Fangqin Fu
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View article: Engineering Artificial Mitochondria with Self‐Amplifying Proton Generation for Autonomous Energy Supply and Metabolic Coupling in Artificial Cells
Engineering Artificial Mitochondria with Self‐Amplifying Proton Generation for Autonomous Energy Supply and Metabolic Coupling in Artificial Cells Open
A continuous and autonomous energy supply is essential for sustaining life‐like biochemical processes in artificial cells. Although considerable efforts have been devoted to engineering artificial organelles that emulate mitochondrial ener…
View article: Physiological pH Transition‐Driven Protein Corona Dynamics Regulate Cellular Uptake and Inflammatory Responses of Silica Nanoparticles
Physiological pH Transition‐Driven Protein Corona Dynamics Regulate Cellular Uptake and Inflammatory Responses of Silica Nanoparticles Open
Protein corona alters the biological identities and interactions of nanoparticles with cells, needing to be thoroughly scrutinized before in vivo applications. Importantly, protein corona is evolving as nanoparticles cross different microe…
View article: <i>In Situ</i> Measurement of Nanoparticle–Blood Protein Adsorption and Its Heterogeneity with Single-Nanoparticle Resolution via Dual Fluorescence Quantification
<i>In Situ</i> Measurement of Nanoparticle–Blood Protein Adsorption and Its Heterogeneity with Single-Nanoparticle Resolution via Dual Fluorescence Quantification Open
The formation of a protein corona gives nanomedicines a distinct biological identity, profoundly influencing their fate in the body. Nonspecific nanoparticle-protein interactions are typically highly heterogeneous, which can lead to unique…
View article: <i>In situ</i> characterization techniques of protein corona around nanomaterials
<i>In situ</i> characterization techniques of protein corona around nanomaterials Open
We discuss here the in situ characterization methods for unraveling nanoparticle–protein interactions, highlighting the challenges of in situ protein corona characterization and its significance for nanomedicine development and clinical tr…
View article: Lyotropic Liquid Crystal Precursor as an Innovative Herpes Simplex Virus Vector for Melanoma Therapy
Lyotropic Liquid Crystal Precursor as an Innovative Herpes Simplex Virus Vector for Melanoma Therapy Open
To overcome the low-efficiency toxic side effects and high recurrence of traditional therapy for malignant melanoma, an in situ gel system, HSV-LLCP, was developed as a local treatment for malignant melanoma in this study. This system was …