Fangping Li
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View article: DeepPGDB: A novel paradigm for AI-guided interactive plant genomic database
DeepPGDB: A novel paradigm for AI-guided interactive plant genomic database Open
View article: GL6.1 integrates grain length regulation and disease resistance via OsWRKY53-mediated signaling in rice
GL6.1 integrates grain length regulation and disease resistance via OsWRKY53-mediated signaling in rice Open
View article: Association between vitamin D serum levels and thyroid cancer: a meta-analysis
Association between vitamin D serum levels and thyroid cancer: a meta-analysis Open
Background Thyroid cancer (TC) has shown a rising prevalence worldwide. While numerous studies have explored the relationship between vitamin D levels and TC risk, their conclusions remain inconsistent. Objective This meta-analysis aims to…
View article: Challenges in Bringing Pangenome Research into Breeding: A Case Study in Rice
Challenges in Bringing Pangenome Research into Breeding: A Case Study in Rice Open
Crop breeding has entered the pangenomics era, unlocking a far more comprehensive view of genetic diversity than a single reference genome can capture. In rice (Oryza sativa), a staple crop critical to global food security, the constructio…
View article: DeepPGDB: A Novel Paradigm for AI-Guided Interactive Plant Genomic Database
DeepPGDB: A Novel Paradigm for AI-Guided Interactive Plant Genomic Database Open
DeepPGDB ( https://www.deeppgdb.chat ) is the first AI-driven plant genomics database designed to lower technical barriers in multi-omics research by enabling natural language-based data access and analysis. Integrating over 50 high-qualit…
View article: Spontaneous brain activity in patients with type 2 diabetes: linking serum neuroproteins to cognitive ability
Spontaneous brain activity in patients with type 2 diabetes: linking serum neuroproteins to cognitive ability Open
Type 2 diabetic patients with MCI exhibit specific serum neuroprotein and functional MRI characteristics. The relationships between these neuroproteins and cognitive ability were mediated by spontaneous brain activities.
View article: Simplified 3D genome and gap-less CC group Oryza genome reveal genetic dynamics of rice triploid lines from distant hybridization
Simplified 3D genome and gap-less CC group Oryza genome reveal genetic dynamics of rice triploid lines from distant hybridization Open
Intergeneric hybridization and domestication breeding is an efficient means for utilizing wild rice germplasm resources. In this study, we constructed gap-less genome assemblies for two CC, two BBCC and one CCDD wild rices to explore the r…
View article: Genome assembly and multi-omics analyses of Isodon lophanthodies provide insights into the distribution of medicinal metabolites induced by exogenous methyl jasmonate
Genome assembly and multi-omics analyses of Isodon lophanthodies provide insights into the distribution of medicinal metabolites induced by exogenous methyl jasmonate Open
This genome assembly provides an essential reference for future research on I. lophanthodies, and enhances our understanding of salicin synthesis and medicinal metabolite profiles in response to exogenous methyl jasmonate.
