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View article: Reconfigurable Magnetic Soft Microrobot for Acoustically Triggered Targeted Bacterial Sterilization
Reconfigurable Magnetic Soft Microrobot for Acoustically Triggered Targeted Bacterial Sterilization Open
Several nanomaterials have been proposed for antibacterial applications, offering promising strategies to combat infections as antibiotic resistance continues to rise due to widespread misuse. However, their clinical translation remains li…
View article: Engineering a streamlined virus-like particle for programmable tissue-specific gene delivery
Engineering a streamlined virus-like particle for programmable tissue-specific gene delivery Open
Transient gene delivery vehicles have emerged as crucial tools in biomedicine, among them, virus-like particles (VLPs) stand out for their unique characteristics, yet the limited tropisms hinder their widespread applications. VLPs have pot…
View article: Engineering single-AAV CRISPR-Cas13 RNA base editors for treatment of inherited retinal diseases
Engineering single-AAV CRISPR-Cas13 RNA base editors for treatment of inherited retinal diseases Open
Site-directed RNA editing, especially RNA base editing, allows for specific manipulation of RNA sequences, making it a useful approach for the correction of pathogenic mutations. Correction of RNA transcripts allows therapeutic gene editin…
View article: Removing GSM and 2-MIB from Actual Raw Water by Iron-Based Advanced Oxidation Technology
Removing GSM and 2-MIB from Actual Raw Water by Iron-Based Advanced Oxidation Technology Open
This study was aimed to apply iron-based advanced oxidation technology (Fe 2+ /H 2 O 2 ) to degrade typical odor substances (GSM and 2-MIB) in actual raw water. The reaction conditions such as initial pH, reaction time, molar ratio of Fe 2…
View article: Topological model for $q$-deformed rational numbers and categorification
Topological model for $q$-deformed rational numbers and categorification Open
Let \mathbf{D}_{3} be a bigraded 3-decorated disk with an arc system \mathbf{A} . We associate a bigraded simple closed arc \hat{\eta}_{r/s} on \mathbf{D}_{3} to any rational number {r}/{s}\in\overline{\mathbb{Q}}=\mathbb{Q}\cup\{\infty\} …
View article: Analysis and Suggestion on the Abnormal Concentrations in Influent of a Wastewater Treatment Plant (WWTP) in the South
Analysis and Suggestion on the Abnormal Concentrations in Influent of a Wastewater Treatment Plant (WWTP) in the South Open
To address the issue of abnormal influent concentration at a wastewater treatment plant in the southern region, this study established 4 key monitoring points along the influent pipeline network. Over a specific period, 12 water quality mo…
View article: Post-genomic era of CRISPR/Cas technology in ornamental plants: advantages, limitations, and prospects
Post-genomic era of CRISPR/Cas technology in ornamental plants: advantages, limitations, and prospects Open
The global ornamental plant industry is still booming, and the demand for new combinations of plant quality, resistance, and germplasm resources is increasing. Traditional hybridization, mutagenesis, and mutation breeding strategies have m…
View article: A fluidic device for continuous on-line inductive sensing of proteolytic cleavages
A fluidic device for continuous on-line inductive sensing of proteolytic cleavages Open
We describe a biosensor for proteolytic cleavage combining tailored fluidic chips with a pulsed-field magnetometer integrated into printed circuit boards.
View article: From Flourish to Nourish: Cultivating Soil Health for Sustainable Floriculture
From Flourish to Nourish: Cultivating Soil Health for Sustainable Floriculture Open
Despite its rapid growth and economic success, the sustainability of the floriculture industry as it is presently conducted is debatable, due to the huge environmental impacts it initiates and incurs. Achieving sustainability requires join…
View article: Directed cardiomyocte generation from human pluripotent stem cells using a chemically defined protocol (GiWi2) v1
Directed cardiomyocte generation from human pluripotent stem cells using a chemically defined protocol (GiWi2) v1 Open
The GSK3 inhibitor and Wnt inhibitor, named GiWi2, are utilized for robust differentiation of human pluripotent stem cells (hPSCs) into cardiomyocytes under serum-free and growth factor-free conditions. This differentiation protocol, devel…
View article: Deep-learning–assisted Sort-Seq enables high-throughput profiling of gene expression characteristics with high precision
Deep-learning–assisted Sort-Seq enables high-throughput profiling of gene expression characteristics with high precision Open
Owing to the nondeterministic and nonlinear nature of gene expression, the steady-state intracellular protein abundance of a clonal population forms a distribution. The characteristics of this distribution, including expression strength an…
View article: Studies of the pollen characteristics and the taxonomic significance of <i>Impatiens</i> from the Yunnan–Guizhou Plateau
Studies of the pollen characteristics and the taxonomic significance of <i>Impatiens</i> from the Yunnan–Guizhou Plateau Open
Impatiens is rich in germplasm resources, with more than 260 species in China. A study on the pollen micromorphology of Impatiens by scanning electron microscopy (SEM) showed that the pollen characteristics were richly diverse, and there w…
