit
A hybrid water quality prediction model based on variational mode decomposition and bidirectional gated recursive unit Open
Water quality predicted accuracy is beneficial to river ecological management and water pollution prevention. Owing to water quality data has the characteristics of nonlinearity and instability, it is difficult to predict the change of wat…
View article: An overview of mechanisms underlying the comorbidity of sleep and depression disorders in the elderly
An overview of mechanisms underlying the comorbidity of sleep and depression disorders in the elderly Open
Sleep disruption is common in older adults and has been linked to many negative health outcomes, including impaired cognitive, emotional, and interpersonal functioning and maladaptive metabolic changes. Sleep disturbance is the most common…
View article: AMH regulates ovarian granulosa cell growth in PCOS rats through SMAD4
AMH regulates ovarian granulosa cell growth in PCOS rats through SMAD4 Open
Background Polycystic Povary syndrome(PCOS) is a diverse condition with an unknown cause. Anti-Mullerian hormone(AMH) is a hormone that belongs to the transforming growth factor-β(TGF-β) class. Mothers against decapentaplegic homolog 4(SMA…
View article: Antiviral Effect of the Viroporin Inhibitors Against Taiwan Isolates of Infectious Bronchitis Virus (Ibv)
Antiviral Effect of the Viroporin Inhibitors Against Taiwan Isolates of Infectious Bronchitis Virus (Ibv) Open
View article: VGGish-based detection of biological sound components and their spatio-temporal variations in a subtropical forest in eastern China
VGGish-based detection of biological sound components and their spatio-temporal variations in a subtropical forest in eastern China Open
Passive acoustic monitoring technology is widely used to monitor the diversity of vocal animals, but the question of how to quickly extract effective sound patterns remains a challenge due to the difficulty of distinguishing biological sou…
View article: Microglia in the pathogenesis of depression, insomnia and their comorbidity
Microglia in the pathogenesis of depression, insomnia and their comorbidity Open
Microglia have been shown to regulate sleep homeostasis and depressive behavior. However, the mechanism of how microglia are involved in the pathogenesis of depression and insomnia is not well understood. Given the complex and interdepende…
View article: Activation of Epac in the BLA disrupts reconsolidation and attenuates heroin‐seeking behaviour
Activation of Epac in the BLA disrupts reconsolidation and attenuates heroin‐seeking behaviour Open
The susceptibility to drug cravings evoked by stimuli poses a formidable hurdle in the treatment of addiction and the prevention of relapse. Pharmacological interventions targeting drug‐associated memories hold promise for curbing relapse …
View article: Perioperative sleep disorders in gynaecological daycase surgery patients and analysis of risk factors: protocol for a cross-sectional study
Perioperative sleep disorders in gynaecological daycase surgery patients and analysis of risk factors: protocol for a cross-sectional study Open
Introduction Sleep disorders are clinical syndromes of disturbed sleep-wake rhythms and abnormal sleep quality. They have various causes, but their main manifestations are difficulty falling asleep, sleep disruption and daytime fatigue. Th…
View article: Salvianolic acid B exerts a protective effect against ZBP1-mediated PANoptosis in macrophages infected by Mycobacterium tuberculosis through its inhibition of the TNF- α/TNFR1 signaling pathway
Salvianolic acid B exerts a protective effect against ZBP1-mediated PANoptosis in macrophages infected by Mycobacterium tuberculosis through its inhibition of the TNF- α/TNFR1 signaling pathway Open
Tuberculosis (TB) is a deadly infectious disease caused by Mycobacterium tuberculosis (Mtb). The increasing rates of drug resistance in Mtb have made controlling TB more challenging, creating an urgent need for new treatment strategies. Th…
View article: Baicalein Suppresses NLRP3 and AIM2 Inflammasome-Mediated Pyroptosis in Macrophages Infected by Mycobacterium tuberculosis via Induced Autophagy
Baicalein Suppresses NLRP3 and AIM2 Inflammasome-Mediated Pyroptosis in Macrophages Infected by Mycobacterium tuberculosis via Induced Autophagy Open
Current strategies for treating drug-resistant tuberculosis have limited efficacy and undesirable side effects; hence, research on new treatments, including innovative medications, is required. Host-directed therapy (HDT) has emerged as a …
View article: Ursolic acid promotes autophagy by inhibiting Akt/mTOR and TNF-α/TNFR1 signaling pathways to alleviate pyroptosis and necroptosis in Mycobacterium tuberculosis-infected macrophages
Ursolic acid promotes autophagy by inhibiting Akt/mTOR and TNF-α/TNFR1 signaling pathways to alleviate pyroptosis and necroptosis in Mycobacterium tuberculosis-infected macrophages Open
As a lethal infectious disease, tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb). Its complex pathophysiological process limits the effectiveness of many clinical treatments. By regulating host cell death, Mtb manipulates ma…
View article: Comprehensive Characterization the Composition Differences of Essential Oils Prepared from Artemisiae Argyi in Different Picking Seasons by Gas Chromatography Orbitrap High-Resolution Mass Spectrometry
Comprehensive Characterization the Composition Differences of Essential Oils Prepared from Artemisiae Argyi in Different Picking Seasons by Gas Chromatography Orbitrap High-Resolution Mass Spectrometry Open
View article: Synthesis and Electrochemical Performance of V6O13 Nanosheets Film Cathodes for LIBs
Synthesis and Electrochemical Performance of V6O13 Nanosheets Film Cathodes for LIBs Open
V6O13 thin films were deposited on indium-doped tin oxide (ITO) conductive glass by a concise low-temperature liquid-phase deposition method and through heat treatment. The obtained films were directly used as electrodes without adding any…