View article: <i>OsSPL5</i> promotes rice outcrossing efficiency by G‐protein pathway
<i>OsSPL5</i> promotes rice outcrossing efficiency by G‐protein pathway Open
View article: Ferroptosis-related biomarkers for adamantinomatous craniopharyngioma treatment: conclusions from machine learning techniques
Ferroptosis-related biomarkers for adamantinomatous craniopharyngioma treatment: conclusions from machine learning techniques Open
Introduction Adamantinomatous craniopharyngioma (ACP) is difficult to cure completely and prone to recurrence after surgery. Ferroptosis as an iron-dependent programmed cell death, may be a critical process in ACP. The study aimed to scree…
View article: Intense simplified strategy for newly diagnosed type 2 diabetes in patients with severe hyperglycaemia: multicentre, open label, randomised trial
Intense simplified strategy for newly diagnosed type 2 diabetes in patients with severe hyperglycaemia: multicentre, open label, randomised trial Open
Objective To evaluate whether the intense simplified strategy, which comprises short term intensive insulin therapy (SIIT) followed by subsequent oral antihyperglycaemic regimens, could improve long term glycaemic outcomes in patients with…
View article: Gonadal hormones and metabolic syndrome in middle-aged and elderly males: results from a prospective cohort study in China
Gonadal hormones and metabolic syndrome in middle-aged and elderly males: results from a prospective cohort study in China Open
Background Research has shown that gonadal hormones are involved in metabolic pathways relevant to metabolic syndrome (MetS). Nevertheless, no longitudinal study has been conducted on the association between SHBG and MetS in Chinese. The o…
View article: Application and design considerations of ROS-based nanomaterials in diabetic kidney disease
Application and design considerations of ROS-based nanomaterials in diabetic kidney disease Open
Diabetic nephropathy (DKD) is a common chronic complication of diabetes mellitus and an important cause of cardiovascular-related death. Oxidative stress is a key mechanism leading to diabetic nephropathy. However, the current main therape…
View article: Efficient targeted mutagenesis in tetraploid <i>Pogostemon cablin</i> by the CRISPR/Cas9-mediated genomic editing system
Efficient targeted mutagenesis in tetraploid <i>Pogostemon cablin</i> by the CRISPR/Cas9-mediated genomic editing system Open
View article: T2T genome for Andrographis paniculata
T2T genome for Andrographis paniculata Open
T2T genome for Andrographis paniculata
View article: Early Oral Antihyperglycemic Regimens after Short-Term Intensive Insulin Therapy Significantly Improve Glycemic Control in Newly Diagnosed Type 2 Diabetes Patients with Severe Hyperglycemia - A Multi-Center, Open-Label, Randomized Trial
Early Oral Antihyperglycemic Regimens after Short-Term Intensive Insulin Therapy Significantly Improve Glycemic Control in Newly Diagnosed Type 2 Diabetes Patients with Severe Hyperglycemia - A Multi-Center, Open-Label, Randomized Trial Open
View article: Bone-targeting engineered milk-derived extracellular vesicles for MRI-assisted therapy of osteoporosis
Bone-targeting engineered milk-derived extracellular vesicles for MRI-assisted therapy of osteoporosis Open
The imbalance between osteoblasts and osteoclasts is the cause of osteoporosis. Milk-derived extracellular vesicles (mEVs), excellent drug delivery nanocarriers, can promote bone formation and inhibit bone resorption. In this study, we con…
View article: Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto’s thyroiditis: A systematic review and meta-analysis
Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto’s thyroiditis: A systematic review and meta-analysis Open
Background: Hashimoto’s thyroiditis (HT) is the prevailing form of autoimmune thyroiditis and the leading cause of hypothyroidism in iodine-sufficient regions worldwide. This study aims to evaluate the efficacy of vitamin D supplementation…
View article: Polyploid Genome Assembly Provides Insights into Morphological Development and Ascorbic Acid Accumulation of Sauropus androgynus
Polyploid Genome Assembly Provides Insights into Morphological Development and Ascorbic Acid Accumulation of Sauropus androgynus Open
Sauropus androgynus (S. androgynus) (2n = 4x = 52) is one of the most popular functional leafy vegetables in South and Southeast Asia. With its rich nutritional and pharmaceutical values, it has traditionally had widespread use for dietary…
View article: AI algorithms for accurate prediction of osteoporotic fractures in patients with diabetes: an up-to-date review
AI algorithms for accurate prediction of osteoporotic fractures in patients with diabetes: an up-to-date review Open