View article: Structure and engineering of miniature<i>Acidibacillus sulfuroxidans</i>Cas12f1
Structure and engineering of miniature<i>Acidibacillus sulfuroxidans</i>Cas12f1 Open
The miniature CRISPR-Cas12f nucleases allow for efficient delivery via cargo-size-limited adeno-associated virus delivery vehicles, thereby showing promising potential for in vivo therapeutic applications. Acidibacillus sulfuroxidans Cas12…
View article: Magneto-engineering towards high thermoelectric performance in topological insulator Bi88Sb12
Magneto-engineering towards high thermoelectric performance in topological insulator Bi88Sb12 Open
High thermoelectric performance is generally achieved by synergistically optimizing two or even three of the contradictorily coupled thermoelectric parameters. Here, we demonstrate magneto-engineering as a strategy to achieve simultaneous …
View article: Creating novel ornamentals via new strategies in the era of genome editing
Creating novel ornamentals via new strategies in the era of genome editing Open
Ornamental breeding has traditionally focused on improving novelty, yield, quality, and resistance to biotic or abiotic stress. However, achieving these goals has often required laborious crossbreeding, while precise breeding techniques ha…
View article: Magnetically Controlled Cyclic Microscale Deformation of<i>In Vitro</i>Cancer Invasion Models
Magnetically Controlled Cyclic Microscale Deformation of<i>In Vitro</i>Cancer Invasion Models Open
Mechanical cues play an important role in the metastatic cascade of cancer. Three-dimensional (3D) tissue matrices with tunable stiffness have been extensively used as model systems of the tumor microenvironment for physiologically relevan…
View article: Ectopic Expression of PgF3′5′H in Commercial Gypsophila paniculata Cultivar through Optimized Agrobacterium-Mediated Transformation
Ectopic Expression of PgF3′5′H in Commercial Gypsophila paniculata Cultivar through Optimized Agrobacterium-Mediated Transformation Open
Gypsophila paniculata is one of the most popular cut flowers in the world whose major cultivars are blooming white. As is well known, blue flowers could be generated via the overexpression of the gene encoding flavonoid 3′5′-hydroxylase (F…
View article: Xanthohumol alleviates oxidative stress and impaired autophagy in experimental severe acute pancreatitis through inhibition of AKT/mTOR
Xanthohumol alleviates oxidative stress and impaired autophagy in experimental severe acute pancreatitis through inhibition of AKT/mTOR Open
Severe acute pancreatitis (SAP) is a lethal gastrointestinal disorder, yet no specific and effective treatment is available. Its pathogenesis involves inflammatory cascade, oxidative stress, and autophagy dysfunction. Xanthohumol (Xn) disp…
View article: Magnetically controlled cyclic microscale deformation of <i>in vitro</i> cancer invasion models
Magnetically controlled cyclic microscale deformation of <i>in vitro</i> cancer invasion models Open
Effects of magnetically controlled cyclic deformation on cancer cell invasion.
View article: Deep-learning-assisted Sort-Seq enables high-throughput profiling of gene expression characteristics with high precision
Deep-learning-assisted Sort-Seq enables high-throughput profiling of gene expression characteristics with high precision Open
As an essential physiological process, gene expression determines the function of each cell. However, owing to the complex nondeterministic and nonlinear nature of gene expression, the steady-state intracellular protein abundance of a clon…
View article: Guide RNA engineering enables efficient CRISPR editing with a miniature Syntrophomonas palmitatica Cas12f1 nuclease
Guide RNA engineering enables efficient CRISPR editing with a miniature Syntrophomonas palmitatica Cas12f1 nuclease Open
Gene therapy is limited by inefficient delivery of large clustered regularly interspaced short palindromic repeat (CRISPR) effectors, such as Cas9 and Cas12a nucleases. Cas12f nucleases are currently one of the most compact CRISPR genome e…
View article: Highly Sensitive Detection Method for HV69-70del in SARS-CoV-2 Alpha and Omicron Variants Based on CRISPR/Cas13a
Highly Sensitive Detection Method for HV69-70del in SARS-CoV-2 Alpha and Omicron Variants Based on CRISPR/Cas13a Open
As SARS-CoV-2 variants continue to evolve, identifying variants with adaptive diagnostic tool is critical to containing the ongoing COVID-19 pandemic. Herein, we establish a highly sensitive and portable on-site detection method for the HV…
View article: Gymnopus wutaishanensis (Omphalotaceae, Agaricales) a new species from North China
Gymnopus wutaishanensis (Omphalotaceae, Agaricales) a new species from North China Open
This dataset contains the digitized treatments in Plazi based on the original journal article Mao, Ning, Liu, Hong, Fan, Li (2022): Gymnopus wutaishanensis (Omphalotaceae, Agaricales) a new species from North China. Phytotaxa 556 (1): 63-7…
View article: Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials
Traditional Chinese medicine Lianhua Qingwen for treating COVID-19: A protocol for a meta-analysis and systematic review of randomized controlled trials Open
Review question / Objective: We aim to conduct a systematic review and metaanalysis of randomised controlled trials (RCTs) to evaluate the efficacy of LHQW in patients with COVID-19.Condition being studied: COVID-19.METHODS Participant or …