Osteoporotic fractures impose a substantial burden on patients with diabetes due to their unique characteristics in bone metabolism, limiting the efficacy of conventional fracture prediction tools. Artificial intelligence (AI) algorithms h…
View article: Unravelling inversions: Technological advances, challenges, and potential impact on crop breeding
Unravelling inversions: Technological advances, challenges, and potential impact on crop breeding Open
Summary Inversions, a type of chromosomal structural variation, significantly influence plant adaptation and gene functions by impacting gene expression and recombination rates. However, compared with other structural variations, their rol…
View article: Elastin-Derived VGVAPG Fragment Decorated Cell-Penetrating Peptide with Improved Gene Delivery Efficacy
Elastin-Derived VGVAPG Fragment Decorated Cell-Penetrating Peptide with Improved Gene Delivery Efficacy Open
Cell-penetrating peptides (CPPs) are attractive non-viral gene delivery vectors due to their high transfection capacity and safety. Previously, we have shown that cell-penetrating peptide RALA can be a promising gene delivery vector for ch…
View article: BMAL1 collaborates with CLOCK to directly promote DNA double-strand break repair and tumor chemoresistance
BMAL1 collaborates with CLOCK to directly promote DNA double-strand break repair and tumor chemoresistance Open
View article: Visualization and review of reads alignment on the graphical pan-genome with VAG
Visualization and review of reads alignment on the graphical pan-genome with VAG Open
Recent advances in pangenomics have led to the rapid development of graph-based pangenomes that code genetic variant as nodes and edges preserve the contiguity of the sequence and structural variation between individuals. Data visualizatio…
View article: Gap-free genome assembly and comparative analysis reveal the evolution and anthocyanin accumulation mechanism of <i>Rhodomyrtus tomentosa</i>
Gap-free genome assembly and comparative analysis reveal the evolution and anthocyanin accumulation mechanism of <i>Rhodomyrtus tomentosa</i> Open
Rhodomyrtus tomentosa is an important fleshy-fruited tree and a well-known medicinal plant of the Myrtaceae family that is widely cultivated in tropical and subtropical areas of the world. However, studies on the evolution and genomic bree…
View article: Association of Body Fat Distribution and Risk of Breast Cancer in Pre- and Postmenopausal Women
Association of Body Fat Distribution and Risk of Breast Cancer in Pre- and Postmenopausal Women Open
Introduction: Obesity is a risk factor for both the development of and mortality from breast cancer in postmenopausal but not in premenopausal women. However, which part of the fat mass is associated with risk remains unclear, and whether …
View article: Chromosome‐level genome assembly and functional characterization of terpene synthases provide insights into the volatile terpenoid biosynthesis of <i>Wurfbainia villosa</i>
Chromosome‐level genome assembly and functional characterization of terpene synthases provide insights into the volatile terpenoid biosynthesis of <i>Wurfbainia villosa</i> Open
SUMMARY Wurfbainia villosa is a well‐known medicinal and edible plant that is widely cultivated in the Lingnan region of China. Its dried fruits (called Fructus Amomi ) are broadly used in traditional Chinese medicine for curing gastrointe…
View article: Gitelman syndrome diagnosed in the first trimester of pregnancy: a case report and literature review
Gitelman syndrome diagnosed in the first trimester of pregnancy: a case report and literature review Open
Objectives Gitelman syndrome is a rare salt-losing tubulopathy caused by inactivating mutations in the SLC12A3 gene, which is expressed in the distal convoluted tubule and accounts for 5–10% of renal sodium reabsorption. Atypical symptoms …
View article: Clinical and Genetic Analysis of a Patient With Coexisting 17a-Hydroxylase/17,20-Lyase Deficiency and Moyamoya Disease
Clinical and Genetic Analysis of a Patient With Coexisting 17a-Hydroxylase/17,20-Lyase Deficiency and Moyamoya Disease Open
17a-Hydroxylase/17,20-lyase deficiency (17OHD) is caused by pathogenic mutations in CYP17A1 . Female patients present with hypertension, hypokalemia, and sexual infantilism while males present with sex development disorder. Moyamoya diseas…
View article: Investigation of the Educational Practice of Normal College Students Based on the “Double Tutor System”
Investigation of the Educational Practice of Normal College Students Based on the “Double Tutor System” Open
In order to improve the training effectiveness of normal students, Xiangnan University actively explored the “double tutor” mode of joint training of normal students by college teachers and primary and secondary school teachers, providing …